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Q96VC4

- CBPYA_EMENI

UniProt

Q96VC4 - CBPYA_EMENI

Protein

Carboxypeptidase Y homolog A

Gene

cpyA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate By similarity.By similarity

    Catalytic activityi

    Release of a C-terminal amino acid with broad specificity.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei275 – 2751PROSITE-ProRule annotation
    Active sitei467 – 4671PROSITE-ProRule annotation
    Active sitei529 – 5291PROSITE-ProRule annotation

    GO - Molecular functioni

    1. carboxypeptidase activity Source: ASPGD
    2. serine-type carboxypeptidase activity Source: UniProtKB

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Protein family/group databases

    MEROPSiS10.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Carboxypeptidase Y homolog A (EC:3.4.16.5)
    Gene namesi
    Name:cpyA
    ORF Names:AN5442.2
    OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
    Taxonomic identifieri227321 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000000560: Chromosome V

    Subcellular locationi

    Vacuole 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: ASPGD
    2. fungal-type vacuole lumen Source: UniProtKB

    Keywords - Cellular componenti

    Vacuole

    Pathology & Biotechi

    Disruption phenotypei

    Decreases strongly intracellular carboxypeptidase activity.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Propeptidei18 – 133116By similarityPRO_0000407449Add
    BLAST
    Chaini134 – 552419Carboxypeptidase Y homolog APRO_0000407450Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi188 ↔ 428By similarity
    Glycosylationi219 – 2191N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi322 ↔ 336By similarity
    Disulfide bondi346 ↔ 369By similarity
    Disulfide bondi353 ↔ 362By similarity
    Disulfide bondi391 ↔ 398By similarity
    Glycosylationi518 – 5181N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Structurei

    3D structure databases

    ProteinModelPortaliQ96VC4.
    SMRiQ96VC4. Positions 133-549.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG2939.
    HOGENOMiHOG000198296.
    KOiK13289.
    OMAiWPGQKEY.
    OrthoDBiEOG7XDBR1.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q96VC4-1 [UniParc]FASTAAdd to Basket

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    MRVLPATLLV GAATAATPAQ QVLGGLQDFG NAVQDAMHEN LPKINKPLEA    50
    FQEQLKSLYE AREFWEEVAN AFPQNLDHNP VFSLPKKHTR RPDSHWDHIV 100
    RGADVQSVWV TGENGEKERE IEGKLEAYDL RIKKTDPSSL GIDPDVKQYT 150
    GYLDDNENDK HLFYWFFESR NDPKNDPVVL WLNGGPGCSS LTGLFMELGP 200
    SSIDENIKPV YNPYAWNSNA SVIFLDQPVN VGYSYSGSTV SDTVAAGKDV 250
    YALLTLFFKQ FPEYAEQDFH IAGESYAGHY IPVFTSEILS HQKRNINLKS 300
    VLIGNGLTDG LTQYEYYRPM ACGEGGYPAV LDESSCRSMD NALGRCQSMI 350
    ESCYNSESAW VCVPASIYCN NALLAPYQRT GQNVYDVRGK CEDESNLCYK 400
    GMGYVSEYLN KPEVRAAVGA EVDGYDSCNF DINRNFLFHG DWMKPYHRLV 450
    PGILEQIPVL IYAGDADFIC NWLGNKAWTE ALEWPGHKEF AAAPMEDLKI 500
    VDNEHTGKKI GQIKTHGNFT FMRLYGGGHM VPMDQPEASL EFFNRWLGGE 550
    WF 552
    Length:552
    Mass (Da):62,066
    Last modified:December 1, 2001 - v1
    Checksum:iF67CF39FDBF7D761
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB051820 Genomic DNA. Translation: BAB56108.1.
    AACD01000094 Genomic DNA. Translation: EAA62602.1.
    BN001305 Genomic DNA. Translation: CBF81902.1.
    PIRiJC7666.
    RefSeqiXP_663046.1. XM_657954.1.

    Genome annotation databases

    EnsemblFungiiCADANIAT00003647; CADANIAP00003647; CADANIAG00003647.
    GeneIDi2871736.
    KEGGiani:AN5442.2.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB051820 Genomic DNA. Translation: BAB56108.1 .
    AACD01000094 Genomic DNA. Translation: EAA62602.1 .
    BN001305 Genomic DNA. Translation: CBF81902.1 .
    PIRi JC7666.
    RefSeqi XP_663046.1. XM_657954.1.

    3D structure databases

    ProteinModelPortali Q96VC4.
    SMRi Q96VC4. Positions 133-549.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi S10.001.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANIAT00003647 ; CADANIAP00003647 ; CADANIAG00003647 .
    GeneIDi 2871736.
    KEGGi ani:AN5442.2.

    Phylogenomic databases

    eggNOGi COG2939.
    HOGENOMi HOG000198296.
    KOi K13289.
    OMAi WPGQKEY.
    OrthoDBi EOG7XDBR1.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    IPR018202. Peptidase_S10_AS.
    IPR008442. Propeptide_carboxypepY.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF05388. Carbpep_Y_N. 1 hit.
    PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the cpyA gene encoding intracellular carboxypeptidase from Aspergillus nidulans."
      Ohsumi K., Matsuda Y., Nakajima H., Kitamoto K.
      Biosci. Biotechnol. Biochem. 65:1175-1180(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
      Strain: A26.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
    3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
      Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
      , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
      Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENOME REANNOTATION.
      Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

    Entry informationi

    Entry nameiCBPYA_EMENI
    AccessioniPrimary (citable) accession number: Q96VC4
    Secondary accession number(s): C8VGH8, Q5B1Y8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3