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Protein
Submitted name:

Laccase B

Gene

lac1

Organism
Trametes versicolor (White-rot fungus) (Coriolus versicolor)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi85 – 851Copper 1; via tele nitrogenCombined sources
Metal bindingi87 – 871Copper 2; via pros nitrogenCombined sources
Metal bindingi130 – 1301Copper 2; via tele nitrogenCombined sources
Metal bindingi132 – 1321Copper 3; via tele nitrogenCombined sources
Binding sitei176 – 1761N-acetyl-D-glucosamine; via amide nitrogenCombined sources
Binding sitei238 – 2381N-acetyl-D-glucosamineCombined sources
Metal bindingi416 – 4161Copper 4; via pros nitrogenCombined sources
Metal bindingi419 – 4191Copper 1; via tele nitrogenCombined sources
Metal bindingi421 – 4211Copper 3; via tele nitrogenCombined sources
Binding sitei457 – 4571N-acetyl-D-glucosamineCombined sources
Metal bindingi473 – 4731Copper 3; via tele nitrogenCombined sources
Metal bindingi474 – 4741Copper 4Combined sources
Metal bindingi475 – 4751Copper 2; via tele nitrogenCombined sources
Metal bindingi479 – 4791Copper 4; via pros nitrogenCombined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseSAAS annotationImported

Keywords - Ligandi

CopperCombined sourcesSAAS annotation, Metal-bindingCombined sourcesSAAS annotation

Enzyme and pathway databases

BRENDAi1.10.3.2. 1626.

Names & Taxonomyi

Protein namesi
Submitted name:
Laccase BImported (EC:1.10.3.2Imported)
Gene namesi
Name:lac1Imported
OrganismiTrametes versicolor (White-rot fungus) (Coriolus versicolor)Imported
Taxonomic identifieri5325 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesPolyporalesTrametes

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 520499Sequence analysisPRO_5004321622Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi106 ↔ 509Combined sources
Disulfide bondi138 ↔ 226Combined sources

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KYAX-ray2.40A/B/C/D22-520[»]
ProteinModelPortaliQ96UT7.
SMRiQ96UT7. Positions 22-520.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96UT7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 151121Plastocyanin-likeInterPro annotationAdd
BLAST
Domaini164 – 305142Plastocyanin-likeInterPro annotationAdd
BLAST
Domaini366 – 491126Plastocyanin-likeInterPro annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni75 – 773N-acetyl-D-glucosamine bindingCombined sources
Regioni354 – 3574N-acetyl-D-glucosamine bindingCombined sources

Sequence similaritiesi

Belongs to the multicopper oxidase family.SAAS annotation

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96UT7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRFHSLFAF VVASLTAVAH AGIGPVADLT ITNAAVSPDG FSRQAVVVNG
60 70 80 90 100
GTPGPLITGN MGDRFQLNVI DNLTNHTMLK STSIHWHGFF QKGTNWADGP
110 120 130 140 150
AFINQCPISS GHSFLYDFQV PDQAGTFWYH SHLSTQYCDG LRGPFVVYDP
160 170 180 190 200
NDPAADLYDV DNDDTVITLV DWYHVAAKLG PAFPLGADAT LINGKGRSPS
210 220 230 240 250
TTTADLSVIS VTPGKRYRFR LVSLSCDPNY TFSIDGHNMT IIETDSINTA
260 270 280 290 300
PLVVDSIQIF AAQRYSFVLE ANQAVDNYWI RANPNFGNVG FTGGINSAIL
310 320 330 340 350
RYDGAAAVEP TTTQTTSTAP LNEVNLHPLV ATAVPGSPVA GGVDLAINMA
360 370 380 390 400
FNFNGTNFFI NGASFTPPTV PVLLQIISGA QNAQDLLPSG SVYSLPSNAD
410 420 430 440 450
IEISFPATAA APGAPHPFHL HGHAFAVVRS AGSTVYNYDN PIFRDVVSTG
460 470 480 490 500
TPAAGDNVTI RFRTDNPGPW FLHCHIDFHL EAGFAVVFAE DIPDVASANP
510 520
VPQAWSDLCP TYDARDPSDQ
Length:520
Mass (Da):55,576
Last modified:December 1, 2001 - v1
Checksum:iF3241CB929C247F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF414109 mRNA. Translation: AAL07440.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF414109 mRNA. Translation: AAL07440.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KYAX-ray2.40A/B/C/D22-520[»]
ProteinModelPortaliQ96UT7.
SMRiQ96UT7. Positions 22-520.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi1.10.3.2. 1626.

Miscellaneous databases

EvolutionaryTraceiQ96UT7.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Crystal structure of a four-copper laccase complexed with an arylamine: insights into substrate recognition and correlation with kinetics."
    Bertrand T., Jolivalt C., Briozzo P., Caminade E., Joly N., Madzak C., Mougin C.
    Biochemistry 41:7325-7333(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 22-520 IN COMPLEX WITH COPPER AND N-ACETYL-D-GLUCOSAMINE, DISULFIDE BONDS.
  2. "Expression of laccase IIIb from the white-rot fungus Trametes versicolor in the yeast Yarrowia lipolytica for environmental applications."
    Jolivalt C., Madzak C., Brault A., Caminade E., Malosse C., Mougin C.
    Appl. Microbiol. Biotechnol. 66:450-456(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC 32745Imported.

Entry informationi

Entry nameiQ96UT7_TRAVE
AccessioniPrimary (citable) accession number: Q96UT7
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.