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Q96T53

- MBOA4_HUMAN

UniProt

Q96T53 - MBOA4_HUMAN

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Protein
Ghrelin O-acyltransferase
Gene
MBOAT4, GOAT, OACT4, FKSG89
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates the octanoylation of ghrelin at 'Ser-3'. Can use a variety of fatty acids as substrates including octanoic acid, decanoic acid and tetradecanoic acid.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei307 – 3071 By similarity
Active sitei338 – 3381 Inferred

GO - Molecular functioni

  1. serine O-acyltransferase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. peptidyl-serine octanoylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

ReactomeiREACT_19189. Synthesis, secretion, and deacylation of Ghrelin.

Names & Taxonomyi

Protein namesi
Recommended name:
Ghrelin O-acyltransferase (EC:2.3.1.-)
Alternative name(s):
Membrane-bound O-acyltransferase domain-containing protein 4
Short name:
O-acyltransferase domain-containing protein 4
Gene namesi
Name:MBOAT4
Synonyms:GOAT, OACT4
ORF Names:FKSG89
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:32311. MBOAT4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621Helical; Reviewed prediction
Add
BLAST
Transmembranei43 – 6321Helical; Reviewed prediction
Add
BLAST
Transmembranei163 – 18321Helical; Reviewed prediction
Add
BLAST
Transmembranei241 – 26121Helical; Reviewed prediction
Add
BLAST
Transmembranei345 – 36521Helical; Reviewed prediction
Add
BLAST
Transmembranei377 – 39721Helical; Reviewed prediction
Add
BLAST
Transmembranei407 – 42721Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: Reactome
  2. integral component of endoplasmic reticulum membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi338 – 3381H → A: Abolishes ability to acylate ghrelin. 1 Publication

Organism-specific databases

PharmGKBiPA142671233.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Ghrelin O-acyltransferase
PRO_0000273024Add
BLAST

Proteomic databases

PaxDbiQ96T53.
PRIDEiQ96T53.

PTM databases

PhosphoSiteiQ96T53.

Expressioni

Tissue specificityi

Expressed predominantly in stomach with moderate levels in pancreas and relatively low levels in most other tissues.1 Publication

Gene expression databases

CleanExiHS_MBOAT4.
GenevestigatoriQ96T53.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000314196.

Structurei

3D structure databases

ProteinModelPortaliQ96T53.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG268942.
HOGENOMiHOG000113492.
HOVERGENiHBG108120.
InParanoidiQ96T53.
OMAiAFSAWWH.
OrthoDBiEOG74TWZX.
PhylomeDBiQ96T53.
TreeFamiTF314906.

Family and domain databases

InterProiIPR004299. MBOAT_fam.
[Graphical view]
PfamiPF03062. MBOAT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96T53-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEWLWLFFLH PISFYQGAAF PFALLFNYLC IMDSFSTRAR YLFLLTGGGA    50
LAVAAMGSYA VLVFTPAVCA VALLCSLAPQ QVHRWTFCFQ MSWQTLCHLG 100
LHYTEYYLHE PPSVRFCITL SSLMLLTQRV TSLSLDICEG KVKAASGGFR 150
SRSSLSEHVC KALPYFSYLL FFPALLGGSL CSFQRFQARV QGSSALHPRH 200
SFWALSWRGL QILGLECLNV AVSRVVDAGA GLTDCQQFEC IYVVWTTAGL 250
FKLTYYSHWI LDDSLLHAAG FGPELGQSPG EEGYVPDADI WTLERTHRIS 300
VFSRKWNQST ARWLRRLVFQ HSRAWPLLQT FAFSAWWHGL HPGQVFGFVC 350
WAVMVEADYL IHSFANEFIR SWPMRLFYRT LTWAHTQLII AYIMLAVEVR 400
SLSSLWLLCN SYNSVFPMVY CILLLLLAKR KHKCN 435
Length:435
Mass (Da):49,716
Last modified:April 8, 2008 - v2
Checksum:i0CF97AAE734F24A7
GO
Isoform 2 (identifier: Q96T53-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-106: Missing.
     107-114: YLHEPPSV → MFFKKLSC

Note: No experimental confirmation available.

Show »
Length:329
Mass (Da):37,721
Checksum:iE1A0D73A81BF9C18
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti46 – 461T → A.1 Publication
Corresponds to variant rs7813902 [ dbSNP | Ensembl ].
VAR_059434
Natural varianti231 – 2311G → E.
Corresponds to variant rs16876563 [ dbSNP | Ensembl ].
VAR_030069

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 106106Missing in isoform 2.
VSP_032958Add
BLAST
Alternative sequencei107 – 1148YLHEPPSV → MFFKKLSC in isoform 2.
VSP_032959

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU518495 mRNA. Translation: ACB05873.2.
AF359269 mRNA. Translation: AAK43717.1.
AC026979 Genomic DNA. No translation available.
CCDSiCCDS47835.1. [Q96T53-1]
RefSeqiNP_001094386.1. NM_001100916.1. [Q96T53-1]
UniGeneiHs.627194.

Genome annotation databases

EnsembliENST00000320542; ENSP00000314196; ENSG00000177669. [Q96T53-1]
GeneIDi619373.
KEGGihsa:619373.
UCSCiuc010lvg.3. human. [Q96T53-1]

Polymorphism databases

DMDMi182676418.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU518495 mRNA. Translation: ACB05873.2 .
AF359269 mRNA. Translation: AAK43717.1 .
AC026979 Genomic DNA. No translation available.
CCDSi CCDS47835.1. [Q96T53-1 ]
RefSeqi NP_001094386.1. NM_001100916.1. [Q96T53-1 ]
UniGenei Hs.627194.

3D structure databases

ProteinModelPortali Q96T53.
ModBasei Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000314196.

PTM databases

PhosphoSitei Q96T53.

Polymorphism databases

DMDMi 182676418.

Proteomic databases

PaxDbi Q96T53.
PRIDEi Q96T53.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000320542 ; ENSP00000314196 ; ENSG00000177669 . [Q96T53-1 ]
GeneIDi 619373.
KEGGi hsa:619373.
UCSCi uc010lvg.3. human. [Q96T53-1 ]

Organism-specific databases

CTDi 619373.
GeneCardsi GC08M029989.
H-InvDB HIX0034281.
HGNCi HGNC:32311. MBOAT4.
MIMi 611940. gene.
neXtProti NX_Q96T53.
PharmGKBi PA142671233.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG268942.
HOGENOMi HOG000113492.
HOVERGENi HBG108120.
InParanoidi Q96T53.
OMAi AFSAWWH.
OrthoDBi EOG74TWZX.
PhylomeDBi Q96T53.
TreeFami TF314906.

Enzyme and pathway databases

Reactomei REACT_19189. Synthesis, secretion, and deacylation of Ghrelin.

Miscellaneous databases

GenomeRNAii 619373.
NextBioi 112914.
PROi Q96T53.
SOURCEi Search...

Gene expression databases

CleanExi HS_MBOAT4.
Genevestigatori Q96T53.

Family and domain databases

InterProi IPR004299. MBOAT_fam.
[Graphical view ]
Pfami PF03062. MBOAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, MUTAGENESIS OF HIS-338, VARIANT ALA-46.
    Tissue: Thyroid carcinoma.
  2. "Identification of FKSG89, a novel gene located on human chromosome 8."
    Wang Y.-G., Gong L.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  3. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiMBOA4_HUMAN
AccessioniPrimary (citable) accession number: Q96T53
Secondary accession number(s): B1Q003
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: April 8, 2008
Last modified: September 3, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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