Q96T25 (ZIC5_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 80.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Zinc finger protein ZIC 5 Alternative name(s): Zinc finger protein of the cerebellum 5 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 663 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA By similarity. |
| Subcellular location | Nucleus By similarity. |
| Sequence similarities | Belongs to the GLI C2H2-type zinc-finger protein family. Contains 4 C2H2-type zinc fingers. |
| Caution | It is uncertain whether Met-1 or Met-25 is the initiator. |
| Sequence caution | The sequence AAK55418.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Differentiation Neurogenesis |
| Cellular component | Nucleus |
| Domain | Repeat Zinc-finger |
| Ligand | DNA-binding Metal-binding Zinc |
| Molecular function | Developmental protein |
| PTM | Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 663 | 663 | Zinc finger protein ZIC 5 | PRO_0000047255 | |||||
Regions | |||||||||
| Zinc finger | 458 – 485 | 28 | C2H2-type 1; atypical | ||||||
| Zinc finger | 491 – 515 | 25 | C2H2-type 2 | ||||||
| Zinc finger | 521 – 545 | 25 | C2H2-type 3 | ||||||
| Zinc finger | 551 – 575 | 25 | C2H2-type 4 | ||||||
| Compositional bias | 106 – 424 | 319 | Pro-rich | ||||||
| Compositional bias | 286 – 345 | 60 | Ala-rich | ||||||
Amino acid modifications | |||||||||
| Modified residue | 578 | 1 | Phosphoserine Ref.3 | ||||||
| Modified residue | 600 | 1 | Phosphoserine Ref.3 | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF378304 mRNA. Translation: AAK55418.1. Different initiation. AL355338 Genomic DNA. Translation: CAH70366.2. |
| IPI | IPI00163395. |
| RefSeq | NP_149123.2. NM_033132.3. |
| UniGene | Hs.508570. |
3D structure databases | |
| ProteinModelPortal | Q96T25. |
| SMR | Q96T25. Positions 390-577. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q96T25. |
PTM databases | |
| PhosphoSite | Q96T25. |
Polymorphism databases | |
| DMDM | 30173473. |
Proteomic databases | |
| PRIDE | Q96T25. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000267294; ENSP00000267294; ENSG00000139800. |
| GeneID | 85416. |
| KEGG | hsa:85416. |
| UCSC | uc001vom.1. human. |
Organism-specific databases | |
| CTD | 85416. |
| GeneCards | GC13M100615. |
| HGNC | HGNC:20322. ZIC5. |
| neXtProt | NX_Q96T25. |
| PharmGKB | PA134941698. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG19187. |
| GeneTree | ENSGT00600000084058. |
| HOGENOM | HBG506538. |
| HOVERGEN | HBG007135. |
| InParanoid | Q96T25. |
| OMA | ICKWIDQ. |
| OrthoDB | EOG4QVCBT. |
| PhylomeDB | Q96T25. |
Gene expression databases | |
| ArrayExpress | Q96T25. |
| Bgee | Q96T25. |
| CleanEx | HS_ZIC5. |
| Genevestigator | Q96T25. |
| GermOnline | ENSG00000139800. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view] |
| Gene3D | G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 4 hits. |
| KO | K09226. |
| Pfam | PF00096. zf-C2H2. 3 hits. [Graphical view] |
| SMART | SM00355. ZnF_C2H2. 5 hits. [Graphical view] |
| PROSITE | PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 4 hits. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 75994. |
Entry information
| Entry name | ZIC5_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q96T25 Secondary accession number(s): Q5VYB0 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 13 Human chromosome 13: entries, gene names and cross-references to MIM |
| SIMILARITY comments Index of protein domains and families |

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