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Q96UM2

- LAC3_BOTFU

UniProt

Q96UM2 - LAC3_BOTFU

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Protein

Laccase-3

Gene
lcc3
Organism
Botryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Lignin degradation and detoxification of lignin-derived products By similarity.

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per monomer By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi29 – 291Copper 1; type 2 By similarity
Metal bindingi31 – 311Copper 2; type 3 By similarity
Metal bindingi73 – 731Copper 2; type 3 By similarity
Metal bindingi75 – 751Copper 3; type 3 By similarity
Metal bindingi375 – 3751Copper 4; type 1 By similarity
Metal bindingi378 – 3781Copper 1; type 2 By similarity
Metal bindingi380 – 3801Copper 3; type 3 By similarity
Metal bindingi437 – 4371Copper 3; type 3 By similarity
Metal bindingi438 – 4381Copper 4; type 1 By similarity
Metal bindingi439 – 4391Copper 2; type 3 By similarity
Metal bindingi443 – 4431Copper 4; type 1 By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-3 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 3
Diphenol oxidase 3
Urishiol oxidase 3
Gene namesi
Name:lcc3
OrganismiBotryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea)
Taxonomic identifieri40559 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeBotrytis

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – ›454›454Laccase-3PRO_0000267639Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi24 – 241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi138 – 1381N-linked (GlcNAc...) Reviewed prediction
Glycosylationi169 – 1691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi218 – 2181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi314 – 3141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi334 – 3341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi395 – 3951N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ96UM2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini‹1 – 95›95Plastocyanin-like 1Add
BLAST
Domaini101 – 252152Plastocyanin-like 2Add
BLAST
Domaini319 – 454136Plastocyanin-like 3Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q96UM2-1 [UniParc]FASTAAdd to Basket

« Hide

PGPTLYADWG DMIQVTLKNS MPDNGTGIHW HGLRQYHTCT EDGVPGITEC    50
PLAPGDTKTY TFQATQFGTS WYHSHYSSQY GEGMLGGIVI NGPATSNYDV 100
DLGVYTISDW YYTPVFALGE RIAHSQAGPP SGDNGLINGS MVAPAGQTGG 150
KYTTNTITAG KKYRLRLINT SVDNHFMVSL DNHAFTVITS DFVPIVPYTA 200
NWIFIGIGQR YDVIITANQT VGSYWFRAEV QNGCGTNNNN GNIKSIFTYS 250
GAASTTPSSS ATPYTGRCTD ETGIIPFWDS FVPSGPLSGN VEQLNVAINI 300
GVDASGPIVT WGINLSAIDV DWKKPILQYV LDGNNSWPAS ENLIELPNAA 350
QWYYWVIQEV PGNVNGNPVS INVPHPMHLH GHDFFLLGTG VGTYNNTING 400
PSLDYDNPTR RDVAMLPAGG WMVLAFQTDN PGAWLMHCHI AWHVSEGLAV 450
QFQG 454
Length:454
Mass (Da):49,323
Last modified:December 1, 2001 - v1
Checksum:iEB56A720394D912A
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei454 – 4541

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY047482 Genomic DNA. Translation: AAL06114.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY047482 Genomic DNA. Translation: AAL06114.1 .

3D structure databases

ProteinModelPortali Q96UM2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 3 hits.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Resveratrol acts as a natural profungicide and induces self-intoxication by a specific laccase."
    Schouten A., Wagemakers L., Stefanato F.L., van der Kaaij R.M., van Kan J.A.L.
    Mol. Microbiol. 43:883-894(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SAS56.

Entry informationi

Entry nameiLAC3_BOTFU
AccessioniPrimary (citable) accession number: Q96UM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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