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Q96UJ9 (DHE4_HEBCY) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NADP-specific glutamate dehydrogenase

Short name=NADP-GDH
EC=1.4.1.4
Alternative name(s):
NADP-dependent glutamate dehydrogenase
OrganismHebeloma cylindrosporum
Taxonomic identifier76867 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesCortinariaceaeHebeloma

Protein attributes

Sequence length450 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Subunit structure

Homohexamer By similarity.

Sequence similarities

Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Ontologies

Keywords
   LigandNADP
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological_processcellular amino acid metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionglutamate dehydrogenase (NADP+) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 450450NADP-specific glutamate dehydrogenase
PRO_0000182788

Sites

Active site1111 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q96UJ9 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 3D0E79953F3E0746

FASTA45048,356
        10         20         30         40         50         60 
MVKPFEPEFQ QALDELTTSL QPFLDANPQY KKALEIVQVP ERVLQFRVVW EDDQGVAQVN 

        70         80         90        100        110        120 
HGFRVQYNSA LGPYKGGLRL HPSVNLSILK FLGFEQTFKN ALTGLSMGGG KGGSDFDPKG 

       130        140        150        160        170        180 
KSDSEIRRFC FSFMGELFRH IGSDTDVPAG DIGTGGREIG FLFGAYKKLR NEFTGMLTGK 

       190        200        210        220        230        240 
GLTWGGSFIR PEATGYGLIY FVEHMIAKAC PEYSLDKPST LVAISGSGNV AQFTALKVIE 

       250        260        270        280        290        300 
LGATVLSLSD SKGSLISDKG YTKEFIRKVA DLKLKGGSLA SLANEEGYTY HAGARPWTLI 

       310        320        330        340        350        360 
PTIHIALPGA TQNEVSAEEA EALLKAGVRI VAEGSNMGCT ADAIDIFESS RKAGPGGVWY 

       370        380        390        400        410        420 
APGKASNCGG VAVSGLEMAQ NSQRLAWTTQ EVDSKLKDIM AECYGICLTA GTKWSGEELT 

       430        440        450 
DEVLPSLLSG ANVAGFIKVA DAMKAQGDWW 

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References

[1]"Nucleotide sequence and expression of NADP(+)-GDH and GS from the ectomycorrhizal fungus Hebeloma cylindrosporum."
Rodriguez-Pastrana B., Javelle A., Belleville R., Morel M., Botton B., Jacob C., Chalot M., Brun A.
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: h1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY052476 mRNA. Translation: AAL06075.1.

3D structure databases

ProteinModelPortalQ96UJ9.
SMRQ96UJ9. Positions 3-449.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ96UJ9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFPIRSF000185. Glu_DH. 1 hit.
PRINTSPR00082. GLFDHDRGNASE.
SMARTSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDHE4_HEBCY
AccessionPrimary (citable) accession number: Q96UJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: December 1, 2001
Last modified: October 16, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families