ID   KCNKH_HUMAN             Reviewed;         332 AA.
AC   Q96T54; E9PB46; Q5TCF4; Q8TAW4; Q9BXD1; Q9H592;
DT   01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   24-JAN-2024, entry version 177.
DE   RecName: Full=Potassium channel subfamily K member 17;
DE   AltName: Full=2P domain potassium channel Talk-2;
DE   AltName: Full=Acid-sensitive potassium channel protein TASK-4;
DE   AltName: Full=TWIK-related acid-sensitive K(+) channel 4;
DE   AltName: Full=TWIK-related alkaline pH-activated K(+) channel 2;
DE            Short=TALK-2;
GN   Name=KCNK17; Synonyms=TALK2, TASK4; ORFNames=UNQ5816/PRO19634;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Pancreas;
RX   PubMed=11263999; DOI=10.1006/bbrc.2001.4562;
RA   Girard C., Duprat F., Terrenoire C., Tinel N., Fosset M., Romey G.,
RA   Lazdunski M., Lesage F.;
RT   "Genomic and functional characteristics of novel human pancreatic 2P domain
RT   K(+) channels.";
RL   Biochem. Biophys. Res. Commun. 282:249-256(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT GLY-21.
RC   TISSUE=Adrenal gland;
RX   PubMed=11248242; DOI=10.1016/s0014-5793(01)02222-0;
RA   Decher N., Maier M., Dittrich W., Gassenhuber J., Brueggemann A.,
RA   Busch A.E., Steinmeyer K.;
RT   "Characterization of TASK-4, a novel member of the pH-sensitive, two-pore
RT   domain potassium channel family.";
RL   FEBS Lett. 492:84-89(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLY-21.
RC   TISSUE=Lung, and Spleen;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Outward rectifying potassium channel. Produces rapidly
CC       activating and non-inactivating outward rectifier K(+) currents.
CC   -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q96T54-3; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q96T54-4; Sequence=VSP_047354;
CC   -!- MISCELLANEOUS: Inhibited by Ba(2+), quinidine, chloroform and
CC       halothane. Activated at alkaline pH. Activated by quinine and
CC       isoflurane.
CC   -!- SIMILARITY: Belongs to the two pore domain potassium channel
CC       (TC 1.A.1.8) family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK28551.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AF358910; AAK49533.1; -; mRNA.
DR   EMBL; AF339912; AAK28551.1; ALT_FRAME; mRNA.
DR   EMBL; AY358853; AAQ89212.1; -; mRNA.
DR   EMBL; AL136087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC025726; AAH25726.1; -; mRNA.
DR   CCDS; CCDS47419.1; -. [Q96T54-4]
DR   CCDS; CCDS4842.1; -. [Q96T54-3]
DR   RefSeq; NP_001128583.1; NM_001135111.1. [Q96T54-4]
DR   RefSeq; NP_113648.2; NM_031460.3. [Q96T54-3]
DR   AlphaFoldDB; Q96T54; -.
DR   SMR; Q96T54; -.
DR   BioGRID; 124608; 1.
DR   STRING; 9606.ENSP00000362328; -.
DR   BindingDB; Q96T54; -.
DR   ChEMBL; CHEMBL4523433; -.
DR   TCDB; 1.A.1.9.6; the voltage-gated ion channel (vic) superfamily.
DR   GlyCosmos; Q96T54; 2 sites, No reported glycans.
DR   GlyGen; Q96T54; 2 sites.
DR   BioMuta; KCNK17; -.
DR   DMDM; 24636280; -.
DR   PaxDb; 9606-ENSP00000362328; -.
DR   PeptideAtlas; Q96T54; -.
DR   Antibodypedia; 45856; 81 antibodies from 19 providers.
DR   DNASU; 89822; -.
DR   Ensembl; ENST00000373231.9; ENSP00000362328.4; ENSG00000124780.14. [Q96T54-3]
DR   Ensembl; ENST00000453413.2; ENSP00000401271.2; ENSG00000124780.14. [Q96T54-4]
DR   GeneID; 89822; -.
DR   KEGG; hsa:89822; -.
DR   MANE-Select; ENST00000373231.9; ENSP00000362328.4; NM_031460.4; NP_113648.2.
DR   UCSC; uc003ooo.4; human. [Q96T54-3]
DR   AGR; HGNC:14465; -.
DR   CTD; 89822; -.
DR   DisGeNET; 89822; -.
DR   GeneCards; KCNK17; -.
DR   HGNC; HGNC:14465; KCNK17.
DR   HPA; ENSG00000124780; Tissue enhanced (lung, thyroid gland).
DR   MIM; 607370; gene.
DR   neXtProt; NX_Q96T54; -.
DR   OpenTargets; ENSG00000124780; -.
DR   PharmGKB; PA30058; -.
DR   VEuPathDB; HostDB:ENSG00000124780; -.
DR   eggNOG; KOG1418; Eukaryota.
DR   GeneTree; ENSGT00940000162681; -.
DR   HOGENOM; CLU_022504_1_0_1; -.
DR   InParanoid; Q96T54; -.
DR   OMA; WRQGPDR; -.
DR   OrthoDB; 600333at2759; -.
DR   PhylomeDB; Q96T54; -.
DR   TreeFam; TF313947; -.
DR   PathwayCommons; Q96T54; -.
DR   Reactome; R-HSA-1299361; TWIK-related alkaline pH activated K+ channel (TALK).
DR   Reactome; R-HSA-5576886; Phase 4 - resting membrane potential.
DR   BioGRID-ORCS; 89822; 12 hits in 1140 CRISPR screens.
DR   ChiTaRS; KCNK17; human.
DR   GeneWiki; KCNK17; -.
DR   GenomeRNAi; 89822; -.
DR   Pharos; Q96T54; Tchem.
DR   PRO; PR:Q96T54; -.
DR   Proteomes; UP000005640; Chromosome 6.
DR   RNAct; Q96T54; Protein.
DR   Bgee; ENSG00000124780; Expressed in ascending aorta and 97 other cell types or tissues.
DR   GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0015271; F:outward rectifier potassium channel activity; IBA:GO_Central.
DR   GO; GO:0005267; F:potassium channel activity; IDA:UniProtKB.
DR   GO; GO:0022841; F:potassium ion leak channel activity; IBA:GO_Central.
DR   GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0006813; P:potassium ion transport; IDA:UniProtKB.
DR   GO; GO:0030322; P:stabilization of membrane potential; IBA:GO_Central.
DR   Gene3D; 1.10.287.70; -; 1.
DR   InterPro; IPR003280; 2pore_dom_K_chnl.
DR   InterPro; IPR003092; 2pore_dom_K_chnl_TASK.
DR   InterPro; IPR013099; K_chnl_dom.
DR   PANTHER; PTHR11003:SF340; POTASSIUM CHANNEL SUBFAMILY K MEMBER 17; 1.
DR   PANTHER; PTHR11003; POTASSIUM CHANNEL, SUBFAMILY K; 1.
DR   Pfam; PF07885; Ion_trans_2; 2.
DR   PIRSF; PIRSF038061; K_channel_subfamily_K_type; 1.
DR   PRINTS; PR01333; 2POREKCHANEL.
DR   PRINTS; PR01095; TASKCHANNEL.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 2.
DR   Genevisible; Q96T54; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Glycoprotein; Ion channel; Ion transport; Membrane;
KW   Potassium; Potassium channel; Potassium transport; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport; Voltage-gated channel.
FT   CHAIN           1..332
FT                   /note="Potassium channel subfamily K member 17"
FT                   /id="PRO_0000101768"
FT   TOPO_DOM        1..20
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        21..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   INTRAMEM        106..124
FT                   /note="Pore-forming; Name=Pore-forming 1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        149..179
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   INTRAMEM        211..230
FT                   /note="Pore-forming; Name=Pore-forming 2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        265..332
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          287..312
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        65
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        94
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         230..332
FT                   /note="GMNPSQRYPLWYKNMVSLWILFGMAWLALIIKLILSQLETPGRVCSCCHHSS
FT                   KEDFKSQSWRQGPDREPESHSPQQGCYPEGPMGIIQHLEPSAHAAGCGKDS -> ASCL
FT                   ISDTRKPNRDWQTLERTSKSSGGLLKYRFLAGHGGSHL (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_047354"
FT   VARIANT         21
FT                   /note="S -> G (in dbSNP:rs10947804)"
FT                   /evidence="ECO:0000269|PubMed:11248242,
FT                   ECO:0000269|PubMed:15489334"
FT                   /id="VAR_032362"
FT   VARIANT         253
FT                   /note="M -> L (in dbSNP:rs35677794)"
FT                   /id="VAR_032363"
FT   VARIANT         296
FT                   /note="R -> Q (in dbSNP:rs2758910)"
FT                   /id="VAR_024683"
SQ   SEQUENCE   332 AA;  36895 MW;  1848DBC06E078158 CRC64;
     MYRPRARAAP EGRVRGCAVP STVLLLLAYL AYLALGTGVF WTLEGRAAQD SSRSFQRDKW
     ELLQNFTCLD RPALDSLIRD VVQAYKNGAS LLSNTTSMGR WELVGSFFFS VSTITTIGYG
     NLSPNTMAAR LFCIFFALVG IPLNLVVLNR LGHLMQQGVN HWASRLGGTW QDPDKARWLA
     GSGALLSGLL LFLLLPPLLF SHMEGWSYTE GFYFAFITLS TVGFGDYVIG MNPSQRYPLW
     YKNMVSLWIL FGMAWLALII KLILSQLETP GRVCSCCHHS SKEDFKSQSW RQGPDREPES
     HSPQQGCYPE GPMGIIQHLE PSAHAAGCGK DS
//