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Q96VK3 (BUR1_EMENI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase bur1

EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
PITALRE-like kinase A
Gene names
Name:ptkA
Synonyms:bur1
ORF Names:AN8865
OrganismEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) [Reference proteome]
Taxonomic identifier227321 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length544 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence caution

The sequence EAA60153.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 544544Serine/threonine-protein kinase bur1
PRO_0000085682

Regions

Domain25 – 326302Protein kinase
Nucleotide binding31 – 399ATP By similarity

Sites

Active site1551Proton acceptor By similarity
Binding site541ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q96VK3 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 4AAB67606F9784E7

FASTA54460,960
        10         20         30         40         50         60 
MGIASLERDT KGGTRFTGCT SIREFEFLGK LGEGTFGEVY KARAKRDGSI VALKKILMHN 

        70         80         90        100        110        120 
ERDGFPITAL REIKLLKMLS HTNIMQLREM AVERSKGEGR KKPSMYMVFP YMEHDLSGLL 

       130        140        150        160        170        180 
ENPEVHFSEA QIKCYMIQLL EGLKYLHGNC ILHRDMKAAN LLISNQGILQ IADFGLARPF 

       190        200        210        220        230        240 
DEAPPQPGKG AGEAKRDYTT LVVTRWYRPP ELLLQLRRYT SAIDMWGVGC VFGEMFKGKP 

       250        260        270        280        290        300 
ILAGNSDLNQ AQLIFSLVGT PTEENMPGWS SLPGCEGVKH FGNRPGNLAE VFKDQGPMAI 

       310        320        330        340        350        360 
SLLTELLKLD WRKRVNAIDA LKHPYFSTPP LPARPGDLPS FEDSHELDRR RFRGQRAAMP 

       370        380        390        400        410        420 
PAPAGGSVGM SRNGGWSTNS GSRTGAETRN PRISSAARSQ GNQLRDAWSN EPQQAWQRRG 

       430        440        450        460        470        480 
NEELKDPNHS FSSRHRDGGL PPKPPAPIQH SWASGHSDKT GRDRGYGARY GGPEGSVDSY 

       490        500        510        520        530        540 
VPNYGGSDRN RDRDQGTAIS DRRGSYYDKS HQTSKLDYSR EIPSRRRSRS PNYRERVDRG 


PYRR 

« Hide

References

« Hide 'large scale' references
[1]"ptkA, a putative PITALRE like kinase of Aspergillus nidulans."
Schier N., Fischer R.
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: SRF200.
[2]"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae."
Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H. expand/collapse author list , Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.
Nature 438:1105-1115(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
[3]"The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G. expand/collapse author list , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ313310 mRNA. Translation: CAC42219.1.
AACD01000163 Genomic DNA. Translation: EAA60153.1. Sequence problems.
BN001303 Genomic DNA. Translation: CBF77846.1.
RefSeqXP_682134.1. XM_677042.1.

3D structure databases

ProteinModelPortalQ96VK3.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADANIAT00006183; CADANIAP00006183; CADANIAG00006183.
GeneID2868366.
KEGGani:AN8865.2.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000233024.
KOK15562.
OMADRRKFHD.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBUR1_EMENI
AccessionPrimary (citable) accession number: Q96VK3
Secondary accession number(s): C8V9B2, Q5AS65
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families