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Protein

Niban-like protein 1

Gene

FAM129B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in apoptosis suppression. May promote melanoma cell invasion in vitro.2 Publications

GO - Biological processi

  • negative regulation of apoptotic process Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Niban-like protein 1
Alternative name(s):
Meg-3
Melanoma invasion by ERK
Short name:
MINERVA
Protein FAM129B
Gene namesi
Name:FAM129B
Synonyms:C9orf88
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:25282. FAM129B.

Subcellular locationi

  • Cytoplasmcytosol
  • Cell junctionadherens junction

  • Note: In exponentially growing cells, exclusively cytoplasmic. Cell membrane localization is observed when cells reach confluency and during telophase. In melanoma cells, targeting to the plasma membrane may be impaired by C-terminal phosphorylation.

GO - Cellular componenti

  • actin cytoskeleton Source: HPA
  • adherens junction Source: UniProtKB
  • cytoplasm Source: HPA
  • cytosol Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • nucleolus Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: HPA
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi641 – 6411S → A: Loss of melanoma cell invasion; when associated with A-646; A-665; A-681; A-679 and A-683. 1 Publication
Mutagenesisi641 – 6411S → D or E: Promotes melanoma cell invasion; when associated with D/E-633; D/E-652; D/E-668; D/E-679 and D/E-683. 1 Publication
Mutagenesisi646 – 6461S → A: Loss of melanoma cell invasion; when associated with A-641; A-665; A-681; A-679 and A-683. 1 Publication
Mutagenesisi646 – 6461S → D or E: Promotes melanoma cell invasion; when associated with D/E-628; D/E-652; D/E-668; D/E-679 and D/E-683. 1 Publication
Mutagenesisi665 – 6651S → A: Loss of melanoma cell invasion; when associated with A-641; A-646; A-681; A-679 and A-683. 1 Publication
Mutagenesisi665 – 6651S → D or E: Promotes melanoma cell invasion; when associated with D/E-628; D/E-633; D/E-668; D/E-679 and D/E-683. 1 Publication
Mutagenesisi681 – 6811S → A: Loss of melanoma cell invasion; when associated with A-641; A-646; A-665; A-679 and A-683. 1 Publication
Mutagenesisi681 – 6811S → D or E: Promotes melanoma cell invasion; when associated with D/E-628; D/E-633; D/E-652; D/E-679 and D/E-683. 1 Publication
Mutagenesisi692 – 6921S → A: Loss of melanoma cell invasion; when associated with A-641; A-646; A-665; A-668 and A-683. 1 Publication
Mutagenesisi692 – 6921S → D or E: Promotes melanoma cell invasion; when associated with D/E-628; D/E-633; D/E-652; D/E-668 and D/E-683. 1 Publication
Mutagenesisi696 – 6961S → A: Loss of melanoma cell invasion; when associated with A-641; A-646; A-665; A-668 and A-679. 1 Publication
Mutagenesisi696 – 6961S → D or E: Promotes melanoma cell invasion; when associated with D/E-628; D/E-633; D/E-652; D/E-668 and D/E-679. 1 Publication

Organism-specific databases

PharmGKBiPA162385984.

Polymorphism and mutation databases

BioMutaiFAM129B.
DMDMi347595791.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 746746Niban-like protein 1PRO_0000213121Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei568 – 5681Phosphoserine1 Publication
Modified residuei574 – 5741Phosphoserine1 Publication
Modified residuei601 – 6011Phosphoserine1 Publication
Modified residuei603 – 6031Phosphoserine1 Publication
Modified residuei606 – 6061Phosphothreonine1 Publication
Modified residuei609 – 6091Phosphoserine1 Publication
Modified residuei624 – 6241Phosphoserine1 Publication
Modified residuei638 – 6381Phosphoserine2 Publications
Modified residuei641 – 6411Phosphoserine3 Publications
Modified residuei646 – 6461Phosphoserine6 Publications
Modified residuei665 – 6651Phosphoserine5 Publications
Modified residuei681 – 6811Phosphoserine5 Publications
Modified residuei692 – 6921Phosphoserine4 Publications
Modified residuei696 – 6961Phosphoserine4 Publications

Post-translational modificationi

Phosphorylated at Ser-641, Ser-646, Ser-692 and Ser-696 by the BRAF/MKK/ERK signaling cascade. In melanoma cells, the C-terminal phosphorylation may prevent targeting to the plasma membrane.1 Publication
As apoptosis proceeds, degraded via an proteasome-independent pathway, probably by caspases.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96TA1.
PaxDbiQ96TA1.
PRIDEiQ96TA1.

PTM databases

PhosphoSiteiQ96TA1.

Expressioni

Gene expression databases

BgeeiQ96TA1.
CleanExiHS_FAM129B.
ExpressionAtlasiQ96TA1. baseline and differential.
GenevisibleiQ96TA1. HS.

Organism-specific databases

HPAiHPA021284.
HPA021417.
HPA023261.
HPA024312.

Interactioni

Protein-protein interaction databases

BioGridi122328. 26 interactions.
IntActiQ96TA1. 5 interactions.
MINTiMINT-1193681.
STRINGi9606.ENSP00000362409.

Structurei

3D structure databases

ProteinModelPortaliQ96TA1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini68 – 192125PHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Niban family.Curated
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG46977.
GeneTreeiENSGT00530000063284.
HOGENOMiHOG000220836.
HOVERGENiHBG026217.
InParanoidiQ96TA1.
OMAiPIDWGEE.
OrthoDBiEOG7GN2MC.
PhylomeDBiQ96TA1.
TreeFamiTF333351.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR026088. Niban_like.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PANTHERiPTHR14392. PTHR14392. 1 hit.
SMARTiSM00233. PH. 1 hit.
[Graphical view]
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96TA1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDVLSTHLD DARRQHIAEK TGKILTEFLQ FYEDQYGVAL FNSMRHEIEG
60 70 80 90 100
TGLPQAQLLW RKVPLDERIV FSGNLFQHQE DSKKWRNRFS LVPHNYGLVL
110 120 130 140 150
YENKAAYERQ VPPRAVINSA GYKILTSVDQ YLELIGNSLP GTTAKSGSAP
160 170 180 190 200
ILKCPTQFPL ILWHPYARHY YFCMMTEAEQ DKWQAVLQDC IRHCNNGIPE
210 220 230 240 250
DSKVEGPAFT DAIRMYRQSK ELYGTWEMLC GNEVQILSNL VMEELGPELK
260 270 280 290 300
AELGPRLKGK PQERQRQWIQ ISDAVYHMVY EQAKARFEEV LSKVQQVQPA
310 320 330 340 350
MQAVIRTDMD QIITSKEHLA SKIRAFILPK AEVCVRNHVQ PYIPSILEAL
360 370 380 390 400
MVPTSQGFTE VRDVFFKEVT DMNLNVINEG GIDKLGEYME KLSRLAYHPL
410 420 430 440 450
KMQSCYEKME SLRLDGLQQR FDVSSTSVFK QRAQIHMREQ MDNAVYTFET
460 470 480 490 500
LLHQELGKGP TKEELCKSIQ RVLERVLKKY DYDSSSVRKR FFREALLQIS
510 520 530 540 550
IPFLLKKLAP TCKSELPRFQ ELIFEDFARF ILVENTYEEV VLQTVMKDIL
560 570 580 590 600
QAVKEAAVQR KHNLYRDSMV MHNSDPNLHL LAEGAPIDWG EEYSNSGGGG
610 620 630 640 650
SPSPSTPESA TLSEKRRRAK QVVSVVQDEE VGLPFEASPE SPPPASPDGV
660 670 680 690 700
TEIRGLLAQG LRPESPPPAG PLLNGAPAGE SPQPKAAPEA SSPPASPLQH
710 720 730 740
LLPGKAVDLG PPKPSDQETG EQVSSPSSHP ALHTTTEDSA GVQTEF
Length:746
Mass (Da):84,138
Last modified:September 21, 2011 - v3
Checksum:i2049835F08356944
GO
Isoform 2 (identifier: Q96TA1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-18: MGDVLSTHLDDARRQHIA → MGWMG

Show »
Length:733
Mass (Da):82,683
Checksum:i38E1C24CF737F3DB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti318 – 3181H → L in AAK57556 (Ref. 1) Curated
Sequence conflicti677 – 6771P → L in AAH01979 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1818MGDVL…RQHIA → MGWMG in isoform 2. 1 PublicationVSP_041810Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151783 mRNA. Translation: AAK57556.1.
AF192911 mRNA. Translation: AAQ13825.1.
AL445222, AL390116 Genomic DNA. Translation: CAH72914.1.
AL445222, AL390116 Genomic DNA. Translation: CAH72915.1.
AL390116, AL445222 Genomic DNA. Translation: CAH73084.1.
AL390116, AL445222 Genomic DNA. Translation: CAH73085.1.
CH471090 Genomic DNA. Translation: EAW87675.1.
CH471090 Genomic DNA. Translation: EAW87677.1.
AB210016 mRNA. Translation: BAE06098.1.
AL137555 mRNA. Translation: CAB70809.1.
BC001979 mRNA. Translation: AAH01979.2.
CCDSiCCDS35144.1. [Q96TA1-2]
CCDS35145.1. [Q96TA1-1]
PIRiT46394.
RefSeqiNP_001030611.1. NM_001035534.2. [Q96TA1-2]
NP_073744.2. NM_022833.3. [Q96TA1-1]
UniGeneiHs.522401.

Genome annotation databases

EnsembliENST00000373312; ENSP00000362409; ENSG00000136830. [Q96TA1-1]
ENST00000373314; ENSP00000362411; ENSG00000136830. [Q96TA1-2]
GeneIDi64855.
KEGGihsa:64855.
UCSCiuc004brh.3. human. [Q96TA1-1]
uc004bri.3. human. [Q96TA1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151783 mRNA. Translation: AAK57556.1.
AF192911 mRNA. Translation: AAQ13825.1.
AL445222, AL390116 Genomic DNA. Translation: CAH72914.1.
AL445222, AL390116 Genomic DNA. Translation: CAH72915.1.
AL390116, AL445222 Genomic DNA. Translation: CAH73084.1.
AL390116, AL445222 Genomic DNA. Translation: CAH73085.1.
CH471090 Genomic DNA. Translation: EAW87675.1.
CH471090 Genomic DNA. Translation: EAW87677.1.
AB210016 mRNA. Translation: BAE06098.1.
AL137555 mRNA. Translation: CAB70809.1.
BC001979 mRNA. Translation: AAH01979.2.
CCDSiCCDS35144.1. [Q96TA1-2]
CCDS35145.1. [Q96TA1-1]
PIRiT46394.
RefSeqiNP_001030611.1. NM_001035534.2. [Q96TA1-2]
NP_073744.2. NM_022833.3. [Q96TA1-1]
UniGeneiHs.522401.

3D structure databases

ProteinModelPortaliQ96TA1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122328. 26 interactions.
IntActiQ96TA1. 5 interactions.
MINTiMINT-1193681.
STRINGi9606.ENSP00000362409.

PTM databases

PhosphoSiteiQ96TA1.

Polymorphism and mutation databases

BioMutaiFAM129B.
DMDMi347595791.

Proteomic databases

MaxQBiQ96TA1.
PaxDbiQ96TA1.
PRIDEiQ96TA1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373312; ENSP00000362409; ENSG00000136830. [Q96TA1-1]
ENST00000373314; ENSP00000362411; ENSG00000136830. [Q96TA1-2]
GeneIDi64855.
KEGGihsa:64855.
UCSCiuc004brh.3. human. [Q96TA1-1]
uc004bri.3. human. [Q96TA1-2]

Organism-specific databases

CTDi64855.
GeneCardsiGC09M130267.
H-InvDBHIX0008401.
HGNCiHGNC:25282. FAM129B.
HPAiHPA021284.
HPA021417.
HPA023261.
HPA024312.
MIMi614045. gene.
neXtProtiNX_Q96TA1.
PharmGKBiPA162385984.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46977.
GeneTreeiENSGT00530000063284.
HOGENOMiHOG000220836.
HOVERGENiHBG026217.
InParanoidiQ96TA1.
OMAiPIDWGEE.
OrthoDBiEOG7GN2MC.
PhylomeDBiQ96TA1.
TreeFamiTF333351.

Miscellaneous databases

ChiTaRSiFAM129B. human.
GenomeRNAii64855.
NextBioi66991.
PROiQ96TA1.
SOURCEiSearch...

Gene expression databases

BgeeiQ96TA1.
CleanExiHS_FAM129B.
ExpressionAtlasiQ96TA1. baseline and differential.
GenevisibleiQ96TA1. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR026088. Niban_like.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
[Graphical view]
PANTHERiPTHR14392. PTHR14392. 1 hit.
SMARTiSM00233. PH. 1 hit.
[Graphical view]
PROSITEiPS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Homo sapiens meg-3 mRNA, complete cds."
    Miyata T., Inagi R., Yasuda Y., Kurokawa K.
    Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Differential screening of human osteoclast maturation associated genes."
    Yamane S., Toyosaki-Maeda T., Tsuruta Y., Suzuki R., Ochi T.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method."
    Nakajima D., Saito K., Yamakawa H., Kikuno R.F., Nakayama M., Ohara R., Okazaki N., Koga H., Nagase T., Ohara O.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-746 (ISOFORM 1).
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 38-733.
    Tissue: Testis.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 278-733.
    Tissue: Cervix.
  8. Cited for: PROTEIN SEQUENCE OF 637-650 AND 688-698, IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-641; SER-646; SER-665; SER-681; SER-692 AND SER-696, MUTAGENESIS OF SER-641; SER-646; SER-665; SER-681; SER-692 AND SER-696.
  9. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-646; SER-665 AND SER-681, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-574; SER-601; SER-603; THR-606; SER-609; SER-638; SER-641; SER-646; SER-692 AND SER-696, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-624; SER-641; SER-646; SER-665; SER-681; SER-692 AND SER-696, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-568; SER-646; SER-665 AND SER-681, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "FAM129B/MINERVA, a novel adherens junction-associated protein, suppresses apoptosis in HeLa cells."
    Chen S., Evans H.G., Evans D.R.
    J. Biol. Chem. 286:10201-10209(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-665 AND SER-681, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-638; SER-646; SER-692 AND SER-696, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiNIBL1_HUMAN
AccessioniPrimary (citable) accession number: Q96TA1
Secondary accession number(s): Q4LE55
, Q5VVW6, Q5VVW7, Q9BUS2, Q9NT35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 13, 2002
Last sequence update: September 21, 2011
Last modified: June 24, 2015
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.