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Reviewed, UniProtKB/Swiss-Prot Q96UF1 (G3P3_RHIRA)

Last modified February 9, 2010. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Glyceraldehyde-3-phosphate dehydrogenase 3
      Short name=GAPDH 3
    EC=1.2.1.12
Gene names
Name: GPD3
OrganismRhizomucor racemosus (Mucor circinelloides f. lusitanicus)
Taxonomic identifier4841 [NCBI]
Taxonomic lineageEukaryota › Fungi › Fungi incertae sedis › Basal fungal lineages › Mucoromycotina › Mucorales › Mucoraceae › Mucor

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Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

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Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNAD or NADH binding

Inferred from electronic annotation. Source: InterPro

glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339Glyceraldehyde-3-phosphate dehydrogenase 3
PRO_0000145578

Regions

Nucleotide binding13 – 142NAD By similarity
Region151 – 1533Glyceraldehyde 3-phosphate binding By similarity
Region211 – 2122Glyceraldehyde 3-phosphate binding By similarity

Sites

Active site1521Nucleophile By similarity
Binding site351NAD By similarity
Binding site801NAD; via carbonyl oxygen By similarity
Binding site1821Glyceraldehyde 3-phosphate By similarity
Binding site2341Glyceraldehyde 3-phosphate By similarity
Binding site3171NAD By similarity
Site1791Activates thiol group during catalysis By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q96UF1-1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: E64470AAABA71BC8

FASTA33936,302
        10         20         30         40         50         60 
MSTINTGING FRSHWPYCLA CSLENPKVKV VAINDPFIDL EYMVYMFKYD STHGRFKGTV 

        70         80         90        100        110        120 
EHKDGKLVVN GHEIAVHAER DPAQIPWGSH GADYVIESTG VFTTKDAASA HLKGGAKKVI 

       130        140        150        160        170        180 
ISAPSADAPM FVVGVNLDKY TSDLTVISNA SCTTNCLAPL AKVIHDNYGI LEGLMTTVHA 

       190        200        210        220        230        240 
TTATQKTVDG PSNKDWRGGR GAGANIIPSS TGAAKAVGKV IPELNGKLTG MAFRVPTPDV 

       250        260        270        280        290        300 
SVVDLTVRLE KPASYDEIKA TIKKASESEE LKGILGYTED QVVSTDFVGD AHSSIFDAKA 

       310        320        330 
GIQLSPTFVK LISWYDNEFG YSTRVVDLLA YVAGKDGAL

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References

[1]"Cloning of glyceraldehyde-3-phosphate dehydrogenase-encoding genes in Mucor circinelloides (Syn. racemosus) and use of the gpd1 promoter for recombinant protein production."
Wolff A.M., Arnau J.
Fungal Genet. Biol. 35:21-29(2002) [PubMed: 11860262] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 90680 / R7B.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ293014 Genomic DNA. Translation: CAC37405.2.

3D structure databases

SMRQ96UF1. Positions 4-336.
ModBaseSearch...

Family and domain databases

InterProIPR020830. GlycerAld_3-P_DH_AS.
IPR020829. GlycerAld_3-P_DH_cat.
IPR020832. GlycerAld_3-P_DH_cat_sub.
IPR020831. GlycerAld_3-P_DH_family.
IPR020828. GlycerAld_3-P_DH_NAD(P)_bd.
IPR000173. GlycerAld_3-P_DH_subfam.
IPR006424. Glyceraldehyde-3-P_DH_1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR10836. GAP_DH. 1 hit.
PfamPF02800. Gp_dh_C. 1 hit.
PF00044. Gp_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF000149. GAP_DH. 1 hit.
PRINTSPR00078. G3PDHDRGNASE.
SMARTSM00846. Gp_dh_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01534. GAPDH-I. 1 hit.
PROSITEPS00071. GAPDH. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameG3P3_RHIRA
AccessionPrimary (citable) accession number: Q96UF1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: December 1, 2001
Last modified: February 9, 2010
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents