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Q96TP5 (ACEA_COCIM) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate lyase

Short name=ICL
Short name=Isocitrase
Short name=Isocitratase
EC=4.1.3.1
Gene names
Name:ICL1
ORF Names:CIMG_01988
OrganismCoccidioides immitis (strain RS) (Valley fever fungus) [Reference proteome]
Taxonomic identifier246410 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides

Protein attributes

Sequence length538 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Isocitrate = succinate + glyoxylate.

Pathway

Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.

Subunit structure

Homotetramer By similarity.

Subcellular location

Peroxisome By similarity.

Sequence similarities

Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.

Ontologies

Keywords
   Biological processGlyoxylate bypass
Tricarboxylic acid cycle
   Cellular componentPeroxisome
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglyoxylate cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentperoxisome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionisocitrate lyase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 538538Isocitrate lyase
PRO_0000068788

Sites

Active site2071 By similarity

Experimental info

Sequence conflict2721N → T in AAK72548. Ref.1
Sequence conflict2721N → T in AAL16915. Ref.1
Sequence conflict328 – 3292AI → TT in AAK72548. Ref.1
Sequence conflict328 – 3292AI → TT in AAL16915. Ref.1
Sequence conflict5221V → I in AAK72548. Ref.1
Sequence conflict5221V → I in AAL16915. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q96TP5 [UniParc].

Last modified October 3, 2006. Version 2.
Checksum: CD722C99DB39502C

FASTA53860,383
        10         20         30         40         50         60 
MSLSVEQEEQ KYWEEVEAVK QWWKDSRWRY TKRPFTAEQI VAKRGNLKIE YPSNVQSKKL 

        70         80         90        100        110        120 
WKLVEEKFKT KTASFTYGCL DPTMVTQMVK YLDTVYVSGW QSSSTASSTD EPSPDLADYP 

       130        140        150        160        170        180 
MNTVPNKVNQ LWMAQLFHDR KQREERLRNP KEKRASLANI DYLAPIIADA DTGHGGLTAV 

       190        200        210        220        230        240 
MKLTKLFIER GAAGIHIEDQ APGTKKCGHM AGKVLVPISE HINRLVAIRA QADIMGTDLL 

       250        260        270        280        290        300 
AIARTDSEAA TLITSTIDPR DHAFVVGSTN PNLEPLNDLM IAAERAGKNG AELQAIEDSW 

       310        320        330        340        350        360 
TAKAGLKRFE DAVIDQIKAS SAANKQAAID AFLREIKGKS NKEARAIARQ ILGTDIFWDW 

       370        380        390        400        410        420 
DAPRTREGYY RYQGGCQCAI NRAVAFAPFA DLIWMESKLP DYAQAKEFAE GVHAVWPQQK 

       430        440        450        460        470        480 
LAYNLSPSFN WKAAMPRDEQ ETYIRRLGEL GYCWQFITLA GLHTTALISD QFAKAYAKQG 

       490        500        510        520        530 
MRAYGELVQE PEMENKVDVV THQKWSGANY VDELLKMVTG GVSSTSAMGK GVTEDQFK 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of isocitrate lyase of Coccidioides immitis."
Shi Q., Ivey F.D., Woitaske M.D., Magee D.M., Cox R.A.
Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]"Comparative genomic analyses of the human fungal pathogens Coccidioides and their relatives."
Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R., Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y., McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M., Barker B.M., Galgiani J.N. expand/collapse author list , Orbach M.J., Kirkland T.N., Cole G.T., Henn M.R., Birren B.W., Taylor J.W.
Genome Res. 19:1722-1731(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RS.
[3]"Population genomic sequencing of Coccidioides fungi reveals recent hybridization and transposon control."
Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J., Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D., Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A., FitzGerald M. expand/collapse author list , Lui A., Macdonald J.P., Priest M., Orbach M.J., Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R., Taylor J.W., Rounsley S.D.
Genome Res. 20:938-946(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: RS.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF420484 Genomic DNA. Translation: AAL16915.1.
AY038602 mRNA. Translation: AAK72548.2.
GG704911 Genomic DNA. Translation: EAS36808.2.
RefSeqXP_001248217.1. XM_001248216.1.
XP_001248391.1. XM_001248390.1.

3D structure databases

ProteinModelPortalQ96TP5.
SMRQ96TP5. Positions 5-521.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4567087.
4567700.
KEGGcim:CIMG_01988.
cim:CIMG_02162.

Phylogenomic databases

KOK01637.
OrthoDBEOG73Z331.

Enzyme and pathway databases

UniPathwayUPA00703; UER00719.

Family and domain databases

Gene3D3.20.20.60. 2 hits.
InterProIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamPF00463. ICL. 1 hit.
[Graphical view]
PIRSFPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMSSF51621. SSF51621. 1 hit.
TIGRFAMsTIGR01346. isocit_lyase. 1 hit.
PROSITEPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACEA_COCIM
AccessionPrimary (citable) accession number: Q96TP5
Secondary accession number(s): J3KKS8, Q1E625
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 3, 2006
Last modified: May 14, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways