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Protein

Insulinoma-associated protein 2

Gene

INSM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri263 – 28321C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri291 – 31323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri426 – 44823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri470 – 49223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri525 – 54824C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Insulinoma-associated protein 2
Alternative name(s):
Zinc finger protein IA-6
Gene namesi
Name:INSM2
Synonyms:IA6
ORF Names:Nbla106
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:17539. INSM2.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134899231.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 566566Insulinoma-associated protein 2PRO_0000331576Add
BLAST

Proteomic databases

PaxDbiQ96T92.
PRIDEiQ96T92.

PTM databases

PhosphoSiteiQ96T92.

Expressioni

Tissue specificityi

Expressed in heart, liver, skeletal muscle, kidney and pancreas, and, to a lesser extent, in brain, lung and spleen. In the pancreas, expressed in islet cells, including insulin- and glucagon-producing alpha- and beta-cells, but not in acinar cells (at protein level). Detected in adrenal glands, particularly in the deeper layer of the cortex (at protein level).1 Publication

Developmental stagei

Expressed in the islet-like cells of the developing pancreas and epithelial cells of the duodenum from gestational weeks 8 to 20 (at protein level).1 Publication

Gene expression databases

BgeeiQ96T92.
CleanExiHS_INSM2.
GenevestigatoriQ96T92.

Organism-specific databases

HPAiHPA044885.

Interactioni

Protein-protein interaction databases

BioGridi124201. 1 interaction.
STRINGi9606.ENSP00000306523.

Structurei

3D structure databases

ProteinModelPortaliQ96T92.
SMRiQ96T92. Positions 280-319, 415-450, 472-553.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2020SNAG domainBy similarityAdd
BLAST

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri263 – 28321C2H2-type 1; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri291 – 31323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri426 – 44823C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri470 – 49223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri525 – 54824C2H2-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG308747.
GeneTreeiENSGT00530000064190.
HOGENOMiHOG000113079.
HOVERGENiHBG052137.
InParanoidiQ96T92.
OMAiPGFGSER.
OrthoDBiEOG7JMGDD.
PhylomeDBiQ96T92.
TreeFamiTF320538.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96T92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRGFLVKRT KRTGGLYRVR LAERVFPLLG PQGAPPFLEE APSASLPGAE
60 70 80 90 100
RATPPTREEP GKGLTAEAAR EQSGSPCRAA GVSPGTGGRE GAEWRAGGRE
110 120 130 140 150
GPGPSPSPSP SPAKPAGAEL RRAFLERCLS SPVSAESFPG GAAAVAAFSC
160 170 180 190 200
SVAPAAAPTP GEQFLLPLRA PFPEPALQPD PAPLSAALQS LKRAAGGERR
210 220 230 240 250
GKAPTDCASG PAAAGIKKPK AMRKLSFADE VTTSPVLGLK IKEEEPGAPS
260 270 280 290 300
RGLGGSRTPL GEFICQLCKE QYADPFALAQ HRCSRIVRVE YRCPECDKVF
310 320 330 340 350
SCPANLASHR RWHKPRPAAA NAATVSSADG KPPSSSSSSS RDSGAIASFL
360 370 380 390 400
AEGKENSRIE RTADQHPQAR DSSGADQHPD SAPRQGLQVL THPEPPLPQG
410 420 430 440 450
PYTEGVLGRR VPVPGSTSGG RGSEIFVCPY CHKKFRRQAY LRKHLSTHEA
460 470 480 490 500
GSARALAPGF GSERGAPLAF ACPLCGAHFP TADIREKHRL WHAVREELLL
510 520 530 540 550
PALAGAPPET SGPSGPSDGS AQQIFSCKHC PSTFFSSPGL TRHINKCHPS
560
ESRQVLLLQM PLRPGC
Length:566
Mass (Da):59,491
Last modified:May 17, 2010 - v3
Checksum:i3603B8ACC8920631
GO

Sequence cautioni

The sequence AAK49393.1 differs from that shown. Reason: Frameshift at positions 123 and 127. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti198 – 1981E → G in BAB69042 (PubMed:12880961).Curated
Sequence conflicti330 – 3301G → E in BAC04830 (PubMed:14702039).Curated
Sequence conflicti390 – 3901L → V in AAK49393 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti206 – 2061D → G.5 Publications
Corresponds to variant rs1958260 [ dbSNP | Ensembl ].
VAR_070885

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260323 mRNA. Translation: AAK49393.1. Frameshift.
JX403968 mRNA. Translation: AFS33107.1.
AB037912 mRNA. Translation: BAB69042.1.
AK096639 mRNA. Translation: BAC04830.1.
AL160231 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65872.1.
BC130377 mRNA. Translation: AAI30378.1.
BC130379 mRNA. Translation: AAI30380.1.
CCDSiCCDS9657.1.
RefSeqiNP_115983.3. NM_032594.3.
UniGeneiHs.62813.

Genome annotation databases

EnsembliENST00000307169; ENSP00000306523; ENSG00000168348.
GeneIDi84684.
KEGGihsa:84684.
UCSCiuc001wth.1. human.

Polymorphism databases

DMDMi296439326.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260323 mRNA. Translation: AAK49393.1. Frameshift.
JX403968 mRNA. Translation: AFS33107.1.
AB037912 mRNA. Translation: BAB69042.1.
AK096639 mRNA. Translation: BAC04830.1.
AL160231 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65872.1.
BC130377 mRNA. Translation: AAI30378.1.
BC130379 mRNA. Translation: AAI30380.1.
CCDSiCCDS9657.1.
RefSeqiNP_115983.3. NM_032594.3.
UniGeneiHs.62813.

3D structure databases

ProteinModelPortaliQ96T92.
SMRiQ96T92. Positions 280-319, 415-450, 472-553.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124201. 1 interaction.
STRINGi9606.ENSP00000306523.

PTM databases

PhosphoSiteiQ96T92.

Polymorphism databases

DMDMi296439326.

Proteomic databases

PaxDbiQ96T92.
PRIDEiQ96T92.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307169; ENSP00000306523; ENSG00000168348.
GeneIDi84684.
KEGGihsa:84684.
UCSCiuc001wth.1. human.

Organism-specific databases

CTDi84684.
GeneCardsiGC14P036003.
HGNCiHGNC:17539. INSM2.
HPAiHPA044885.
MIMi614027. gene.
neXtProtiNX_Q96T92.
PharmGKBiPA134899231.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG308747.
GeneTreeiENSGT00530000064190.
HOGENOMiHOG000113079.
HOVERGENiHBG052137.
InParanoidiQ96T92.
OMAiPGFGSER.
OrthoDBiEOG7JMGDD.
PhylomeDBiQ96T92.
TreeFamiTF320538.

Miscellaneous databases

GenomeRNAii84684.
NextBioi74728.
PROiQ96T92.
SOURCEiSearch...

Gene expression databases

BgeeiQ96T92.
CleanExiHS_INSM2.
GenevestigatoriQ96T92.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel insulinoma-associated gene IA-6 with C2H2-type zinc finger motifs expressed in neuroendocrine tissues."
    Cai T., Notkins A.L.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-206.
  2. "Insm2 is expressed in the developing mammalian retina."
    Halford S., Broadgate S.L.
    Submitted (JUN-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-206.
  3. "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma."
    Ohira M., Morohashi A., Nakamura Y., Isogai E., Furuya K., Hamano S., Machida T., Aoyama M., Fukumura M., Miyazaki K., Suzuki Y., Sugano S., Hirato J., Nakagawara A.
    Cancer Lett. 197:63-68(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-206.
    Tissue: Neuroblastoma.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLY-206.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-206.
    Tissue: Brain.
  8. "Expression of insulinoma-associated 2 (INSM2) in pancreatic islet cells is regulated by the transcription factors Ngn3 and NeuroD1."
    Cai T., Chen X., Wang R., Xu H., You Y., Zhang T., Lan M.S., Notkins A.L.
    Endocrinology 152:1961-1969(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiINSM2_HUMAN
AccessioniPrimary (citable) accession number: Q96T92
Secondary accession number(s): A1L432
, J9Y024, Q8N8K7, Q96Q84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 28, 2008
Last sequence update: May 17, 2010
Last modified: January 6, 2015
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.