ID   UBC2_EMENI              Reviewed;         151 AA.
AC   Q96UP5; Q5B286;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   16-JUN-2009, entry version 49.
DE   RecName: Full=Ubiquitin-conjugating enzyme E2 2;
DE            EC=6.3.2.19;
DE   AltName: Full=Ubiquitin-protein ligase ubc2;
DE   AltName: Full=Ubiquitin carrier protein ubc2;
DE   AltName: Full=UV sensitivity protein J;
GN   Name=uvsJ; Synonyms=ubc2; ORFNames=AN5344;
OS   Emericella nidulans (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Emericella.
OX   NCBI_TaxID=162425;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Jang Y.-K., Kaefer E., Chae S.-K.;
RT   "Mutagenic DNA-repair genes in Aspergillus nidulans: isolation and
RT   characterization of a RAD6 homolog gene.";
RL   Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC 4;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R.,
RA   Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J.,
RA   Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J.,
RA   Purcell S., Harris S., Braus G.H., Draht O., Busch S., D'Enfert C.,
RA   Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S.,
RA   Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U.,
RA   Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T.,
RA   Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W.,
RA   Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
CC   -!- FUNCTION: Catalyzes the covalent attachment of ubiquitin to other
CC       proteins. Plays a role in transcription regulation by catalyzing
CC       the monoubiquitination of histone H2B to form H2BK123ub1.
CC       H2BK123ub1 gives a specific tag for epigenetic transcriptional
CC       activation and is also a prerequisite for H3K4me and H3K79me
CC       formation. Also involved in postreplication repair of UV-damaged
CC       DNA, in N-end rule-dependent protein degradation and in
CC       sporulation (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + ubiquitin + protein lysine = AMP +
CC       diphosphate + protein N-ubiquityllysine.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA62504.1; Type=Erroneous gene model prediction;
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DR   EMBL; AY032592; AAK50144.1; -; Genomic_DNA.
DR   EMBL; AACD01000093; EAA62504.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_662948.1; -.
DR   HSSP; P06104; 1AYZ.
DR   SMR; Q96UP5; 2-151.
DR   GeneID; 2871622; -.
DR   KEGG; ani:AN5344.2; -.
DR   BRENDA; 6.3.2.19; 3859.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004842; F:ubiquitin-protein ligase activity; IEA:EC.
DR   GO; GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   GO; GO:0019941; P:modification-dependent protein catabolic pr...; IEA:UniProtKB-KW.
DR   GO; GO:0043687; P:post-translational protein modification; IEA:InterPro.
DR   GO; GO:0051246; P:regulation of protein metabolic process; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cel...; IEA:UniProtKB-KW.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR016135; UBQ-conjugat/RWD-like.
DR   InterPro; IPR000608; UBQ-conjugat_E2.
DR   Gene3D; G3DSA:3.10.110.10; UBQ-conjugat_E2; 1.
DR   Pfam; PF00179; UQ_con; 1.
DR   ProDom; PD000461; UBQ_conjugat; 1.
DR   SMART; SM00212; UBCc; 1.
DR   PROSITE; PS00183; UBIQUITIN_CONJUGAT_1; 1.
DR   PROSITE; PS50127; UBIQUITIN_CONJUGAT_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chromatin regulator; Cytoplasm; DNA damage; DNA repair;
KW   Ligase; Nucleotide-binding; Nucleus; Sporulation; Transcription;
KW   Transcription regulation; Ubl conjugation pathway.
FT   CHAIN         1    151       Ubiquitin-conjugating enzyme E2 2.
FT                                /FTId=PRO_0000082532.
FT   ACT_SITE     88     88       Glycyl thioester intermediate (By
FT                                similarity).
SQ   SEQUENCE   151 AA;  17211 MW;  88845B6BB0E65556 CRC64;
     MSTSARRRLM RDFKRMQTDP PAGVSASPVA DNVMTWNAVI IGPADTPFED GTFRLVMHFE
     EQYPNKPPGV KFISQMFHPN VYGTGELCLD ILQNRWSPTY DVAAILTSIQ SLLNDPNTSS
     PANVEASNLY RDNRKEYIKR VRETVEKSWE E
//