Q96UI1 (GAL7_HYPJE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Galactose-1-phosphate uridylyltransferase
Short name=Gal-1-P uridylyltransferase
EC=2.7.7.12

Alternative name(s):
UDP-glucose--hexose-1-phosphate uridylyltransferase

Gene names

Name:

gal7

Organism

Hypocrea jecorina (Trichoderma reesei)

Taxonomic identifier

51453 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Sordariomycetes › Hypocreomycetidae › Hypocreales › Hypocreaceae › Hypocrea

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose.
Cofactor	Binds 1 iron ion per subunit Potential. Binds 1 zinc ion per subunit Potential.
Pathway	Carbohydrate metabolism; galactose metabolism.
Sequence similarities	Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Ligand	Iron Metal-binding Zinc
Molecular function	Nucleotidyltransferase Transferase
Gene Ontology (GO)
Biological process	galactose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	UDP-glucose:hexose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 382	382	Galactose-1-phosphate uridylyltransferase		PRO_0000169892
Sites
	Active site	198	1	Tele-UMP-histidine intermediate By similarity
	Metal binding	52	1	Zinc By similarity
	Metal binding	55	1	Zinc Potential
	Metal binding	121	1	Zinc By similarity
	Metal binding	196	1	Zinc Potential
	Metal binding	214	1	Iron Potential
	Metal binding	313	1	Iron Potential
	Metal binding	330	1	Iron Potential
	Metal binding	332	1	Iron Potential

Sequences

	Sequence		Length	Mass (Da)
	Q96UI1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 25A08CC695C39794	FASTA	382	43,781
	10 20 30 40 50 60 MPDKILDDIS HRRYNPLTDS WLLVSPHRTK RPWQGQQEGA AVTTLPEYDP KCYLCPGNSR 70 80 90 100 110 120 AAGDQNPNYE QTFAFVNDYS AVKEQQPDYE VDQSSDDLES LLLRAQGVKG VCYVLTFSPK 130 140 150 160 170 180 HNVTLADMSA KDILPTINHW TRLYANHLSP SNPLSAVAAQ LQLPISKEEA PVPKDNYRYM 190 200 210 220 230 240 QIFENKGAAM GCSNPHPHCQ AWTTSTMPEE PGKELVQMAK YRQQHGRHLL ADYIKLELAK 250 260 270 280 290 300 EERVVWQNDS FVVVCPWWAI WPFEVLVLPK RHVRALVDLT ADERLQLAEA IQEVTRRYDN 310 320 330 340 350 360 LFECHFPYSS GIHQAPLDGT PEEIENAYFH MHFYPPLLRS ATVKKFLVGF ELMAEAQRDI 370 380 TPEQATIRLR ACDGELYRNK LS

References

[1]	"Lactose metabolism and cellulase production in Hypocrea jecorina: the gal7 (galactose-1-phosphate uridylyltransferase) gene is essential for growth on galactose but not for cellulase induction." Seiboth B., Hofmann G., Kubicek C.P. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: QM9414 / Rut C-30.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY057108 Genomic DNA. Translation: AAL14201.1.
3D structure databases
ProteinModelPortal	Q96UI1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96UI1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001937. GalP_UDPtransf1. IPR019779. GalP_UDPtransf1_His-AS. IPR005850. GalP_Utransf_C. IPR005849. GalP_Utransf_N. IPR011146. His_triad-like_motif. IPR011151. His_triad_motif. [Graphical view]
Gene3D	G3DSA:3.30.428.10. His_triad_motif. 2 hits.
PANTHER	PTHR11943. GalP_UDPtransf1. 1 hit.
Pfam	PF02744. GalP_UDP_tr_C. 1 hit. PF01087. GalP_UDP_transf. 1 hit. [Graphical view]
PIRSF	PIRSF000808. GalT. 1 hit.
SUPFAM	SSF54197. His_triad-like_motif. 2 hits.
TIGRFAMs	TIGR00209. GalT_1. 1 hit.
PROSITE	PS00117. GAL_P_UDP_TRANSF_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GAL7_HYPJE

Accession

Primary (citable) accession number: Q96UI1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 30, 2003
Last sequence update:	December 1, 2001
Last modified:	October 19, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program