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Q96T51

- RUFY1_HUMAN

UniProt

Q96T51 - RUFY1_HUMAN

Protein

RUN and FYVE domain-containing protein 1

Gene

RUFY1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 2 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri642 – 70059FYVE-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. lipid binding Source: UniProtKB-KW
    2. protein binding Source: IntAct
    3. protein transporter activity Source: Ensembl
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. endocytosis Source: UniProtKB-KW
    2. regulation of endocytosis Source: Ensembl

    Keywords - Biological processi

    Endocytosis, Protein transport, Transport

    Keywords - Ligandi

    Lipid-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RUN and FYVE domain-containing protein 1
    Alternative name(s):
    FYVE-finger protein EIP1
    La-binding protein 1
    Rab4-interacting protein
    Zinc finger FYVE domain-containing protein 12
    Gene namesi
    Name:RUFY1
    Synonyms:RABIP4, ZFYVE12
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:19760. RUFY1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. early endosome membrane Source: UniProtKB-SubCell
    3. intracellular membrane-bounded organelle Source: HPA
    4. nucleus Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Endosome, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi389 – 3891Y → F: Abolishes phosphorylation and endosomal targeting; when associated with F-400. 1 Publication
    Mutagenesisi400 – 4001Y → F: Abolishes phosphorylation and endosomal targeting; when associated with F-389. 1 Publication

    Organism-specific databases

    PharmGKBiPA134944787.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 708708RUN and FYVE domain-containing protein 1PRO_0000097530Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei389 – 3891Phosphotyrosine1 Publication
    Modified residuei400 – 4001Phosphotyrosine1 Publication

    Post-translational modificationi

    Phosphorylation on Tyr-389 and/or Tyr-400 is required for interaction with BMX and endosomal targeting.1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96T51.
    PaxDbiQ96T51.
    PRIDEiQ96T51.

    PTM databases

    PhosphoSiteiQ96T51.

    Expressioni

    Tissue specificityi

    Broadly expressed, with highest levels in lung, testis, kidney and brain.1 Publication

    Gene expression databases

    BgeeiQ96T51.
    CleanExiHS_RUFY1.
    GenevestigatoriQ96T51.

    Organism-specific databases

    HPAiHPA038804.

    Interactioni

    Subunit structurei

    Interacts with BMX. May interact with SSB. Interacts with RAB4 and RAB5 that have been activated by GTP-binding.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PIAS2O759283EBI-3941207,EBI-348555

    Protein-protein interaction databases

    BioGridi123193. 23 interactions.
    IntActiQ96T51. 4 interactions.
    MINTiMINT-7302811.
    STRINGi9606.ENSP00000377094.

    Structurei

    Secondary structure

    1
    708
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni649 – 6513
    Beta strandi657 – 6593
    Beta strandi661 – 6633
    Turni665 – 6673
    Beta strandi670 – 6723
    Helixi674 – 6763
    Beta strandi678 – 6803
    Beta strandi683 – 6875
    Beta strandi689 – 6913
    Helixi693 – 6986

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2YQMNMR-A627-708[»]
    2YW8X-ray3.00A627-708[»]
    ProteinModelPortaliQ96T51.
    SMRiQ96T51. Positions 109-275, 588-708.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ96T51.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini139 – 271133RUNPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni615 – 62511Interaction with RAB4By similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili321 – 37454Sequence AnalysisAdd
    BLAST
    Coiled coili405 – 617213Sequence AnalysisAdd
    BLAST

    Domaini

    The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns3P-enriched membranes is substantially increased in acidic conditions.1 Publication

    Sequence similaritiesi

    Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
    Contains 1 RUN domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri642 – 70059FYVE-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG270133.
    HOVERGENiHBG057053.
    InParanoidiQ96T51.
    KOiK12482.
    OMAiMMKLSVK.
    OrthoDBiEOG722J98.
    PhylomeDBiQ96T51.
    TreeFamiTF323904.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR004012. Run.
    IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR011011. Znf_FYVE_PHD.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF01363. FYVE. 1 hit.
    PF02759. RUN. 1 hit.
    [Graphical view]
    SMARTiSM00064. FYVE. 1 hit.
    SM00593. RUN. 1 hit.
    [Graphical view]
    SUPFAMiSSF57903. SSF57903. 1 hit.
    PROSITEiPS50826. RUN. 1 hit.
    PS50178. ZF_FYVE. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96T51-1) [UniParc]FASTAAdd to Basket

    Also known as: rabip4'

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MADREGGCAA GRGRELEPEL EPGPGPGSAL EPGEEFEIVD RSQLPGPGDL    50
    RSATRPRAAE GWSAPILTLA RRATGNLSAS CGSALRAAAG LGGGDSGDGT 100
    ARAASKCQMM EERANLMHMM KLSIKVLLQS ALSLGRSLDA DHAPLQQFFV 150
    VMEHCLKHGL KVKKSFIGQN KSFFGPLELV EKLCPEASDI ATSVRNLPEL 200
    KTAVGRGRAW LYLALMQKKL ADYLKVLIDN KHLLSEFYEP EALMMEEEGM 250
    VIVGLLVGLN VLDANLCLKG EDLDSQVGVI DFSLYLKDVQ DLDGGKEHER 300
    ITDVLDQKNY VEELNRHLSC TVGDLQTKID GLEKTNSKLQ EELSAATDRI 350
    CSLQEEQQQL REQNELIRER SEKSVEITKQ DTKVELETYK QTRQGLDEMY 400
    SDVWKQLKEE KKVRLELEKE LELQIGMKTE MEIAMKLLEK DTHEKQDTLV 450
    ALRQQLEEVK AINLQMFHKA QNAESSLQQK NEAITSFEGK TNQVMSSMKQ 500
    MEERLQHSER ARQGAEERSH KLQQELGGRI GALQLQLSQL HEQCSSLEKE 550
    LKSEKEQRQA LQRELQHEKD TSSLLRMELQ QVEGLKKELR ELQDEKAELQ 600
    KICEEQEQAL QEMGLHLSQS KLKMEDIKEV NQALKGHAWL KDDEATHCRQ 650
    CEKEFSISRR KHHCRNCGHI FCNTCSSNEL ALPSYPKPVR VCDSCHTLLL 700
    QRCSSTAS 708
    Length:708
    Mass (Da):79,818
    Last modified:July 11, 2006 - v2
    Checksum:i6697B4BC108AD54F
    GO
    Isoform 2 (identifier: Q96T51-2) [UniParc]FASTAAdd to Basket

    Also known as: rabip4

    The sequence of this isoform differs from the canonical sequence as follows:
         1-108: Missing.

    Show »
    Length:600
    Mass (Da):69,078
    Checksum:i44EEEB383C18FC47
    GO
    Isoform 3 (identifier: Q96T51-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         343-412: LSAATDRICS...VWKQLKEEKK → EERMKGQDKG...RRTAAVKRTK
         413-708: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:412
    Mass (Da):44,489
    Checksum:iDB0F4DA2BD8EEA83
    GO

    Sequence cautioni

    The sequence AAK50771.1 differs from that shown. Reason: Frameshift at positions 47 and 88.
    The sequence BAB15276.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti519 – 52810SHKLQQELGG → TTSCSRSWAV in AAQ14554. (PubMed:14617813)Curated
    Sequence conflicti570 – 5701D → N in AAQ14554. (PubMed:14617813)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti267 – 2671C → F in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035985
    Natural varianti298 – 2981H → Q.
    Corresponds to variant rs6879322 [ dbSNP | Ensembl ].
    VAR_051327

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 108108Missing in isoform 2. 2 PublicationsVSP_019785Add
    BLAST
    Alternative sequencei343 – 41270LSAAT…KEEKK → EERMKGQDKGGLSRGRELAA SCPAVSLLDTSCLLLAGGGC SALLRLSTAFSCNRPNLLTS RRTAAVKRTK in isoform 3. 1 PublicationVSP_019786Add
    BLAST
    Alternative sequencei413 – 708296Missing in isoform 3. 1 PublicationVSP_019787Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF312367 mRNA. Translation: AAQ14554.1.
    AK025904 mRNA. Translation: BAB15276.1. Different initiation.
    AK075021 mRNA. No translation available.
    BC032571 mRNA. Translation: AAH32571.1.
    AF361055 mRNA. Translation: AAK50771.1. Frameshift.
    AB209507 mRNA. Translation: BAD92744.1.
    CCDSiCCDS34312.1. [Q96T51-2]
    CCDS4445.2. [Q96T51-1]
    RefSeqiNP_001035541.1. NM_001040451.2. [Q96T51-2]
    NP_001035542.1. NM_001040452.2. [Q96T51-2]
    NP_079434.3. NM_025158.4. [Q96T51-1]
    UniGeneiHs.306769.

    Genome annotation databases

    EnsembliENST00000319449; ENSP00000325594; ENSG00000176783. [Q96T51-1]
    ENST00000393438; ENSP00000377087; ENSG00000176783. [Q96T51-2]
    ENST00000437570; ENSP00000390025; ENSG00000176783. [Q96T51-2]
    GeneIDi80230.
    KEGGihsa:80230.
    UCSCiuc003mka.2. human. [Q96T51-1]

    Polymorphism databases

    DMDMi110282993.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF312367 mRNA. Translation: AAQ14554.1 .
    AK025904 mRNA. Translation: BAB15276.1 . Different initiation.
    AK075021 mRNA. No translation available.
    BC032571 mRNA. Translation: AAH32571.1 .
    AF361055 mRNA. Translation: AAK50771.1 . Frameshift.
    AB209507 mRNA. Translation: BAD92744.1 .
    CCDSi CCDS34312.1. [Q96T51-2 ]
    CCDS4445.2. [Q96T51-1 ]
    RefSeqi NP_001035541.1. NM_001040451.2. [Q96T51-2 ]
    NP_001035542.1. NM_001040452.2. [Q96T51-2 ]
    NP_079434.3. NM_025158.4. [Q96T51-1 ]
    UniGenei Hs.306769.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2YQM NMR - A 627-708 [» ]
    2YW8 X-ray 3.00 A 627-708 [» ]
    ProteinModelPortali Q96T51.
    SMRi Q96T51. Positions 109-275, 588-708.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123193. 23 interactions.
    IntActi Q96T51. 4 interactions.
    MINTi MINT-7302811.
    STRINGi 9606.ENSP00000377094.

    PTM databases

    PhosphoSitei Q96T51.

    Polymorphism databases

    DMDMi 110282993.

    Proteomic databases

    MaxQBi Q96T51.
    PaxDbi Q96T51.
    PRIDEi Q96T51.

    Protocols and materials databases

    DNASUi 80230.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000319449 ; ENSP00000325594 ; ENSG00000176783 . [Q96T51-1 ]
    ENST00000393438 ; ENSP00000377087 ; ENSG00000176783 . [Q96T51-2 ]
    ENST00000437570 ; ENSP00000390025 ; ENSG00000176783 . [Q96T51-2 ]
    GeneIDi 80230.
    KEGGi hsa:80230.
    UCSCi uc003mka.2. human. [Q96T51-1 ]

    Organism-specific databases

    CTDi 80230.
    GeneCardsi GC05P178977.
    HGNCi HGNC:19760. RUFY1.
    HPAi HPA038804.
    MIMi 610327. gene.
    neXtProti NX_Q96T51.
    PharmGKBi PA134944787.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG270133.
    HOVERGENi HBG057053.
    InParanoidi Q96T51.
    KOi K12482.
    OMAi MMKLSVK.
    OrthoDBi EOG722J98.
    PhylomeDBi Q96T51.
    TreeFami TF323904.

    Miscellaneous databases

    ChiTaRSi RUFY1. human.
    EvolutionaryTracei Q96T51.
    GeneWikii RUFY1.
    GenomeRNAii 80230.
    NextBioi 70661.
    PROi Q96T51.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96T51.
    CleanExi HS_RUFY1.
    Genevestigatori Q96T51.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR004012. Run.
    IPR000306. Znf_FYVE.
    IPR017455. Znf_FYVE-rel.
    IPR011011. Znf_FYVE_PHD.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF01363. FYVE. 1 hit.
    PF02759. RUN. 1 hit.
    [Graphical view ]
    SMARTi SM00064. FYVE. 1 hit.
    SM00593. RUN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57903. SSF57903. 1 hit.
    PROSITEi PS50826. RUN. 1 hit.
    PS50178. ZF_FYVE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH SSB; RAB4 AND RAB5, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, FUNCTION.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    4. "Interaction between tyrosine kinase Etk and a RUN-domain and FYVE-domain containing protein RUFY1. A possible role of Etk in regulation of vesicle trafficking."
      Yang J., Kim O., Wu J., Qiu Y.
      J. Biol. Chem. 277:30219-30226(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-708 (ISOFORM 1), TISSUE SPECIFICITY, SUBCELLULAR LOCATION, INTERACTION WITH BMX, PHOSPHORYLATION AT TYR-389 AND TYR-400, MUTAGENESIS OF TYR-389 AND TYR-400.
    5. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F.
      Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 90-708 (ISOFORM 3).
      Tissue: Brain.
    6. Cited for: DOMAIN FYVE-TYPE ZINC-FINGER.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Solution structure of the FYVE domain in zinc finger FYVE domain-containing protein 12."
      RIKEN structural genomics initiative (RSGI)
      Submitted (OCT-2007) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 627-708.
    9. Cited for: VARIANT [LARGE SCALE ANALYSIS] PHE-267.

    Entry informationi

    Entry nameiRUFY1_HUMAN
    AccessioniPrimary (citable) accession number: Q96T51
    Secondary accession number(s): Q59FF3, Q71S93, Q9H6I3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 119 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3