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Protein

Serine/threonine-protein kinase bur1

Gene

ptkA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei54ATPPROSITE-ProRule annotation1
Active sitei155Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi31 – 39ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase bur1 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
PITALRE-like kinase A
Gene namesi
Name:ptkA
Synonyms:bur1
ORF Names:AN8865
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000000560 Componenti: Chromosome III
  • UP000005890 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000856821 – 544Serine/threonine-protein kinase bur1Add BLAST544

Interactioni

Protein-protein interaction databases

STRINGi162425.CADANIAP00006183

Structurei

3D structure databases

ProteinModelPortaliQ96VK3
SMRiQ96VK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 326Protein kinasePROSITE-ProRule annotationAdd BLAST302

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000233024
InParanoidiQ96VK3
KOiK15562
OMAiIWDLMGS
OrthoDBiEOG092C2FL8

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q96VK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIASLERDT KGGTRFTGCT SIREFEFLGK LGEGTFGEVY KARAKRDGSI
60 70 80 90 100
VALKKILMHN ERDGFPITAL REIKLLKMLS HTNIMQLREM AVERSKGEGR
110 120 130 140 150
KKPSMYMVFP YMEHDLSGLL ENPEVHFSEA QIKCYMIQLL EGLKYLHGNC
160 170 180 190 200
ILHRDMKAAN LLISNQGILQ IADFGLARPF DEAPPQPGKG AGEAKRDYTT
210 220 230 240 250
LVVTRWYRPP ELLLQLRRYT SAIDMWGVGC VFGEMFKGKP ILAGNSDLNQ
260 270 280 290 300
AQLIFSLVGT PTEENMPGWS SLPGCEGVKH FGNRPGNLAE VFKDQGPMAI
310 320 330 340 350
SLLTELLKLD WRKRVNAIDA LKHPYFSTPP LPARPGDLPS FEDSHELDRR
360 370 380 390 400
RFRGQRAAMP PAPAGGSVGM SRNGGWSTNS GSRTGAETRN PRISSAARSQ
410 420 430 440 450
GNQLRDAWSN EPQQAWQRRG NEELKDPNHS FSSRHRDGGL PPKPPAPIQH
460 470 480 490 500
SWASGHSDKT GRDRGYGARY GGPEGSVDSY VPNYGGSDRN RDRDQGTAIS
510 520 530 540
DRRGSYYDKS HQTSKLDYSR EIPSRRRSRS PNYRERVDRG PYRR
Length:544
Mass (Da):60,960
Last modified:December 1, 2001 - v1
Checksum:i4AAB67606F9784E7
GO

Sequence cautioni

The sequence EAA60153 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ313310 mRNA Translation: CAC42219.1
AACD01000163 Genomic DNA Translation: EAA60153.1 Sequence problems.
BN001303 Genomic DNA Translation: CBF77846.1
RefSeqiXP_682134.1, XM_677042.1

Genome annotation databases

EnsemblFungiiCADANIAT00006183; CADANIAP00006183; CADANIAG00006183
EAA60153; EAA60153; AN8865.2
GeneIDi2868366
KEGGiani:AN8865.2

Similar proteinsi

Entry informationi

Entry nameiBUR1_EMENI
AccessioniPrimary (citable) accession number: Q96VK3
Secondary accession number(s): C8V9B2, Q5AS65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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