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Q96T25 (ZIC5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein ZIC 5
Alternative name(s):
Zinc finger protein of the cerebellum 5
Gene names
Name:ZIC5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length663 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate. Binds to DNA By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the GLI C2H2-type zinc-finger protein family.

Contains 4 C2H2-type zinc fingers.

Caution

It is uncertain whether Met-1 or Met-25 is the initiator.

Sequence caution

The sequence AAK55418.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 663663Zinc finger protein ZIC 5
PRO_0000047255

Regions

Zinc finger458 – 48528C2H2-type 1; atypical
Zinc finger491 – 51525C2H2-type 2
Zinc finger521 – 54525C2H2-type 3
Zinc finger551 – 57525C2H2-type 4
Compositional bias106 – 424319Pro-rich
Compositional bias286 – 34560Ala-rich

Amino acid modifications

Modified residue6001Phosphoserine Ref.3 Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q96T25 [UniParc].

Last modified April 5, 2011. Version 2.
Checksum: 90C16FF2EEB1F54A

FASTA66368,448
        10         20         30         40         50         60 
MFLKAGRGNK VPPVRVYGPD CVVLMEPPLS KRNPPALRLA DLATAQVQPL QNMTGFPALA 

        70         80         90        100        110        120 
GPPAHSQLRA AVAHLRLRDL GADPGVATTP LGPEHMAQAS TLGLSPPSQA FPAHPEAPAA 

       130        140        150        160        170        180 
AARAAALVAH PGAGSYPCGG GSSGAQPSAP PPPAPPLPPT PSPPPPPPPP PPPALSGYTT 

       190        200        210        220        230        240 
TNSGGGGSSG KGHSRDFVLR RDLSATAPAA AMHGAPLGGE QRSGTGSPQH PAPPPHSAGM 

       250        260        270        280        290        300 
FISASGTYAG PDGSGGPALF PALHDTPGAP GGHPHPLNGQ MRLGLAAAAA AAAAELYGRA 

       310        320        330        340        350        360 
EPPFAPRSGD AHYGAVAAAA AAALHGYGAV NLNLNLAAAA AAAAAGPGPH LQHHAPPPAP 

       370        380        390        400        410        420 
PPPPAPAQHP HQHHPHLPGA AGAFLRYMRQ PIKQELICKW IDPDELAGLP PPPPPPPPPP 

       430        440        450        460        470        480 
PPPPAGGAKP CSKTFGTMHE LVNHVTVEHV GGPEQSSHVC FWEDCPREGK PFKAKYKLIN 

       490        500        510        520        530        540 
HIRVHTGEKP FPCPFPGCGK VFARSENLKI HKRTHTGEKP FKCEFDGCDR KFANSSDRKK 

       550        560        570        580        590        600 
HSHVHTSDKP YYCKIRGCDK SYTHPSSLRK HMKIHCKSPP PSPGPLGYSS VGTPVGAPLS 

       610        620        630        640        650        660 
PVLDPARSHS STLSPQVTNL NEWYVCQASG APSHLHTPSS NGTTSETEDE EIYGNPEVVR 


TIH 

« Hide

References

« Hide 'large scale' references
[1]"A novel human zinc finger gene, hZic5."
Gou D.M., Li W.X., Gao L., Sun Y.
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-600, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[4]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-600, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF378304 mRNA. Translation: AAK55418.1. Different initiation.
AL355338 Genomic DNA. Translation: CAH70366.2.
CCDSCCDS9494.2.
RefSeqNP_149123.2. NM_033132.3.
UniGeneHs.508570.

3D structure databases

ProteinModelPortalQ96T25.
SMRQ96T25. Positions 390-640.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124522. 1 interaction.
IntActQ96T25. 1 interaction.
MINTMINT-7969483.
STRING9606.ENSP00000267294.

PTM databases

PhosphoSiteQ96T25.

Polymorphism databases

DMDM327478546.

Proteomic databases

PaxDbQ96T25.
PRIDEQ96T25.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000267294; ENSP00000267294; ENSG00000139800.
GeneID85416.
KEGGhsa:85416.
UCSCuc001vom.1. human.

Organism-specific databases

CTD85416.
GeneCardsGC13M100615.
HGNCHGNC:20322. ZIC5.
neXtProtNX_Q96T25.
PharmGKBPA134941698.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000232057.
HOVERGENHBG007135.
InParanoidQ96T25.
KOK09226.
OMAGAYGHAE.
OrthoDBEOG76472R.
PhylomeDBQ96T25.
TreeFamTF351425.

Gene expression databases

BgeeQ96T25.
CleanExHS_ZIC5.
GenevestigatorQ96T25.

Family and domain databases

Gene3D3.30.160.60. 4 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 5 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi85416.
NextBio75994.
PROQ96T25.

Entry information

Entry nameZIC5_HUMAN
AccessionPrimary (citable) accession number: Q96T25
Secondary accession number(s): Q5VYB0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 5, 2011
Last modified: July 9, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM