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Q96TP5

- ACEA_COCIM

UniProt

Q96TP5 - ACEA_COCIM

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Protein

Isocitrate lyase

Gene
ICL1, CIMG_01988
Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Isocitrate = succinate + glyoxylate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei207 – 2071 By similarity

GO - Molecular functioni

  1. isocitrate lyase activity Source: UniProtKB-EC

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00703; UER00719.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate lyase (EC:4.1.3.1)
Short name:
ICL
Short name:
Isocitrase
Short name:
Isocitratase
Gene namesi
Name:ICL1
ORF Names:CIMG_01988
OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
Taxonomic identifieri246410 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000001261: Unassembled WGS sequence

Subcellular locationi

Peroxisome By similarity

GO - Cellular componenti

  1. peroxisome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 538538Isocitrate lyasePRO_0000068788Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ96TP5.
SMRiQ96TP5. Positions 5-521.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01637.
OrthoDBiEOG73Z331.

Family and domain databases

Gene3Di3.20.20.60. 2 hits.
InterProiIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamiPF00463. ICL. 1 hit.
[Graphical view]
PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96TP5-1 [UniParc]FASTAAdd to Basket

« Hide

MSLSVEQEEQ KYWEEVEAVK QWWKDSRWRY TKRPFTAEQI VAKRGNLKIE    50
YPSNVQSKKL WKLVEEKFKT KTASFTYGCL DPTMVTQMVK YLDTVYVSGW 100
QSSSTASSTD EPSPDLADYP MNTVPNKVNQ LWMAQLFHDR KQREERLRNP 150
KEKRASLANI DYLAPIIADA DTGHGGLTAV MKLTKLFIER GAAGIHIEDQ 200
APGTKKCGHM AGKVLVPISE HINRLVAIRA QADIMGTDLL AIARTDSEAA 250
TLITSTIDPR DHAFVVGSTN PNLEPLNDLM IAAERAGKNG AELQAIEDSW 300
TAKAGLKRFE DAVIDQIKAS SAANKQAAID AFLREIKGKS NKEARAIARQ 350
ILGTDIFWDW DAPRTREGYY RYQGGCQCAI NRAVAFAPFA DLIWMESKLP 400
DYAQAKEFAE GVHAVWPQQK LAYNLSPSFN WKAAMPRDEQ ETYIRRLGEL 450
GYCWQFITLA GLHTTALISD QFAKAYAKQG MRAYGELVQE PEMENKVDVV 500
THQKWSGANY VDELLKMVTG GVSSTSAMGK GVTEDQFK 538
Length:538
Mass (Da):60,383
Last modified:October 3, 2006 - v2
Checksum:iCD722C99DB39502C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti272 – 2721N → T in AAK72548. 1 Publication
Sequence conflicti272 – 2721N → T in AAL16915. 1 Publication
Sequence conflicti328 – 3292AI → TT in AAK72548. 1 Publication
Sequence conflicti328 – 3292AI → TT in AAL16915. 1 Publication
Sequence conflicti522 – 5221V → I in AAK72548. 1 Publication
Sequence conflicti522 – 5221V → I in AAL16915. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF420484 Genomic DNA. Translation: AAL16915.1.
AY038602 mRNA. Translation: AAK72548.2.
GG704911 Genomic DNA. Translation: EAS36808.2.
RefSeqiXP_001248217.1. XM_001248216.1.
XP_001248391.1. XM_001248390.1.

Genome annotation databases

GeneIDi4567087.
4567700.
KEGGicim:CIMG_01988.
cim:CIMG_02162.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF420484 Genomic DNA. Translation: AAL16915.1 .
AY038602 mRNA. Translation: AAK72548.2 .
GG704911 Genomic DNA. Translation: EAS36808.2 .
RefSeqi XP_001248217.1. XM_001248216.1.
XP_001248391.1. XM_001248390.1.

3D structure databases

ProteinModelPortali Q96TP5.
SMRi Q96TP5. Positions 5-521.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4567087.
4567700.
KEGGi cim:CIMG_01988.
cim:CIMG_02162.

Phylogenomic databases

KOi K01637.
OrthoDBi EOG73Z331.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00719 .

Family and domain databases

Gene3Di 3.20.20.60. 2 hits.
InterProi IPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
PANTHERi PTHR21631:SF3. PTHR21631:SF3. 1 hit.
Pfami PF00463. ICL. 1 hit.
[Graphical view ]
PIRSFi PIRSF001362. Isocit_lyase. 1 hit.
SUPFAMi SSF51621. SSF51621. 1 hit.
TIGRFAMsi TIGR01346. isocit_lyase. 1 hit.
PROSITEi PS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of isocitrate lyase of Coccidioides immitis."
    Shi Q., Ivey F.D., Woitaske M.D., Magee D.M., Cox R.A.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RS.
  3. Cited for: GENOME REANNOTATION.
    Strain: RS.

Entry informationi

Entry nameiACEA_COCIM
AccessioniPrimary (citable) accession number: Q96TP5
Secondary accession number(s): J3KKS8, Q1E625
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: October 3, 2006
Last modified: May 14, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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