Reviewed, UniProtKB/Swiss-Prot Q96VC9 (LIP3_YARLI)

Names and origin

Protein names

Recommended name:
    Lipase 3
    EC=3.1.1.3

Gene names

Name:	LIP3
Ordered Locus Names:	YALI0B08030g

Organism

Yarrowia lipolytica (Candida lipolytica) [Complete proteome]

Taxonomic identifier

4952 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Dipodascaceae › Yarrowia

Protein attributes

Sequence length	498 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Triacylglycerol + H2O = diacylglycerol + a carboxylate.
Sequence similarities	Belongs to the type-B carboxylesterase/lipase family.

Ontologies

Keywords
Biological process	Lipid degradation
Domain	Signal
Molecular function	Hydrolase
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	triglyceride lipase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – ?		Potential
	Chain	? – 498		Lipase 3		PRO_0000008628
Sites
	Active site	200	1	Acyl-ester intermediate By similarity
	Active site	409	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	193	1	N-linked (GlcNAc...) Potential
	Glycosylation	384	1	N-linked (GlcNAc...) Potential
	Glycosylation	418	1	N-linked (GlcNAc...) Potential
	Disulfide bond	60 ↔ 91		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q96VC9-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 0F11DE0449B5580F	FASTA	498	55,872
	10 20 30 40 50 60 MPLELPSLNA SIVGNTVQNG AVEQFLNIRY ADIPGKFEKP VLKNDWNGAE IDATKVGPVC 70 80 90 100 110 120 PQPRTPFNFF SVPDDLWEKV NVDTYQDGLL CDNLIVTRPK GVSANARLPT VVWIHGGSNI 130 140 150 160 170 180 EGSIYNLIYE PQFLVAESVR VGKPIVHVCI EYRLGLAGFL TKNGKGNWGT WDQYTGCQWV 190 200 210 220 230 240 NRHIQDFGGD PLNVTLTGES AGSVAVHNML IKDSMNGRKL FRNAVMMSGT LETITPQPPK 250 260 270 280 290 300 WHARLEEKVA KVTGKEVADL ASLSDKELLD AQIKLNVAVC MTCDDGDFFE PGWKQHLTPD 310 320 330 340 350 360 WLDKLIISDC KDEGMLYFLP VNAQDDEELL AKVAKSPVGK EISELYGIKE GGDIKSACLD 370 380 390 400 410 420 LKTDATFNYF NHLLFKKMEE ARNNGSTSRV YRLAVDEPNP HNPDQRAHHA VDVLYMFNST 430 440 450 460 470 480 KFNEHGDKLS RLFQSHFLRL AYGLEPWDHR NFGVYRNGGY QQLPLSELNK VRPVERYEAL 490 SKMDFGQVGR LSNALSRL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and characterization of genes encoding lipase activities in Yarrowia lipolytica." Choupina A. Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: INAG135668.
[2]	"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIB 122 / E 150.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ249751 Genomic DNA. Translation: CAC43239.1. CR382128 Genomic DNA. Translation: CAG82865.1.
RefSeq	XP_500624.1.
3D structure databases
HSSP	HSSP built from PDB template 1QE3 based on UniProtKB P37967.
ModBase	Search...
Genome annotation databases
GeneID	2907630.
GenomeReviews	Gene locus YALI0B08030g in contig CR382128_GR.
KEGG	yli:YALI0B08030g.
Phylogenomic databases
OMA	HEKITET.
Enzyme and pathway databases
BRENDA	3.1.1.3. 3602.
Family and domain databases
InterPro	IPR002018. CarbesteraseB. IPR019826. Carboxylesterase_B_AS. [Graphical view]
PANTHER	PTHR11559. CarbesteraseB. 1 hit.
Pfam	PF00135. COesterase. 1 hit. [Graphical view]
PROSITE	PS00122. CARBOXYLESTERASE_B_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LIP3_YARLI

Accession

Primary (citable) accession number: Q96VC9
Secondary accession number(s): Q6CFD8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	December 1, 2001
Last modified:	November 3, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)