ID   ZIC5_HUMAN              Reviewed;         639 AA.
AC   Q96T25; Q5VYB0;
DT   23-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   13-OCT-2009, entry version 60.
DE   RecName: Full=Zinc finger protein ZIC 5;
DE   AltName: Full=Zinc finger protein of the cerebellum 5;
GN   Name=ZIC5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Gou D.M., Li W.X., Gao L., Sun Y.;
RT   "A novel human zinc finger gene, hZic5.";
RL   Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057823; DOI=10.1038/nature02379;
RA   Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA   Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E.,
RA   Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.,
RA   Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R.,
RA   Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S.,
RA   Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M.,
RA   Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J.,
RA   Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E.,
RA   Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L.,
RA   Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J.,
RA   Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S.,
RA   Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J.,
RA   Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M.,
RA   King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A.,
RA   Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S.,
RA   Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA   Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S.,
RA   Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A.,
RA   Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L.,
RA   Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M.,
RA   Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.;
RT   "The DNA sequence and analysis of human chromosome 13.";
RL   Nature 428:522-528(2004).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-554 AND SER-576, AND
RP   MASS SPECTROMETRY.
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC   -!- FUNCTION: Essential for neural crest development, converting cells
CC       from an epidermal fate to a neural crest cell fate (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- SIMILARITY: Belongs to the GLI C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 4 C2H2-type zinc fingers.
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DR   EMBL; AF378304; AAK55418.1; -; mRNA.
DR   EMBL; AL355338; CAH70366.2; -; Genomic_DNA.
DR   IPI; IPI00163395; -.
DR   RefSeq; NP_149123.2; -.
DR   UniGene; Hs.508570; -.
DR   HSSP; P08047; 1SP2.
DR   STRING; Q96T25; -.
DR   PhosphoSite; Q96T25; -.
DR   PRIDE; Q96T25; -.
DR   Ensembl; ENST00000267294; ENSP00000267294; ENSG00000139800; Homo sapiens.
DR   Ensembl; ENST00000397451; ENSP00000380593; ENSG00000139800; Homo sapiens.
DR   Ensembl; ENST00000397455; ENSP00000380596; ENSG00000139800; Homo sapiens.
DR   GeneID; 85416; -.
DR   KEGG; hsa:85416; -.
DR   UCSC; uc001vom.1; human.
DR   CTD; 85416; -.
DR   GeneCards; GC13M099415; -.
DR   HGNC; HGNC:20322; ZIC5.
DR   PharmGKB; PA134941698; -.
DR   HOGENOM; Q96T25; -.
DR   HOVERGEN; Q96T25; -.
DR   NextBio; 75994; -.
DR   ArrayExpress; Q96T25; -.
DR   Bgee; Q96T25; -.
DR   CleanEx; HS_ZIC5; -.
DR   Genevestigator; Q96T25; -.
DR   GermOnline; ENSG00000139800; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 3.
DR   Pfam; PF00096; zf-C2H2; 4.
DR   ProDom; PD000003; Znf_C2H2; 1.
DR   SMART; SM00355; ZnF_C2H2; 5.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE   1: Evidence at protein level;
KW   Complete proteome; Developmental protein; Differentiation;
KW   DNA-binding; Metal-binding; Neurogenesis; Nucleus; Phosphoprotein;
KW   Repeat; Zinc; Zinc-finger.
FT   CHAIN         1    639       Zinc finger protein ZIC 5.
FT                                /FTId=PRO_0000047255.
FT   ZN_FING     434    461       C2H2-type 1; atypical.
FT   ZN_FING     467    491       C2H2-type 2.
FT   ZN_FING     497    521       C2H2-type 3.
FT   ZN_FING     527    551       C2H2-type 4.
FT   COMPBIAS     82    400       Pro-rich.
FT   COMPBIAS    262    321       Ala-rich.
FT   MOD_RES     554    554       Phosphoserine.
FT   MOD_RES     576    576       Phosphoserine.
SQ   SEQUENCE   639 AA;  65849 MW;  FB1E966ED28D38BF CRC64;
     MEPPLSKRNP PALRLADLAT AQVQPLQNMT GFPALAGPPA HSQLRAAVAH LRLRDLGADP
     GVATTPLGPE HMAQASTLGL SPPSQAFPAH PEAPAAAARA AALVAHPGAG SYPCGGGSSG
     AQPSAPPPPA PPLPPTPSPP PPPPPPPPPA LSGYTTTNSG GGGSSGKGHS RDFVLRRDLS
     ATAPAAAMHG APLGGEQRSG TGSPQHPAPP PHSAGMFISA SGTYAGPDGS GGPALFPALH
     DTPGAPGGHP HPLNGQMRLG LAAAAAAAAA ELYGRAEPPF APRSGDAHYG AVAAAAAAAL
     HGYGAVNLNL NLAAAAAAAA AGPGPHLQHH APPPAPPPPP APAQHPHQHH PHLPGAAGAF
     LRYMRQPIKQ ELICKWIDPD ELAGLPPPPP PPPPPPPPPP AGGAKPCSKT FGTMHELVNH
     VTVEHVGGPE QSSHVCFWED CPREGKPFKA KYKLINHIRV HTGEKPFPCP FPGCGKVFAR
     SENLKIHKRT HTGEKPFKCE FDGCDRKFAN SSDRKKHSHV HTSDKPYYCK IRGCDKSYTH
     PSSLRKHMKI HCKSPPPSPG PLGYSSVGTP VGAPLSPVLD PARSHSSTLS PQVTNLNEWY
     VCQASGAPSH LHTPSSNGTT SETEDEEIYG NPEVVRTIH
//