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Protein

Mitochondrial glycine transporter

Gene

mic-13

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial glycine transporterUniRule annotation
Alternative name(s):
Solute carrier family 25 member 38 homologUniRule annotation
Gene namesi
Name:mic-13
ORF Names:B7F18.090, NCU02973
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 1, Linkage Group I

Organism-specific databases

EuPathDBiFungiDB:NCU02973

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 41Helical; Name=1UniRule annotationAdd BLAST26
Transmembranei69 – 95Helical; Name=2UniRule annotationAdd BLAST27
Transmembranei136 – 161Helical; Name=3UniRule annotationAdd BLAST26
Transmembranei189 – 212Helical; Name=4UniRule annotationAdd BLAST24
Transmembranei253 – 279Helical; Name=5UniRule annotationAdd BLAST27
Transmembranei308 – 326Helical; Name=6UniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003789401 – 348Mitochondrial glycine transporterAdd BLAST348

Structurei

3D structure databases

ProteinModelPortaliQ96U08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati10 – 94Solcar 1UniRule annotationAdd BLAST85
Repeati130 – 214Solcar 2UniRule annotationAdd BLAST85
Repeati249 – 333Solcar 3UniRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000006978
InParanoidiQ96U08
KOiK15118
OMAiTVYEQMM
OrthoDBiEOG092C3NVU

Family and domain databases

Gene3Di1.50.40.10, 2 hits
HAMAPiMF_03064 SLC25A38, 1 hit
InterProiView protein in InterPro
IPR030847 Hem25/SLC25A38
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
SUPFAMiSSF103506 SSF103506, 3 hits
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q96U08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDGSRKSGT KSTFHFVAGL GSGVLSAILL QPIDLLKTRV QQSGKHSLRA
60 70 80 90 100
ALAELRSSQQ GLLPSLWRGT LPSALRTGFG SAIYFTTLNT IRENAARHLP
110 120 130 140 150
SLAAAAPTIA AASGIVAPNA NQTSSSLPKL SNTGNLLAGA VARSFAGFIL
160 170 180 190 200
MPLTVLKVRY ESSFYKYTSL AGAARDIART EGARGFFAGF GATAIRDAPY
210 220 230 240 250
AGLYVLFYEK SKQHLSNLFP QPPQPQLSTT TTLEAAAGQD GGGRMSQSRA
260 270 280 290 300
ASINFASGVF SAIICSIISN PFDAVKTRIQ LQPKKYRNMV QASRKMLAEE
310 320 330 340
GVRSMMDGLA LRMSRKAMSS ALAWTVYEEL IRRAEGAWTK RGPEEVQL
Length:348
Mass (Da):37,240
Last modified:December 1, 2001 - v1
Checksum:iA2B44FA6FBE9D1E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL389891 Genomic DNA Translation: CAD11801.1
CM002236 Genomic DNA Translation: EAA36124.1
PIRiT50990
RefSeqiXP_965360.1, XM_960267.1

Genome annotation databases

EnsemblFungiiEAA36124; EAA36124; NCU02973
GeneIDi3881523
KEGGincr:NCU02973

Similar proteinsi

Entry informationi

Entry nameiS2538_NEUCR
AccessioniPrimary (citable) accession number: Q96U08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: December 1, 2001
Last modified: April 25, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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