Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

MMS19 nucleotide excision repair protein homolog

Gene

MMS19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor (ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.5 Publications

GO - Molecular functioni

  • estrogen receptor binding Source: UniProtKB
  • protein binding, bridging Source: UniProtKB
  • receptor signaling complex scaffold activity Source: UniProtKB
  • transcription coactivator activity Source: UniProtKB

GO - Biological processi

  • cellular response to DNA damage stimulus Source: UniProtKB
  • chromosome segregation Source: UniProtKB
  • DNA metabolic process Source: UniProtKB
  • DNA repair Source: UniProtKB
  • iron-sulfur cluster assembly Source: UniProtKB
  • nucleotide-excision repair Source: UniProtKB
  • phosphorelay signal transduction system Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • response to hormone Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Chromosome partition, DNA damage, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000155229-MONOMER.
ReactomeiR-HSA-2564830. Cytosolic iron-sulfur cluster assembly.

Names & Taxonomyi

Protein namesi
Recommended name:
MMS19 nucleotide excision repair protein homolog
Short name:
hMMS19
Alternative name(s):
MET18 homolog
MMS19-like protein
Gene namesi
Name:MMS19
Synonyms:MMS19L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:13824. MMS19.

Subcellular locationi

GO - Cellular componenti

  • CIA complex Source: UniProtKB
  • cytoplasm Source: UniProtKB
  • holo TFIIH complex Source: UniProtKB
  • membrane Source: UniProtKB
  • MMXD complex Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • spindle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi64210.
OpenTargetsiENSG00000155229.
PharmGKBiPA162395974.

Polymorphism and mutation databases

BioMutaiMMS19.
DMDMi150421597.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000965142 – 1030MMS19 nucleotide excision repair protein homologAdd BLAST1029

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei496N6-acetyllysineCombined sources1
Modified residuei1027PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96T76.
MaxQBiQ96T76.
PaxDbiQ96T76.
PeptideAtlasiQ96T76.
PRIDEiQ96T76.
TopDownProteomicsiQ96T76-6. [Q96T76-6]

PTM databases

iPTMnetiQ96T76.
PhosphoSitePlusiQ96T76.

Expressioni

Tissue specificityi

Ubiquitously expressed with higher expression in testis.2 Publications

Gene expression databases

BgeeiENSG00000155229.
CleanExiHS_MMS19.
ExpressionAtlasiQ96T76. baseline and differential.
GenevisibleiQ96T76. HS.

Organism-specific databases

HPAiHPA051936.
HPA056299.

Interactioni

Subunit structurei

Component of the CIA complex. Component of the MMXD complex, composed of CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with FAM96B; the interaction is direct. Interacts with ERCC2/XPD; the interaction is direct. Interacts with ERCC3/XPB and NCOA3/RAC3. Interacts with RTEL1; the interaction mediates the association of RTEL1 with the CIA complex.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CIAO1O760715EBI-10190644,EBI-725145

GO - Molecular functioni

  • estrogen receptor binding Source: UniProtKB
  • protein binding, bridging Source: UniProtKB
  • receptor signaling complex scaffold activity Source: UniProtKB

Protein-protein interaction databases

BioGridi122103. 189 interactors.
IntActiQ96T76. 16 interactors.
STRINGi9606.ENSP00000359818.

Structurei

3D structure databases

ProteinModelPortaliQ96T76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati43 – 81HEAT 1Add BLAST39
Repeati253 – 291HEAT 2Add BLAST39
Repeati387 – 426HEAT 3Add BLAST40
Repeati866 – 904HEAT 4Add BLAST39
Repeati908 – 946HEAT 5Add BLAST39
Repeati949 – 987HEAT 6Add BLAST39
Repeati990 – 1028HEAT 7Add BLAST39

Sequence similaritiesi

Belongs to the MET18/MMS19 family.Curated
Contains 7 HEAT repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1967. Eukaryota.
ENOG410XNMZ. LUCA.
GeneTreeiENSGT00390000015583.
HOGENOMiHOG000038024.
HOVERGENiHBG057358.
InParanoidiQ96T76.
KOiK15075.
OMAiSMPEKEP.
OrthoDBiEOG091G00K8.
PhylomeDBiQ96T76.
TreeFamiTF314469.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024687. MMS19_C.
[Graphical view]
PfamiPF12460. MMS19_C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96T76-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAAVEAA APMGALWGLV HDFVVGQQEG PADQVAADVK SGNYTVLQVV
60 70 80 90 100
EALGSSLENP EPRTRARAIQ LLSQVLLHCH TLLLEKEVVH LILFYENRLK
110 120 130 140 150
DHHLVIPSVL QGLKALSLCV ALPPGLAVSV LKAIFQEVHV QSLPQVDRHT
160 170 180 190 200
VYNIITNFMR TREEELKSLG ADFTFGFIQV MDGEKDPRNL LVAFRIVHDL
210 220 230 240 250
ISRDYSLGPF VEELFEVTSC YFPIDFTPPP NDPHGIQRED LILSLRAVLA
260 270 280 290 300
STPRFAEFLL PLLIEKVDSE VLSAKLDSLQ TLNACCAVYG QKELKDFLPS
310 320 330 340 350
LWASIRREVF QTASERVEAE GLAALHSLTA CLSRSVLRAD AEDLLDSFLS
360 370 380 390 400
NILQDCRHHL CEPDMKLVWP SAKLLQAAAG ASARACDSVT SNVLPLLLEQ
410 420 430 440 450
FHKHSQSSQR RTILEMLLGF LKLQQKWSYE DKDQRPLNGF KDQLCSLVFM
460 470 480 490 500
ALTDPSTQLQ LVGIRTLTVL GAQPDLLSYE DLELAVGHLY RLSFLKEDSQ
510 520 530 540 550
SCRVAALEAS GTLAALYPVA FSSHLVPKLA EELRVGESNL TNGDEPTQCS
560 570 580 590 600
RHLCCLQALS AVSTHPSIVK ETLPLLLQHL WQVNRGNMVA QSSDVIAVCQ
610 620 630 640 650
SLRQMAEKCQ QDPESCWYFH QTAIPCLLAL AVQASMPEKE PSVLRKVLLE
660 670 680 690 700
DEVLAAMVSV IGTATTHLSP ELAAQSVTHI VPLFLDGNVS FLPENSFPSR
710 720 730 740 750
FQPFQDGSSG QRRLIALLMA FVCSLPRNVE IPQLNQLMRE LLELSCCHSC
760 770 780 790 800
PFSSTAAAKC FAGLLNKHPA GQQLDEFLQL AVDKVEAGLG SGPCRSQAFT
810 820 830 840 850
LLLWVTKALV LRYHPLSSCL TARLMGLLSD PELGPAAADG FSLLMSDCTD
860 870 880 890 900
VLTRAGHAEV RIMFRQRFFT DNVPALVQGF HAAPQDVKPN YLKGLSHVLN
910 920 930 940 950
RLPKPVLLPE LPTLLSLLLE ALSCPDCVVQ LSTLSCLQPL LLEAPQVMSL
960 970 980 990 1000
HVDTLVTKFL NLSSSPSMAV RIAALQCMHA LTRLPTPVLL PYKPQVIRAL
1010 1020 1030
AKPLDDKKRL VRKEAVSARG EWFLLGSPGS
Length:1,030
Mass (Da):113,290
Last modified:June 26, 2007 - v2
Checksum:i7EC22CF0E38EFE1D
GO
Isoform 2 (identifier: Q96T76-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     309-318: VFQTASERVE → TAGTTCVNRT
     319-1030: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:318
Mass (Da):35,203
Checksum:i26BF6FED00AB85D4
GO
Isoform 3 (identifier: Q96T76-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-40: DVK → GPL
     41-1030: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:40
Mass (Da):3,888
Checksum:i9AE881188641ECFA
GO
Isoform 4 (identifier: Q96T76-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     309-406: Missing.

Note: No experimental confirmation available.
Show »
Length:932
Mass (Da):102,639
Checksum:iD55192BDBC190D1A
GO
Isoform 5 (identifier: Q96T76-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRGEPVSSHRPYPLPRSLVRVM

Note: No experimental confirmation available.
Show »
Length:1,051
Mass (Da):115,705
Checksum:i1E9C9F27F55B9F62
GO
Isoform 6 (identifier: Q96T76-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     165-207: Missing.

Note: No experimental confirmation available.
Show »
Length:987
Mass (Da):108,380
Checksum:i5BDE355AA44E8D1B
GO

Sequence cautioni

The sequence AAH80532 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence BAB55315 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB71223 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence BAG51657 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAC29239 differs from that shown. Reason: Frameshift at positions 373 and 412.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti179Q → H in AAK70402 (PubMed:11279242).Curated1
Sequence conflicti389V → D in AAK70402 (PubMed:11279242).Curated1
Sequence conflicti394L → P in AAK70402 (PubMed:11279242).Curated1
Sequence conflicti473Q → R in BAG51657 (PubMed:14702039).Curated1
Sequence conflicti502 – 503CR → W in BAG51657 (PubMed:14702039).Curated2
Sequence conflicti607E → K in BAG65145 (PubMed:14702039).Curated1
Sequence conflicti640E → G in BAB55315 (PubMed:14702039).Curated1
Sequence conflicti661I → V in BAG65145 (PubMed:14702039).Curated1
Sequence conflicti741L → F in AAK70402 (PubMed:11279242).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02344868A → G.7 PublicationsCorresponds to variant rs2275586dbSNPEnsembl.1
Natural variantiVAR_02344998R → W.1 PublicationCorresponds to variant rs29001280dbSNPEnsembl.1
Natural variantiVAR_023450197V → I.1 PublicationCorresponds to variant rs29001285dbSNPEnsembl.1
Natural variantiVAR_023451306R → H.1 PublicationCorresponds to variant rs29001306dbSNPEnsembl.1
Natural variantiVAR_023452365M → V.1 PublicationCorresponds to variant rs29001309dbSNPEnsembl.1
Natural variantiVAR_023453409Q → P.1 PublicationCorresponds to variant rs29001311dbSNPEnsembl.1
Natural variantiVAR_023454434Q → E.1 PublicationCorresponds to variant rs29001314dbSNPEnsembl.1
Natural variantiVAR_023455526V → I.1 PublicationCorresponds to variant rs17112809dbSNPEnsembl.1
Natural variantiVAR_023456558A → V.1 PublicationCorresponds to variant rs12360068dbSNPEnsembl.1
Natural variantiVAR_023457790G → D.3 PublicationsCorresponds to variant rs3740526dbSNPEnsembl.1
Natural variantiVAR_023458983R → H.1 PublicationCorresponds to variant rs29001332dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0441821M → MRGEPVSSHRPYPLPRSLVR VM in isoform 5. 1 Publication1
Alternative sequenceiVSP_04031038 – 40DVK → GPL in isoform 3. 1 Publication3
Alternative sequenceiVSP_04031141 – 1030Missing in isoform 3. 1 PublicationAdd BLAST990
Alternative sequenceiVSP_044183165 – 207Missing in isoform 6. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_015565309 – 406Missing in isoform 4. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_040312309 – 318VFQTASERVE → TAGTTCVNRT in isoform 2. 1 Publication10
Alternative sequenceiVSP_040313319 – 1030Missing in isoform 2. 1 PublicationAdd BLAST712

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306408 mRNA. Translation: CAC29239.1. Frameshift.
AF357881 mRNA. Translation: AAK70402.1.
AF319947 mRNA. Translation: AAK52668.1.
AK027710 mRNA. Translation: BAB55315.1. Different initiation.
AK056244 mRNA. Translation: BAG51657.1. Different initiation.
AK056581 mRNA. Translation: BAB71223.1. Sequence problems.
AK298995 mRNA. Translation: BAG61084.1.
AK304287 mRNA. Translation: BAG65145.1.
AY974244 Genomic DNA. Translation: AAX59033.1.
AL355490, AL359388 Genomic DNA. Translation: CAI40770.1.
AL355490, AL359388 Genomic DNA. Translation: CAQ10792.1.
AL359388, AL355490 Genomic DNA. Translation: CAI14189.1.
AL359388, AL355490 Genomic DNA. Translation: CAQ08641.1.
CH471066 Genomic DNA. Translation: EAW49924.1.
CH471066 Genomic DNA. Translation: EAW49927.1.
CH471066 Genomic DNA. Translation: EAW49928.1.
BC002692 mRNA. Translation: AAH02692.1.
BC006575 mRNA. Translation: AAH06575.2.
BC009396 mRNA. Translation: AAH09396.2.
BC080532 mRNA. Translation: AAH80532.1. Sequence problems.
BC117129 mRNA. Translation: AAI17130.1.
CCDSiCCDS73177.1. [Q96T76-9]
CCDS7464.1. [Q96T76-1]
CCDS81493.1. [Q96T76-5]
RefSeqiNP_001276332.1. NM_001289403.1. [Q96T76-9]
NP_001276333.1. NM_001289404.1.
NP_001276334.1. NM_001289405.1. [Q96T76-1]
NP_001317057.1. NM_001330128.1.
NP_071757.4. NM_022362.4. [Q96T76-1]
XP_016872013.1. XM_017016524.1.
UniGeneiHs.500721.

Genome annotation databases

EnsembliENST00000327238; ENSP00000320059; ENSG00000155229. [Q96T76-5]
ENST00000355839; ENSP00000348097; ENSG00000155229. [Q96T76-9]
ENST00000370782; ENSP00000359818; ENSG00000155229. [Q96T76-1]
ENST00000415383; ENSP00000395045; ENSG00000155229. [Q96T76-6]
ENST00000438925; ENSP00000412698; ENSG00000155229. [Q96T76-1]
ENST00000441194; ENSP00000413801; ENSG00000155229. [Q96T76-6]
GeneIDi64210.
KEGGihsa:64210.
UCSCiuc001kns.5. human. [Q96T76-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306408 mRNA. Translation: CAC29239.1. Frameshift.
AF357881 mRNA. Translation: AAK70402.1.
AF319947 mRNA. Translation: AAK52668.1.
AK027710 mRNA. Translation: BAB55315.1. Different initiation.
AK056244 mRNA. Translation: BAG51657.1. Different initiation.
AK056581 mRNA. Translation: BAB71223.1. Sequence problems.
AK298995 mRNA. Translation: BAG61084.1.
AK304287 mRNA. Translation: BAG65145.1.
AY974244 Genomic DNA. Translation: AAX59033.1.
AL355490, AL359388 Genomic DNA. Translation: CAI40770.1.
AL355490, AL359388 Genomic DNA. Translation: CAQ10792.1.
AL359388, AL355490 Genomic DNA. Translation: CAI14189.1.
AL359388, AL355490 Genomic DNA. Translation: CAQ08641.1.
CH471066 Genomic DNA. Translation: EAW49924.1.
CH471066 Genomic DNA. Translation: EAW49927.1.
CH471066 Genomic DNA. Translation: EAW49928.1.
BC002692 mRNA. Translation: AAH02692.1.
BC006575 mRNA. Translation: AAH06575.2.
BC009396 mRNA. Translation: AAH09396.2.
BC080532 mRNA. Translation: AAH80532.1. Sequence problems.
BC117129 mRNA. Translation: AAI17130.1.
CCDSiCCDS73177.1. [Q96T76-9]
CCDS7464.1. [Q96T76-1]
CCDS81493.1. [Q96T76-5]
RefSeqiNP_001276332.1. NM_001289403.1. [Q96T76-9]
NP_001276333.1. NM_001289404.1.
NP_001276334.1. NM_001289405.1. [Q96T76-1]
NP_001317057.1. NM_001330128.1.
NP_071757.4. NM_022362.4. [Q96T76-1]
XP_016872013.1. XM_017016524.1.
UniGeneiHs.500721.

3D structure databases

ProteinModelPortaliQ96T76.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122103. 189 interactors.
IntActiQ96T76. 16 interactors.
STRINGi9606.ENSP00000359818.

PTM databases

iPTMnetiQ96T76.
PhosphoSitePlusiQ96T76.

Polymorphism and mutation databases

BioMutaiMMS19.
DMDMi150421597.

Proteomic databases

EPDiQ96T76.
MaxQBiQ96T76.
PaxDbiQ96T76.
PeptideAtlasiQ96T76.
PRIDEiQ96T76.
TopDownProteomicsiQ96T76-6. [Q96T76-6]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000327238; ENSP00000320059; ENSG00000155229. [Q96T76-5]
ENST00000355839; ENSP00000348097; ENSG00000155229. [Q96T76-9]
ENST00000370782; ENSP00000359818; ENSG00000155229. [Q96T76-1]
ENST00000415383; ENSP00000395045; ENSG00000155229. [Q96T76-6]
ENST00000438925; ENSP00000412698; ENSG00000155229. [Q96T76-1]
ENST00000441194; ENSP00000413801; ENSG00000155229. [Q96T76-6]
GeneIDi64210.
KEGGihsa:64210.
UCSCiuc001kns.5. human. [Q96T76-1]

Organism-specific databases

CTDi64210.
DisGeNETi64210.
GeneCardsiMMS19.
H-InvDBHIX0009091.
HGNCiHGNC:13824. MMS19.
HPAiHPA051936.
HPA056299.
MIMi614777. gene.
neXtProtiNX_Q96T76.
OpenTargetsiENSG00000155229.
PharmGKBiPA162395974.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1967. Eukaryota.
ENOG410XNMZ. LUCA.
GeneTreeiENSGT00390000015583.
HOGENOMiHOG000038024.
HOVERGENiHBG057358.
InParanoidiQ96T76.
KOiK15075.
OMAiSMPEKEP.
OrthoDBiEOG091G00K8.
PhylomeDBiQ96T76.
TreeFamiTF314469.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000155229-MONOMER.
ReactomeiR-HSA-2564830. Cytosolic iron-sulfur cluster assembly.

Miscellaneous databases

ChiTaRSiMMS19. human.
GeneWikiiMMS19.
GenomeRNAii64210.
PROiQ96T76.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000155229.
CleanExiHS_MMS19.
ExpressionAtlasiQ96T76. baseline and differential.
GenevisibleiQ96T76. HS.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR024687. MMS19_C.
[Graphical view]
PfamiPF12460. MMS19_C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiMMS19_HUMAN
AccessioniPrimary (citable) accession number: Q96T76
Secondary accession number(s): B0QZ75
, B3KPE5, B4DQX2, B4E2I3, D3DR55, F8W9Y2, Q17RZ8, Q5T455, Q66K82, Q7L4W8, Q969Z1, Q96DF1, Q96MR1, Q96RK5, Q96SK1, Q9BUE2, Q9BYS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: June 26, 2007
Last modified: November 30, 2016
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.