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Q96T54

- KCNKH_HUMAN

UniProt

Q96T54 - KCNKH_HUMAN

Protein

Potassium channel subfamily K member 17

Gene

KCNK17

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K+ currents.

    GO - Molecular functioni

    1. potassium channel activity Source: UniProtKB
    2. voltage-gated ion channel activity Source: UniProtKB-KW

    GO - Biological processi

    1. potassium ion transport Source: UniProtKB
    2. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_75850. TWIK-related alkaline pH activated K+ channel (TALK).

    Protein family/group databases

    TCDBi1.A.1.9.6. the voltage-gated ion channel (vic) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel subfamily K member 17
    Alternative name(s):
    2P domain potassium channel Talk-2
    Acid-sensitive potassium channel protein TASK-4
    TWIK-related acid-sensitive K(+) channel 4
    TWIK-related alkaline pH-activated K(+) channel 2
    Short name:
    TALK-2
    Gene namesi
    Name:KCNK17
    Synonyms:TALK2, TASK4
    ORF Names:UNQ5816/PRO19634
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:14465. KCNK17.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30058.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 332332Potassium channel subfamily K member 17PRO_0000101768Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ96T54.
    PRIDEiQ96T54.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96T54.
    BgeeiQ96T54.
    CleanExiHS_KCNK17.
    GenevestigatoriQ96T54.

    Organism-specific databases

    HPAiHPA043892.

    Interactioni

    Subunit structurei

    Homodimer.Curated

    Protein-protein interaction databases

    BioGridi124608. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96T54.
    SMRiQ96T54. Positions 36-272.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini149 – 17931CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini265 – 33268CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei106 – 12419Pore-forming; Name=Pore-forming 1Sequence AnalysisAdd
    BLAST
    Intramembranei211 – 23020Pore-forming; Name=Pore-forming 2Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4323HelicalSequence AnalysisAdd
    BLAST
    Transmembranei128 – 14821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei180 – 20021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei244 – 26421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG317582.
    HOGENOMiHOG000074161.
    HOVERGENiHBG052240.
    KOiK04925.
    OMAiSMGRWEF.
    OrthoDBiEOG77M8NK.
    PhylomeDBiQ96T54.
    TreeFamiTF313947.

    Family and domain databases

    InterProiIPR003280. 2pore_dom_K_chnl.
    IPR013099. 2pore_dom_K_chnl_dom.
    IPR003092. 2pore_dom_K_chnl_TASK.
    [Graphical view]
    PfamiPF07885. Ion_trans_2. 2 hits.
    [Graphical view]
    PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
    PRINTSiPR01333. 2POREKCHANEL.
    PR01095. TASKCHANNEL.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96T54-3) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MYRPRARAAP EGRVRGCAVP STVLLLLAYL AYLALGTGVF WTLEGRAAQD    50
    SSRSFQRDKW ELLQNFTCLD RPALDSLIRD VVQAYKNGAS LLSNTTSMGR 100
    WELVGSFFFS VSTITTIGYG NLSPNTMAAR LFCIFFALVG IPLNLVVLNR 150
    LGHLMQQGVN HWASRLGGTW QDPDKARWLA GSGALLSGLL LFLLLPPLLF 200
    SHMEGWSYTE GFYFAFITLS TVGFGDYVIG MNPSQRYPLW YKNMVSLWIL 250
    FGMAWLALII KLILSQLETP GRVCSCCHHS SKEDFKSQSW RQGPDREPES 300
    HSPQQGCYPE GPMGIIQHLE PSAHAAGCGK DS 332
    Length:332
    Mass (Da):36,895
    Last modified:December 1, 2001 - v1
    Checksum:i1848DBC06E078158
    GO
    Isoform 2 (identifier: Q96T54-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         230-332: GMNPSQRYPL...AHAAGCGKDS → ASCLISDTRK...FLAGHGGSHL

    Note: No experimental confirmation available. Gene prediction based on EST data.

    Show »
    Length:271
    Mass (Da):29,972
    Checksum:iA6FD5ECA6E494D5D
    GO

    Sequence cautioni

    The sequence AAK28551.1 differs from that shown. Reason: Frameshift at position 260.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti21 – 211S → G.2 Publications
    Corresponds to variant rs10947804 [ dbSNP | Ensembl ].
    VAR_032362
    Natural varianti253 – 2531M → L.
    Corresponds to variant rs35677794 [ dbSNP | Ensembl ].
    VAR_032363
    Natural varianti296 – 2961R → Q.
    Corresponds to variant rs2758910 [ dbSNP | Ensembl ].
    VAR_024683

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei230 – 332103GMNPS…CGKDS → ASCLISDTRKPNRDWQTLER TSKSSGGLLKYRFLAGHGGS HL in isoform 2. CuratedVSP_047354Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF358910 mRNA. Translation: AAK49533.1.
    AF339912 mRNA. Translation: AAK28551.1. Frameshift.
    AY358853 mRNA. Translation: AAQ89212.1.
    AL136087 Genomic DNA. Translation: CAI19536.1.
    BC025726 mRNA. Translation: AAH25726.1.
    CCDSiCCDS47419.1. [Q96T54-4]
    CCDS4842.1. [Q96T54-3]
    RefSeqiNP_001128583.1. NM_001135111.1. [Q96T54-4]
    NP_113648.2. NM_031460.3. [Q96T54-3]
    UniGeneiHs.162282.

    Genome annotation databases

    EnsembliENST00000373231; ENSP00000362328; ENSG00000124780. [Q96T54-3]
    ENST00000453413; ENSP00000401271; ENSG00000124780. [Q96T54-4]
    GeneIDi89822.
    KEGGihsa:89822.
    UCSCiuc003ooo.3. human. [Q96T54-3]

    Polymorphism databases

    DMDMi24636280.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF358910 mRNA. Translation: AAK49533.1 .
    AF339912 mRNA. Translation: AAK28551.1 . Frameshift.
    AY358853 mRNA. Translation: AAQ89212.1 .
    AL136087 Genomic DNA. Translation: CAI19536.1 .
    BC025726 mRNA. Translation: AAH25726.1 .
    CCDSi CCDS47419.1. [Q96T54-4 ]
    CCDS4842.1. [Q96T54-3 ]
    RefSeqi NP_001128583.1. NM_001135111.1. [Q96T54-4 ]
    NP_113648.2. NM_031460.3. [Q96T54-3 ]
    UniGenei Hs.162282.

    3D structure databases

    ProteinModelPortali Q96T54.
    SMRi Q96T54. Positions 36-272.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124608. 1 interaction.

    Protein family/group databases

    TCDBi 1.A.1.9.6. the voltage-gated ion channel (vic) superfamily.

    Polymorphism databases

    DMDMi 24636280.

    Proteomic databases

    PaxDbi Q96T54.
    PRIDEi Q96T54.

    Protocols and materials databases

    DNASUi 89822.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373231 ; ENSP00000362328 ; ENSG00000124780 . [Q96T54-3 ]
    ENST00000453413 ; ENSP00000401271 ; ENSG00000124780 . [Q96T54-4 ]
    GeneIDi 89822.
    KEGGi hsa:89822.
    UCSCi uc003ooo.3. human. [Q96T54-3 ]

    Organism-specific databases

    CTDi 89822.
    GeneCardsi GC06M039266.
    HGNCi HGNC:14465. KCNK17.
    HPAi HPA043892.
    MIMi 607370. gene.
    neXtProti NX_Q96T54.
    PharmGKBi PA30058.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG317582.
    HOGENOMi HOG000074161.
    HOVERGENi HBG052240.
    KOi K04925.
    OMAi SMGRWEF.
    OrthoDBi EOG77M8NK.
    PhylomeDBi Q96T54.
    TreeFami TF313947.

    Enzyme and pathway databases

    Reactomei REACT_75850. TWIK-related alkaline pH activated K+ channel (TALK).

    Miscellaneous databases

    GeneWikii KCNK17.
    GenomeRNAii 89822.
    NextBioi 76303.
    PROi Q96T54.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96T54.
    Bgeei Q96T54.
    CleanExi HS_KCNK17.
    Genevestigatori Q96T54.

    Family and domain databases

    InterProi IPR003280. 2pore_dom_K_chnl.
    IPR013099. 2pore_dom_K_chnl_dom.
    IPR003092. 2pore_dom_K_chnl_TASK.
    [Graphical view ]
    Pfami PF07885. Ion_trans_2. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF038061. K_channel_subfamily_K_type. 1 hit.
    PRINTSi PR01333. 2POREKCHANEL.
    PR01095. TASKCHANNEL.
    ProtoNeti Search...

    Publicationsi

    1. "Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels."
      Girard C., Duprat F., Terrenoire C., Tinel N., Fosset M., Romey G., Lazdunski M., Lesage F.
      Biochem. Biophys. Res. Commun. 282:249-256(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pancreas.
    2. "Characterization of TASK-4, a novel member of the pH-sensitive, two-pore domain potassium channel family."
      Decher N., Maier M., Dittrich W., Gassenhuber J., Brueggemann A., Busch A.E., Steinmeyer K.
      FEBS Lett. 492:84-89(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-21.
      Tissue: Adrenal gland.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-21.
      Tissue: Lung and Spleen.

    Entry informationi

    Entry nameiKCNKH_HUMAN
    AccessioniPrimary (citable) accession number: Q96T54
    Secondary accession number(s): E9PB46
    , Q5TCF4, Q8TAW4, Q9BXD1, Q9H592
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Inhibited by Ba2+, quinidine, chloroform and halothane. Activated at alkaline pH. Activated by quinine and isoflurane.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3