Q96T54 (KCNKH_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Potassium channel subfamily K member 17

Alternative name(s):
2P domain potassium channel Talk-2
Acid-sensitive potassium channel protein TASK-4
TWIK-related acid-sensitive K(+) channel 4
TWIK-related alkaline pH-activated K(+) channel 2
Short name=TALK-2

Gene names

Name:	KCNK17
Synonyms:	TALK2, TASK4
ORF Names:	UNQ5816/PRO19634

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K+ currents.
Subunit structure	Homodimer Potential.
Subcellular location	Membrane; Multi-pass membrane protein.
Miscellaneous	Inhibited by Ba2+, quinidine, chloroform and halothane. Activated at alkaline pH. Activated by quinine and isoflurane.
Sequence similarities	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]
Sequence caution	The sequence AAK28551.1 differs from that shown. Reason: Frameshift at position 260.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	potassium channel activity Inferred from direct assay Ref.2. Source: UniProtKB voltage-gated ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 332	332	Potassium channel subfamily K member 17		PRO_0000101768
Regions
	Topological domain	1 – 20	20	Cytoplasmic Potential
	Transmembrane	21 – 43	23	Helical; Potential
	Intramembrane	106 – 124	19	Pore-forming; Name=Pore-forming 1; Potential
	Transmembrane	128 – 148	21	Helical; Potential
	Topological domain	149 – 179	31	Cytoplasmic Potential
	Transmembrane	180 – 200	21	Helical; Potential
	Intramembrane	211 – 230	20	Pore-forming; Name=Pore-forming 2; Potential
	Transmembrane	244 – 264	21	Helical; Potential
	Topological domain	265 – 332	68	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	65	1	N-linked (GlcNAc...) Potential
	Glycosylation	94	1	N-linked (GlcNAc...) Potential
Natural variations
	Natural variant	21	1	S → G. Ref.2 Ref.5 Corresponds to variant rs10947804 [ dbSNP | Ensembl ].		VAR_032362
	Natural variant	253	1	M → L. Corresponds to variant rs35677794 [ dbSNP | Ensembl ].		VAR_032363
	Natural variant	296	1	R → Q. Corresponds to variant rs2758910 [ dbSNP | Ensembl ].		VAR_024683

Sequences

	Sequence		Length	Mass (Da)
	Q96T54 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 1848DBC06E078158	FASTA	332	36,895
	10 20 30 40 50 60 MYRPRARAAP EGRVRGCAVP STVLLLLAYL AYLALGTGVF WTLEGRAAQD SSRSFQRDKW 70 80 90 100 110 120 ELLQNFTCLD RPALDSLIRD VVQAYKNGAS LLSNTTSMGR WELVGSFFFS VSTITTIGYG 130 140 150 160 170 180 NLSPNTMAAR LFCIFFALVG IPLNLVVLNR LGHLMQQGVN HWASRLGGTW QDPDKARWLA 190 200 210 220 230 240 GSGALLSGLL LFLLLPPLLF SHMEGWSYTE GFYFAFITLS TVGFGDYVIG MNPSQRYPLW 250 260 270 280 290 300 YKNMVSLWIL FGMAWLALII KLILSQLETP GRVCSCCHHS SKEDFKSQSW RQGPDREPES 310 320 330 HSPQQGCYPE GPMGIIQHLE PSAHAAGCGK DS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels." Girard C., Duprat F., Terrenoire C., Tinel N., Fosset M., Romey G., Lazdunski M., Lesage F. Biochem. Biophys. Res. Commun. 282:249-256(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pancreas.
[2]	"Characterization of TASK-4, a novel member of the pH-sensitive, two-pore domain potassium channel family." Decher N., Maier M., Dittrich W., Gassenhuber J., Brueggemann A., Busch A.E., Steinmeyer K. FEBS Lett. 492:84-89(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-21. Tissue: Adrenal gland.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-21. Tissue: Lung and Spleen.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF358910 mRNA. Translation: AAK49533.1. AF339912 mRNA. Translation: AAK28551.1. Frameshift. AY358853 mRNA. Translation: AAQ89212.1. AL136087 Genomic DNA. Translation: CAI19536.1. BC025726 mRNA. Translation: AAH25726.1.
IPI	IPI00027805.
RefSeq	NP_001128583.1. NM_001135111.1. NP_113648.2. NM_031460.3.
UniGene	Hs.162282.
3D structure databases
ProteinModelPortal	Q96T54.
ModBase	Search...
Protein family/group databases
TCDB	1.A.1.9.6. voltage-gated ion channel (VIC) superfamily.
Polymorphism databases
DMDM	24636280.
Proteomic databases
PaxDb	Q96T54.
PRIDE	Q96T54.
Protocols and materials databases
DNASU	89822.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000373231; ENSP00000362328; ENSG00000124780.
GeneID	89822.
KEGG	hsa:89822.
UCSC	uc003ooo.3. human.
Organism-specific databases
CTD	89822.
GeneCards	GC06M039266.
HGNC	HGNC:14465. KCNK17.
HPA	HPA043892.
MIM	607370. gene.
neXtProt	NX_Q96T54.
PharmGKB	PA30058.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG317582.
HOGENOM	HOG000074161.
HOVERGEN	HBG052240.
KO	K04925.
OMA	QRYPLWY.
OrthoDB	EOG4GMTXC.
Enzyme and pathway databases
Reactome	REACT_13685. Neuronal System.
Gene expression databases
ArrayExpress	Q96T54.
Bgee	Q96T54.
CleanEx	HS_KCNK17.
Genevestigator	Q96T54.
GermOnline	ENSG00000124780. Homo sapiens.
Family and domain databases
InterPro	IPR003280. 2pore_dom_K_chnl. IPR003092. 2pore_dom_K_chnl_TASK. IPR022306. 2pore_dom_K_chnl_TASK/TWIK. IPR013099. Ion_trans_2. [Graphical view]
Pfam	PF07885. Ion_trans_2. 2 hits. [Graphical view]
PIRSF	PIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTS	PR01333. 2POREKCHANEL. PR01095. TASKCHANNEL.
ProtoNet	Search...
Other
GenomeRNAi	89822.
NextBio	76303.
SOURCE	Search...

Entry information

Entry name

KCNKH_HUMAN

Accession

Primary (citable) accession number: Q96T54
Secondary accession number(s): Q5TCF4 , Q8TAW4, Q9BXD1, Q9H592

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 107 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.