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Q96TA2

- YMEL1_HUMAN

UniProt

Q96TA2 - YMEL1_HUMAN

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Protein

ATP-dependent zinc metalloprotease YME1L1

Gene

YME1L1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Requires to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). Seems to act in the processing of OPA1.2 Publications

Cofactori

Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi599 – 5991Zinc; catalyticBy similarity
Active sitei600 – 6001By similarity
Metal bindingi603 – 6031Zinc; catalyticBy similarity
Metal bindingi677 – 6771Zinc; catalyticBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi379 – 3868ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. metalloendopeptidase activity Source: InterPro

GO - Biological processi

  1. cell proliferation Source: UniProtKB
  2. misfolded or incompletely synthesized protein catabolic process Source: UniProtKB
  3. mitochondrion organization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Protein family/group databases

MEROPSiM41.026.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent zinc metalloprotease YME1L1 (EC:3.4.24.-)
Alternative name(s):
ATP-dependent metalloprotease FtsH1
Meg-4
Presenilin-associated metalloprotease
Short name:
PAMP
YME1-like protein 1
Gene namesi
Name:YME1L1
Synonyms:FTSH1, YME1L
ORF Names:UNQ1868/PRO4304
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:12843. YME1L1.

Subcellular locationi

Mitochondrion inner membrane 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 295295Mitochondrial matrixSequence AnalysisAdd
BLAST
Transmembranei296 – 31621HelicalSequence AnalysisAdd
BLAST
Topological domaini317 – 773457Mitochondrial intermembraneSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: UniProtKB
  3. mitochondrial inner membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37434.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 773773ATP-dependent zinc metalloprotease YME1L1PRO_0000084667Add
BLAST

Proteomic databases

MaxQBiQ96TA2.
PaxDbiQ96TA2.
PRIDEiQ96TA2.

PTM databases

PhosphoSiteiQ96TA2.

Expressioni

Tissue specificityi

High expression in cardiac and skeletal muscle mitochondria.1 Publication

Gene expression databases

BgeeiQ96TA2.
CleanExiHS_YME1L1.
ExpressionAtlasiQ96TA2. baseline and differential.
GenevestigatoriQ96TA2.

Interactioni

Subunit structurei

Exists in several complexes of 600-1100 kDa.1 Publication

Protein-protein interaction databases

BioGridi115954. 17 interactions.
IntActiQ96TA2. 12 interactions.
MINTiMINT-3058738.
STRINGi9606.ENSP00000318480.

Structurei

3D structure databases

ProteinModelPortaliQ96TA2.
SMRiQ96TA2. Positions 334-765.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the AAA ATPase family.Curated
In the C-terminal section; belongs to the peptidase M41 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0465.
GeneTreeiENSGT00550000074836.
HOGENOMiHOG000217276.
HOVERGENiHBG057127.
InParanoidiQ96TA2.
KOiK08955.
OMAiWHTSHVS.
OrthoDBiEOG7BP824.
PhylomeDBiQ96TA2.
TreeFamiTF105005.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01458. FtsH.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. FtsH.
IPR027417. P-loop_NTPase.
IPR000642. Peptidase_M41.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01241. FtsH_fam. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96TA2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSLSSTVQP QVTVPLSHLI NAFHTPKNTS VSLSGVSVSQ NQHRDVVPEH
60 70 80 90 100
EAPSSECMFS DFLTKLNIVS IGKGKIFEGY RSMFMEPAKR MKKSLDTTDN
110 120 130 140 150
WHIRPEPFSL SIPPSLNLRD LGLSELKIGQ IDQLVENLLP GFCKGKNISS
160 170 180 190 200
HWHTSHVSAQ SFFENKYGNL DIFSTLRSSC LYRHHSRALQ SICSDLQYWP
210 220 230 240 250
VFIQSRGFKT LKSRTRRLQS TSERLAETQN IAPSFVKGFL LRDRGSDVES
260 270 280 290 300
LDKLMKTKNI PEAHQDAFKT GFAEGFLKAQ ALTQKTNDSL RRTRLILFVL
310 320 330 340 350
LLFGIYGLLK NPFLSVRFRT TTGLDSAVDP VQMKNVTFEH VKGVEEAKQE
360 370 380 390 400
LQEVVEFLKN PQKFTILGGK LPKGILLVGP PGTGKTLLAR AVAGEADVPF
410 420 430 440 450
YYASGSEFDE MFVGVGASRI RNLFREAKAN APCVIFIDEL DSVGGKRIES
460 470 480 490 500
PMHPYSRQTI NQLLAEMDGF KPNEGVIIIG ATNFPEALDN ALIRPGRFDM
510 520 530 540 550
QVTVPRPDVK GRTEILKWYL NKIKFDQSVD PEIIARGTVG FSGAELENLV
560 570 580 590 600
NQAALKAAVD GKEMVTMKEL EFSKDKILMG PERRSVEIDN KNKTITAYHE
610 620 630 640 650
SGHAIIAYYT KDAMPINKAT IMPRGPTLGH VSLLPENDRW NETRAQLLAQ
660 670 680 690 700
MDVSMGGRVA EELIFGTDHI TTGASSDFDN ATKIAKRMVT KFGMSEKLGV
710 720 730 740 750
MTYSDTGKLS PETQSAIEQE IRILLRDSYE RAKHILKTHA KEHKNLAEAL
760 770
LTYETLDAKE IQIVLEGKKL EVR
Length:773
Mass (Da):86,455
Last modified:April 13, 2004 - v2
Checksum:iFB77990F4D7B3A58
GO
Isoform 2 (identifier: Q96TA2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-113: Missing.

Note: Mutagenesis of Glu-543 to Gln does not complement excessive accumulation of subunits (NDUFB6, COX4,ND1) due to YME1 deletion mutant. Probably has no ATPase activity.

Show »
Length:716
Mass (Da):79,832
Checksum:i17828316886DF7C5
GO
Isoform 3 (identifier: Q96TA2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     57-113: Missing.
     168-200: Missing.

Show »
Length:683
Mass (Da):75,982
Checksum:i8A037ED99ED7D2E3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121V → F in AAK57555. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei57 – 11357Missing in isoform 2 and isoform 3. 4 PublicationsVSP_010017Add
BLAST
Alternative sequencei168 – 20033Missing in isoform 3. 1 PublicationVSP_045336Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151782 mRNA. Translation: AAK57555.1.
AJ132637 mRNA. Translation: CAB51858.1.
AY358484 mRNA. Translation: AAQ88848.1.
AK297973 mRNA. Translation: BAG60283.1.
AL162272 Genomic DNA. Translation: CAC19650.2.
AL162272, AL160291 Genomic DNA. Translation: CAI12217.1.
AL160291, AL162272 Genomic DNA. Translation: CAI16906.1.
AL160291, AL162272 Genomic DNA. Translation: CAI16907.1.
CH471072 Genomic DNA. Translation: EAW86068.1.
CH471072 Genomic DNA. Translation: EAW86069.1.
CH471072 Genomic DNA. Translation: EAW86070.1.
CH471072 Genomic DNA. Translation: EAW86071.1.
CH471072 Genomic DNA. Translation: EAW86072.1.
BC023507 mRNA. Translation: AAH23507.1.
BC024032 mRNA. Translation: AAH24032.1.
CCDSiCCDS58072.1. [Q96TA2-3]
CCDS7151.1. [Q96TA2-2]
CCDS7152.1. [Q96TA2-1]
RefSeqiNP_001240795.1. NM_001253866.1. [Q96TA2-3]
NP_055078.1. NM_014263.3. [Q96TA2-2]
NP_647473.1. NM_139312.2. [Q96TA2-1]
UniGeneiHs.499145.
Hs.74647.

Genome annotation databases

EnsembliENST00000326799; ENSP00000318480; ENSG00000136758. [Q96TA2-1]
ENST00000376016; ENSP00000365184; ENSG00000136758. [Q96TA2-2]
ENST00000613434; ENSP00000481724; ENSG00000136758. [Q96TA2-3]
GeneIDi10730.
KEGGihsa:10730.
UCSCiuc001iti.3. human. [Q96TA2-1]
uc001itj.3. human. [Q96TA2-2]
uc010qdl.2. human.

Polymorphism databases

DMDMi46397258.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151782 mRNA. Translation: AAK57555.1 .
AJ132637 mRNA. Translation: CAB51858.1 .
AY358484 mRNA. Translation: AAQ88848.1 .
AK297973 mRNA. Translation: BAG60283.1 .
AL162272 Genomic DNA. Translation: CAC19650.2 .
AL162272 , AL160291 Genomic DNA. Translation: CAI12217.1 .
AL160291 , AL162272 Genomic DNA. Translation: CAI16906.1 .
AL160291 , AL162272 Genomic DNA. Translation: CAI16907.1 .
CH471072 Genomic DNA. Translation: EAW86068.1 .
CH471072 Genomic DNA. Translation: EAW86069.1 .
CH471072 Genomic DNA. Translation: EAW86070.1 .
CH471072 Genomic DNA. Translation: EAW86071.1 .
CH471072 Genomic DNA. Translation: EAW86072.1 .
BC023507 mRNA. Translation: AAH23507.1 .
BC024032 mRNA. Translation: AAH24032.1 .
CCDSi CCDS58072.1. [Q96TA2-3 ]
CCDS7151.1. [Q96TA2-2 ]
CCDS7152.1. [Q96TA2-1 ]
RefSeqi NP_001240795.1. NM_001253866.1. [Q96TA2-3 ]
NP_055078.1. NM_014263.3. [Q96TA2-2 ]
NP_647473.1. NM_139312.2. [Q96TA2-1 ]
UniGenei Hs.499145.
Hs.74647.

3D structure databases

ProteinModelPortali Q96TA2.
SMRi Q96TA2. Positions 334-765.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115954. 17 interactions.
IntActi Q96TA2. 12 interactions.
MINTi MINT-3058738.
STRINGi 9606.ENSP00000318480.

Protein family/group databases

MEROPSi M41.026.

PTM databases

PhosphoSitei Q96TA2.

Polymorphism databases

DMDMi 46397258.

Proteomic databases

MaxQBi Q96TA2.
PaxDbi Q96TA2.
PRIDEi Q96TA2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000326799 ; ENSP00000318480 ; ENSG00000136758 . [Q96TA2-1 ]
ENST00000376016 ; ENSP00000365184 ; ENSG00000136758 . [Q96TA2-2 ]
ENST00000613434 ; ENSP00000481724 ; ENSG00000136758 . [Q96TA2-3 ]
GeneIDi 10730.
KEGGi hsa:10730.
UCSCi uc001iti.3. human. [Q96TA2-1 ]
uc001itj.3. human. [Q96TA2-2 ]
uc010qdl.2. human.

Organism-specific databases

CTDi 10730.
GeneCardsi GC10M027439.
H-InvDB HIX0127242.
HGNCi HGNC:12843. YME1L1.
MIMi 607472. gene.
neXtProti NX_Q96TA2.
PharmGKBi PA37434.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0465.
GeneTreei ENSGT00550000074836.
HOGENOMi HOG000217276.
HOVERGENi HBG057127.
InParanoidi Q96TA2.
KOi K08955.
OMAi WHTSHVS.
OrthoDBi EOG7BP824.
PhylomeDBi Q96TA2.
TreeFami TF105005.

Miscellaneous databases

ChiTaRSi YME1L1. human.
GeneWikii YME1L1.
GenomeRNAii 10730.
NextBioi 40734.
PROi Q96TA2.
SOURCEi Search...

Gene expression databases

Bgeei Q96TA2.
CleanExi HS_YME1L1.
ExpressionAtlasi Q96TA2. baseline and differential.
Genevestigatori Q96TA2.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_01458. FtsH.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. FtsH.
IPR027417. P-loop_NTPase.
IPR000642. Peptidase_M41.
[Graphical view ]
Pfami PF00004. AAA. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR01241. FtsH_fam. 1 hit.
PROSITEi PS00674. AAA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human ATP-dependent metalloprotease (FtsH1) homolog mRNA."
    Miyata T., Inagi R., Yasuda Y., Kurokawa K.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Identification and characterization of YME1L1, a novel paraplegin-related gene."
    Coppola M., Pizzigoni A., Banfi S., Bassi M.T., Casari G., Incerti B.
    Genomics 66:48-54(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION.
    Tissue: Fetal brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  5. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Muscle and Placenta.
  8. "Metalloprotease-mediated OPA1 processing is modulated by the mitochondrial membrane potential."
    Guillery O., Malka F., Landes T., Guillou E., Blackstone C., Lombes A., Belenguer P., Arnoult D., Rojo M.
    Biol. Cell 100:315-325(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PROCESSING OF OPA1.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis and cell proliferation."
    Stiburek L., Cesnekova J., Kostkova O., Fornuskova D., Vinsova K., Wenchich L., Houstek J., Zeman J.
    Mol. Biol. Cell 23:1010-1023(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, FUNCTION, SUBUNIT, MUTAGENESIS (ISOFORM 2).

Entry informationi

Entry nameiYMEL1_HUMAN
AccessioniPrimary (citable) accession number: Q96TA2
Secondary accession number(s): B4DNM1
, D3DRV8, D3DRV9, Q5T8D9, Q9H1Q0, Q9UMR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: November 26, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3