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Protein

Solute carrier family 25 member 38 homolog

Gene

B7F18.090

Organism
Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial carrier required for the biosynthesis of heme, possibly by facilitating 5-aminolevulinate (ALA) production. May act by importing glycine into mitochondria or by exchanging glycine for ALA across the mitochondrial inner membrane.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 38 homologUniRule annotation
Gene namesi
ORF Names:B7F18.090, NCU02973
OrganismiNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Taxonomic identifieri367110 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeSordarialesSordariaceaeNeurospora
Proteomesi
  • UP000001805 Componenti: Chromosome 1, Linkage Group I

Organism-specific databases

EuPathDBiFungiDB:NCU02973.

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 41Helical; Name=1UniRule annotationAdd BLAST26
Transmembranei69 – 95Helical; Name=2UniRule annotationAdd BLAST27
Transmembranei136 – 161Helical; Name=3UniRule annotationAdd BLAST26
Transmembranei189 – 212Helical; Name=4UniRule annotationAdd BLAST24
Transmembranei253 – 279Helical; Name=5UniRule annotationAdd BLAST27
Transmembranei308 – 326Helical; Name=6UniRule annotationAdd BLAST19

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003789401 – 348Solute carrier family 25 member 38 homologAdd BLAST348

Structurei

3D structure databases

ProteinModelPortaliQ96U08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati10 – 94Solcar 1Add BLAST85
Repeati130 – 214Solcar 2Add BLAST85
Repeati249 – 333Solcar 3Add BLAST85

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000006978.
InParanoidiQ96U08.
KOiK15118.
OMAiTVYEQMM.
OrthoDBiEOG092C3NVU.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
HAMAPiMF_03064. SLC25A38. 1 hit.
InterProiView protein in InterPro
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
IPR030847. SLC25A38.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
SUPFAMiSSF103506. SSF103506. 3 hits.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Q96U08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDGSRKSGT KSTFHFVAGL GSGVLSAILL QPIDLLKTRV QQSGKHSLRA
60 70 80 90 100
ALAELRSSQQ GLLPSLWRGT LPSALRTGFG SAIYFTTLNT IRENAARHLP
110 120 130 140 150
SLAAAAPTIA AASGIVAPNA NQTSSSLPKL SNTGNLLAGA VARSFAGFIL
160 170 180 190 200
MPLTVLKVRY ESSFYKYTSL AGAARDIART EGARGFFAGF GATAIRDAPY
210 220 230 240 250
AGLYVLFYEK SKQHLSNLFP QPPQPQLSTT TTLEAAAGQD GGGRMSQSRA
260 270 280 290 300
ASINFASGVF SAIICSIISN PFDAVKTRIQ LQPKKYRNMV QASRKMLAEE
310 320 330 340
GVRSMMDGLA LRMSRKAMSS ALAWTVYEEL IRRAEGAWTK RGPEEVQL
Length:348
Mass (Da):37,240
Last modified:December 1, 2001 - v1
Checksum:iA2B44FA6FBE9D1E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL389891 Genomic DNA. Translation: CAD11801.1.
CM002236 Genomic DNA. Translation: EAA36124.1.
PIRiT50990.
RefSeqiXP_965360.1. XM_960267.1.

Genome annotation databases

EnsemblFungiiEAA36124; EAA36124; NCU02973.
GeneIDi3881523.
KEGGincr:NCU02973.

Similar proteinsi

Entry informationi

Entry nameiS2538_NEUCR
AccessioniPrimary (citable) accession number: Q96U08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: December 1, 2001
Last modified: June 7, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families