Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96T92

- INSM2_HUMAN

UniProt

Q96T92 - INSM2_HUMAN

Protein

Insulinoma-associated protein 2

Gene

INSM2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri263 – 28321C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri291 – 31323C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri426 – 44823C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri470 – 49223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri525 – 54824C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Insulinoma-associated protein 2
    Alternative name(s):
    Zinc finger protein IA-6
    Gene namesi
    Name:INSM2
    Synonyms:IA6
    ORF Names:Nbla106
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:17539. INSM2.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134899231.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 566566Insulinoma-associated protein 2PRO_0000331576Add
    BLAST

    Proteomic databases

    PaxDbiQ96T92.
    PRIDEiQ96T92.

    PTM databases

    PhosphoSiteiQ96T92.

    Expressioni

    Tissue specificityi

    Expressed in heart, liver, skeletal muscle, kidney and pancreas, and, to a lesser extent, in brain, lung and spleen. In the pancreas, expressed in islet cells, including insulin- and glucagon-producing alpha- and beta-cells, but not in acinar cells (at protein level). Detected in adrenal glands, particularly in the deeper layer of the cortex (at protein level).1 Publication

    Developmental stagei

    Expressed in the islet-like cells of the developing pancreas and epithelial cells of the duodenum from gestational weeks 8 to 20 (at protein level).1 Publication

    Gene expression databases

    BgeeiQ96T92.
    CleanExiHS_INSM2.
    GenevestigatoriQ96T92.

    Organism-specific databases

    HPAiHPA044885.

    Interactioni

    Protein-protein interaction databases

    BioGridi124201. 1 interaction.
    STRINGi9606.ENSP00000306523.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96T92.
    SMRiQ96T92. Positions 255-338, 415-553.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2020SNAG domainBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri263 – 28321C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri291 – 31323C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri426 – 44823C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri470 – 49223C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri525 – 54824C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG308747.
    HOGENOMiHOG000113079.
    HOVERGENiHBG052137.
    InParanoidiQ96T92.
    OMAiKKPKAMR.
    OrthoDBiEOG7JMGDD.
    PhylomeDBiQ96T92.
    TreeFamiTF320538.

    Family and domain databases

    Gene3Di3.30.160.60. 2 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 2 hits.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 5 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96T92-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRGFLVKRT KRTGGLYRVR LAERVFPLLG PQGAPPFLEE APSASLPGAE    50
    RATPPTREEP GKGLTAEAAR EQSGSPCRAA GVSPGTGGRE GAEWRAGGRE 100
    GPGPSPSPSP SPAKPAGAEL RRAFLERCLS SPVSAESFPG GAAAVAAFSC 150
    SVAPAAAPTP GEQFLLPLRA PFPEPALQPD PAPLSAALQS LKRAAGGERR 200
    GKAPTDCASG PAAAGIKKPK AMRKLSFADE VTTSPVLGLK IKEEEPGAPS 250
    RGLGGSRTPL GEFICQLCKE QYADPFALAQ HRCSRIVRVE YRCPECDKVF 300
    SCPANLASHR RWHKPRPAAA NAATVSSADG KPPSSSSSSS RDSGAIASFL 350
    AEGKENSRIE RTADQHPQAR DSSGADQHPD SAPRQGLQVL THPEPPLPQG 400
    PYTEGVLGRR VPVPGSTSGG RGSEIFVCPY CHKKFRRQAY LRKHLSTHEA 450
    GSARALAPGF GSERGAPLAF ACPLCGAHFP TADIREKHRL WHAVREELLL 500
    PALAGAPPET SGPSGPSDGS AQQIFSCKHC PSTFFSSPGL TRHINKCHPS 550
    ESRQVLLLQM PLRPGC 566
    Length:566
    Mass (Da):59,491
    Last modified:May 18, 2010 - v3
    Checksum:i3603B8ACC8920631
    GO

    Sequence cautioni

    The sequence AAK49393.1 differs from that shown. Reason: Frameshift at positions 123 and 127.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti198 – 1981E → G in BAB69042. (PubMed:12880961)Curated
    Sequence conflicti330 – 3301G → E in BAC04830. (PubMed:14702039)Curated
    Sequence conflicti390 – 3901L → V in AAK49393. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti206 – 2061D → G.5 Publications
    Corresponds to variant rs1958260 [ dbSNP | Ensembl ].
    VAR_070885

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF260323 mRNA. Translation: AAK49393.1. Frameshift.
    JX403968 mRNA. Translation: AFS33107.1.
    AB037912 mRNA. Translation: BAB69042.1.
    AK096639 mRNA. Translation: BAC04830.1.
    AL160231 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW65872.1.
    BC130377 mRNA. Translation: AAI30378.1.
    BC130379 mRNA. Translation: AAI30380.1.
    CCDSiCCDS9657.1.
    RefSeqiNP_115983.3. NM_032594.3.
    UniGeneiHs.62813.

    Genome annotation databases

    EnsembliENST00000307169; ENSP00000306523; ENSG00000168348.
    GeneIDi84684.
    KEGGihsa:84684.
    UCSCiuc001wth.1. human.

    Polymorphism databases

    DMDMi296439326.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF260323 mRNA. Translation: AAK49393.1 . Frameshift.
    JX403968 mRNA. Translation: AFS33107.1 .
    AB037912 mRNA. Translation: BAB69042.1 .
    AK096639 mRNA. Translation: BAC04830.1 .
    AL160231 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW65872.1 .
    BC130377 mRNA. Translation: AAI30378.1 .
    BC130379 mRNA. Translation: AAI30380.1 .
    CCDSi CCDS9657.1.
    RefSeqi NP_115983.3. NM_032594.3.
    UniGenei Hs.62813.

    3D structure databases

    ProteinModelPortali Q96T92.
    SMRi Q96T92. Positions 255-338, 415-553.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124201. 1 interaction.
    STRINGi 9606.ENSP00000306523.

    PTM databases

    PhosphoSitei Q96T92.

    Polymorphism databases

    DMDMi 296439326.

    Proteomic databases

    PaxDbi Q96T92.
    PRIDEi Q96T92.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307169 ; ENSP00000306523 ; ENSG00000168348 .
    GeneIDi 84684.
    KEGGi hsa:84684.
    UCSCi uc001wth.1. human.

    Organism-specific databases

    CTDi 84684.
    GeneCardsi GC14P036003.
    HGNCi HGNC:17539. INSM2.
    HPAi HPA044885.
    MIMi 614027. gene.
    neXtProti NX_Q96T92.
    PharmGKBi PA134899231.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG308747.
    HOGENOMi HOG000113079.
    HOVERGENi HBG052137.
    InParanoidi Q96T92.
    OMAi KKPKAMR.
    OrthoDBi EOG7JMGDD.
    PhylomeDBi Q96T92.
    TreeFami TF320538.

    Miscellaneous databases

    GenomeRNAii 84684.
    NextBioi 74728.
    PROi Q96T92.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96T92.
    CleanExi HS_INSM2.
    Genevestigatori Q96T92.

    Family and domain databases

    Gene3Di 3.30.160.60. 2 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 2 hits.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 5 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 4 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel insulinoma-associated gene IA-6 with C2H2-type zinc finger motifs expressed in neuroendocrine tissues."
      Cai T., Notkins A.L.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-206.
    2. "Insm2 is expressed in the developing mammalian retina."
      Halford S., Broadgate S.L.
      Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-206.
    3. "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma."
      Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., Hirato J., Nakagawara A.
      Cancer Lett. 197:63-68(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-206.
      Tissue: Neuroblastoma.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLY-206.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-206.
      Tissue: Brain.
    8. "Expression of insulinoma-associated 2 (INSM2) in pancreatic islet cells is regulated by the transcription factors Ngn3 and NeuroD1."
      Cai T., Chen X., Wang R., Xu H., You Y., Zhang T., Lan M.S., Notkins A.L.
      Endocrinology 152:1961-1969(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiINSM2_HUMAN
    AccessioniPrimary (citable) accession number: Q96T92
    Secondary accession number(s): A1L432
    , J9Y024, Q8N8K7, Q96Q84
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 96 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3