Q96VB9 (HSP7F_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Heat shock protein homolog SSE1

Alternative name(s):
Chaperone protein MSI3

Gene names

Name:	MSI3
Synonyms:	SSE1
ORF Names:	CaO19.2435, CaO19.9971

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	701 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Ineracts with CGR1.
Subcellular location	Cytoplasm Ref.3.
Miscellaneous	Has antigenic properties. Elicits a specific immune response in systemic candidiasis human patients undergoing malignant hematological disorders.
Sequence similarities	Belongs to the heat shock protein 70 family.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	cellular response to drug Inferred from mutant phenotype PubMed 22713118. Source: CGD pathogenesis Inferred from mutant phenotype PubMed 22713118. Source: CGD response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from sequence or structural similarity Ref.1. Source: CGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 701	701	Heat shock protein homolog SSE1		PRO_0000078392
Natural variations
	Natural variant	409	1	E → EE in strain: NBRC 1060.

Sequences

	Sequence		Length	Mass (Da)
	Q96VB9 [UniParc]. Last modified October 19, 2011. Version 2. Checksum: C968DD3E0BB365BC	FASTA	701	78,525
	10 20 30 40 50 60 MSIPFGVDLG NNNTVIACAK NRGIDIVVNE VSNRSTPSLV GFGHKSRYLG ESAKNQQTSN 70 80 90 100 110 120 IKNTVDNLKR IVGLPHDHPD FEIEKKFFTI PLIKNEVDGG VSGKVKYLTK NHEFTATQLL 130 140 150 160 170 180 AMYLDKIKDT ALKETKGNIS DICLSVPGWY TEKQRRAAAD ACKIAGLNPV RIVNEVTAAA 190 200 210 220 230 240 VGYGVFKAGE LPEDEYKKVA FVDVGHSSYQ VSIAAVKKGE LKILGSAYDK HFGGRNFDFA 250 260 270 280 290 300 IAEHFAKEFK SKYKIDVHEN PKAFYRVLVA AEKLKKVLSA NTQAPFNIES VMNDVDVSSS 310 320 330 340 350 360 LTREELEELV QPLLDRINVP IETALKDAGI TVDELDSIEV IGGSSRIPAV KTRISEIFGK 370 380 390 400 410 420 PLSFTLNQDE AIAKGNAYIC ACHSPTVRVR PFKFEDYNQY TVSYFWDKED EEDDHLEVFP 430 440 450 460 470 480 KGGLFPSTKI ITLFRKGPSF EIEAKYTKPE ELPKGTELHI AKWKISGVVP NEGESSIATK 490 500 510 520 530 540 IKLRNDPSGF YTIESAHTVE EQIVKELIEP AEGEEVDEDA EPQYREVKKL VKKNDLTIEC 550 560 570 580 590 600 ESAALPDAEL QAFIEKEASM VMEDKLVFDT EERKNQLEEY IYELRGKLDE EYKDFASDQE 610 620 630 640 650 660 KEKLSGLLMK AEDWLYEDGE DSTKAKYIAK YEELASIGNV IKGRYLAKEQ EKKEQYRQKQ 670 680 690 700 EAAQAAAMAE KMAAQREASK KQESSSSGKN NKDTEGDVDM D

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation and sequencing of the Candida albicans MSI3, a putative novel member of the HSP70 family." Cho T., Toyoda M., Sudoh M., Nakashima Y., Calderone R.A., Kaminishi H. Yeast 20:149-156(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INTERACTION WITH CGR1. Strain: ATCC 10259 / CBS 5796 / DSM 5817 / JCM 2078 / NBRC 1060.
[2]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.
[3]	"Proteomics-based identification of novel Candida albicans antigens for diagnosis of systemic candidiasis in patients with underlying hematological malignancies." Pitarch A., Abian J., Carrascal M., Sanchez M., Nombela C., Gil C. Proteomics 4:3084-3106(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 26-34, SUBCELLULAR LOCATION, ANTIGENICITY. Strain: SC5314 / ATCC MYA-2876. Tissue: Protoplast.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB061274 Genomic DNA. Translation: BAB71816.1. AACQ01000041 Genomic DNA. Translation: EAK99532.1. AACQ01000040 Genomic DNA. Translation: EAK99620.1.
RefSeq	XP_718458.1. XM_713365.1. XP_718541.1. XM_713448.1.
3D structure databases
ProteinModelPortal	Q96VB9.
SMR	Q96VB9. Positions 1-652.
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAL0001523.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3639813. 3639821.
KEGG	cal:CaO19.2435. cal:CaO19.9971.
Organism-specific databases
CGD	CAL0001523. MSI3.
Phylogenomic databases
eggNOG	COG0443.
KO	K09485.
Family and domain databases
InterPro	IPR018181. Heat_shock_70_CS. IPR013126. Hsp_70_fam. [Graphical view]
Pfam	PF00012. HSP70. 1 hit. [Graphical view]
PRINTS	PR00301. HEATSHOCK70.
PROSITE	PS00297. HSP70_1. False negative. PS00329. HSP70_2. False negative. PS01036. HSP70_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HSP7F_CANAL

Accession

Primary (citable) accession number: Q96VB9
Secondary accession number(s): P83785, Q5AA49

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	October 19, 2011
Last modified:	April 3, 2013
This is version 50 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program