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Q96UM2

- LAC3_BOTFU

UniProt

Q96UM2 - LAC3_BOTFU

Protein

Laccase-3

Gene

lcc3

Organism
Botryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Lignin degradation and detoxification of lignin-derived products.By similarity

    Catalytic activityi

    4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

    Cofactori

    Binds 4 copper ions per monomer.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi29 – 291Copper 1; type 2By similarity
    Metal bindingi31 – 311Copper 2; type 3By similarity
    Metal bindingi73 – 731Copper 2; type 3By similarity
    Metal bindingi75 – 751Copper 3; type 3By similarity
    Metal bindingi375 – 3751Copper 4; type 1By similarity
    Metal bindingi378 – 3781Copper 1; type 2By similarity
    Metal bindingi380 – 3801Copper 3; type 3By similarity
    Metal bindingi437 – 4371Copper 3; type 3By similarity
    Metal bindingi438 – 4381Copper 4; type 1By similarity
    Metal bindingi439 – 4391Copper 2; type 3By similarity
    Metal bindingi443 – 4431Copper 4; type 1By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lignin catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lignin degradation

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Laccase-3 (EC:1.10.3.2)
    Alternative name(s):
    Benzenediol:oxygen oxidoreductase 3
    Diphenol oxidase 3
    Urishiol oxidase 3
    Gene namesi
    Name:lcc3
    OrganismiBotryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea)
    Taxonomic identifieri40559 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaLeotiomycetesHelotialesSclerotiniaceaeBotrytis

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – ›454›454Laccase-3PRO_0000267639Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi334 – 3341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi395 – 3951N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ96UM2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini‹1 – 95›95Plastocyanin-like 1Add
    BLAST
    Domaini101 – 252152Plastocyanin-like 2Add
    BLAST
    Domaini319 – 454136Plastocyanin-like 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the multicopper oxidase family.Curated
    Contains 3 plastocyanin-like domains.Curated

    Keywords - Domaini

    Repeat

    Family and domain databases

    Gene3Di2.60.40.420. 3 hits.
    InterProiIPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    [Graphical view]
    PfamiPF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 3 hits.
    PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q96UM2-1 [UniParc]FASTAAdd to Basket

    « Hide

    PGPTLYADWG DMIQVTLKNS MPDNGTGIHW HGLRQYHTCT EDGVPGITEC    50
    PLAPGDTKTY TFQATQFGTS WYHSHYSSQY GEGMLGGIVI NGPATSNYDV 100
    DLGVYTISDW YYTPVFALGE RIAHSQAGPP SGDNGLINGS MVAPAGQTGG 150
    KYTTNTITAG KKYRLRLINT SVDNHFMVSL DNHAFTVITS DFVPIVPYTA 200
    NWIFIGIGQR YDVIITANQT VGSYWFRAEV QNGCGTNNNN GNIKSIFTYS 250
    GAASTTPSSS ATPYTGRCTD ETGIIPFWDS FVPSGPLSGN VEQLNVAINI 300
    GVDASGPIVT WGINLSAIDV DWKKPILQYV LDGNNSWPAS ENLIELPNAA 350
    QWYYWVIQEV PGNVNGNPVS INVPHPMHLH GHDFFLLGTG VGTYNNTING 400
    PSLDYDNPTR RDVAMLPAGG WMVLAFQTDN PGAWLMHCHI AWHVSEGLAV 450
    QFQG 454
    Length:454
    Mass (Da):49,323
    Last modified:December 1, 2001 - v1
    Checksum:iEB56A720394D912A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Non-terminal residuei454 – 4541

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY047482 Genomic DNA. Translation: AAL06114.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY047482 Genomic DNA. Translation: AAL06114.1 .

    3D structure databases

    ProteinModelPortali Q96UM2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.40.420. 3 hits.
    InterProi IPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    [Graphical view ]
    Pfami PF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 3 hits.
    PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Resveratrol acts as a natural profungicide and induces self-intoxication by a specific laccase."
      Schouten A., Wagemakers L., Stefanato F.L., van der Kaaij R.M., van Kan J.A.L.
      Mol. Microbiol. 43:883-894(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: SAS56.

    Entry informationi

    Entry nameiLAC3_BOTFU
    AccessioniPrimary (citable) accession number: Q96UM2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3