Reviewed, UniProtKB/Swiss-Prot Q96VB8 (CATA_CANBO)

Names and origin

Protein names

Recommended name:
    Peroxisomal catalase
    EC=1.11.1.6

Gene names

Name:

CTA1

Organism

Candida boidinii (Yeast)

Taxonomic identifier

5477 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	504 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.
Catalytic activity	2 H2O2 = O2 + 2 H2O.
Cofactor	Heme group.
Subcellular location	Peroxisome. Note: Bimodally distributed between the cytosol and peroxisomes in methanol-grown cells but is localized exclusively in peroxisomes in oleate- and D-alanine-grown cells. Ref.1
Sequence similarities	Belongs to the catalase family.

Ontologies

Keywords
Biological process	Hydrogen peroxide
Cellular component	Peroxisome
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
Gene Ontology (GO)
Biological process	hydrogen peroxide catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	catalase activity Inferred from electronic annotation. Source: EC heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 504	504	Peroxisomal catalase		PRO_0000084919
Regions
	Motif	502 – 504	3	Microbody targeting signal
Sites
	Active site	63	1	By similarity
	Active site	136	1	By similarity
	Metal binding	345	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q96VB8-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: CCF63C4FA752DC3B	FASTA	504	57,095
	10 20 30 40 50 60 MSNPPTYTTS QGCPVSDAFS TQRISGTKIS IKTPVGPLLL QDFKFLDSLA HFDRERIPER 70 80 90 100 110 120 VVHAKGAGAY GVFEVTEDIS DICSAKFLDT VGKKTKIFTR FSTVGGEKGS SDSARDPRGF 130 140 150 160 170 180 ATKFYTEEGN LDLVYNNTPI FFIRDPTKFP HFIHTQKRNP ATNCKDANMF WDYLTNNPES 190 200 210 220 230 240 LHQIMYLFSN RGTPTSYRKM NGYSGHSYKW YNAKGEWVSS VHFISNQGVH NMTDEEAGDL 250 260 270 280 290 300 SGKDPDFQTM DLYKAIEQGD YPSWECYVQT MTLEEAKKQP FSVYDLTKVW PHKDFPLRHF 310 320 330 340 350 360 GKFTLNENAQ NYFAEVEQAA FSPSHTVPGM EPSNDPVLQS RLFSYPDTHR HRLGVNYSQI 370 380 390 400 410 420 PVNCPMRAVF APQIRDGSMM VNGNLGGTPN YAGAYNCPVQ YQAPIKASSK TPEEQYEGET 430 440 450 460 470 480 LSYDWTEVNE YDFYQPGRFW EVLGKTKGEQ EALVHNVANH VSGADEFIQD RVFAYFSKAN 490 500 PVIGDLIRKE VLKKSPRGAS KNKF

References

[1]

"Peroxisomal catalase in the methylotrophic yeast Candida boidinii: transport efficiency and metabolic significance." Horiguchi H., Yurimoto H., Goh T.K., Nakagawa T., Kato N., Sakai Y. J. Bacteriol. 183:6372-6383(2001) [PubMed: 11591682] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], SUBCELLULAR LOCATION. Strain: S2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB064338 Genomic DNA. Translation: BAB69893.1.
3D structure databases
SMR	Q96VB8. Positions 1-490.
ModBase	Search...
Protein family/group databases
PeroxiBase	5262. CboiKat01.
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-13166.
BRENDA	1.11.1.6. 675.
Family and domain databases
InterPro	IPR002226. Catalase. IPR020835. Catalase-like_haem-dep. IPR010582. Catalase-rel_immune_responsive. IPR011614. Catalase_N. IPR018028. Catalase_rel_subgroup. [Graphical view]
Gene3D	G3DSA:2.40.180.10. Catalase_N. 1 hit.
PANTHER	PTHR11465. Catalase. 1 hit.
Pfam	PF00199. Catalase. 1 hit. PF06628. Catalase-rel. 1 hit. [Graphical view]
PRINTS	PR00067. CATALASE.
PROSITE	PS00437. CATALASE_1. 1 hit. PS00438. CATALASE_2. 1 hit. PS51402. CATALASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CATA_CANBO

Accession

Primary (citable) accession number: Q96VB8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 23, 2003
Last sequence update:	December 1, 2001
Last modified:	January 19, 2010
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)