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Protein

MICOS complex subunit MIC10

Gene

MIC10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.3 Publications

GO - Biological processi

  1. cristae formation Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-29419-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
MICOS complex subunit MIC10
Alternative name(s):
Mitochondrial contact site complex 10 kDa subunit
Mitochondrial inner membrane organization component of 10 kDa
Mitochondrial organizing structure protein 1
Short name:
MitOS1
Gene namesi
Name:MIC10
Synonyms:MCS10, MIO10, MOS1
Ordered Locus Names:YCL057C-A
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome III

Organism-specific databases

CYGDiYCL057c-a.
SGDiS000007547. MIC10.

Subcellular locationi

Mitochondrion inner membrane 4 Publications; Single-pass membrane protein 4 Publications
Note: The C-terminus is located in the intermembrane space, while the location of the N-terminus has not been determined yet. As some programs predict the presence of 2 closely apposed membrane domains, it has been proposed that the protein may cross the membrane twice and that both termini may face the intermembrane space (PubMed:22114354). Enriched at crista junctions.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei36 – 5823HelicalSequence AnalysisAdd
BLAST
Topological domaini59 – 9739Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. MICOS complex Source: SGD
  2. mitochondrial crista junction Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Partially altered shape of the mitochondrial network with condensed, fragmented mitochondria accumulating at the periphery of cells. 60-70% of mitochondria exhibit an increased inner membrane surface and stacks of lamellar cristae disconnected from the inner boundary membrane.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9797MICOS complex subunit MIC10PRO_0000221640Add
BLAST

Proteomic databases

MaxQBiQ96VH5.
PaxDbiQ96VH5.

Expressioni

Gene expression databases

GenevestigatoriQ96VH5.

Interactioni

Subunit structurei

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MIC10, MIC12, MIC19, MIC26, MIC27 and MIC60. This complex was also known under the names MINOS or MitOS complex. Interacts with OM45 and POR1.4 Publications

Protein-protein interaction databases

BioGridi30928. 39 interactions.
IntActiQ96VH5. 9 interactions.
MINTiMINT-4988418.
STRINGi4932.YCL057C-A.

Structurei

3D structure databases

ProteinModelPortaliQ96VH5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MICOS complex subunit Mic10 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG149266.
HOGENOMiHOG000205880.
InParanoidiQ96VH5.
KOiK17784.
OMAiGDAIFRS.
OrthoDBiEOG7CVQB0.

Family and domain databases

InterProiIPR007512. DUF543.
[Graphical view]
PANTHERiPTHR21304. PTHR21304. 1 hit.
PfamiPF04418. DUF543. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96VH5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEQAQTQQP AKSTPSKDSN KNGSSVSTIL DTKWDIVLSN MLVKTAMGFG
60 70 80 90
VGVFTSVLFF KRRAFPVWLG IGFGVGRGYA EGDAIFRSSA GLRSSKV
Length:97
Mass (Da):10,408
Last modified:December 1, 2001 - v1
Checksum:iD6C214612BD35E26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAC42954.1.
BK006937 Genomic DNA. Translation: DAA07428.1.
PIRiS78709.
RefSeqiNP_065435.1. NM_001184448.1.

Genome annotation databases

EnsemblFungiiYCL057C-A; YCL057C-A; YCL057C-A.
GeneIDi850300.
KEGGisce:YCL057C-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X59720 Genomic DNA. Translation: CAC42954.1.
BK006937 Genomic DNA. Translation: DAA07428.1.
PIRiS78709.
RefSeqiNP_065435.1. NM_001184448.1.

3D structure databases

ProteinModelPortaliQ96VH5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi30928. 39 interactions.
IntActiQ96VH5. 9 interactions.
MINTiMINT-4988418.
STRINGi4932.YCL057C-A.

Proteomic databases

MaxQBiQ96VH5.
PaxDbiQ96VH5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYCL057C-A; YCL057C-A; YCL057C-A.
GeneIDi850300.
KEGGisce:YCL057C-A.

Organism-specific databases

CYGDiYCL057c-a.
SGDiS000007547. MIC10.

Phylogenomic databases

eggNOGiNOG149266.
HOGENOMiHOG000205880.
InParanoidiQ96VH5.
KOiK17784.
OMAiGDAIFRS.
OrthoDBiEOG7CVQB0.

Enzyme and pathway databases

BioCyciYEAST:G3O-29419-MONOMER.

Miscellaneous databases

NextBioi965676.

Gene expression databases

GenevestigatoriQ96VH5.

Family and domain databases

InterProiIPR007512. DUF543.
[Graphical view]
PANTHERiPTHR21304. PTHR21304. 1 hit.
PfamiPF04418. DUF543. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The complete DNA sequence of yeast chromosome III."
    Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M., Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G., Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A., Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M.
    , Carcano C., Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M., Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C., Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F., Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C., Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E., Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P., Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J., Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P., Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M., Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P., Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G., Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E., Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F., Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L., Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J., Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M., Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A., Richterich P., Roberts A.B., Rodriguez F., Sanz E., Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J., Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I., Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M., Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M., Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D., Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K., Sgouros J.G.
    Nature 357:38-46(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: FUNCTION, IDENTIFICATION IN THE MICOS COMPLEX, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
  4. "The mitochondrial contact site complex, a determinant of mitochondrial architecture."
    Harner M., Korner C., Walther D., Mokranjac D., Kaesmacher J., Welsch U., Griffith J., Mann M., Reggiori F., Neupert W.
    EMBO J. 30:4356-4370(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE MICOS COMPLEX, MASS SPECTROMETRY, SUBCELLULAR LOCATION, TOPOLOGY.
  5. "A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria."
    Hoppins S., Collins S.R., Cassidy-Stone A., Hummel E., Devay R.M., Lackner L.L., Westermann B., Schuldiner M., Weissman J.S., Nunnari J.
    J. Cell Biol. 195:323-340(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE MICOS COMPLEX, INTERACTION WITH OM45 AND POR1, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
  6. "MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization."
    Alkhaja A.K., Jans D.C., Nikolov M., Vukotic M., Lytovchenko O., Ludewig F., Schliebs W., Riedel D., Urlaub H., Jakobs S., Deckers M.
    Mol. Biol. Cell 23:247-257(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE MICOS COMPLEX, SUBCELLULAR LOCATION, TOPOLOGY.
  7. Cited for: NOMENCLATURE.

Entry informationi

Entry nameiMIC10_YEAST
AccessioniPrimary (citable) accession number: Q96VH5
Secondary accession number(s): D6VQV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: December 1, 2001
Last modified: January 7, 2015
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome III
    Yeast (Saccharomyces cerevisiae) chromosome III: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.