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Q96V52

- GLNA_EMENI

UniProt

Q96V52 - GLNA_EMENI

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Protein

Glutamine synthetase

Gene

glnA

Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular response to farnesol Source: ASPGD
  2. glutamine biosynthetic process Source: ASPGD
  3. nitrogen compound metabolic process Source: ASPGD
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Short name:
GS
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:glnA
ORF Names:AN4159
OrganismiEmericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Taxonomic identifieri227321 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000000560: Chromosome II

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357Glutamine synthetasePRO_0000153156Add
BLAST

Interactioni

Subunit structurei

Homooctamer.By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the glutamine synthetase family.Curated

Phylogenomic databases

eggNOGiCOG0174.
HOGENOMiHOG000061500.
InParanoidiQ96V52.
KOiK01915.
OMAiRIPRNVG.
OrthoDBiEOG7GTTD8.

Family and domain databases

Gene3Di3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96V52-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDSTNVSNT ENLMKYMSLD QRGSVMAEYI WIDAHGGTRS KTKTLSKAPS
60 70 80 90 100
SVDELPEWNF DGSSTAQAPG DNSDVYLRPV AMYPDPFRRG DNILVLCETW
110 120 130 140 150
DSDGSPNKFN YRHDCARLME THAKEEFWFG LEQEYTLLGP DGWPYGWPKG
160 170 180 190 200
GFPGAQGPYY CGVGTGKVYC RDIVEAHYRA CLYAGVKISG INAEVMPSQW
210 220 230 240 250
EYQVGPCHGI EMGDHLWISR FLLHRVAEEF GVKISFDPKP IKGDWNGAGL
260 270 280 290 300
HTNVSTTSTR AEGGIKAIES YMKKLEARHV EHIAVYGEGN EERLTGRHET
310 320 330 340 350
GNIDKFSYGV ADRGGSIRIP RQVAKDGKGY FEDRRPASNA DPYQITGIIA

ETLCGGL
Length:357
Mass (Da):39,714
Last modified:November 16, 2011 - v3
Checksum:i3A8D1110050EE9CA
GO

Sequence cautioni

The sequence AAK70354.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence EAA59420.1 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti236 – 2361F → N in AAK70354. (PubMed:11566979)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF333968 Genomic DNA. Translation: AAK70354.1. Sequence problems.
AACD01000067 Genomic DNA. Translation: EAA59420.1. Sequence problems.
BN001302 Genomic DNA. Translation: CBF74586.1.
RefSeqiXP_661763.1. XM_656671.1.

Genome annotation databases

EnsemblFungiiCADANIAT00004514; CADANIAP00004514; CADANIAG00004514.
GeneIDi2873585.
KEGGiani:AN4159.2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF333968 Genomic DNA. Translation: AAK70354.1 . Sequence problems.
AACD01000067 Genomic DNA. Translation: EAA59420.1 . Sequence problems.
BN001302 Genomic DNA. Translation: CBF74586.1 .
RefSeqi XP_661763.1. XM_656671.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANIAT00004514 ; CADANIAP00004514 ; CADANIAG00004514 .
GeneIDi 2873585.
KEGGi ani:AN4159.2.

Phylogenomic databases

eggNOGi COG0174.
HOGENOMi HOG000061500.
InParanoidi Q96V52.
KOi K01915.
OMAi RIPRNVG.
OrthoDBi EOG7GTTD8.

Family and domain databases

Gene3Di 3.30.590.10. 1 hit.
InterProi IPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view ]
Pfami PF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF54368. SSF54368. 1 hit.
PROSITEi PS00180. GLNA_1. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Role of glutamine synthetase in nitrogen metabolite repression in Aspergillus nidulans."
    Margelis S., D'Souza C., Small A.J., Hynes M.J., Adams T.H., Davis M.A.
    J. Bacteriol. 183:5826-5833(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.
  3. "The 2008 update of the Aspergillus nidulans genome annotation: a community effort."
    Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J., Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H., Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M., Estrada C.G.
    , Geysens S., Goldman G., de Groot P.W., Hansen K., Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G., Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L., Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M., van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P., Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J., Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A., Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X., Robson G., Seiboth B., van Solingen P., Specht T., Sun J., Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H., van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y., Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J., Oliver S.G., Turner G.
    Fungal Genet. Biol. 46:S2-13(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139.

Entry informationi

Entry nameiGLNA_EMENI
AccessioniPrimary (citable) accession number: Q96V52
Secondary accession number(s): C8V4Q5, Q5B5M1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: November 16, 2011
Last modified: October 29, 2014
This is version 69 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3