##gff-version 3 Q96T53 UniProtKB Chain 1 435 . . . ID=PRO_0000273024;Note=Ghrelin O-acyltransferase Q96T53 UniProtKB Topological domain 1 5 . . . Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q96T53 UniProtKB Transmembrane 6 26 . . . Note=Helical;Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:P0C7A3,ECO:0000255 Q96T53 UniProtKB Topological domain 27 40 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q96T53 UniProtKB Transmembrane 41 56 . . . Note=Helical;Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:P0C7A3,ECO:0000255 Q96T53 UniProtKB Topological domain 57 59 . . . Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q96T53 UniProtKB Transmembrane 60 76 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C7A3 Q96T53 UniProtKB Topological domain 77 82 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q96T53 UniProtKB Transmembrane 83 101 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C7A3 Q96T53 UniProtKB Topological domain 102 120 . . . Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q96T53 UniProtKB Transmembrane 121 136 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C7A3 Q96T53 UniProtKB Topological domain 137 206 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:24045953;Dbxref=PMID:24045953 Q96T53 UniProtKB Transmembrane 207 227 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C7A3 Q96T53 UniProtKB Topological domain 228 240 . . . Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q96T53 UniProtKB Transmembrane 241 261 . . . Note=Helical;Ontology_term=ECO:0000250,ECO:0000255;evidence=ECO:0000250|UniProtKB:P0C7A3,ECO:0000255 Q96T53 UniProtKB Topological domain 262 324 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:24045953;Dbxref=PMID:24045953 Q96T53 UniProtKB Transmembrane 325 338 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C7A3 Q96T53 UniProtKB Topological domain 339 340 . . . Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q96T53 UniProtKB Transmembrane 341 357 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P0C7A3 Q96T53 UniProtKB Topological domain 358 376 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q96T53 UniProtKB Transmembrane 377 397 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q96T53 UniProtKB Topological domain 398 407 . . . Note=Lumenal;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q96T53 UniProtKB Transmembrane 408 428 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q96T53 UniProtKB Topological domain 429 435 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q96T53 UniProtKB Active site 307 307 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q96T53 UniProtKB Active site 338 338 . . . Ontology_term=ECO:0000305;evidence=ECO:0000305 Q96T53 UniProtKB Alternative sequence 1 106 . . . ID=VSP_032958;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 Q96T53 UniProtKB Alternative sequence 107 114 . . . ID=VSP_032959;Note=In isoform 2. YLHEPPSV->MFFKKLSC;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.2 Q96T53 UniProtKB Natural variant 46 46 . . . ID=VAR_059434;Note=Does not affect octanoyltransferase activity. T->A;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:18443287,ECO:0000269|PubMed:24045953;Dbxref=dbSNP:rs7813902,PMID:18443287,PMID:24045953 Q96T53 UniProtKB Natural variant 231 231 . . . ID=VAR_030069;Note=G->E;Dbxref=dbSNP:rs16876563 Q96T53 UniProtKB Mutagenesis 338 338 . . . Note=Abolishes ability to acylate ghrelin. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18443287;Dbxref=PMID:18443287