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Protein

Glycoprotein hormone alpha-2

Gene

GPHA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates the thyroid. Binds and activates THSR, leads to increased cAMP production.1 Publication

GO - Biological processi

  • positive regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein hormone alpha-2
Alternative name(s):
Putative secreted protein Zsig51
Thyrostimulin subunit alpha
Gene namesi
Name:GPHA2
Synonyms:GPA2, ZSIG51
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:18054. GPHA2.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28839.

Polymorphism and mutation databases

BioMutaiGPHA2.
DMDMi48474600.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 129106Glycoprotein hormone alpha-2PRO_0000011672Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi31 ↔ 89PROSITE-ProRule annotation
Glycosylationi37 – 371N-linked (GlcNAc...)Sequence analysis
Disulfide bondi48 ↔ 103PROSITE-ProRule annotation
Disulfide bondi57 ↔ 119PROSITE-ProRule annotation
Disulfide bondi61 ↔ 121PROSITE-ProRule annotation
Glycosylationi81 – 811N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96T91.
PRIDEiQ96T91.

Expressioni

Tissue specificityi

Found in a variety of tissues.1 Publication

Gene expression databases

BgeeiQ96T91.
CleanExiHS_GPHA2.
ExpressionAtlasiQ96T91. baseline and differential.
GenevisibleiQ96T91. HS.

Interactioni

Subunit structurei

Heterodimer with GPHB5.

Protein-protein interaction databases

BioGridi128064. 21 interactions.
STRINGi9606.ENSP00000279168.

Structurei

3D structure databases

ProteinModelPortaliQ96T91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYM3. Eukaryota.
ENOG4112671. LUCA.
GeneTreeiENSGT00390000009379.
HOGENOMiHOG000236306.
HOVERGENiHBG051795.
InParanoidiQ96T91.
OMAiSRCCTIS.
OrthoDBiEOG722JBD.
PhylomeDBiQ96T91.
TreeFamiTF332313.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR006207. Cys_knot_C.
IPR029034. Cystine-knot_cytokine.
IPR004133. DAN.
IPR000476. Glyco_hormone.
[Graphical view]
PfamiPF03045. DAN. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS01225. CTCK_2. 1 hit.
PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96T91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPMASPQTLV LYLLVLAVTE AWGQEAVIPG CHLHPFNVTV RSDRQGTCQG
60 70 80 90 100
SHVAQACVGH CESSAFPSRY SVLVASGYRH NITSVSQCCT ISGLKKVKVQ
110 120
LQCVGSRREE LEIFTARACQ CDMCRLSRY
Length:129
Mass (Da):14,163
Last modified:December 1, 2001 - v1
Checksum:i6E924AF7BE8D7A70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260739 mRNA. Translation: AAK51638.1.
BC093960 mRNA. Translation: AAH93960.1.
BC093962 mRNA. Translation: AAH93962.1.
BC101523 mRNA. Translation: AAI01524.1.
CCDSiCCDS8086.1.
RefSeqiNP_570125.1. NM_130769.3.
XP_011543077.1. XM_011544775.1.
XP_011543078.1. XM_011544776.1.
UniGeneiHs.436119.

Genome annotation databases

EnsembliENST00000279168; ENSP00000279168; ENSG00000149735.
ENST00000533257; ENSP00000432918; ENSG00000149735.
GeneIDi170589.
KEGGihsa:170589.
UCSCiuc001oca.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260739 mRNA. Translation: AAK51638.1.
BC093960 mRNA. Translation: AAH93960.1.
BC093962 mRNA. Translation: AAH93962.1.
BC101523 mRNA. Translation: AAI01524.1.
CCDSiCCDS8086.1.
RefSeqiNP_570125.1. NM_130769.3.
XP_011543077.1. XM_011544775.1.
XP_011543078.1. XM_011544776.1.
UniGeneiHs.436119.

3D structure databases

ProteinModelPortaliQ96T91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128064. 21 interactions.
STRINGi9606.ENSP00000279168.

Polymorphism and mutation databases

BioMutaiGPHA2.
DMDMi48474600.

Proteomic databases

PaxDbiQ96T91.
PRIDEiQ96T91.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279168; ENSP00000279168; ENSG00000149735.
ENST00000533257; ENSP00000432918; ENSG00000149735.
GeneIDi170589.
KEGGihsa:170589.
UCSCiuc001oca.3. human.

Organism-specific databases

CTDi170589.
GeneCardsiGPHA2.
HGNCiHGNC:18054. GPHA2.
MIMi609651. gene.
neXtProtiNX_Q96T91.
PharmGKBiPA28839.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYM3. Eukaryota.
ENOG4112671. LUCA.
GeneTreeiENSGT00390000009379.
HOGENOMiHOG000236306.
HOVERGENiHBG051795.
InParanoidiQ96T91.
OMAiSRCCTIS.
OrthoDBiEOG722JBD.
PhylomeDBiQ96T91.
TreeFamiTF332313.

Miscellaneous databases

GeneWikiiGPHA2.
GenomeRNAii170589.
NextBioi89049.
PROiQ96T91.
SOURCEiSearch...

Gene expression databases

BgeeiQ96T91.
CleanExiHS_GPHA2.
ExpressionAtlasiQ96T91. baseline and differential.
GenevisibleiQ96T91. HS.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR006207. Cys_knot_C.
IPR029034. Cystine-knot_cytokine.
IPR004133. DAN.
IPR000476. Glyco_hormone.
[Graphical view]
PfamiPF03045. DAN. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS01225. CTCK_2. 1 hit.
PS50277. GLYCO_HORMONE_ALPHA_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel cysteine knot protein expressed in pancreatic acinar cells."
    Ching A., Gilbert T., Lok S., Sheppard P., Webster P., O'Hara P.J.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor."
    Nakabayashi K., Matsumi H., Bhalla A., Bae J., Mosselman S., Hsu S.Y., Hsueh A.J.W.
    J. Clin. Invest. 109:1445-1452(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH GPHA2, GLYCOSYLATION.
  4. "Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5."
    Hsu S.Y., Nakabayashi K., Bhalla A.
    Mol. Endocrinol. 16:1538-1551(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiGPHA2_HUMAN
AccessioniPrimary (citable) accession number: Q96T91
Secondary accession number(s): Q52LE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 1, 2001
Last modified: November 11, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.