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Q96VH5

- MIC10_YEAST

UniProt

Q96VH5 - MIC10_YEAST

Protein

MICOS complex subunit MIC10

Gene

MIC10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.3 Publications

    GO - Biological processi

    1. cristae formation Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29419-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MICOS complex subunit MIC10
    Alternative name(s):
    Mitochondrial contact site complex 10 kDa subunit
    Mitochondrial inner membrane organization component of 10 kDa
    Mitochondrial organizing structure protein 1
    Short name:
    MitOS1
    Gene namesi
    Name:MIC10
    Synonyms:MCS10, MIO10, MOS1
    Ordered Locus Names:YCL057C-A
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome III

    Organism-specific databases

    CYGDiYCL057c-a.
    SGDiS000007547. MIC10.

    Subcellular locationi

    Mitochondrion inner membrane 4 Publications; Single-pass membrane protein 4 Publications
    Note: The C-terminus is located in the intermembrane space, while the location of the N-terminus has not been determined yet. As some programs predict the presence of 2 closely apposed membrane domains, it has been proposed that the protein may cross the membrane twice and that both termini may face the intermembrane space (PubMed:22114354). Enriched at crista junctions.1 Publication

    GO - Cellular componenti

    1. MICOS complex Source: SGD
    2. mitochondrial crista junction Source: SGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Disruption phenotypei

    Partially altered shape of the mitochondrial network with condensed, fragmented mitochondria accumulating at the periphery of cells. 60-70% of mitochondria exhibit an increased inner membrane surface and stacks of lamellar cristae disconnected from the inner boundary membrane.2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9797MICOS complex subunit MIC10PRO_0000221640Add
    BLAST

    Proteomic databases

    MaxQBiQ96VH5.
    PaxDbiQ96VH5.

    Expressioni

    Gene expression databases

    GenevestigatoriQ96VH5.

    Interactioni

    Subunit structurei

    Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MIC10, MIC12, MIC19, MIC26, MIC27 and MIC60. This complex was also known under the names MINOS or MitOS complex. Interacts with OM45 and POR1.4 Publications

    Protein-protein interaction databases

    BioGridi30928. 38 interactions.
    IntActiQ96VH5. 5 interactions.
    MINTiMINT-4988418.
    STRINGi4932.YCL057C-A.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96VH5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3535Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini59 – 9739Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 5823HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MICOS complex subunit Mic10 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG149266.
    HOGENOMiHOG000205880.
    KOiK17784.
    OMAiAIFRSNH.
    OrthoDBiEOG7CVQB0.

    Family and domain databases

    InterProiIPR007512. DUF543.
    [Graphical view]
    PANTHERiPTHR21304. PTHR21304. 1 hit.
    PfamiPF04418. DUF543. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96VH5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEQAQTQQP AKSTPSKDSN KNGSSVSTIL DTKWDIVLSN MLVKTAMGFG   50
    VGVFTSVLFF KRRAFPVWLG IGFGVGRGYA EGDAIFRSSA GLRSSKV 97
    Length:97
    Mass (Da):10,408
    Last modified:December 1, 2001 - v1
    Checksum:iD6C214612BD35E26
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59720 Genomic DNA. Translation: CAC42954.1.
    BK006937 Genomic DNA. Translation: DAA07428.1.
    PIRiS78709.
    RefSeqiNP_065435.1. NM_001184448.1.

    Genome annotation databases

    EnsemblFungiiYCL057C-A; YCL057C-A; YCL057C-A.
    GeneIDi850300.
    KEGGisce:YCL057C-A.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X59720 Genomic DNA. Translation: CAC42954.1 .
    BK006937 Genomic DNA. Translation: DAA07428.1 .
    PIRi S78709.
    RefSeqi NP_065435.1. NM_001184448.1.

    3D structure databases

    ProteinModelPortali Q96VH5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 30928. 38 interactions.
    IntActi Q96VH5. 5 interactions.
    MINTi MINT-4988418.
    STRINGi 4932.YCL057C-A.

    Proteomic databases

    MaxQBi Q96VH5.
    PaxDbi Q96VH5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YCL057C-A ; YCL057C-A ; YCL057C-A .
    GeneIDi 850300.
    KEGGi sce:YCL057C-A.

    Organism-specific databases

    CYGDi YCL057c-a.
    SGDi S000007547. MIC10.

    Phylogenomic databases

    eggNOGi NOG149266.
    HOGENOMi HOG000205880.
    KOi K17784.
    OMAi AIFRSNH.
    OrthoDBi EOG7CVQB0.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29419-MONOMER.

    Miscellaneous databases

    NextBioi 965676.

    Gene expression databases

    Genevestigatori Q96VH5.

    Family and domain databases

    InterProi IPR007512. DUF543.
    [Graphical view ]
    PANTHERi PTHR21304. PTHR21304. 1 hit.
    Pfami PF04418. DUF543. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete DNA sequence of yeast chromosome III."
      Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
      , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
      Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: FUNCTION, IDENTIFICATION IN THE MICOS COMPLEX, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
    4. "The mitochondrial contact site complex, a determinant of mitochondrial architecture."
      Harner M., Korner C., Walther D., Mokranjac D., Kaesmacher J., Welsch U., Griffith J., Mann M., Reggiori F., Neupert W.
      EMBO J. 30:4356-4370(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE MICOS COMPLEX, MASS SPECTROMETRY, SUBCELLULAR LOCATION, TOPOLOGY.
    5. "A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria."
      Hoppins S., Collins S.R., Cassidy-Stone A., Hummel E., Devay R.M., Lackner L.L., Westermann B., Schuldiner M., Weissman J.S., Nunnari J.
      J. Cell Biol. 195:323-340(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN THE MICOS COMPLEX, INTERACTION WITH OM45 AND POR1, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
    6. "MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization."
      Alkhaja A.K., Jans D.C., Nikolov M., Vukotic M., Lytovchenko O., Ludewig F., Schliebs W., Riedel D., Urlaub H., Jakobs S., Deckers M.
      Mol. Biol. Cell 23:247-257(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN THE MICOS COMPLEX, SUBCELLULAR LOCATION, TOPOLOGY.
    7. Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiMIC10_YEAST
    AccessioniPrimary (citable) accession number: Q96VH5
    Secondary accession number(s): D6VQV9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome III
      Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

    External Data

    Dasty 3