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Protein

NADP-specific glutamate dehydrogenase

Gene

GDH2

Organism
Gibberella fujikuroi (Bakanae and foot rot disease fungus) (Fusarium fujikuroi)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei114 – 1141PROSITE-ProRule annotation

GO - Molecular functioni

  1. glutamate dehydrogenase (NADP+) activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular amino acid metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-specific glutamate dehydrogenase (EC:1.4.1.4)
Short name:
NADP-GDH
Alternative name(s):
NADP-dependent glutamate dehydrogenase
Gene namesi
Name:GDH2
OrganismiGibberella fujikuroi (Bakanae and foot rot disease fungus) (Fusarium fujikuroi)
Taxonomic identifieri5127 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesNectriaceaeFusariumFusarium fujikuroi species complex

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 451451NADP-specific glutamate dehydrogenasePRO_0000182787Add
BLAST

Proteomic databases

PRIDEiQ96VJ7.

Interactioni

Subunit structurei

Homohexamer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ96VJ7.
SMRiQ96VJ7. Positions 4-450.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96VJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHLPQEPEF EQAYGELASA LENSSLFNEH PEYRTALAVA AIPERVIQFR
60 70 80 90 100
VVWNDDKGNL QVNRGYRVQF NGALGPYKGG LRFHPSVNLS ILKFLGFEQI
110 120 130 140 150
FKNALTGLNM GGGKGGADFD PKGKSDAEIR RFCQAFMTEL SKHIGAETDV
160 170 180 190 200
PAGDIGVGGR EIGYLFGAYR KFANRWEGVL TGKGLSWGGS LIRPEATGYG
210 220 230 240 250
LVYYVEYMLK HANRGTFEGK RVALSGSGNV AQYAALKIIE LGGSVVSLSD
260 270 280 290 300
SKGALVAKEG SSFTPEQIHN IAALKIKHQA LTTFEHDGQF TWIEGARPWV
310 320 330 340 350
HVGKVDIALP SATQNEVSKE EAQALVDAGA FIVAEGSNMG CTAEAIDVFE
360 370 380 390 400
AHRKEKGAEA LWYAPGKASN CGGVAVSGLE MAQNSQRIQW TEKEVDDRLK
410 420 430 440 450
AIMKDAFVAG LETAQKYVEA KEGELPSLIA GSNIAGFIKV AEAMHDQGDW

F
Length:451
Mass (Da):48,826
Last modified:November 30, 2001 - v1
Checksum:i171867950A9B8E85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ315471 Genomic DNA. Translation: CAC45043.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ315471 Genomic DNA. Translation: CAC45043.1.

3D structure databases

ProteinModelPortaliQ96VJ7.
SMRiQ96VJ7. Positions 4-450.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ96VJ7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of the NADP-depending glutamate dehydrogenase gene from Gibberella fujikuroi."
    Tudzynski B.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: m567.

Entry informationi

Entry nameiDHE4_GIBFU
AccessioniPrimary (citable) accession number: Q96VJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2004
Last sequence update: November 30, 2001
Last modified: September 30, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.