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UniProtKB - Q96T37 (RBM15_HUMAN)

UniProt

Q96T37 - RBM15_HUMAN

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Protein

Putative RNA-binding protein 15

Gene

RBM15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing. High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing. May be implicated in HOX gene regulation.2 Publications

GO - Molecular functioni

  • nucleic acid binding Source: GO_Central
  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

SIGNORiQ96T37.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative RNA-binding protein 15
Alternative name(s):
One-twenty two protein 1
RNA-binding motif protein 15
Gene namesi
Name:RBM15
Synonyms:OTT, OTT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:14959. RBM15.

Subcellular locationi

GO - Cellular componenti

  • nuclear membrane Source: UniProtKB-SubCell
  • nuclear speck Source: UniProtKB
  • nucleoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving RBM15 may be a cause of acute megakaryoblastic leukemia. Translocation t(1;22)(p13;q13) with MKL1. Although both reciprocal fusion transcripts are detected in acute megakaryoblastic leukemia (AMKL, FAB-M7), the RBM15-MKL1 chimeric protein has all the putative functional domains encoded by each gene and is the candidate oncogene.

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi795 – 7951K → A: Disrupts interaction with SETD1B. 1 Publication
Mutagenesisi898 – 8981K → A: Disrupts interaction with SETD1B. 1 Publication
Mutagenesisi923 – 9231F → A: Disrupts interaction with SETD1B. 1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei954 – 9552Breakpoint for translocation to form RBM15-MKL1

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

MalaCardsiRBM15.
Orphaneti402023. 'Megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13)'.
PharmGKBiPA34264.

Polymorphism and mutation databases

BioMutaiRBM15.
DMDMi32363506.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 977977Putative RNA-binding protein 15PRO_0000081777Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei109 – 1091PhosphoserineCombined sources
Modified residuei179 – 1791PhosphoserineCombined sources
Modified residuei208 – 2081PhosphoserineCombined sources
Modified residuei210 – 2101PhosphoserineCombined sources
Modified residuei253 – 2531PhosphoserineCombined sources
Modified residuei257 – 2571PhosphoserineCombined sources
Modified residuei259 – 2591PhosphoserineCombined sources
Modified residuei266 – 2661PhosphotyrosineCombined sources
Modified residuei292 – 2921PhosphoserineCombined sources
Modified residuei294 – 2941PhosphoserineCombined sources
Modified residuei365 – 3651PhosphoserineCombined sources
Modified residuei450 – 4501N6-acetyllysineCombined sources
Modified residuei568 – 5681PhosphothreonineCombined sources
Modified residuei622 – 6221PhosphoserineCombined sources
Modified residuei656 – 6561PhosphoserineCombined sources
Modified residuei670 – 6701PhosphoserineCombined sources
Modified residuei674 – 6741PhosphoserineCombined sources
Modified residuei700 – 7001PhosphoserineCombined sources
Modified residuei741 – 7411PhosphoserineCombined sources
Modified residuei765 – 7651PhosphoserineCombined sources
Modified residuei767 – 7671PhosphoserineCombined sources
Modified residuei781 – 7811PhosphoserineCombined sources
Modified residuei935 – 9351PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96T37.
MaxQBiQ96T37.
PaxDbiQ96T37.
PeptideAtlasiQ96T37.
PRIDEiQ96T37.

PTM databases

iPTMnetiQ96T37.
PhosphoSiteiQ96T37.
SwissPalmiQ96T37.

Expressioni

Gene expression databases

BgeeiENSG00000162775.
ExpressionAtlasiQ96T37. baseline and differential.
GenevisibleiQ96T37. HS.

Organism-specific databases

HPAiCAB015201.
HPA019824.
HPA049642.

Interactioni

Subunit structurei

Interacts with Epstein-Barr virus BSFL2/BMLF1. Interacts (via SPOC domain) with SETD1B. Interacts with NXF1, the interaction is required to promote mRNA export. Component of the WTAP complex composed of WTAP, ZC3H13, CBLL1, KIAA1429, RBM15, BCLAF1 and THRAP3 (PubMed:24100041).5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CALCOCO2Q131373EBI-2514922,EBI-739580
CEP44Q9C0F13EBI-2514922,EBI-744115
DDX17Q928415EBI-2514922,EBI-746012
LZTS2Q9BRK43EBI-2514922,EBI-741037
NAV2Q8IVL13EBI-2514922,EBI-741200

Protein-protein interaction databases

BioGridi122293. 46 interactions.
IntActiQ96T37. 18 interactions.
MINTiMINT-4131981.
STRINGi9606.ENSP00000358799.

Structurei

3D structure databases

ProteinModelPortaliQ96T37.
SMRiQ96T37. Positions 172-271, 358-532, 783-943.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini170 – 25283RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini374 – 45178RRM 2PROSITE-ProRule annotationAdd
BLAST
Domaini455 – 52975RRM 3PROSITE-ProRule annotationAdd
BLAST
Domaini777 – 956180SPOCPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi60 – 166107Gly/Ser-richAdd
BLAST
Compositional biasi616 – 732117Arg-richAdd
BLAST

Sequence similaritiesi

Belongs to the RRM Spen family.Curated
Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation
Contains 1 SPOC domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0112. Eukaryota.
ENOG410XSAC. LUCA.
GeneTreeiENSGT00530000063730.
HOVERGENiHBG058366.
InParanoidiQ96T37.
KOiK13190.
OMAiVMIIVRV.
OrthoDBiEOG091G0615.
PhylomeDBiQ96T37.
TreeFamiTF315637.

Family and domain databases

Gene3Di2.40.290.10. 1 hit.
3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR016194. SPOC-like_C_dom.
IPR012921. SPOC_C.
IPR010912. SPOC_met.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
PF07744. SPOC. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF100939. SSF100939. 1 hit.
SSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 3 hits.
PS50917. SPOC. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

Isoform 1 (identifier: Q96T37-1) [UniParc]FASTAAdd to basket
Also known as: RBM15s+ae

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRTAGRDPVP RRSPRWRRAV PLCETSAGRR VTQLRGDDLR RPATMKGKER 
        60         70         80         90        100
SPVKAKRSRG GEDSTSRGER SKKLGGSGGS NGSSSGKTDS GGGSRRSLHL 
       110        120        130        140        150
DKSSSRGGSR EYDTGGGSSS SRLHSYSSPS TKNSSGGGES RSSSRGGGGE 
       160        170        180        190        200
SRSSGAASSA PGGGDGAEYK TLKISELGSQ LSDEAVEDGL FHEFKRFGDV 
       210        220        230        240        250
SVKISHLSGS GSGDERVAFV NFRRPEDARA AKHARGRLVL YDRPLKIEAV 
       260        270        280        290        300
YVSRRRSRSP LDKDTYPPSA SVVGASVGGH RHPPGGGGGQ RSLSPGGAAL 
       310        320        330        340        350
GYRDYRLQQL ALGRLPPPPP PPLPRDLERE RDYPFYERVR PAYSLEPRVG 
       360        370        380        390        400
AGAGAAPFRE VDEISPEDDQ RANRTLFLGN LDITVTESDL RRAFDRFGVI 
       410        420        430        440        450
TEVDIKRPSR GQTSTYGFLK FENLDMSHRA KLAMSGKIII RNPIKIGYGK 
       460        470        480        490        500
ATPTTRLWVG GLGPWVPLAA LAREFDRFGT IRTIDYRKGD SWAYIQYESL 
       510        520        530        540        550
DAAHAAWTHM RGFPLGGPDR RLRVDFADTE HRYQQQYLQP LPLTHYELVT 
       560        570        580        590        600
DAFGHRAPDP LRGARDRTPP LLYRDRDRDL YPDSDWVPPP PPVRERSTRT 
       610        620        630        640        650
AATSVPAYEP LDSLDRRRDG WSLDRDRGDR DLPSSRDQPR KRRLPEESGG 
       660        670        680        690        700
RHLDRSPESD RPRKRHCAPS PDRSPELSSS RDRYNSDNDR SSRLLLERPS 
       710        720        730        740        750
PIRDRRGSLE KSQGDKRDRK NSASAERDRK HRTTAPTEGK SPLKKEDRSD 
       760        770        780        790        800
GSAPSTSTAS SKLKSPSQKQ DGGTAPVASA SPKLCLAWQG MLLLKNSNFP 
       810        820        830        840        850
SNMHLLQGDL QVASSLLVEG STGGKVAQLK ITQRLRLDQP KLDEVTRRIK 
       860        870        880        890        900
VAGPNGYAIL LAVPGSSDSR SSSSSAASDT ATSTQRPLRN LVSYLKQKQA 
       910        920        930        940        950
AGVISLPVGG NKDKENTGVL HAFPPCEFSQ QFLDSPAKAL AKSEEDYLVM 
       960        970 
IIVRGFGFQI GVRYENKKRE NLALTLL
Length:977
Mass (Da):107,189
Last modified:June 27, 2003 - v2
Checksum:iFB26AFE246E40282
GO
Isoform 2 (identifier: Q96T37-2) [UniParc]FASTAAdd to basket
Also known as: RBM15L

The sequence of this isoform differs from the canonical sequence as follows:
     956-977: FGFQIGVRYENKKRENLALTLL → AS

Show »
Length:957
Mass (Da):104,755
Checksum:i72893E069306B4E0
GO
Isoform 3 (identifier: Q96T37-3) [UniParc]FASTAAdd to basket
Also known as: RBM15S

The sequence of this isoform differs from the canonical sequence as follows:
     955-977: GFGFQIGVRYENKKRENLALTLL → AKLVEQRMKIWNSKL

Show »
Length:969
Mass (Da):106,366
Checksum:iE2E52058E76FE38D
GO
Isoform 4 (identifier: Q96T37-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: Missing.
     956-977: FGFQIGVRYENKKRENLALTLL → AS

Note: Produced by alternative initiation of isoform 2.
Show »
Length:913
Mass (Da):99,701
Checksum:i1B4E29CDD062A5AC
GO

Sequence cautioni

The sequence BAB14088 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB15185 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti99 – 991H → L in AAK54722 (PubMed:11431691).Curated
Sequence conflicti99 – 991H → L in AAK54723 (PubMed:11431691).Curated
Sequence conflicti99 – 991H → L in AAK54724 (PubMed:11431691).Curated
Sequence conflicti99 – 991H → L in BAB14088 (Ref. 3) Curated
Sequence conflicti227 – 2271D → N in AAI03494 (PubMed:15489334).Curated
Sequence conflicti705 – 7051R → G in AAK54722 (PubMed:11431691).Curated
Sequence conflicti705 – 7051R → G in AAK54723 (PubMed:11431691).Curated
Sequence conflicti705 – 7051R → G in AAK54724 (PubMed:11431691).Curated
Sequence conflicti705 – 7051R → G in BAB14088 (Ref. 3) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4444Missing in isoform 4. CuratedVSP_053877Add
BLAST
Alternative sequencei955 – 97723GFGFQ…ALTLL → AKLVEQRMKIWNSKL in isoform 3. 2 PublicationsVSP_005812Add
BLAST
Alternative sequencei956 – 97722FGFQI…ALTLL → AS in isoform 2 and isoform 4. 1 PublicationVSP_005811Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF368062 mRNA. Translation: AAK54722.1.
AF368063 mRNA. Translation: AAK54723.1.
AF368064 mRNA. Translation: AAK54724.1.
AF364035 mRNA. Translation: AAK56920.1. Different termination.
AJ303089 mRNA. Translation: CAC38828.1. Different termination.
AJ303090 mRNA. Translation: CAC38829.1. Different termination.
AJ297259 Genomic DNA. Translation: CAC38861.1.
AJ297259 Genomic DNA. Translation: CAC38862.1.
AK022541 mRNA. Translation: BAB14088.1. Different initiation.
AK025596 mRNA. Translation: BAB15185.1. Different initiation.
AL355488 Genomic DNA. Translation: CAI19077.1.
CH471122 Genomic DNA. Translation: EAW56439.1.
BC006397 mRNA. Translation: AAH06397.2.
BC047479 mRNA. Translation: AAH47479.1.
BC062316 mRNA. Translation: AAH62316.1.
BC098140 mRNA. Translation: AAH98140.1.
BC103493 mRNA. Translation: AAI03494.1.
BC103507 mRNA. Translation: AAI03508.1.
BK005915 mRNA. Translation: DAA05818.1.
CCDSiCCDS59198.1. [Q96T37-3]
CCDS822.1. [Q96T37-1]
RefSeqiNP_001188474.1. NM_001201545.1. [Q96T37-3]
NP_073605.4. NM_022768.4. [Q96T37-1]
UniGeneiHs.435947.
Hs.708172.

Genome annotation databases

EnsembliENST00000369784; ENSP00000358799; ENSG00000162775. [Q96T37-1]
ENST00000487146; ENSP00000473552; ENSG00000162775. [Q96T37-3]
ENST00000602849; ENSP00000473638; ENSG00000162775. [Q96T37-2]
ENST00000618772; ENSP00000483133; ENSG00000162775. [Q96T37-1]
GeneIDi64783.
KEGGihsa:64783.
UCSCiuc001dzl.1. human. [Q96T37-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF368062 mRNA. Translation: AAK54722.1.
AF368063 mRNA. Translation: AAK54723.1.
AF368064 mRNA. Translation: AAK54724.1.
AF364035 mRNA. Translation: AAK56920.1. Different termination.
AJ303089 mRNA. Translation: CAC38828.1. Different termination.
AJ303090 mRNA. Translation: CAC38829.1. Different termination.
AJ297259 Genomic DNA. Translation: CAC38861.1.
AJ297259 Genomic DNA. Translation: CAC38862.1.
AK022541 mRNA. Translation: BAB14088.1. Different initiation.
AK025596 mRNA. Translation: BAB15185.1. Different initiation.
AL355488 Genomic DNA. Translation: CAI19077.1.
CH471122 Genomic DNA. Translation: EAW56439.1.
BC006397 mRNA. Translation: AAH06397.2.
BC047479 mRNA. Translation: AAH47479.1.
BC062316 mRNA. Translation: AAH62316.1.
BC098140 mRNA. Translation: AAH98140.1.
BC103493 mRNA. Translation: AAI03494.1.
BC103507 mRNA. Translation: AAI03508.1.
BK005915 mRNA. Translation: DAA05818.1.
CCDSiCCDS59198.1. [Q96T37-3]
CCDS822.1. [Q96T37-1]
RefSeqiNP_001188474.1. NM_001201545.1. [Q96T37-3]
NP_073605.4. NM_022768.4. [Q96T37-1]
UniGeneiHs.435947.
Hs.708172.

3D structure databases

ProteinModelPortaliQ96T37.
SMRiQ96T37. Positions 172-271, 358-532, 783-943.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122293. 46 interactions.
IntActiQ96T37. 18 interactions.
MINTiMINT-4131981.
STRINGi9606.ENSP00000358799.

PTM databases

iPTMnetiQ96T37.
PhosphoSiteiQ96T37.
SwissPalmiQ96T37.

Polymorphism and mutation databases

BioMutaiRBM15.
DMDMi32363506.

Proteomic databases

EPDiQ96T37.
MaxQBiQ96T37.
PaxDbiQ96T37.
PeptideAtlasiQ96T37.
PRIDEiQ96T37.

Protocols and materials databases

DNASUi64783.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369784; ENSP00000358799; ENSG00000162775. [Q96T37-1]
ENST00000487146; ENSP00000473552; ENSG00000162775. [Q96T37-3]
ENST00000602849; ENSP00000473638; ENSG00000162775. [Q96T37-2]
ENST00000618772; ENSP00000483133; ENSG00000162775. [Q96T37-1]
GeneIDi64783.
KEGGihsa:64783.
UCSCiuc001dzl.1. human. [Q96T37-1]

Organism-specific databases

CTDi64783.
GeneCardsiRBM15.
HGNCiHGNC:14959. RBM15.
HPAiCAB015201.
HPA019824.
HPA049642.
MalaCardsiRBM15.
MIMi606077. gene.
neXtProtiNX_Q96T37.
Orphaneti402023. 'Megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13)'.
PharmGKBiPA34264.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0112. Eukaryota.
ENOG410XSAC. LUCA.
GeneTreeiENSGT00530000063730.
HOVERGENiHBG058366.
InParanoidiQ96T37.
KOiK13190.
OMAiVMIIVRV.
OrthoDBiEOG091G0615.
PhylomeDBiQ96T37.
TreeFamiTF315637.

Enzyme and pathway databases

SIGNORiQ96T37.

Miscellaneous databases

ChiTaRSiRBM15. human.
GeneWikiiRBM15.
GenomeRNAii64783.
PROiQ96T37.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162775.
ExpressionAtlasiQ96T37. baseline and differential.
GenevisibleiQ96T37. HS.

Family and domain databases

Gene3Di2.40.290.10. 1 hit.
3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR016194. SPOC-like_C_dom.
IPR012921. SPOC_C.
IPR010912. SPOC_met.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
PF07744. SPOC. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF100939. SSF100939. 1 hit.
SSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 3 hits.
PS50917. SPOC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRBM15_HUMAN
AccessioniPrimary (citable) accession number: Q96T37
Secondary accession number(s): A1A693
, Q3ZB86, Q4V760, Q5D058, Q5T613, Q86VW9, Q96PE4, Q96SC5, Q96SC6, Q96SC9, Q96SD0, Q96T38, Q9BRA5, Q9H6R8, Q9H9Y0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: June 27, 2003
Last modified: September 7, 2016
This is version 157 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.