Q96VC7 (ACS2_ZYGBA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase 2
EC=6.2.1.1

Alternative name(s):
Acetate--CoA ligase 2
Acyl-activating enzyme 2

Gene names

Name:

ACS2

Organism

Zygosaccharomyces bailii

Taxonomic identifier

4954 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Zygosaccharomyces

Protein attributes

Sequence length	675 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 675	675	Acetyl-coenzyme A synthetase 2		PRO_0000208422

Sequences

	Sequence		Length	Mass (Da)
	Q96VC7 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: A19D1E670263F619	FASTA	675	74,508
	10 20 30 40 50 60 MTVKEHKVVH EAQNVEALHA PEHFYKSQPG PSYIKDMKQY KEMYKQSVED PENFFGEKAR 70 80 90 100 110 120 ELLDWDRPFT RSKYGSLENG DVTWFLNGEL NAAYNCVDRH AFANPDKPAL IYEADEEADN 130 140 150 160 170 180 RMITFSELLR QVSRVAGVLQ SWGVKKGDTV AVYLPMIPEA VVAMLAIARL GAIHSVVFAG 190 200 210 220 230 240 FSAGSLKDRV VDAGCKVVIT CDEGKRGGKT VHTKKIVDEG LNGISLVSHI LVFQRTGSEG 250 260 270 280 290 300 IPMTAGRDYW WHEETAKQRS YLPPVPCNSE DPLFLLYTSG STGSPKGVVH STAGYLLGAA 310 320 330 340 350 360 MTTRYVFDIH PEDVLFTAGD VGWITGHTYA LYGPLVLGTA SIIFESTPAY PDYGRYWRII 370 380 390 400 410 420 QRHKATHFYV APTALRLIKR VGEAEIPKYD ISSLRVLGSV GEPISPELWE WYYEKVGNKN 430 440 450 460 470 480 CVICDTMWQT ESGSHLIAPQ AGAVPTKPGS ATVPFFGVDA CIIDPVTGIE LQGNDVEGVL 490 500 510 520 530 540 AVKSSWPSMA RSVWQNHHRY VDTYLKPYPG YYFTGDGAGR DHDGYYWIRG RVDDVVNVSG 550 560 570 580 590 600 HRLSTAEIEA SLTNHDNVSE SAVVGIADEL TGQSVIAFVS LKDGSSRESS AVVAMRRELV 610 620 630 640 650 660 LQVRGEIGPF AAPKCVILVK DLPKTRSGKI MRRVLRKVAS NEADQLGDLS TMANSEVVPS 670 IIAAVDEQFF AEKKK

References

[1]	"Acetyl-CoA synthetase gene (ZbACS2) from Zygosaccharomyces bailii ISA 1307." Rodrigues F., Luovico P., Sousa M.J., Steensma H.Y., Corte-Real M., Leao C. Appl. Environ. Microbiol. 69:649-653(2003) [PubMed: 12514054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ISA 1307.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ314837 Genomic DNA. Translation: CAC41017.1.
3D structure databases
ProteinModelPortal	Q96VC7.
SMR	Q96VC7. Positions 38-641.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACS2_ZYGBA

Accession

Primary (citable) accession number: Q96VC7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	December 1, 2001
Last modified:	October 19, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program