Q96TA2 (YMEL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP-dependent zinc metalloprotease YME1L1
EC=3.4.24.-

Alternative name(s):
ATP-dependent metalloprotease FtsH1
Meg-4
Presenilin-associated metalloprotease
Short name=PAMP
YME1-like protein 1

Gene names

Name:	YME1L1
Synonyms:	FTSH1, YME1L
ORF Names:	UNQ1868/PRO4304

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	773 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Putative ATP-dependent protease which plays a role in mitochondrial protein metabolism. Ensures cell proliferation, maintains normal cristae morphology and complex I respiration activity, promotes antiapoptotic activity and protects mitochondria from the accumulation of oxidatively damaged membrane proteins. Requires to control the accumulation of nonassembled respiratory chain subunits (NDUFB6, OX4 and ND1). Seems to act in the processing of OPA1. Ref.8 Ref.10
Cofactor	Binds 1 zinc ion per subunit Potential.
Subunit structure	Exists in several complexes of 600-1100 kDa. Ref.10
Subcellular location	Mitochondrion inner membrane Ref.2 Ref.10.
Tissue specificity	High expression in cardiac and skeletal muscle mitochondria. Ref.10
Sequence similarities	In the N-terminal section; belongs to the AAA ATPase family. In the C-terminal section; belongs to the peptidase M41 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell proliferation Inferred from mutant phenotype Ref.10. Source: UniProtKB misfolded or incompletely synthesized protein catabolic process Inferred from mutant phenotype Ref.10. Source: UniProtKB mitochondrion organization Inferred from mutant phenotype Ref.10. Source: UniProtKB
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from direct assay Ref.10. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metalloendopeptidase activity Inferred from electronic annotation. Source: InterPro nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96TA2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96TA2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     57-113: Missing.

Note: Mutagenesis of Glu-543 to Gln does not complement excessive accumulation of subunits (NDUFB6, COX4,ND1) due to YME1 deletion mutant. Probably has no ATPase activity.

Isoform 3 (identifier: Q96TA2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     57-113: Missing.
     168-200: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 773	773	ATP-dependent zinc metalloprotease YME1L1		PRO_0000084667
Regions
	Topological domain	1 – 295	295	Mitochondrial matrix Potential
	Transmembrane	296 – 316	21	Helical; Potential
	Topological domain	317 – 773	457	Mitochondrial intermembrane Potential
	Nucleotide binding	379 – 386	8	ATP Potential
Sites
	Active site	600	1	By similarity
	Metal binding	599	1	Zinc; catalytic By similarity
	Metal binding	603	1	Zinc; catalytic By similarity
	Metal binding	677	1	Zinc; catalytic By similarity
Natural variations
	Alternative sequence	57 – 113	57	Missing in isoform 2 and isoform 3.		VSP_010017
	Alternative sequence	168 – 200	33	Missing in isoform 3.		VSP_045336
Experimental info
	Sequence conflict	12	1	V → F in AAK57555. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 13, 2004. Version 2. Checksum: FB77990F4D7B3A58	FASTA	773	86,455
	10 20 30 40 50 60 MFSLSSTVQP QVTVPLSHLI NAFHTPKNTS VSLSGVSVSQ NQHRDVVPEH EAPSSECMFS 70 80 90 100 110 120 DFLTKLNIVS IGKGKIFEGY RSMFMEPAKR MKKSLDTTDN WHIRPEPFSL SIPPSLNLRD 130 140 150 160 170 180 LGLSELKIGQ IDQLVENLLP GFCKGKNISS HWHTSHVSAQ SFFENKYGNL DIFSTLRSSC 190 200 210 220 230 240 LYRHHSRALQ SICSDLQYWP VFIQSRGFKT LKSRTRRLQS TSERLAETQN IAPSFVKGFL 250 260 270 280 290 300 LRDRGSDVES LDKLMKTKNI PEAHQDAFKT GFAEGFLKAQ ALTQKTNDSL RRTRLILFVL 310 320 330 340 350 360 LLFGIYGLLK NPFLSVRFRT TTGLDSAVDP VQMKNVTFEH VKGVEEAKQE LQEVVEFLKN 370 380 390 400 410 420 PQKFTILGGK LPKGILLVGP PGTGKTLLAR AVAGEADVPF YYASGSEFDE MFVGVGASRI 430 440 450 460 470 480 RNLFREAKAN APCVIFIDEL DSVGGKRIES PMHPYSRQTI NQLLAEMDGF KPNEGVIIIG 490 500 510 520 530 540 ATNFPEALDN ALIRPGRFDM QVTVPRPDVK GRTEILKWYL NKIKFDQSVD PEIIARGTVG 550 560 570 580 590 600 FSGAELENLV NQAALKAAVD GKEMVTMKEL EFSKDKILMG PERRSVEIDN KNKTITAYHE 610 620 630 640 650 660 SGHAIIAYYT KDAMPINKAT IMPRGPTLGH VSLLPENDRW NETRAQLLAQ MDVSMGGRVA 670 680 690 700 710 720 EELIFGTDHI TTGASSDFDN ATKIAKRMVT KFGMSEKLGV MTYSDTGKLS PETQSAIEQE 730 740 750 760 770 IRILLRDSYE RAKHILKTHA KEHKNLAEAL LTYETLDAKE IQIVLEGKKL EVR
	Isoform 2 [UniParc]. Checksum: 17828316886DF7C5	FASTA	716	79,832
	10 20 30 40 50 60 MFSLSSTVQP QVTVPLSHLI NAFHTPKNTS VSLSGVSVSQ NQHRDVVPEH EAPSSEPSLN 70 80 90 100 110 120 LRDLGLSELK IGQIDQLVEN LLPGFCKGKN ISSHWHTSHV SAQSFFENKY GNLDIFSTLR 130 140 150 160 170 180 SSCLYRHHSR ALQSICSDLQ YWPVFIQSRG FKTLKSRTRR LQSTSERLAE TQNIAPSFVK 190 200 210 220 230 240 GFLLRDRGSD VESLDKLMKT KNIPEAHQDA FKTGFAEGFL KAQALTQKTN DSLRRTRLIL 250 260 270 280 290 300 FVLLLFGIYG LLKNPFLSVR FRTTTGLDSA VDPVQMKNVT FEHVKGVEEA KQELQEVVEF 310 320 330 340 350 360 LKNPQKFTIL GGKLPKGILL VGPPGTGKTL LARAVAGEAD VPFYYASGSE FDEMFVGVGA 370 380 390 400 410 420 SRIRNLFREA KANAPCVIFI DELDSVGGKR IESPMHPYSR QTINQLLAEM DGFKPNEGVI 430 440 450 460 470 480 IIGATNFPEA LDNALIRPGR FDMQVTVPRP DVKGRTEILK WYLNKIKFDQ SVDPEIIARG 490 500 510 520 530 540 TVGFSGAELE NLVNQAALKA AVDGKEMVTM KELEFSKDKI LMGPERRSVE IDNKNKTITA 550 560 570 580 590 600 YHESGHAIIA YYTKDAMPIN KATIMPRGPT LGHVSLLPEN DRWNETRAQL LAQMDVSMGG 610 620 630 640 650 660 RVAEELIFGT DHITTGASSD FDNATKIAKR MVTKFGMSEK LGVMTYSDTG KLSPETQSAI 670 680 690 700 710 EQEIRILLRD SYERAKHILK THAKEHKNLA EALLTYETLD AKEIQIVLEG KKLEVR
	Isoform 3 [UniParc]. Checksum: 8A037ED99ED7D2E3	FASTA	683	75,982
	10 20 30 40 50 60 MFSLSSTVQP QVTVPLSHLI NAFHTPKNTS VSLSGVSVSQ NQHRDVVPEH EAPSSEPSLN 70 80 90 100 110 120 LRDLGLSELK IGQIDQLVEN LLPGFCKGKN ISSHWHTSHV SAQSFFENKY VFIQSRGFKT 130 140 150 160 170 180 LKSRTRRLQS TSERLAETQN IAPSFVKGFL LRDRGSDVES LDKLMKTKNI PEAHQDAFKT 190 200 210 220 230 240 GFAEGFLKAQ ALTQKTNDSL RRTRLILFVL LLFGIYGLLK NPFLSVRFRT TTGLDSAVDP 250 260 270 280 290 300 VQMKNVTFEH VKGVEEAKQE LQEVVEFLKN PQKFTILGGK LPKGILLVGP PGTGKTLLAR 310 320 330 340 350 360 AVAGEADVPF YYASGSEFDE MFVGVGASRI RNLFREAKAN APCVIFIDEL DSVGGKRIES 370 380 390 400 410 420 PMHPYSRQTI NQLLAEMDGF KPNEGVIIIG ATNFPEALDN ALIRPGRFDM QVTVPRPDVK 430 440 450 460 470 480 GRTEILKWYL NKIKFDQSVD PEIIARGTVG FSGAELENLV NQAALKAAVD GKEMVTMKEL 490 500 510 520 530 540 EFSKDKILMG PERRSVEIDN KNKTITAYHE SGHAIIAYYT KDAMPINKAT IMPRGPTLGH 550 560 570 580 590 600 VSLLPENDRW NETRAQLLAQ MDVSMGGRVA EELIFGTDHI TTGASSDFDN ATKIAKRMVT 610 620 630 640 650 660 KFGMSEKLGV MTYSDTGKLS PETQSAIEQE IRILLRDSYE RAKHILKTHA KEHKNLAEAL 670 680 LTYETLDAKE IQIVLEGKKL EVR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human ATP-dependent metalloprotease (FtsH1) homolog mRNA." Miyata T., Inagi R., Yasuda Y., Kurokawa K. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Identification and characterization of YME1L1, a novel paraplegin-related gene." Coppola M., Pizzigoni A., Banfi S., Bassi M.T., Casari G., Incerti B. Genomics 66:48-54(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION. Tissue: Fetal brain.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[5]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Muscle and Placenta.
[8]	"Metalloprotease-mediated OPA1 processing is modulated by the mitochondrial membrane potential." Guillery O., Malka F., Landes T., Guillou E., Blackstone C., Lombes A., Belenguer P., Arnoult D., Rojo M. Biol. Cell 100:315-325(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN PROCESSING OF OPA1.
[9]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]	"YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis and cell proliferation." Stiburek L., Cesnekova J., Kostkova O., Fornuskova D., Vinsova K., Wenchich L., Houstek J., Zeman J. Mol. Biol. Cell 23:1010-1023(2012) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, FUNCTION, SUBUNIT, MUTAGENESIS (ISOFORM 2).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF151782 mRNA. Translation: AAK57555.1. AJ132637 mRNA. Translation: CAB51858.1. AY358484 mRNA. Translation: AAQ88848.1. AK297973 mRNA. Translation: BAG60283.1. AL162272 Genomic DNA. Translation: CAC19650.2. AL162272, AL160291 Genomic DNA. Translation: CAI12217.1. AL160291, AL162272 Genomic DNA. Translation: CAI16906.1. AL160291, AL162272 Genomic DNA. Translation: CAI16907.1. CH471072 Genomic DNA. Translation: EAW86068.1. CH471072 Genomic DNA. Translation: EAW86069.1. CH471072 Genomic DNA. Translation: EAW86070.1. CH471072 Genomic DNA. Translation: EAW86071.1. CH471072 Genomic DNA. Translation: EAW86072.1. BC023507 mRNA. Translation: AAH23507.1. BC024032 mRNA. Translation: AAH24032.1.
IPI	IPI00045946. IPI00099529.
RefSeq	NP_001240795.1. NM_001253866.1. NP_055078.1. NM_014263.3. NP_647473.1. NM_139312.2.
UniGene	Hs.499145. Hs.74647.
3D structure databases
ProteinModelPortal	Q96TA2.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96TA2. 7 interactions.
STRING	9606.ENSP00000318480.
Protein family/group databases
MEROPS	M41.A20.
PTM databases
PhosphoSite	Q96TA2.
Polymorphism databases
DMDM	46397258.
Proteomic databases
PaxDb	Q96TA2.
PRIDE	Q96TA2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000326799; ENSP00000318480; ENSG00000136758. ENST00000375972; ENSP00000365139; ENSG00000136758. ENST00000376016; ENSP00000365184; ENSG00000136758.
GeneID	10730.
KEGG	hsa:10730.
UCSC	uc001iti.3. human. uc001itj.3. human.
Organism-specific databases
CTD	10730.
GeneCards	GC10M027439.
H-InvDB	HIX0127242.
HGNC	HGNC:12843. YME1L1.
MIM	607472. gene.
neXtProt	NX_Q96TA2.
PharmGKB	PA37434.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0465.
HOGENOM	HOG000217276.
HOVERGEN	HBG057127.
InParanoid	Q96TA2.
KO	K08955.
OMA	HTSHVSA.
PhylomeDB	Q96TA2.
Gene expression databases
ArrayExpress	Q96TA2.
Bgee	Q96TA2.
CleanEx	HS_YME1L1.
Genevestigator	Q96TA2.
GermOnline	ENSG00000136758. Homo sapiens.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003959. ATPase_AAA_core. IPR003960. ATPase_AAA_CS. IPR005936. FtsH. IPR000642. Peptidase_M41. [Graphical view]
Pfam	PF00004. AAA. 1 hit. PF01434. Peptidase_M41. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01241. FtsH_fam. 1 hit.
PROSITE	PS00674. AAA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	YME1L1. human.
GenomeRNAi	10730.
NextBio	40734.
SOURCE	Search...

Entry information

Entry name

YMEL1_HUMAN

Accession

Primary (citable) accession number: Q96TA2
Secondary accession number(s): B4DNM1 , D3DRV8, D3DRV9, Q5T8D9, Q9H1Q0, Q9UMR9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	April 13, 2004
Last modified:	May 1, 2013
This is version 114 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.