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Q96TA2

- YMEL1_HUMAN

UniProt

Q96TA2 - YMEL1_HUMAN

Protein

ATP-dependent zinc metalloprotease YME1L1

Gene

YME1L1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (13 Apr 2004)
      Previous versions | rss
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    Functioni

    Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Requires to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). Seems to act in the processing of OPA1.2 Publications

    Cofactori

    Binds 1 zinc ion per subunit.Curated

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi599 – 5991Zinc; catalyticBy similarity
    Active sitei600 – 6001By similarity
    Metal bindingi603 – 6031Zinc; catalyticBy similarity
    Metal bindingi677 – 6771Zinc; catalyticBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi379 – 3868ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. metalloendopeptidase activity Source: InterPro
    4. nucleoside-triphosphatase activity Source: InterPro

    GO - Biological processi

    1. cell proliferation Source: UniProtKB
    2. misfolded or incompletely synthesized protein catabolic process Source: UniProtKB
    3. mitochondrion organization Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Protein family/group databases

    MEROPSiM41.026.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent zinc metalloprotease YME1L1 (EC:3.4.24.-)
    Alternative name(s):
    ATP-dependent metalloprotease FtsH1
    Meg-4
    Presenilin-associated metalloprotease
    Short name:
    PAMP
    YME1-like protein 1
    Gene namesi
    Name:YME1L1
    Synonyms:FTSH1, YME1L
    ORF Names:UNQ1868/PRO4304
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:12843. YME1L1.

    Subcellular locationi

    Mitochondrion inner membrane 2 Publications

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. membrane Source: UniProtKB
    3. mitochondrial inner membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37434.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 773773ATP-dependent zinc metalloprotease YME1L1PRO_0000084667Add
    BLAST

    Proteomic databases

    MaxQBiQ96TA2.
    PaxDbiQ96TA2.
    PRIDEiQ96TA2.

    PTM databases

    PhosphoSiteiQ96TA2.

    Expressioni

    Tissue specificityi

    High expression in cardiac and skeletal muscle mitochondria.1 Publication

    Gene expression databases

    ArrayExpressiQ96TA2.
    BgeeiQ96TA2.
    CleanExiHS_YME1L1.
    GenevestigatoriQ96TA2.

    Interactioni

    Subunit structurei

    Exists in several complexes of 600-1100 kDa.1 Publication

    Protein-protein interaction databases

    BioGridi115954. 17 interactions.
    IntActiQ96TA2. 12 interactions.
    MINTiMINT-3058738.
    STRINGi9606.ENSP00000318480.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96TA2.
    SMRiQ96TA2. Positions 334-765.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 295295Mitochondrial matrixSequence AnalysisAdd
    BLAST
    Topological domaini317 – 773457Mitochondrial intermembraneSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei296 – 31621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    In the N-terminal section; belongs to the AAA ATPase family.Curated
    In the C-terminal section; belongs to the peptidase M41 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0465.
    HOGENOMiHOG000217276.
    HOVERGENiHBG057127.
    InParanoidiQ96TA2.
    KOiK08955.
    OMAiWHTSHVS.
    OrthoDBiEOG7BP824.
    PhylomeDBiQ96TA2.
    TreeFamiTF105005.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_01458. FtsH.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR005936. FtsH.
    IPR027417. P-loop_NTPase.
    IPR000642. Peptidase_M41.
    [Graphical view]
    PfamiPF00004. AAA. 1 hit.
    PF01434. Peptidase_M41. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR01241. FtsH_fam. 1 hit.
    PROSITEiPS00674. AAA. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96TA2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFSLSSTVQP QVTVPLSHLI NAFHTPKNTS VSLSGVSVSQ NQHRDVVPEH    50
    EAPSSECMFS DFLTKLNIVS IGKGKIFEGY RSMFMEPAKR MKKSLDTTDN 100
    WHIRPEPFSL SIPPSLNLRD LGLSELKIGQ IDQLVENLLP GFCKGKNISS 150
    HWHTSHVSAQ SFFENKYGNL DIFSTLRSSC LYRHHSRALQ SICSDLQYWP 200
    VFIQSRGFKT LKSRTRRLQS TSERLAETQN IAPSFVKGFL LRDRGSDVES 250
    LDKLMKTKNI PEAHQDAFKT GFAEGFLKAQ ALTQKTNDSL RRTRLILFVL 300
    LLFGIYGLLK NPFLSVRFRT TTGLDSAVDP VQMKNVTFEH VKGVEEAKQE 350
    LQEVVEFLKN PQKFTILGGK LPKGILLVGP PGTGKTLLAR AVAGEADVPF 400
    YYASGSEFDE MFVGVGASRI RNLFREAKAN APCVIFIDEL DSVGGKRIES 450
    PMHPYSRQTI NQLLAEMDGF KPNEGVIIIG ATNFPEALDN ALIRPGRFDM 500
    QVTVPRPDVK GRTEILKWYL NKIKFDQSVD PEIIARGTVG FSGAELENLV 550
    NQAALKAAVD GKEMVTMKEL EFSKDKILMG PERRSVEIDN KNKTITAYHE 600
    SGHAIIAYYT KDAMPINKAT IMPRGPTLGH VSLLPENDRW NETRAQLLAQ 650
    MDVSMGGRVA EELIFGTDHI TTGASSDFDN ATKIAKRMVT KFGMSEKLGV 700
    MTYSDTGKLS PETQSAIEQE IRILLRDSYE RAKHILKTHA KEHKNLAEAL 750
    LTYETLDAKE IQIVLEGKKL EVR 773
    Length:773
    Mass (Da):86,455
    Last modified:April 13, 2004 - v2
    Checksum:iFB77990F4D7B3A58
    GO
    Isoform 2 (identifier: Q96TA2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         57-113: Missing.

    Note: Mutagenesis of Glu-543 to Gln does not complement excessive accumulation of subunits (NDUFB6, COX4,ND1) due to YME1 deletion mutant. Probably has no ATPase activity.

    Show »
    Length:716
    Mass (Da):79,832
    Checksum:i17828316886DF7C5
    GO
    Isoform 3 (identifier: Q96TA2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         57-113: Missing.
         168-200: Missing.

    Show »
    Length:683
    Mass (Da):75,982
    Checksum:i8A037ED99ED7D2E3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti12 – 121V → F in AAK57555. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei57 – 11357Missing in isoform 2 and isoform 3. 4 PublicationsVSP_010017Add
    BLAST
    Alternative sequencei168 – 20033Missing in isoform 3. 1 PublicationVSP_045336Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151782 mRNA. Translation: AAK57555.1.
    AJ132637 mRNA. Translation: CAB51858.1.
    AY358484 mRNA. Translation: AAQ88848.1.
    AK297973 mRNA. Translation: BAG60283.1.
    AL162272 Genomic DNA. Translation: CAC19650.2.
    AL162272, AL160291 Genomic DNA. Translation: CAI12217.1.
    AL160291, AL162272 Genomic DNA. Translation: CAI16906.1.
    AL160291, AL162272 Genomic DNA. Translation: CAI16907.1.
    CH471072 Genomic DNA. Translation: EAW86068.1.
    CH471072 Genomic DNA. Translation: EAW86069.1.
    CH471072 Genomic DNA. Translation: EAW86070.1.
    CH471072 Genomic DNA. Translation: EAW86071.1.
    CH471072 Genomic DNA. Translation: EAW86072.1.
    BC023507 mRNA. Translation: AAH23507.1.
    BC024032 mRNA. Translation: AAH24032.1.
    CCDSiCCDS58072.1. [Q96TA2-3]
    CCDS7151.1. [Q96TA2-2]
    CCDS7152.1. [Q96TA2-1]
    RefSeqiNP_001240795.1. NM_001253866.1. [Q96TA2-3]
    NP_055078.1. NM_014263.3. [Q96TA2-2]
    NP_647473.1. NM_139312.2. [Q96TA2-1]
    UniGeneiHs.499145.
    Hs.74647.

    Genome annotation databases

    EnsembliENST00000326799; ENSP00000318480; ENSG00000136758. [Q96TA2-1]
    ENST00000375972; ENSP00000365139; ENSG00000136758. [Q96TA2-3]
    ENST00000376016; ENSP00000365184; ENSG00000136758. [Q96TA2-2]
    GeneIDi10730.
    KEGGihsa:10730.
    UCSCiuc001iti.3. human. [Q96TA2-1]
    uc001itj.3. human. [Q96TA2-2]
    uc010qdl.2. human.

    Polymorphism databases

    DMDMi46397258.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151782 mRNA. Translation: AAK57555.1 .
    AJ132637 mRNA. Translation: CAB51858.1 .
    AY358484 mRNA. Translation: AAQ88848.1 .
    AK297973 mRNA. Translation: BAG60283.1 .
    AL162272 Genomic DNA. Translation: CAC19650.2 .
    AL162272 , AL160291 Genomic DNA. Translation: CAI12217.1 .
    AL160291 , AL162272 Genomic DNA. Translation: CAI16906.1 .
    AL160291 , AL162272 Genomic DNA. Translation: CAI16907.1 .
    CH471072 Genomic DNA. Translation: EAW86068.1 .
    CH471072 Genomic DNA. Translation: EAW86069.1 .
    CH471072 Genomic DNA. Translation: EAW86070.1 .
    CH471072 Genomic DNA. Translation: EAW86071.1 .
    CH471072 Genomic DNA. Translation: EAW86072.1 .
    BC023507 mRNA. Translation: AAH23507.1 .
    BC024032 mRNA. Translation: AAH24032.1 .
    CCDSi CCDS58072.1. [Q96TA2-3 ]
    CCDS7151.1. [Q96TA2-2 ]
    CCDS7152.1. [Q96TA2-1 ]
    RefSeqi NP_001240795.1. NM_001253866.1. [Q96TA2-3 ]
    NP_055078.1. NM_014263.3. [Q96TA2-2 ]
    NP_647473.1. NM_139312.2. [Q96TA2-1 ]
    UniGenei Hs.499145.
    Hs.74647.

    3D structure databases

    ProteinModelPortali Q96TA2.
    SMRi Q96TA2. Positions 334-765.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115954. 17 interactions.
    IntActi Q96TA2. 12 interactions.
    MINTi MINT-3058738.
    STRINGi 9606.ENSP00000318480.

    Protein family/group databases

    MEROPSi M41.026.

    PTM databases

    PhosphoSitei Q96TA2.

    Polymorphism databases

    DMDMi 46397258.

    Proteomic databases

    MaxQBi Q96TA2.
    PaxDbi Q96TA2.
    PRIDEi Q96TA2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326799 ; ENSP00000318480 ; ENSG00000136758 . [Q96TA2-1 ]
    ENST00000375972 ; ENSP00000365139 ; ENSG00000136758 . [Q96TA2-3 ]
    ENST00000376016 ; ENSP00000365184 ; ENSG00000136758 . [Q96TA2-2 ]
    GeneIDi 10730.
    KEGGi hsa:10730.
    UCSCi uc001iti.3. human. [Q96TA2-1 ]
    uc001itj.3. human. [Q96TA2-2 ]
    uc010qdl.2. human.

    Organism-specific databases

    CTDi 10730.
    GeneCardsi GC10M027439.
    H-InvDB HIX0127242.
    HGNCi HGNC:12843. YME1L1.
    MIMi 607472. gene.
    neXtProti NX_Q96TA2.
    PharmGKBi PA37434.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0465.
    HOGENOMi HOG000217276.
    HOVERGENi HBG057127.
    InParanoidi Q96TA2.
    KOi K08955.
    OMAi WHTSHVS.
    OrthoDBi EOG7BP824.
    PhylomeDBi Q96TA2.
    TreeFami TF105005.

    Miscellaneous databases

    ChiTaRSi YME1L1. human.
    GeneWikii YME1L1.
    GenomeRNAii 10730.
    NextBioi 40734.
    PROi Q96TA2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96TA2.
    Bgeei Q96TA2.
    CleanExi HS_YME1L1.
    Genevestigatori Q96TA2.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_01458. FtsH.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR003960. ATPase_AAA_CS.
    IPR005936. FtsH.
    IPR027417. P-loop_NTPase.
    IPR000642. Peptidase_M41.
    [Graphical view ]
    Pfami PF00004. AAA. 1 hit.
    PF01434. Peptidase_M41. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR01241. FtsH_fam. 1 hit.
    PROSITEi PS00674. AAA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human ATP-dependent metalloprotease (FtsH1) homolog mRNA."
      Miyata T., Inagi R., Yasuda Y., Kurokawa K.
      Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Identification and characterization of YME1L1, a novel paraplegin-related gene."
      Coppola M., Pizzigoni A., Banfi S., Bassi M.T., Casari G., Incerti B.
      Genomics 66:48-54(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION.
      Tissue: Fetal brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    5. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Muscle and Placenta.
    8. "Metalloprotease-mediated OPA1 processing is modulated by the mitochondrial membrane potential."
      Guillery O., Malka F., Landes T., Guillou E., Blackstone C., Lombes A., Belenguer P., Arnoult D., Rojo M.
      Biol. Cell 100:315-325(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PROCESSING OF OPA1.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis and cell proliferation."
      Stiburek L., Cesnekova J., Kostkova O., Fornuskova D., Vinsova K., Wenchich L., Houstek J., Zeman J.
      Mol. Biol. Cell 23:1010-1023(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, FUNCTION, SUBUNIT, MUTAGENESIS (ISOFORM 2).

    Entry informationi

    Entry nameiYMEL1_HUMAN
    AccessioniPrimary (citable) accession number: Q96TA2
    Secondary accession number(s): B4DNM1
    , D3DRV8, D3DRV9, Q5T8D9, Q9H1Q0, Q9UMR9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Peptidase families
      Classification of peptidase families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3