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Protein

Potassium channel subfamily K member 17

Gene

KCNK17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K+ currents.

Miscellaneous

Inhibited by Ba2+, quinidine, chloroform and halothane. Activated at alkaline pH. Activated by quinine and isoflurane.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-HSA-1299361 TWIK-related alkaline pH activated K+ channel (TALK)
R-HSA-5576886 Phase 4 - resting membrane potential

Protein family/group databases

TCDBi1.A.1.9.6 the voltage-gated ion channel (vic) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 17
Alternative name(s):
2P domain potassium channel Talk-2
Acid-sensitive potassium channel protein TASK-4
TWIK-related acid-sensitive K(+) channel 4
TWIK-related alkaline pH-activated K(+) channel 2
Short name:
TALK-2
Gene namesi
Name:KCNK17
Synonyms:TALK2, TASK4
ORF Names:UNQ5816/PRO19634
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124780.13
HGNCiHGNC:14465 KCNK17
MIMi607370 gene
neXtProtiNX_Q96T54

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 43HelicalSequence analysisAdd BLAST23
Intramembranei106 – 124Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST19
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Topological domaini149 – 179CytoplasmicSequence analysisAdd BLAST31
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Intramembranei211 – 230Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST20
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Topological domaini265 – 332CytoplasmicSequence analysisAdd BLAST68

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi89822
OpenTargetsiENSG00000124780
PharmGKBiPA30058

Chemistry databases

GuidetoPHARMACOLOGYi526

Polymorphism and mutation databases

BioMutaiKCNK17
DMDMi24636280

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001017681 – 332Potassium channel subfamily K member 17Add BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96T54
PeptideAtlasiQ96T54
PRIDEiQ96T54

Expressioni

Gene expression databases

BgeeiENSG00000124780
CleanExiHS_KCNK17
GenevisibleiQ96T54 HS

Organism-specific databases

HPAiHPA043892

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

BioGridi124608, 1 interactor
STRINGi9606.ENSP00000362328

Structurei

3D structure databases

ProteinModelPortaliQ96T54
SMRiQ96T54
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1418 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118858
HOGENOMiHOG000074161
HOVERGENiHBG052240
InParanoidiQ96T54
KOiK04925
OMAiSMGRWEF
OrthoDBiEOG091G08DF
PhylomeDBiQ96T54
TreeFamiTF313947

Family and domain databases

InterProiView protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR003092 2pore_dom_K_chnl_TASK
IPR013099 K_chnl_dom
PfamiView protein in Pfam
PF07885 Ion_trans_2, 2 hits
PIRSFiPIRSF038061 K_channel_subfamily_K_type, 1 hit
PRINTSiPR01333 2POREKCHANEL
PR01095 TASKCHANNEL

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96T54-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYRPRARAAP EGRVRGCAVP STVLLLLAYL AYLALGTGVF WTLEGRAAQD
60 70 80 90 100
SSRSFQRDKW ELLQNFTCLD RPALDSLIRD VVQAYKNGAS LLSNTTSMGR
110 120 130 140 150
WELVGSFFFS VSTITTIGYG NLSPNTMAAR LFCIFFALVG IPLNLVVLNR
160 170 180 190 200
LGHLMQQGVN HWASRLGGTW QDPDKARWLA GSGALLSGLL LFLLLPPLLF
210 220 230 240 250
SHMEGWSYTE GFYFAFITLS TVGFGDYVIG MNPSQRYPLW YKNMVSLWIL
260 270 280 290 300
FGMAWLALII KLILSQLETP GRVCSCCHHS SKEDFKSQSW RQGPDREPES
310 320 330
HSPQQGCYPE GPMGIIQHLE PSAHAAGCGK DS
Length:332
Mass (Da):36,895
Last modified:December 1, 2001 - v1
Checksum:i1848DBC06E078158
GO
Isoform 2 (identifier: Q96T54-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     230-332: GMNPSQRYPL...AHAAGCGKDS → ASCLISDTRK...FLAGHGGSHL

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:271
Mass (Da):29,972
Checksum:iA6FD5ECA6E494D5D
GO

Sequence cautioni

The sequence AAK28551 differs from that shown. Reason: Frameshift at position 260.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03236221S → G2 PublicationsCorresponds to variant dbSNP:rs10947804Ensembl.1
Natural variantiVAR_032363253M → L. Corresponds to variant dbSNP:rs35677794Ensembl.1
Natural variantiVAR_024683296R → Q. Corresponds to variant dbSNP:rs2758910Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047354230 – 332GMNPS…CGKDS → ASCLISDTRKPNRDWQTLER TSKSSGGLLKYRFLAGHGGS HL in isoform 2. CuratedAdd BLAST103

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF358910 mRNA Translation: AAK49533.1
AF339912 mRNA Translation: AAK28551.1 Frameshift.
AY358853 mRNA Translation: AAQ89212.1
AL136087 Genomic DNA No translation available.
BC025726 mRNA Translation: AAH25726.1
CCDSiCCDS47419.1 [Q96T54-4]
CCDS4842.1 [Q96T54-3]
RefSeqiNP_001128583.1, NM_001135111.1 [Q96T54-4]
NP_113648.2, NM_031460.3 [Q96T54-3]
UniGeneiHs.162282

Genome annotation databases

EnsembliENST00000373231; ENSP00000362328; ENSG00000124780 [Q96T54-3]
ENST00000453413; ENSP00000401271; ENSG00000124780 [Q96T54-4]
GeneIDi89822
KEGGihsa:89822
UCSCiuc003ooo.4 human [Q96T54-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKCNKH_HUMAN
AccessioniPrimary (citable) accession number: Q96T54
Secondary accession number(s): E9PB46
, Q5TCF4, Q8TAW4, Q9BXD1, Q9H592
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: April 25, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health