Laccase-3 - Botryotinia fuckeliana (Noble rot fungus)

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Reviewed, UniProtKB/Swiss-Prot Q96UM2 (LAC3_BOTFU)

Last modified January 19, 2010. Version 35. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
    Laccase-3
    EC=1.10.3.2
Alternative name(s):
    Benzenediol:oxygen oxidoreductase 3
    Urishiol oxidase 3
    Diphenol oxidase 3

Gene names

Name:

lcc3

Organism

Botryotinia fuckeliana (Noble rot fungus) (Botrytis cinerea)

Taxonomic identifier

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Leotiomycetes › Helotiales › Sclerotiniaceae › Botryotinia

Protein attributes

Sequence length	454 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Lignin degradation and detoxification of lignin-derived products By similarity.
Catalytic activity	4 benzenediol + O₂ = 4 benzosemiquinone + 2 H₂O.
Cofactor	Binds 4 copper ions per monomer By similarity.
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the multicopper oxidase family. Contains 3 plastocyanin-like domains.

Ontologies

Keywords
Biological process	Lignin degradation
Cellular component	Secreted
Domain	Repeat
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	lignin catabolic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW laccase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

‹1 – ›454

›454

Laccase-3

PRO_0000267639

Regions

Domain

›95

Plastocyanin-like 1

Domain

152

Plastocyanin-like 2

Domain

136

Plastocyanin-like 3

Sites

Metal binding

1

Copper 1; type 2 By similarity

Metal binding

1

Copper 2; type 3 By similarity

Metal binding

1

Copper 2; type 3 By similarity

Metal binding

1

Copper 3; type 3 By similarity

Metal binding

1

Copper 4; type 1 By similarity

Metal binding

1

Copper 1; type 2 By similarity

Metal binding

1

Copper 3; type 3 By similarity

Metal binding

1

Copper 3; type 3 By similarity

Metal binding

1

Copper 4; type 1 By similarity

Metal binding

1

Copper 2; type 3 By similarity

Metal binding

1

Copper 4; type 1 By similarity

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Experimental info

Non-terminal residue

1

Non-terminal residue

1

Sequences

Sequence

Length

Mass (Da)

Tools

Q96UM2-1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: EB56A720394D912A
Show »

454

49,323

        10         20         30         40         50         60 
PGPTLYADWG DMIQVTLKNS MPDNGTGIHW HGLRQYHTCT EDGVPGITEC PLAPGDTKTY 

        70         80         90        100        110        120 
TFQATQFGTS WYHSHYSSQY GEGMLGGIVI NGPATSNYDV DLGVYTISDW YYTPVFALGE 

       130        140        150        160        170        180 
RIAHSQAGPP SGDNGLINGS MVAPAGQTGG KYTTNTITAG KKYRLRLINT SVDNHFMVSL 

       190        200        210        220        230        240 
DNHAFTVITS DFVPIVPYTA NWIFIGIGQR YDVIITANQT VGSYWFRAEV QNGCGTNNNN 

       250        260        270        280        290        300 
GNIKSIFTYS GAASTTPSSS ATPYTGRCTD ETGIIPFWDS FVPSGPLSGN VEQLNVAINI 

       310        320        330        340        350        360 
GVDASGPIVT WGINLSAIDV DWKKPILQYV LDGNNSWPAS ENLIELPNAA QWYYWVIQEV 

       370        380        390        400        410        420 
PGNVNGNPVS INVPHPMHLH GHDFFLLGTG VGTYNNTING PSLDYDNPTR RDVAMLPAGG 

       430        440        450 
WMVLAFQTDN PGAWLMHCHI AWHVSEGLAV QFQG

References

[1]

"Resveratrol acts as a natural profungicide and induces self-intoxication by a specific laccase."
Schouten A., Wagemakers L., Stefanato F.L., van der Kaaij R.M., van Kan J.A.L.
Mol. Microbiol. 43:883-894(2002) [PubMed: 11929539] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: SAS56.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY047482 Genomic DNA. Translation: AAL06114.1.
3D structure databases
HSSP	HSSP built from PDB template 1GW0 based on UniProtKB Q70KY3.
SMR	Q96UM2. Positions 1-453.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.10.3.2. 290409.
Family and domain databases
InterPro	IPR001117. Cu-oxidase. IPR011706. Cu-oxidase_2. IPR011707. Cu-oxidase_3. IPR002355. Cu_oxidase_Cu_BS. IPR008972. Cupredoxin. [Graphical view]
Gene3D	G3DSA:2.60.40.420. Cupredoxin. 3 hits.
Pfam	PF00394. Cu-oxidase. 1 hit. PF07731. Cu-oxidase_2. 1 hit. PF07732. Cu-oxidase_3. 1 hit. [Graphical view]
PROSITE	PS00079. MULTICOPPER_OXIDASE1. 1 hit. PS00080. MULTICOPPER_OXIDASE2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LAC3_BOTFU

Accession

Primary (citable) accession number: Q96UM2

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	December 1, 2001
Last modified:	January 19, 2010
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents