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Protein

Niban-like protein 1

Gene

FAM129B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro.2 Publications

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

GO - Biological processi

  • negative regulation of apoptotic process Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136830-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Niban-like protein 1
Alternative name(s):
Meg-3
Melanoma invasion by ERK
Short name:
MINERVA
Protein FAM129B
Gene namesi
Name:FAM129B
Synonyms:C9orf88
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:25282. FAM129B.

Subcellular locationi

  • Cytoplasmcytosol
  • Cell junctionadherens junction
  • Membrane Curated; Lipid-anchor Curated

  • Note: In exponentially growing cells, exclusively cytoplasmic. Cell membrane localization is observed when cells reach confluency and during telophase. In melanoma cells, targeting to the plasma membrane may be impaired by C-terminal phosphorylation.

GO - Cellular componenti

  • actin cytoskeleton Source: HPA
  • adherens junction Source: UniProtKB
  • cell-cell adherens junction Source: BHF-UCL
  • cytoplasm Source: HPA
  • cytosol Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • nucleolus Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: HPA
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi641S → A: Loss of melanoma cell invasion; when associated with A-646; A-665; A-681; A-679 and A-683. 1 Publication1
Mutagenesisi641S → D or E: Promotes melanoma cell invasion; when associated with D/E-633; D/E-652; D/E-668; D/E-679 and D/E-683. 1 Publication1
Mutagenesisi646S → A: Loss of melanoma cell invasion; when associated with A-641; A-665; A-681; A-679 and A-683. 1 Publication1
Mutagenesisi646S → D or E: Promotes melanoma cell invasion; when associated with D/E-628; D/E-652; D/E-668; D/E-679 and D/E-683. 1 Publication1
Mutagenesisi665S → A: Loss of melanoma cell invasion; when associated with A-641; A-646; A-681; A-679 and A-683. 1 Publication1
Mutagenesisi665S → D or E: Promotes melanoma cell invasion; when associated with D/E-628; D/E-633; D/E-668; D/E-679 and D/E-683. 1 Publication1
Mutagenesisi681S → A: Loss of melanoma cell invasion; when associated with A-641; A-646; A-665; A-679 and A-683. 1 Publication1
Mutagenesisi681S → D or E: Promotes melanoma cell invasion; when associated with D/E-628; D/E-633; D/E-652; D/E-679 and D/E-683. 1 Publication1
Mutagenesisi692S → A: Loss of melanoma cell invasion; when associated with A-641; A-646; A-665; A-668 and A-683. 1 Publication1
Mutagenesisi692S → D or E: Promotes melanoma cell invasion; when associated with D/E-628; D/E-633; D/E-652; D/E-668 and D/E-683. 1 Publication1
Mutagenesisi696S → A: Loss of melanoma cell invasion; when associated with A-641; A-646; A-665; A-668 and A-679. 1 Publication1
Mutagenesisi696S → D or E: Promotes melanoma cell invasion; when associated with D/E-628; D/E-633; D/E-652; D/E-668 and D/E-679. 1 Publication1

Organism-specific databases

DisGeNETi64855.
OpenTargetsiENSG00000136830.
PharmGKBiPA162385984.

Polymorphism and mutation databases

BioMutaiFAM129B.
DMDMi347595791.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00002131212 – 746Niban-like protein 1Add BLAST745

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine2 Publications1
Modified residuei568PhosphoserineCombined sources1
Modified residuei574PhosphoserineCombined sources1
Modified residuei601PhosphoserineCombined sources1
Modified residuei603PhosphoserineCombined sources1
Modified residuei606PhosphothreonineCombined sources1
Modified residuei609PhosphoserineCombined sources1
Modified residuei624PhosphoserineCombined sources1
Modified residuei638PhosphoserineCombined sources1
Modified residuei641PhosphoserineCombined sources1 Publication1
Modified residuei646PhosphoserineCombined sources1 Publication1
Modified residuei665PhosphoserineCombined sources1 Publication1
Modified residuei681PhosphoserineCombined sources1 Publication1
Modified residuei692PhosphoserineCombined sources1 Publication1
Modified residuei696PhosphoserineCombined sources1 Publication1

Post-translational modificationi

Phosphorylated at Ser-641, Ser-646, Ser-692 and Ser-696 by the BRAF/MKK/ERK signaling cascade. In melanoma cells, the C-terminal phosphorylation may prevent targeting to the plasma membrane.1 Publication
As apoptosis proceeds, degraded via an proteasome-independent pathway, probably by caspases.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ96TA1.
MaxQBiQ96TA1.
PaxDbiQ96TA1.
PeptideAtlasiQ96TA1.
PRIDEiQ96TA1.

PTM databases

iPTMnetiQ96TA1.
PhosphoSitePlusiQ96TA1.
SwissPalmiQ96TA1.

Expressioni

Gene expression databases

BgeeiENSG00000136830.
CleanExiHS_FAM129B.
ExpressionAtlasiQ96TA1. baseline and differential.
GenevisibleiQ96TA1. HS.

Organism-specific databases

HPAiHPA021284.
HPA021417.
HPA023261.
HPA024312.

Interactioni

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi122328. 29 interactors.
IntActiQ96TA1. 6 interactors.
MINTiMINT-1193681.
STRINGi9606.ENSP00000362409.

Structurei

3D structure databases

ProteinModelPortaliQ96TA1.
SMRiQ96TA1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 192PHPROSITE-ProRule annotationAdd BLAST125

Sequence similaritiesi

Belongs to the Niban family.Curated
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IFR1. Eukaryota.
ENOG41102BB. LUCA.
GeneTreeiENSGT00530000063284.
HOGENOMiHOG000220836.
HOVERGENiHBG026217.
InParanoidiQ96TA1.
OMAiPIDWGEE.
OrthoDBiEOG091G02BX.
PhylomeDBiQ96TA1.
TreeFamiTF333351.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR026088. Niban-like.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR14392. PTHR14392. 1 hit.
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96TA1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDVLSTHLD DARRQHIAEK TGKILTEFLQ FYEDQYGVAL FNSMRHEIEG
60 70 80 90 100
TGLPQAQLLW RKVPLDERIV FSGNLFQHQE DSKKWRNRFS LVPHNYGLVL
110 120 130 140 150
YENKAAYERQ VPPRAVINSA GYKILTSVDQ YLELIGNSLP GTTAKSGSAP
160 170 180 190 200
ILKCPTQFPL ILWHPYARHY YFCMMTEAEQ DKWQAVLQDC IRHCNNGIPE
210 220 230 240 250
DSKVEGPAFT DAIRMYRQSK ELYGTWEMLC GNEVQILSNL VMEELGPELK
260 270 280 290 300
AELGPRLKGK PQERQRQWIQ ISDAVYHMVY EQAKARFEEV LSKVQQVQPA
310 320 330 340 350
MQAVIRTDMD QIITSKEHLA SKIRAFILPK AEVCVRNHVQ PYIPSILEAL
360 370 380 390 400
MVPTSQGFTE VRDVFFKEVT DMNLNVINEG GIDKLGEYME KLSRLAYHPL
410 420 430 440 450
KMQSCYEKME SLRLDGLQQR FDVSSTSVFK QRAQIHMREQ MDNAVYTFET
460 470 480 490 500
LLHQELGKGP TKEELCKSIQ RVLERVLKKY DYDSSSVRKR FFREALLQIS
510 520 530 540 550
IPFLLKKLAP TCKSELPRFQ ELIFEDFARF ILVENTYEEV VLQTVMKDIL
560 570 580 590 600
QAVKEAAVQR KHNLYRDSMV MHNSDPNLHL LAEGAPIDWG EEYSNSGGGG
610 620 630 640 650
SPSPSTPESA TLSEKRRRAK QVVSVVQDEE VGLPFEASPE SPPPASPDGV
660 670 680 690 700
TEIRGLLAQG LRPESPPPAG PLLNGAPAGE SPQPKAAPEA SSPPASPLQH
710 720 730 740
LLPGKAVDLG PPKPSDQETG EQVSSPSSHP ALHTTTEDSA GVQTEF
Length:746
Mass (Da):84,138
Last modified:September 21, 2011 - v3
Checksum:i2049835F08356944
GO
Isoform 2 (identifier: Q96TA1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MGDVLSTHLDDARRQHIA → MGWMG

Show »
Length:733
Mass (Da):82,683
Checksum:i38E1C24CF737F3DB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti318H → L in AAK57556 (Ref. 1) Curated1
Sequence conflicti677P → L in AAH01979 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0418101 – 18MGDVL…RQHIA → MGWMG in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151783 mRNA. Translation: AAK57556.1.
AF192911 mRNA. Translation: AAQ13825.1.
AL445222, AL390116 Genomic DNA. Translation: CAH72914.1.
AL445222, AL390116 Genomic DNA. Translation: CAH72915.1.
AL390116, AL445222 Genomic DNA. Translation: CAH73084.1.
AL390116, AL445222 Genomic DNA. Translation: CAH73085.1.
CH471090 Genomic DNA. Translation: EAW87675.1.
CH471090 Genomic DNA. Translation: EAW87677.1.
AB210016 mRNA. Translation: BAE06098.1.
AL137555 mRNA. Translation: CAB70809.1.
BC001979 mRNA. Translation: AAH01979.2.
CCDSiCCDS35144.1. [Q96TA1-2]
CCDS35145.1. [Q96TA1-1]
PIRiT46394.
RefSeqiNP_001030611.1. NM_001035534.2. [Q96TA1-2]
NP_073744.2. NM_022833.3. [Q96TA1-1]
UniGeneiHs.522401.

Genome annotation databases

EnsembliENST00000373312; ENSP00000362409; ENSG00000136830. [Q96TA1-1]
ENST00000373314; ENSP00000362411; ENSG00000136830. [Q96TA1-2]
GeneIDi64855.
KEGGihsa:64855.
UCSCiuc004brh.5. human. [Q96TA1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151783 mRNA. Translation: AAK57556.1.
AF192911 mRNA. Translation: AAQ13825.1.
AL445222, AL390116 Genomic DNA. Translation: CAH72914.1.
AL445222, AL390116 Genomic DNA. Translation: CAH72915.1.
AL390116, AL445222 Genomic DNA. Translation: CAH73084.1.
AL390116, AL445222 Genomic DNA. Translation: CAH73085.1.
CH471090 Genomic DNA. Translation: EAW87675.1.
CH471090 Genomic DNA. Translation: EAW87677.1.
AB210016 mRNA. Translation: BAE06098.1.
AL137555 mRNA. Translation: CAB70809.1.
BC001979 mRNA. Translation: AAH01979.2.
CCDSiCCDS35144.1. [Q96TA1-2]
CCDS35145.1. [Q96TA1-1]
PIRiT46394.
RefSeqiNP_001030611.1. NM_001035534.2. [Q96TA1-2]
NP_073744.2. NM_022833.3. [Q96TA1-1]
UniGeneiHs.522401.

3D structure databases

ProteinModelPortaliQ96TA1.
SMRiQ96TA1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122328. 29 interactors.
IntActiQ96TA1. 6 interactors.
MINTiMINT-1193681.
STRINGi9606.ENSP00000362409.

PTM databases

iPTMnetiQ96TA1.
PhosphoSitePlusiQ96TA1.
SwissPalmiQ96TA1.

Polymorphism and mutation databases

BioMutaiFAM129B.
DMDMi347595791.

Proteomic databases

EPDiQ96TA1.
MaxQBiQ96TA1.
PaxDbiQ96TA1.
PeptideAtlasiQ96TA1.
PRIDEiQ96TA1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373312; ENSP00000362409; ENSG00000136830. [Q96TA1-1]
ENST00000373314; ENSP00000362411; ENSG00000136830. [Q96TA1-2]
GeneIDi64855.
KEGGihsa:64855.
UCSCiuc004brh.5. human. [Q96TA1-1]

Organism-specific databases

CTDi64855.
DisGeNETi64855.
GeneCardsiFAM129B.
H-InvDBHIX0008401.
HGNCiHGNC:25282. FAM129B.
HPAiHPA021284.
HPA021417.
HPA023261.
HPA024312.
MIMi614045. gene.
neXtProtiNX_Q96TA1.
OpenTargetsiENSG00000136830.
PharmGKBiPA162385984.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFR1. Eukaryota.
ENOG41102BB. LUCA.
GeneTreeiENSGT00530000063284.
HOGENOMiHOG000220836.
HOVERGENiHBG026217.
InParanoidiQ96TA1.
OMAiPIDWGEE.
OrthoDBiEOG091G02BX.
PhylomeDBiQ96TA1.
TreeFamiTF333351.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000136830-MONOMER.

Miscellaneous databases

ChiTaRSiFAM129B. human.
GenomeRNAii64855.
PROiQ96TA1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136830.
CleanExiHS_FAM129B.
ExpressionAtlasiQ96TA1. baseline and differential.
GenevisibleiQ96TA1. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR026088. Niban-like.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR14392. PTHR14392. 1 hit.
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNIBL1_HUMAN
AccessioniPrimary (citable) accession number: Q96TA1
Secondary accession number(s): Q4LE55
, Q5VVW6, Q5VVW7, Q9BUS2, Q9NT35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: September 21, 2011
Last modified: November 2, 2016
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.