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Q96TP5

- ACEA_COCIM

UniProt

Q96TP5 - ACEA_COCIM

Protein

Isocitrate lyase

Gene

ICL1

Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 2 (03 Oct 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate = succinate + glyoxylate.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei207 – 2071PROSITE-ProRule annotation

    GO - Molecular functioni

    1. isocitrate lyase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-UniPathway
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Enzyme and pathway databases

    UniPathwayiUPA00703; UER00719.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate lyase (EC:4.1.3.1)
    Short name:
    ICL
    Short name:
    Isocitrase
    Short name:
    Isocitratase
    Gene namesi
    Name:ICL1
    ORF Names:CIMG_01988
    OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
    Taxonomic identifieri246410 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
    ProteomesiUP000001261: Unassembled WGS sequence

    Subcellular locationi

    Peroxisome By similarity

    GO - Cellular componenti

    1. peroxisome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 538538Isocitrate lyasePRO_0000068788Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ96TP5.
    SMRiQ96TP5. Positions 5-521.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    KOiK01637.
    OrthoDBiEOG73Z331.

    Family and domain databases

    Gene3Di3.20.20.60. 2 hits.
    InterProiIPR006254. Isocitrate_lyase.
    IPR018523. Isocitrate_lyase_ph_CS.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view]
    PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
    PfamiPF00463. ICL. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
    SUPFAMiSSF51621. SSF51621. 1 hit.
    TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
    PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96TP5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLSVEQEEQ KYWEEVEAVK QWWKDSRWRY TKRPFTAEQI VAKRGNLKIE    50
    YPSNVQSKKL WKLVEEKFKT KTASFTYGCL DPTMVTQMVK YLDTVYVSGW 100
    QSSSTASSTD EPSPDLADYP MNTVPNKVNQ LWMAQLFHDR KQREERLRNP 150
    KEKRASLANI DYLAPIIADA DTGHGGLTAV MKLTKLFIER GAAGIHIEDQ 200
    APGTKKCGHM AGKVLVPISE HINRLVAIRA QADIMGTDLL AIARTDSEAA 250
    TLITSTIDPR DHAFVVGSTN PNLEPLNDLM IAAERAGKNG AELQAIEDSW 300
    TAKAGLKRFE DAVIDQIKAS SAANKQAAID AFLREIKGKS NKEARAIARQ 350
    ILGTDIFWDW DAPRTREGYY RYQGGCQCAI NRAVAFAPFA DLIWMESKLP 400
    DYAQAKEFAE GVHAVWPQQK LAYNLSPSFN WKAAMPRDEQ ETYIRRLGEL 450
    GYCWQFITLA GLHTTALISD QFAKAYAKQG MRAYGELVQE PEMENKVDVV 500
    THQKWSGANY VDELLKMVTG GVSSTSAMGK GVTEDQFK 538
    Length:538
    Mass (Da):60,383
    Last modified:October 3, 2006 - v2
    Checksum:iCD722C99DB39502C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti272 – 2721N → T in AAK72548. 1 PublicationCurated
    Sequence conflicti272 – 2721N → T in AAL16915. 1 PublicationCurated
    Sequence conflicti328 – 3292AI → TT in AAK72548. 1 PublicationCurated
    Sequence conflicti328 – 3292AI → TT in AAL16915. 1 PublicationCurated
    Sequence conflicti522 – 5221V → I in AAK72548. 1 PublicationCurated
    Sequence conflicti522 – 5221V → I in AAL16915. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF420484 Genomic DNA. Translation: AAL16915.1.
    AY038602 mRNA. Translation: AAK72548.2.
    GG704911 Genomic DNA. Translation: EAS36808.2.
    RefSeqiXP_001248217.1. XM_001248216.1.
    XP_001248391.1. XM_001248390.1.

    Genome annotation databases

    GeneIDi4567087.
    4567700.
    KEGGicim:CIMG_01988.
    cim:CIMG_02162.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF420484 Genomic DNA. Translation: AAL16915.1 .
    AY038602 mRNA. Translation: AAK72548.2 .
    GG704911 Genomic DNA. Translation: EAS36808.2 .
    RefSeqi XP_001248217.1. XM_001248216.1.
    XP_001248391.1. XM_001248390.1.

    3D structure databases

    ProteinModelPortali Q96TP5.
    SMRi Q96TP5. Positions 5-521.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4567087.
    4567700.
    KEGGi cim:CIMG_01988.
    cim:CIMG_02162.

    Phylogenomic databases

    KOi K01637.
    OrthoDBi EOG73Z331.

    Enzyme and pathway databases

    UniPathwayi UPA00703 ; UER00719 .

    Family and domain databases

    Gene3Di 3.20.20.60. 2 hits.
    InterProi IPR006254. Isocitrate_lyase.
    IPR018523. Isocitrate_lyase_ph_CS.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view ]
    PANTHERi PTHR21631:SF3. PTHR21631:SF3. 1 hit.
    Pfami PF00463. ICL. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001362. Isocit_lyase. 1 hit.
    SUPFAMi SSF51621. SSF51621. 1 hit.
    TIGRFAMsi TIGR01346. isocit_lyase. 1 hit.
    PROSITEi PS00161. ISOCITRATE_LYASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of isocitrate lyase of Coccidioides immitis."
      Shi Q., Ivey F.D., Woitaske M.D., Magee D.M., Cox R.A.
      Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RS.
    3. Cited for: GENOME REANNOTATION.
      Strain: RS.

    Entry informationi

    Entry nameiACEA_COCIM
    AccessioniPrimary (citable) accession number: Q96TP5
    Secondary accession number(s): J3KKS8, Q1E625
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: October 3, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3