ID   DHE4_HEBCY              Reviewed;         450 AA.
AC   Q96UJ9;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   16-JUN-2009, entry version 34.
DE   RecName: Full=NADP-specific glutamate dehydrogenase;
DE            Short=NADP-GDH;
DE            EC=1.4.1.4;
DE   AltName: Full=NADP-dependent glutamate dehydrogenase;
OS   Hebeloma cylindrosporum.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina;
OC   Homobasidiomycetes; Agaricomycetidae; Agaricales; Cortinariaceae;
OC   Hebeloma.
OX   NCBI_TaxID=76867;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=h1;
RA   Rodriguez-Pastrana B., Javelle A., Belleville R., Morel M., Botton B.,
RA   Jacob C., Chalot M., Brun A.;
RT   "Nucleotide sequence and expression of NADP(+)-GDH and GS from the
RT   ectomycorrhizal fungus Hebeloma cylindrosporum.";
RL   Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: L-glutamate + H(2)O + NADP(+) = 2-oxoglutarate
CC       + NH(3) + NADPH.
CC   -!- SUBUNIT: Homohexamer (By similarity).
CC   -!- SIMILARITY: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
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DR   EMBL; AY052476; AAL06075.1; -; mRNA.
DR   HSSP; P24295; 1AUP.
DR   BRENDA; 1.4.1.4; 280602.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004354; F:glutamate dehydrogenase (NADP+) activity; IEA:EC.
DR   GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR006095; Glu/Leu/Phe/Val_DH.
DR   InterPro; IPR006096; Glu/Leu/Phe/Val_DH_C.
DR   InterPro; IPR006097; Glu/Leu/Phe/Val_DH_dimer.
DR   InterPro; IPR014362; Glu_DH.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR11606:SF2; GLFV_DH; 1.
DR   Pfam; PF00208; ELFV_dehydrog; 1.
DR   Pfam; PF02812; ELFV_dehydrog_N; 1.
DR   PIRSF; PIRSF000185; Glu_DH; 1.
DR   PRINTS; PR00082; GLFDHDRGNASE.
DR   PROSITE; PS00074; GLFV_DEHYDROGENASE; 1.
PE   2: Evidence at transcript level;
KW   NADP; Oxidoreductase.
FT   CHAIN         1    450       NADP-specific glutamate dehydrogenase.
FT                                /FTId=PRO_0000182788.
FT   ACT_SITE    111    111       By similarity.
SQ   SEQUENCE   450 AA;  48356 MW;  3D0E79953F3E0746 CRC64;
     MVKPFEPEFQ QALDELTTSL QPFLDANPQY KKALEIVQVP ERVLQFRVVW EDDQGVAQVN
     HGFRVQYNSA LGPYKGGLRL HPSVNLSILK FLGFEQTFKN ALTGLSMGGG KGGSDFDPKG
     KSDSEIRRFC FSFMGELFRH IGSDTDVPAG DIGTGGREIG FLFGAYKKLR NEFTGMLTGK
     GLTWGGSFIR PEATGYGLIY FVEHMIAKAC PEYSLDKPST LVAISGSGNV AQFTALKVIE
     LGATVLSLSD SKGSLISDKG YTKEFIRKVA DLKLKGGSLA SLANEEGYTY HAGARPWTLI
     PTIHIALPGA TQNEVSAEEA EALLKAGVRI VAEGSNMGCT ADAIDIFESS RKAGPGGVWY
     APGKASNCGG VAVSGLEMAQ NSQRLAWTTQ EVDSKLKDIM AECYGICLTA GTKWSGEELT
     DEVLPSLLSG ANVAGFIKVA DAMKAQGDWW
//