ID   ZIC5_HUMAN              Reviewed;         663 AA.
AC   Q96T25; Q5VYB0;
DT   23-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 2.
DT   25-JAN-2012, entry version 80.
DE   RecName: Full=Zinc finger protein ZIC 5;
DE   AltName: Full=Zinc finger protein of the cerebellum 5;
GN   Name=ZIC5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Gou D.M., Li W.X., Gao L., Sun Y.;
RT   "A novel human zinc finger gene, hZic5.";
RL   Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057823; DOI=10.1038/nature02379;
RA   Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA   Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E.,
RA   Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.,
RA   Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R.,
RA   Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S.,
RA   Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M.,
RA   Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J.,
RA   Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E.,
RA   Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L.,
RA   Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J.,
RA   Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S.,
RA   Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J.,
RA   Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M.,
RA   King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A.,
RA   Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S.,
RA   Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA   Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I.,
RA   Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S.,
RA   Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A.,
RA   Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B.,
RA   Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L.,
RA   Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M.,
RA   Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.;
RT   "The DNA sequence and analysis of human chromosome 13.";
RL   Nature 428:522-528(2004).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-578 AND SER-600, AND
RP   MASS SPECTROMETRY.
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
CC   -!- FUNCTION: Essential for neural crest development, converting cells
CC       from an epidermal fate to a neural crest cell fate. Binds to DNA
CC       (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- SIMILARITY: Belongs to the GLI C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 4 C2H2-type zinc fingers.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-25 is the initiator.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAK55418.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
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DR   EMBL; AF378304; AAK55418.1; ALT_INIT; mRNA.
DR   EMBL; AL355338; CAH70366.2; -; Genomic_DNA.
DR   IPI; IPI00163395; -.
DR   RefSeq; NP_149123.2; NM_033132.3.
DR   UniGene; Hs.508570; -.
DR   ProteinModelPortal; Q96T25; -.
DR   SMR; Q96T25; 390-577.
DR   STRING; Q96T25; -.
DR   PhosphoSite; Q96T25; -.
DR   DMDM; 30173473; -.
DR   PRIDE; Q96T25; -.
DR   Ensembl; ENST00000267294; ENSP00000267294; ENSG00000139800.
DR   GeneID; 85416; -.
DR   KEGG; hsa:85416; -.
DR   UCSC; uc001vom.1; human.
DR   CTD; 85416; -.
DR   GeneCards; GC13M100615; -.
DR   HGNC; HGNC:20322; ZIC5.
DR   neXtProt; NX_Q96T25; -.
DR   PharmGKB; PA134941698; -.
DR   eggNOG; prNOG19187; -.
DR   GeneTree; ENSGT00600000084058; -.
DR   HOGENOM; HBG506538; -.
DR   HOVERGEN; HBG007135; -.
DR   InParanoid; Q96T25; -.
DR   OMA; ICKWIDQ; -.
DR   OrthoDB; EOG4QVCBT; -.
DR   PhylomeDB; Q96T25; -.
DR   NextBio; 75994; -.
DR   ArrayExpress; Q96T25; -.
DR   Bgee; Q96T25; -.
DR   CleanEx; HS_ZIC5; -.
DR   Genevestigator; Q96T25; -.
DR   GermOnline; ENSG00000139800; Homo sapiens.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 4.
DR   KO; K09226; -.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00355; ZnF_C2H2; 5.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE   1: Evidence at protein level;
KW   Complete proteome; Developmental protein; Differentiation;
KW   DNA-binding; Metal-binding; Neurogenesis; Nucleus; Phosphoprotein;
KW   Reference proteome; Repeat; Zinc; Zinc-finger.
FT   CHAIN         1    663       Zinc finger protein ZIC 5.
FT                                /FTId=PRO_0000047255.
FT   ZN_FING     458    485       C2H2-type 1; atypical.
FT   ZN_FING     491    515       C2H2-type 2.
FT   ZN_FING     521    545       C2H2-type 3.
FT   ZN_FING     551    575       C2H2-type 4.
FT   COMPBIAS    106    424       Pro-rich.
FT   COMPBIAS    286    345       Ala-rich.
FT   MOD_RES     578    578       Phosphoserine.
FT   MOD_RES     600    600       Phosphoserine.
SQ   SEQUENCE   663 AA;  68448 MW;  90C16FF2EEB1F54A CRC64;
     MFLKAGRGNK VPPVRVYGPD CVVLMEPPLS KRNPPALRLA DLATAQVQPL QNMTGFPALA
     GPPAHSQLRA AVAHLRLRDL GADPGVATTP LGPEHMAQAS TLGLSPPSQA FPAHPEAPAA
     AARAAALVAH PGAGSYPCGG GSSGAQPSAP PPPAPPLPPT PSPPPPPPPP PPPALSGYTT
     TNSGGGGSSG KGHSRDFVLR RDLSATAPAA AMHGAPLGGE QRSGTGSPQH PAPPPHSAGM
     FISASGTYAG PDGSGGPALF PALHDTPGAP GGHPHPLNGQ MRLGLAAAAA AAAAELYGRA
     EPPFAPRSGD AHYGAVAAAA AAALHGYGAV NLNLNLAAAA AAAAAGPGPH LQHHAPPPAP
     PPPPAPAQHP HQHHPHLPGA AGAFLRYMRQ PIKQELICKW IDPDELAGLP PPPPPPPPPP
     PPPPAGGAKP CSKTFGTMHE LVNHVTVEHV GGPEQSSHVC FWEDCPREGK PFKAKYKLIN
     HIRVHTGEKP FPCPFPGCGK VFARSENLKI HKRTHTGEKP FKCEFDGCDR KFANSSDRKK
     HSHVHTSDKP YYCKIRGCDK SYTHPSSLRK HMKIHCKSPP PSPGPLGYSS VGTPVGAPLS
     PVLDPARSHS STLSPQVTNL NEWYVCQASG APSHLHTPSS NGTTSETEDE EIYGNPEVVR
     TIH
//