Q96TA1 (NIBL1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Niban-like protein 1

Alternative name(s):
Meg-3
Melanoma invasion by ERK
Short name=MINERVA
Protein FAM129B

Gene names

Name:	FAM129B
Synonyms:	C9orf88

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	746 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro. Ref.8 Ref.14
Subcellular location	Cytoplasm › cytosol. Cell junction › adherens junction. Note: In exponentially growing cells, exclusively cytoplasmic. Cell membrane localization is observed when cells reach confluency and during telophase. In melanoma cells, targeting to the plasma membrane may be impaired by C-terminal phosphorylation. Ref.8 Ref.14
Post-translational modification	Phosphorylated at Ser-641, Ser-646, Ser-692 and Ser-696 by the BRAF/MKK/ERK signaling cascade. In melanoma cells, the C-terminal phosphorylation may prevent targeting to the plasma membrane. Ref.8 As apoptosis proceeds, degraded via an proteasome-independent pathway, probably by caspases (Ref.14).
Sequence similarities	Belongs to the Niban family. Contains 1 PH domain.

Ontologies

Keywords
Cellular component	Cell junction Cytoplasm
Coding sequence diversity	Alternative splicing
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of apoptotic process Inferred from mutant phenotype Ref.14. Source: UniProtKB
Cellular_component	adherens junction Inferred from direct assay Ref.14. Source: UniProtKB cytosol Inferred from direct assay Ref.14. Source: UniProtKB
Molecular_function	phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Fam129b	Q8R1F1	1	EBI-2514593,EBI-2552549	From a different organism.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96TA1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96TA1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MGDVLSTHLDDARRQHIA → MGWMG

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 746	746	Niban-like protein 1		PRO_0000213121
Regions
	Domain	68 – 192	125	PH
Amino acid modifications
	Modified residue	568	1	Phosphoserine Ref.12
	Modified residue	574	1	Phosphoserine Ref.10
	Modified residue	601	1	Phosphoserine Ref.10
	Modified residue	603	1	Phosphoserine Ref.10
	Modified residue	606	1	Phosphothreonine Ref.10
	Modified residue	609	1	Phosphoserine Ref.10
	Modified residue	624	1	Phosphoserine Ref.11
	Modified residue	638	1	Phosphoserine Ref.10 Ref.12
	Modified residue	641	1	Phosphoserine Ref.8 Ref.10 Ref.11 Ref.12
	Modified residue	646	1	Phosphoserine Ref.8 Ref.9 Ref.10 Ref.11 Ref.12
	Modified residue	665	1	Phosphoserine Ref.8 Ref.9 Ref.11 Ref.12 Ref.15
	Modified residue	681	1	Phosphoserine Ref.8 Ref.9 Ref.11 Ref.12 Ref.15
	Modified residue	692	1	Phosphoserine Ref.8 Ref.10 Ref.11
	Modified residue	696	1	Phosphoserine Ref.8 Ref.10 Ref.11
Natural variations
	Alternative sequence	1 – 18	18	MGDVL…RQHIA → MGWMG in isoform 2.		VSP_041810
Experimental info
	Mutagenesis	641	1	S → A: Loss of melanoma cell invasion; when associated with A-646; A-665; A-681; A-679 and A-683. Ref.8
	Mutagenesis	641	1	S → D or E: Promotes melanoma cell invasion; when associated with D/E-633; D/E-652; D/E-668; D/E-679 and D/E-683. Ref.8
	Mutagenesis	646	1	S → A: Loss of melanoma cell invasion; when associated with A-641; A-665; A-681; A-679 and A-683. Ref.8
	Mutagenesis	646	1	S → D or E: Promotes melanoma cell invasion; when associated with D/E-628; D/E-652; D/E-668; D/E-679 and D/E-683. Ref.8
	Mutagenesis	665	1	S → A: Loss of melanoma cell invasion; when associated with A-641; A-646; A-681; A-679 and A-683. Ref.8
	Mutagenesis	665	1	S → D or E: Promotes melanoma cell invasion; when associated with D/E-628; D/E-633; D/E-668; D/E-679 and D/E-683. Ref.8
	Mutagenesis	681	1	S → A: Loss of melanoma cell invasion; when associated with A-641; A-646; A-665; A-679 and A-683. Ref.8
	Mutagenesis	681	1	S → D or E: Promotes melanoma cell invasion; when associated with D/E-628; D/E-633; D/E-652; D/E-679 and D/E-683. Ref.8
	Mutagenesis	692	1	S → A: Loss of melanoma cell invasion; when associated with A-641; A-646; A-665; A-668 and A-683. Ref.8
	Mutagenesis	692	1	S → D or E: Promotes melanoma cell invasion; when associated with D/E-628; D/E-633; D/E-652; D/E-668 and D/E-683. Ref.8
	Mutagenesis	696	1	S → A: Loss of melanoma cell invasion; when associated with A-641; A-646; A-665; A-668 and A-679. Ref.8
	Mutagenesis	696	1	S → D or E: Promotes melanoma cell invasion; when associated with D/E-628; D/E-633; D/E-652; D/E-668 and D/E-679. Ref.8
	Sequence conflict	318	1	H → L in AAK57556. Ref.1
	Sequence conflict	677	1	P → L in AAH01979. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 21, 2011. Version 3. Checksum: 2049835F08356944	FASTA	746	84,138
	10 20 30 40 50 60 MGDVLSTHLD DARRQHIAEK TGKILTEFLQ FYEDQYGVAL FNSMRHEIEG TGLPQAQLLW 70 80 90 100 110 120 RKVPLDERIV FSGNLFQHQE DSKKWRNRFS LVPHNYGLVL YENKAAYERQ VPPRAVINSA 130 140 150 160 170 180 GYKILTSVDQ YLELIGNSLP GTTAKSGSAP ILKCPTQFPL ILWHPYARHY YFCMMTEAEQ 190 200 210 220 230 240 DKWQAVLQDC IRHCNNGIPE DSKVEGPAFT DAIRMYRQSK ELYGTWEMLC GNEVQILSNL 250 260 270 280 290 300 VMEELGPELK AELGPRLKGK PQERQRQWIQ ISDAVYHMVY EQAKARFEEV LSKVQQVQPA 310 320 330 340 350 360 MQAVIRTDMD QIITSKEHLA SKIRAFILPK AEVCVRNHVQ PYIPSILEAL MVPTSQGFTE 370 380 390 400 410 420 VRDVFFKEVT DMNLNVINEG GIDKLGEYME KLSRLAYHPL KMQSCYEKME SLRLDGLQQR 430 440 450 460 470 480 FDVSSTSVFK QRAQIHMREQ MDNAVYTFET LLHQELGKGP TKEELCKSIQ RVLERVLKKY 490 500 510 520 530 540 DYDSSSVRKR FFREALLQIS IPFLLKKLAP TCKSELPRFQ ELIFEDFARF ILVENTYEEV 550 560 570 580 590 600 VLQTVMKDIL QAVKEAAVQR KHNLYRDSMV MHNSDPNLHL LAEGAPIDWG EEYSNSGGGG 610 620 630 640 650 660 SPSPSTPESA TLSEKRRRAK QVVSVVQDEE VGLPFEASPE SPPPASPDGV TEIRGLLAQG 670 680 690 700 710 720 LRPESPPPAG PLLNGAPAGE SPQPKAAPEA SSPPASPLQH LLPGKAVDLG PPKPSDQETG 730 740 EQVSSPSSHP ALHTTTEDSA GVQTEF
	Isoform 2 [UniParc]. Checksum: 38E1C24CF737F3DB	FASTA	733	82,683
	10 20 30 40 50 60 MGWMGEKTGK ILTEFLQFYE DQYGVALFNS MRHEIEGTGL PQAQLLWRKV PLDERIVFSG 70 80 90 100 110 120 NLFQHQEDSK KWRNRFSLVP HNYGLVLYEN KAAYERQVPP RAVINSAGYK ILTSVDQYLE 130 140 150 160 170 180 LIGNSLPGTT AKSGSAPILK CPTQFPLILW HPYARHYYFC MMTEAEQDKW QAVLQDCIRH 190 200 210 220 230 240 CNNGIPEDSK VEGPAFTDAI RMYRQSKELY GTWEMLCGNE VQILSNLVME ELGPELKAEL 250 260 270 280 290 300 GPRLKGKPQE RQRQWIQISD AVYHMVYEQA KARFEEVLSK VQQVQPAMQA VIRTDMDQII 310 320 330 340 350 360 TSKEHLASKI RAFILPKAEV CVRNHVQPYI PSILEALMVP TSQGFTEVRD VFFKEVTDMN 370 380 390 400 410 420 LNVINEGGID KLGEYMEKLS RLAYHPLKMQ SCYEKMESLR LDGLQQRFDV SSTSVFKQRA 430 440 450 460 470 480 QIHMREQMDN AVYTFETLLH QELGKGPTKE ELCKSIQRVL ERVLKKYDYD SSSVRKRFFR 490 500 510 520 530 540 EALLQISIPF LLKKLAPTCK SELPRFQELI FEDFARFILV ENTYEEVVLQ TVMKDILQAV 550 560 570 580 590 600 KEAAVQRKHN LYRDSMVMHN SDPNLHLLAE GAPIDWGEEY SNSGGGGSPS PSTPESATLS 610 620 630 640 650 660 EKRRRAKQVV SVVQDEEVGL PFEASPESPP PASPDGVTEI RGLLAQGLRP ESPPPAGPLL 670 680 690 700 710 720 NGAPAGESPQ PKAAPEASSP PASPLQHLLP GKAVDLGPPK PSDQETGEQV SSPSSHPALH 730 TTTEDSAGVQ TEF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Homo sapiens meg-3 mRNA, complete cds." Miyata T., Inagi R., Yasuda Y., Kurokawa K. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[2]	"Differential screening of human osteoclast maturation associated genes." Yamane S., Toyosaki-Maeda T., Tsuruta Y., Suzuki R., Ochi T. Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method." Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-746 (ISOFORM 1).
[6]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 38-733. Tissue: Testis.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 278-733. Tissue: Cervix.
[8]	"Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma." Old W.M., Shabb J.B., Houel S., Wang H., Couts K.L., Yen C.Y., Litman E.S., Croy C.H., Meyer-Arendt K., Miranda J.G., Brown R.A., Witze E.S., Schweppe R.E., Resing K.A., Ahn N.G. Mol. Cell 34:115-131(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 637-650 AND 688-698, MASS SPECTROMETRY, FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-641; SER-646; SER-665; SER-681; SER-692 AND SER-696, MUTAGENESIS OF SER-641; SER-646; SER-665; SER-681; SER-692 AND SER-696.
[9]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-646; SER-665 AND SER-681, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-574; SER-601; SER-603; THR-606; SER-609; SER-638; SER-641; SER-646; SER-692 AND SER-696, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-624; SER-641; SER-646; SER-665; SER-681; SER-692 AND SER-696, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[12]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-568; SER-638; SER-641; SER-646; SER-665 AND SER-681, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]	"FAM129B/MINERVA, a novel adherens junction-associated protein, suppresses apoptosis in HeLa cells." Chen S., Evans H.G., Evans D.R. J. Biol. Chem. 286:10201-10209(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[15]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-665 AND SER-681, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF151783 mRNA. Translation: AAK57556.1. AF192911 mRNA. Translation: AAQ13825.1. AL445222, AL390116 Genomic DNA. Translation: CAH72914.1. AL445222, AL390116 Genomic DNA. Translation: CAH72915.1. AL390116, AL445222 Genomic DNA. Translation: CAH73084.1. AL390116, AL445222 Genomic DNA. Translation: CAH73085.1. CH471090 Genomic DNA. Translation: EAW87675.1. CH471090 Genomic DNA. Translation: EAW87677.1. AB210016 mRNA. Translation: BAE06098.1. AL137555 mRNA. Translation: CAB70809.1. BC001979 mRNA. Translation: AAH01979.2.
IPI	IPI00456750. IPI00647286.
PIR	T46394.
RefSeq	NP_001030611.1. NM_001035534.1. NP_073744.2. NM_022833.2.
UniGene	Hs.522401.
3D structure databases
ProteinModelPortal	Q96TA1.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96TA1. 2 interactions.
MINT	MINT-1193681.
STRING	9606.ENSP00000362409.
PTM databases
PhosphoSite	Q96TA1.
Polymorphism databases
DMDM	22256935.
Proteomic databases
PaxDb	Q96TA1.
PRIDE	Q96TA1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000373312; ENSP00000362409; ENSG00000136830. ENST00000373314; ENSP00000362411; ENSG00000136830.
GeneID	64855.
KEGG	hsa:64855.
UCSC	uc004brh.3. human. uc004bri.3. human.
Organism-specific databases
CTD	64855.
GeneCards	GC09M130267.
H-InvDB	HIX0008401.
HGNC	HGNC:25282. FAM129B.
HPA	HPA021284. HPA021417. HPA023261. HPA024312.
MIM	614045. gene.
neXtProt	NX_Q96TA1.
PharmGKB	PA162385984.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG46977.
HOGENOM	HOG000220836.
HOVERGEN	HBG026217.
OMA	QGFTEVR.
OrthoDB	EOG4JQ3X5.
Gene expression databases
ArrayExpress	Q96TA1.
Bgee	Q96TA1.
CleanEx	HS_FAM129B.
Genevestigator	Q96TA1.
GermOnline	ENSG00000136830. Homo sapiens.
Family and domain databases
Gene3D	2.30.29.30. 1 hit.
InterPro	IPR026088. Niban_like. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. [Graphical view]
PANTHER	PTHR14392. PTHR14392. 1 hit.
SMART	SM00233. PH. 1 hit. [Graphical view]
PROSITE	PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FAM129B. human.
GenomeRNAi	64855.
NextBio	66991.
SOURCE	Search...

Entry information

Entry name

NIBL1_HUMAN

Accession

Primary (citable) accession number: Q96TA1
Secondary accession number(s): Q4LE55 , Q5VVW6, Q5VVW7, Q9BUS2, Q9NT35

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 2002
Last sequence update:	September 21, 2011
Last modified:	April 3, 2013
This is version 99 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.