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Reviewed, UniProtKB/Swiss-Prot Q96T25 (ZIC5_HUMAN)

Last modified March 2, 2010. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
Zinc finger protein ZIC 5
Alternative name(s):
Zinc finger protein of the cerebellum 5
Gene names
Name:ZIC5
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length639 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the GLI C2H2-type zinc-finger protein family.

Contains 4 C2H2-type zinc fingers.

Ontologies

Keywords
   Biological processDifferentiation
Neurogenesis
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionDevelopmental protein
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processcell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 639639Zinc finger protein ZIC 5
PRO_0000047255

Regions

Zinc finger434 – 46128C2H2-type 1; atypical
Zinc finger467 – 49125C2H2-type 2
Zinc finger497 – 52125C2H2-type 3
Zinc finger527 – 55125C2H2-type 4
Compositional bias82 – 400319Pro-rich
Compositional bias262 – 32160Ala-rich

Amino acid modifications

Modified residue5541Phosphoserine Ref.3
Modified residue5761Phosphoserine Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q96T25-1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: FB1E966ED28D38BF

FASTA63965,849
        10         20         30         40         50         60 
MEPPLSKRNP PALRLADLAT AQVQPLQNMT GFPALAGPPA HSQLRAAVAH LRLRDLGADP 

        70         80         90        100        110        120 
GVATTPLGPE HMAQASTLGL SPPSQAFPAH PEAPAAAARA AALVAHPGAG SYPCGGGSSG 

       130        140        150        160        170        180 
AQPSAPPPPA PPLPPTPSPP PPPPPPPPPA LSGYTTTNSG GGGSSGKGHS RDFVLRRDLS 

       190        200        210        220        230        240 
ATAPAAAMHG APLGGEQRSG TGSPQHPAPP PHSAGMFISA SGTYAGPDGS GGPALFPALH 

       250        260        270        280        290        300 
DTPGAPGGHP HPLNGQMRLG LAAAAAAAAA ELYGRAEPPF APRSGDAHYG AVAAAAAAAL 

       310        320        330        340        350        360 
HGYGAVNLNL NLAAAAAAAA AGPGPHLQHH APPPAPPPPP APAQHPHQHH PHLPGAAGAF 

       370        380        390        400        410        420 
LRYMRQPIKQ ELICKWIDPD ELAGLPPPPP PPPPPPPPPP AGGAKPCSKT FGTMHELVNH 

       430        440        450        460        470        480 
VTVEHVGGPE QSSHVCFWED CPREGKPFKA KYKLINHIRV HTGEKPFPCP FPGCGKVFAR 

       490        500        510        520        530        540 
SENLKIHKRT HTGEKPFKCE FDGCDRKFAN SSDRKKHSHV HTSDKPYYCK IRGCDKSYTH 

       550        560        570        580        590        600 
PSSLRKHMKI HCKSPPPSPG PLGYSSVGTP VGAPLSPVLD PARSHSSTLS PQVTNLNEWY 

       610        620        630 
VCQASGAPSH LHTPSSNGTT SETEDEEIYG NPEVVRTIH 

« Hide

References

« Hide 'large scale' references
[1]"A novel human zinc finger gene, hZic5."
Gou D.M., Li W.X., Gao L., Sun Y.
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed: 15057823] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-554 AND SER-576, MASS SPECTROMETRY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF378304 mRNA. Translation: AAK55418.1.
AL355338 Genomic DNA. Translation: CAH70366.2.
IPIIPI00163395.
RefSeqNP_149123.2.
UniGeneHs.508570

3D structure databases

SMRQ96T25. Positions 366-468, 405-551.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ96T25.

PTM databases

PhosphoSiteQ96T25.

Proteomic databases

PRIDEQ96T25.

Genome annotation databases

EnsemblENST00000267294; ENSP00000267294; ENSG00000139800; Homo sapiens. [Genome view]
GeneID85416.
KEGGhsa:85416.
UCSCuc001vom.1. human.

Organism-specific databases

CTD85416.
GeneCardsGC13M099415.
HGNCHGNC:20322. ZIC5.
PharmGKBPA134941698.
GenAtlasSearch...

Phylogenomic databases

eggNOGprNOG19187.
HOGENOMHBG506538.
HOVERGENHBG007135.
InParanoidQ96T25.
PhylomeDBQ96T25.

Gene expression databases

ArrayExpressQ96T25.
BgeeQ96T25.
CleanExHS_ZIC5.
GenevestigatorQ96T25.
GermOnlineENSG00000139800. Homo sapiens.

Family and domain databases

InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
Gene3DG3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 3 hits.
PfamPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio75994.

Entry information

Entry nameZIC5_HUMAN
AccessionPrimary (citable) accession number: Q96T25
Secondary accession number(s): Q5VYB0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: December 1, 2001
Last modified: March 2, 2010
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents