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Protein

Putative protocadherin beta-18

Gene

PCDHB18P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

Potential calcium-dependent cell-adhesion protein.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000146001-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative protocadherin beta-18
Short name:
PCDH-beta-18
Alternative name(s):
PCDH-psi2
Gene namesi
Name:PCDHB18P
Synonyms:PCDHB18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:14548. PCDHB18P.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei638 – 658HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi74762698.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003393621 – 734Putative protocadherin beta-18Add BLAST734

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi115N-linked (GlcNAc...)Sequence analysis1
Glycosylationi365N-linked (GlcNAc...)Sequence analysis1
Glycosylationi383N-linked (GlcNAc...)Sequence analysis1
Glycosylationi514N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PeptideAtlasiQ96TA0.
PRIDEiQ96TA0.

PTM databases

iPTMnetiQ96TA0.
PhosphoSitePlusiQ96TA0.

Structurei

3D structure databases

ProteinModelPortaliQ96TA0.
SMRiQ96TA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 79Cadherin 1PROSITE-ProRule annotationAdd BLAST79
Domaini80 – 188Cadherin 2PROSITE-ProRule annotationAdd BLAST109
Domaini189 – 293Cadherin 3PROSITE-ProRule annotationAdd BLAST105
Domaini294 – 398Cadherin 4PROSITE-ProRule annotationAdd BLAST105
Domaini399 – 508Cadherin 5PROSITE-ProRule annotationAdd BLAST110
Domaini515 – 621Cadherin 6PROSITE-ProRule annotationAdd BLAST107

Sequence similaritiesi

Contains 6 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ96TA0.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 4 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96TA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWKTWLQGGA RVIFDDYKPY LRLDPQNGDL LLNEQLDREA LCDLTEPCIL
60 70 80 90 100
HFQVLFENPL QFFRAELLVK DINDHTPTFL NNHMLLKISE GATLGTLFQI
110 120 130 140 150
DSAQDLDVGK NGVQNYTISP NPHFHLKLRD SDEGRKYPEL VLDQSLDREK
160 170 180 190 200
VSEFSLTLTA VDGGSPPRSG TTLINVVVLD ISDNAPEFEK PVYEVLVPES
210 220 230 240 250
SPLDSLIIKA SATDLDAGIN GELSYSFSHV SRDVRKTFEI HPISGEVYLK
260 270 280 290 300
APLDFEIIQS YIINIQAIEG GSLSGKSSIL VRVVDVNDNP PEIAMTSLTS
310 320 330 340 350
PIPENSSPEM VVAVFSIRDQ DAGDNGRTVC SIQDNLPFVL KPTFKNFYAL
360 370 380 390 400
VTEHPLDREV RNEYNITITV TDLGTPRLKT EHNITVLVSD VNDNAPIFTQ
410 420 430 440 450
TSYTLFVREN NSPALHIGSV SATDRDSGTN AQVTYSLLPP QDPHLPLTSL
460 470 480 490 500
VSINADNGHL FALRSLDYEA LQEFGFRVGA ADHGSPALSS EVLVRVLVLD
510 520 530 540 550
ANDNSPFVLY PLQNGSAPCT ELVPRAAEPG YLVTKVVAVD GDSGQNAWLS
560 570 580 590 600
YQLLKATEPG LFGVWAHNGE GRTARLLSER DAAKHRLVVL VKDNGEPPRS
610 620 630 640 650
ATATLHVLLV EGFSQPYLPL TEAAPSQAQA DSLTVYLVVA LASVSSLFLF
660 670 680 690 700
SVFLFVAVRL CRRSRAASMG RCSVPECPFP GHLVDVSGTG TLSQSYQYEV
710 720 730
CLTGGSGANE FKFLKPVIPN LLSRDSEMEK APPF
Length:734
Mass (Da):80,449
Last modified:April 1, 2015 - v2
Checksum:iE10B2681F75F74E4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti196L → H in AAK51611 (PubMed:11322959).Curated1
Sequence conflicti196L → H in BAG53070 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217743 mRNA. Translation: AAK51611.1.
AK095496 mRNA. Translation: BAG53070.1.
AC244517 Genomic DNA. No translation available.
UniGeneiHs.676071.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217743 mRNA. Translation: AAK51611.1.
AK095496 mRNA. Translation: BAG53070.1.
AC244517 Genomic DNA. No translation available.
UniGeneiHs.676071.

3D structure databases

ProteinModelPortaliQ96TA0.
SMRiQ96TA0.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ96TA0.
PhosphoSitePlusiQ96TA0.

Polymorphism and mutation databases

DMDMi74762698.

Proteomic databases

PeptideAtlasiQ96TA0.
PRIDEiQ96TA0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiPCDHB18P.
HGNCiHGNC:14548. PCDHB18P.
neXtProtiNX_Q96TA0.
GenAtlasiSearch...

Phylogenomic databases

HOGENOMiHOG000220892.
HOVERGENiHBG054878.
InParanoidiQ96TA0.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000146001-MONOMER.

Family and domain databases

Gene3Di2.60.40.60. 5 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR032455. Cadherin_C.
IPR020894. Cadherin_CS.
IPR013164. Cadherin_N.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF08266. Cadherin_2. 1 hit.
PF16492. Cadherin_C_2. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 5 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 5 hits.
PROSITEiPS00232. CADHERIN_1. 4 hits.
PS50268. CADHERIN_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPCDBI_HUMAN
AccessioniPrimary (citable) accession number: Q96TA0
Secondary accession number(s): B3KTF8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: April 1, 2015
Last modified: November 2, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene. In contrast to other members of the family, lacks a signal sequence due to a frameshift, suggesting that it is not functional (PubMed:11322959, PubMed:11230163 and PubMed:10380929).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.