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Q96VT7

- DAPB_ASPNG

UniProt

Q96VT7 - DAPB_ASPNG

Protein

Dipeptidyl-aminopeptidase B

Gene

dapB

Organism
Aspergillus niger
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.1 Publication

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei739 – 7391Charge relay systemBy similarity
    Active sitei816 – 8161Charge relay systemBy similarity
    Active sitei849 – 8491Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Enzyme and pathway databases

    BRENDAi3.4.14.5. 277.

    Protein family/group databases

    MEROPSiS09.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:dapB
    OrganismiAspergillus niger
    Taxonomic identifieri5061 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

    Subcellular locationi

    Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 901901Dipeptidyl-aminopeptidase BPRO_0000412137Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi334 – 3341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi625 – 6251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi793 – 7931N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ96VT7.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 7676CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini98 – 901804VacuolarSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei77 – 9721Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1506.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q96VT7-1 [UniParc]FASTAAdd to Basket

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    MSSPRPSTSS TSSDSGLSVD TTAYPEESKY TSTAPGAGGL SDENRYRDVE    50
    EGEAGADEPF LPSAKKQAAS GSRTSRLIWG LVILCVAGWL WGLVLFVTQN 100
    RSAQQSVSEA LQSHESGAIS GSSSSGKPVT LEQVLTGQWL PRSHAVSWIA 150
    GPNGEDGLLV EQGEDQGKGY LRVDDIRSRK GDATSQESRV LMEKAIVQVD 200
    GRTIFPVSTW PSPNLNKVLL LSEREKNWRH SFTGKYWIFD VATQTAQPLD 250
    PSNPDGRVQL AIWSPTSDMV AFVRDNNLYL RRLSSKEVVP ITKDGGADLF 300
    YGIPDWVYEE EVFSGNSVTW WSGDGKYVAF LRTNETAVPE FPVQYYLSRP 350
    SGKRPPPGLE DYPEVREIKY PKAGAPNPVV SLQFYDVEKQ EVFSIEAPDD 400
    FEDDDRIVIE IVWGTEGKIL VRATNRESDV LKVFLFDTKA RTSKLVRTEN 450
    VADIDGGWVE PTQYTWFIPA DPSNGRPHDG YLDTVIHEGY EHLGYFTPLD 500
    NSEPILLTQG EWEVVDAPTA VDLRKGIVYF ISTKESPTER HLYQVNLDGS 550
    NLKPLTDTSK PGYYDVSFSH GTGYALLSYR GPSIPWQAIV NTETDELKYE 600
    ETIEDNAGLA RMVDSYALPT EIYQNVTIDG FTLQVVERRP PHFNPAKKYP 650
    VLFYLYNGPR SQTVDRKFSI DFQSYVASSL GYIVVTVDGR GTGFSGRKTR 700
    CIVRGNLGYY EAYDQITTAN LWGEKPYVDE TRMSIWGWSY GGFMTLKTLE 750
    QDAGQTFQYG MAVAPVTDWR HYDSIYTERY MHTPAHNPNG YDNTSITDMT 800
    ALQQTVRFLV IHGASDDNVH IQNTLVLVDK LDLAGVQNYD LHFYPDSDHS 850
    INFHNAHRMV YERLSSWLVN AFNDEWHRIA DPVPDDSMWE KVKRSLPMLV 900
    N 901
    Length:901
    Mass (Da):101,256
    Last modified:December 1, 2001 - v1
    Checksum:i3A519512C903D784
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ278532 Genomic DNA. Translation: CAC41019.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ278532 Genomic DNA. Translation: CAC41019.1 .

    3D structure databases

    ProteinModelPortali Q96VT7.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S09.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG1506.

    Enzyme and pathway databases

    BRENDAi 3.4.14.5. 277.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterisation of the Aspergillus niger dapB gene, which encodes a novel fungal type IV dipeptidyl aminopeptidase."
      Jalving R., Godefrooij J., Veen W.J., van Ooyen A.J., Schaap P.J.
      Mol. Genet. Genomics 273:319-325(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
      Strain: ATCC 9029 / NRRL 3 / CBS 120.49 / DSM 2466 / N400.

    Entry informationi

    Entry nameiDAPB_ASPNG
    AccessioniPrimary (citable) accession number: Q96VT7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3