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Q96T54 (KCNKH_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel subfamily K member 17
Alternative name(s):
2P domain potassium channel Talk-2
Acid-sensitive potassium channel protein TASK-4
TWIK-related acid-sensitive K(+) channel 4
TWIK-related alkaline pH-activated K(+) channel 2
Short name=TALK-2
Gene names
Name:KCNK17
Synonyms:TALK2, TASK4
ORF Names:UNQ5816/PRO19634
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length332 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K+ currents.

Subunit structure

Homodimer Potential.

Subcellular location

Membrane; Multi-pass membrane protein.

Miscellaneous

Inhibited by Ba2+, quinidine, chloroform and halothane. Activated at alkaline pH. Activated by quinine and isoflurane.

Sequence similarities

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]

Sequence caution

The sequence AAK28551.1 differs from that shown. Reason: Frameshift at position 260.

Ontologies

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96T54-3)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96T54-4)

The sequence of this isoform differs from the canonical sequence as follows:
     230-332: GMNPSQRYPL...AHAAGCGKDS → ASCLISDTRK...FLAGHGGSHL
Note: No experimental confirmation available. Gene prediction based on EST data.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 332332Potassium channel subfamily K member 17
PRO_0000101768

Regions

Topological domain1 – 2020Cytoplasmic Potential
Transmembrane21 – 4323Helical; Potential
Intramembrane106 – 12419Pore-forming; Name=Pore-forming 1; Potential
Transmembrane128 – 14821Helical; Potential
Topological domain149 – 17931Cytoplasmic Potential
Transmembrane180 – 20021Helical; Potential
Intramembrane211 – 23020Pore-forming; Name=Pore-forming 2; Potential
Transmembrane244 – 26421Helical; Potential
Topological domain265 – 33268Cytoplasmic Potential

Amino acid modifications

Glycosylation651N-linked (GlcNAc...) Potential
Glycosylation941N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence230 – 332103GMNPS…CGKDS → ASCLISDTRKPNRDWQTLER TSKSSGGLLKYRFLAGHGGS HL in isoform 2.
VSP_047354
Natural variant211S → G. Ref.2 Ref.5
Corresponds to variant rs10947804 [ dbSNP | Ensembl ].
VAR_032362
Natural variant2531M → L.
Corresponds to variant rs35677794 [ dbSNP | Ensembl ].
VAR_032363
Natural variant2961R → Q.
Corresponds to variant rs2758910 [ dbSNP | Ensembl ].
VAR_024683

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 1848DBC06E078158

FASTA33236,895
        10         20         30         40         50         60 
MYRPRARAAP EGRVRGCAVP STVLLLLAYL AYLALGTGVF WTLEGRAAQD SSRSFQRDKW 

        70         80         90        100        110        120 
ELLQNFTCLD RPALDSLIRD VVQAYKNGAS LLSNTTSMGR WELVGSFFFS VSTITTIGYG 

       130        140        150        160        170        180 
NLSPNTMAAR LFCIFFALVG IPLNLVVLNR LGHLMQQGVN HWASRLGGTW QDPDKARWLA 

       190        200        210        220        230        240 
GSGALLSGLL LFLLLPPLLF SHMEGWSYTE GFYFAFITLS TVGFGDYVIG MNPSQRYPLW 

       250        260        270        280        290        300 
YKNMVSLWIL FGMAWLALII KLILSQLETP GRVCSCCHHS SKEDFKSQSW RQGPDREPES 

       310        320        330 
HSPQQGCYPE GPMGIIQHLE PSAHAAGCGK DS 

« Hide

Isoform 2 [UniParc].

Checksum: A6FD5ECA6E494D5D
Show »

FASTA27129,972

References

« Hide 'large scale' references
[1]"Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels."
Girard C., Duprat F., Terrenoire C., Tinel N., Fosset M., Romey G., Lazdunski M., Lesage F.
Biochem. Biophys. Res. Commun. 282:249-256(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pancreas.
[2]"Characterization of TASK-4, a novel member of the pH-sensitive, two-pore domain potassium channel family."
Decher N., Maier M., Dittrich W., Gassenhuber J., Brueggemann A., Busch A.E., Steinmeyer K.
FEBS Lett. 492:84-89(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-21.
Tissue: Adrenal gland.
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The DNA sequence and analysis of human chromosome 6."
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-21.
Tissue: Lung and Spleen.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF358910 mRNA. Translation: AAK49533.1.
AF339912 mRNA. Translation: AAK28551.1. Frameshift.
AY358853 mRNA. Translation: AAQ89212.1.
AL136087 Genomic DNA. Translation: CAI19536.1.
BC025726 mRNA. Translation: AAH25726.1.
RefSeqNP_001128583.1. NM_001135111.1.
NP_113648.2. NM_031460.3.
UniGeneHs.162282.

3D structure databases

ProteinModelPortalQ96T54.
SMRQ96T54. Positions 36-272.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124608. 1 interaction.

Protein family/group databases

TCDB1.A.1.9.6. the voltage-gated ion channel (vic) superfamily.

Polymorphism databases

DMDM24636280.

Proteomic databases

PaxDbQ96T54.
PRIDEQ96T54.

Protocols and materials databases

DNASU89822.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000373231; ENSP00000362328; ENSG00000124780. [Q96T54-3]
ENST00000453413; ENSP00000401271; ENSG00000124780. [Q96T54-4]
GeneID89822.
KEGGhsa:89822.
UCSCuc003ooo.3. human. [Q96T54-3]

Organism-specific databases

CTD89822.
GeneCardsGC06M039266.
HGNCHGNC:14465. KCNK17.
HPAHPA043892.
MIM607370. gene.
neXtProtNX_Q96T54.
PharmGKBPA30058.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG317582.
HOGENOMHOG000074161.
HOVERGENHBG052240.
KOK04925.
OMASMGRWEF.
OrthoDBEOG77M8NK.
PhylomeDBQ96T54.
TreeFamTF313947.

Enzyme and pathway databases

ReactomeREACT_13685. Neuronal System.

Gene expression databases

ArrayExpressQ96T54.
BgeeQ96T54.
CleanExHS_KCNK17.
GenevestigatorQ96T54.

Family and domain databases

InterProIPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR003092. 2pore_dom_K_chnl_TASK.
[Graphical view]
PfamPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSPR01333. 2POREKCHANEL.
PR01095. TASKCHANNEL.
ProtoNetSearch...

Other

GeneWikiKCNK17.
GenomeRNAi89822.
NextBio76303.
PROQ96T54.
SOURCESearch...

Entry information

Entry nameKCNKH_HUMAN
AccessionPrimary (citable) accession number: Q96T54
Secondary accession number(s): E9PB46 expand/collapse secondary AC list , Q5TCF4, Q8TAW4, Q9BXD1, Q9H592
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM