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Q96VH5

- MOS1_YEAST

UniProt

Q96VH5 - MOS1_YEAST

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Protein
Mitochondrial organizing structure protein 1
Gene
MOS1, MIO10, YCL057C-A
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

As a component of the mitochondrial inner membrane organizing system (MINOS/MitOS) complex, important for normal mitochondrial morphology.3 Publications

GO - Biological processi

  1. cristae formation Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-29419-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial organizing structure protein 1
Short name:
MitOS1
Alternative name(s):
Mitochondrial inner membrane organization component of 10 kDa
Gene namesi
Name:MOS1
Synonyms:MIO10
Ordered Locus Names:YCL057C-A
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome III

Organism-specific databases

CYGDiYCL057c-a.
SGDiS000007547. MOS1.

Subcellular locationi

Mitochondrion inner membrane; Single-pass membrane protein
Note: The C-terminus is located in the intermembrane space, while the location of the N-terminus has not been determined yet. As some programs predict the presence of 2 closely apposed membrane domains, it has been proposed that the protein may cross the membrane twice and that both termini may face the intermembrane space (1 Publication).3 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5823Helical; Reviewed prediction
Add
BLAST
Topological domaini59 – 9739Mitochondrial intermembrane Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. MICOS complex Source: SGD
  2. mitochondrial crista junction Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Partially altered shape of the mitochondrial network with condensed, fragmented mitochondria accumulating at the periphery of cells. 60-70% of mitochondria exhibit an increased inner membrane surface and stacks of lamellar cristae disconnected from the inner boundary membrane.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9797Mitochondrial organizing structure protein 1
PRO_0000221640Add
BLAST

Proteomic databases

MaxQBiQ96VH5.
PaxDbiQ96VH5.

Expressioni

Gene expression databases

GenevestigatoriQ96VH5.

Interactioni

Subunit structurei

Core component of the MINOS/MitOS complex, that includes FCJ1, AIM5, AIM13, AIM37, MOS1 and MOS2. Interacts with OM45 and POR1.3 Publications

Protein-protein interaction databases

BioGridi30928. 38 interactions.
IntActiQ96VH5. 5 interactions.
MINTiMINT-4988418.
STRINGi4932.YCL057C-A.

Structurei

3D structure databases

ProteinModelPortaliQ96VH5.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG149266.
HOGENOMiHOG000205880.
KOiK17784.
OMAiAIFRSNH.
OrthoDBiEOG7CVQB0.

Family and domain databases

InterProiIPR007512. DUF543.
[Graphical view]
PANTHERiPTHR21304. PTHR21304. 1 hit.
PfamiPF04418. DUF543. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96VH5-1 [UniParc]FASTAAdd to Basket

« Hide

MSEQAQTQQP AKSTPSKDSN KNGSSVSTIL DTKWDIVLSN MLVKTAMGFG   50
VGVFTSVLFF KRRAFPVWLG IGFGVGRGYA EGDAIFRSSA GLRSSKV 97
Length:97
Mass (Da):10,408
Last modified:December 1, 2001 - v1
Checksum:iD6C214612BD35E26
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59720 Genomic DNA. Translation: CAC42954.1.
BK006937 Genomic DNA. Translation: DAA07428.1.
PIRiS78709.
RefSeqiNP_065435.1. NM_001184448.1.

Genome annotation databases

EnsemblFungiiYCL057C-A; YCL057C-A; YCL057C-A.
GeneIDi850300.
KEGGisce:YCL057C-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X59720 Genomic DNA. Translation: CAC42954.1 .
BK006937 Genomic DNA. Translation: DAA07428.1 .
PIRi S78709.
RefSeqi NP_065435.1. NM_001184448.1.

3D structure databases

ProteinModelPortali Q96VH5.
ModBasei Search...

Protein-protein interaction databases

BioGridi 30928. 38 interactions.
IntActi Q96VH5. 5 interactions.
MINTi MINT-4988418.
STRINGi 4932.YCL057C-A.

Proteomic databases

MaxQBi Q96VH5.
PaxDbi Q96VH5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YCL057C-A ; YCL057C-A ; YCL057C-A .
GeneIDi 850300.
KEGGi sce:YCL057C-A.

Organism-specific databases

CYGDi YCL057c-a.
SGDi S000007547. MOS1.

Phylogenomic databases

eggNOGi NOG149266.
HOGENOMi HOG000205880.
KOi K17784.
OMAi AIFRSNH.
OrthoDBi EOG7CVQB0.

Enzyme and pathway databases

BioCyci YEAST:G3O-29419-MONOMER.

Miscellaneous databases

NextBioi 965676.

Gene expression databases

Genevestigatori Q96VH5.

Family and domain databases

InterProi IPR007512. DUF543.
[Graphical view ]
PANTHERi PTHR21304. PTHR21304. 1 hit.
Pfami PF04418. DUF543. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: FUNCTION, IDENTIFICATION IN THE MINOS/MITOS COMPLEX, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
  4. "A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria."
    Hoppins S., Collins S.R., Cassidy-Stone A., Hummel E., Devay R.M., Lackner L.L., Westermann B., Schuldiner M., Weissman J.S., Nunnari J.
    J. Cell Biol. 195:323-340(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE MINOS/MITOS COMPLEX, INTERACTION WITH OM45 AND POR1, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
  5. "MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization."
    Alkhaja A.K., Jans D.C., Nikolov M., Vukotic M., Lytovchenko O., Ludewig F., Schliebs W., Riedel D., Urlaub H., Jakobs S., Deckers M.
    Mol. Biol. Cell 23:247-257(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE MINOS/MITOS COMPLEX, SUBCELLULAR LOCATION, TOPOLOGY.

Entry informationi

Entry nameiMOS1_YEAST
AccessioniPrimary (citable) accession number: Q96VH5
Secondary accession number(s): D6VQV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: December 1, 2001
Last modified: June 11, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

External Data

Dasty 3

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