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Protein

Potassium channel subfamily K member 17

Gene

KCNK17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K+ currents.

GO - Molecular functioni

GO - Biological processi

  • potassium ion transport Source: UniProtKB
  • stabilization of membrane potential Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124780-MONOMER.
ReactomeiR-HSA-1299361. TWIK-related alkaline pH activated K+ channel (TALK).
R-HSA-5576886. Phase 4 - resting membrane potential.

Protein family/group databases

TCDBi1.A.1.9.6. the voltage-gated ion channel (vic) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 17
Alternative name(s):
2P domain potassium channel Talk-2
Acid-sensitive potassium channel protein TASK-4
TWIK-related acid-sensitive K(+) channel 4
TWIK-related alkaline pH-activated K(+) channel 2
Short name:
TALK-2
Gene namesi
Name:KCNK17
Synonyms:TALK2, TASK4
ORF Names:UNQ5816/PRO19634
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:14465. KCNK17.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 43HelicalSequence analysisAdd BLAST23
Intramembranei106 – 124Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST19
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Topological domaini149 – 179CytoplasmicSequence analysisAdd BLAST31
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Intramembranei211 – 230Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST20
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Topological domaini265 – 332CytoplasmicSequence analysisAdd BLAST68

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi89822.
OpenTargetsiENSG00000124780.
PharmGKBiPA30058.

Polymorphism and mutation databases

BioMutaiKCNK17.
DMDMi24636280.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001017681 – 332Potassium channel subfamily K member 17Add BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi65N-linked (GlcNAc...)Sequence analysis1
Glycosylationi94N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96T54.
PeptideAtlasiQ96T54.
PRIDEiQ96T54.

Expressioni

Gene expression databases

BgeeiENSG00000124780.
CleanExiHS_KCNK17.
GenevisibleiQ96T54. HS.

Organism-specific databases

HPAiHPA043892.

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

BioGridi124608. 1 interactor.
STRINGi9606.ENSP00000362328.

Structurei

3D structure databases

ProteinModelPortaliQ96T54.
SMRiQ96T54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000074161.
HOVERGENiHBG052240.
InParanoidiQ96T54.
KOiK04925.
OMAiSMGRWEF.
OrthoDBiEOG091G08DF.
PhylomeDBiQ96T54.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01095. TASKCHANNEL.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96T54-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYRPRARAAP EGRVRGCAVP STVLLLLAYL AYLALGTGVF WTLEGRAAQD
60 70 80 90 100
SSRSFQRDKW ELLQNFTCLD RPALDSLIRD VVQAYKNGAS LLSNTTSMGR
110 120 130 140 150
WELVGSFFFS VSTITTIGYG NLSPNTMAAR LFCIFFALVG IPLNLVVLNR
160 170 180 190 200
LGHLMQQGVN HWASRLGGTW QDPDKARWLA GSGALLSGLL LFLLLPPLLF
210 220 230 240 250
SHMEGWSYTE GFYFAFITLS TVGFGDYVIG MNPSQRYPLW YKNMVSLWIL
260 270 280 290 300
FGMAWLALII KLILSQLETP GRVCSCCHHS SKEDFKSQSW RQGPDREPES
310 320 330
HSPQQGCYPE GPMGIIQHLE PSAHAAGCGK DS
Length:332
Mass (Da):36,895
Last modified:December 1, 2001 - v1
Checksum:i1848DBC06E078158
GO
Isoform 2 (identifier: Q96T54-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     230-332: GMNPSQRYPL...AHAAGCGKDS → ASCLISDTRK...FLAGHGGSHL

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:271
Mass (Da):29,972
Checksum:iA6FD5ECA6E494D5D
GO

Sequence cautioni

The sequence AAK28551 differs from that shown. Reason: Frameshift at position 260.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03236221S → G.2 PublicationsCorresponds to variant rs10947804dbSNPEnsembl.1
Natural variantiVAR_032363253M → L.Corresponds to variant rs35677794dbSNPEnsembl.1
Natural variantiVAR_024683296R → Q.Corresponds to variant rs2758910dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047354230 – 332GMNPS…CGKDS → ASCLISDTRKPNRDWQTLER TSKSSGGLLKYRFLAGHGGS HL in isoform 2. CuratedAdd BLAST103

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF358910 mRNA. Translation: AAK49533.1.
AF339912 mRNA. Translation: AAK28551.1. Frameshift.
AY358853 mRNA. Translation: AAQ89212.1.
AL136087 Genomic DNA. Translation: CAI19536.1.
BC025726 mRNA. Translation: AAH25726.1.
CCDSiCCDS47419.1. [Q96T54-4]
CCDS4842.1. [Q96T54-3]
RefSeqiNP_001128583.1. NM_001135111.1. [Q96T54-4]
NP_113648.2. NM_031460.3. [Q96T54-3]
UniGeneiHs.162282.

Genome annotation databases

EnsembliENST00000373231; ENSP00000362328; ENSG00000124780. [Q96T54-3]
ENST00000453413; ENSP00000401271; ENSG00000124780. [Q96T54-4]
GeneIDi89822.
KEGGihsa:89822.
UCSCiuc003ooo.4. human. [Q96T54-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF358910 mRNA. Translation: AAK49533.1.
AF339912 mRNA. Translation: AAK28551.1. Frameshift.
AY358853 mRNA. Translation: AAQ89212.1.
AL136087 Genomic DNA. Translation: CAI19536.1.
BC025726 mRNA. Translation: AAH25726.1.
CCDSiCCDS47419.1. [Q96T54-4]
CCDS4842.1. [Q96T54-3]
RefSeqiNP_001128583.1. NM_001135111.1. [Q96T54-4]
NP_113648.2. NM_031460.3. [Q96T54-3]
UniGeneiHs.162282.

3D structure databases

ProteinModelPortaliQ96T54.
SMRiQ96T54.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124608. 1 interactor.
STRINGi9606.ENSP00000362328.

Protein family/group databases

TCDBi1.A.1.9.6. the voltage-gated ion channel (vic) superfamily.

Polymorphism and mutation databases

BioMutaiKCNK17.
DMDMi24636280.

Proteomic databases

PaxDbiQ96T54.
PeptideAtlasiQ96T54.
PRIDEiQ96T54.

Protocols and materials databases

DNASUi89822.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373231; ENSP00000362328; ENSG00000124780. [Q96T54-3]
ENST00000453413; ENSP00000401271; ENSG00000124780. [Q96T54-4]
GeneIDi89822.
KEGGihsa:89822.
UCSCiuc003ooo.4. human. [Q96T54-3]

Organism-specific databases

CTDi89822.
DisGeNETi89822.
GeneCardsiKCNK17.
HGNCiHGNC:14465. KCNK17.
HPAiHPA043892.
MIMi607370. gene.
neXtProtiNX_Q96T54.
OpenTargetsiENSG00000124780.
PharmGKBiPA30058.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1418. Eukaryota.
COG1226. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000074161.
HOVERGENiHBG052240.
InParanoidiQ96T54.
KOiK04925.
OMAiSMGRWEF.
OrthoDBiEOG091G08DF.
PhylomeDBiQ96T54.
TreeFamiTF313947.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124780-MONOMER.
ReactomeiR-HSA-1299361. TWIK-related alkaline pH activated K+ channel (TALK).
R-HSA-5576886. Phase 4 - resting membrane potential.

Miscellaneous databases

GeneWikiiKCNK17.
GenomeRNAii89822.
PROiQ96T54.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124780.
CleanExiHS_KCNK17.
GenevisibleiQ96T54. HS.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR013099. K_chnl_dom.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01095. TASKCHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNKH_HUMAN
AccessioniPrimary (citable) accession number: Q96T54
Secondary accession number(s): E9PB46
, Q5TCF4, Q8TAW4, Q9BXD1, Q9H592
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Inhibited by Ba2+, quinidine, chloroform and halothane. Activated at alkaline pH. Activated by quinine and isoflurane.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.