Reviewed, UniProtKB/Swiss-Prot Q96T25 (ZIC5_HUMAN)

Names and origin

Protein names

Recommended name:
Zinc finger protein ZIC 5

Alternative name(s):
Zinc finger protein of the cerebellum 5

Gene names

Name:

ZIC5

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	639 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Essential for neural crest development, converting cells from an epidermal fate to a neural crest cell fate By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the GLI C2H2-type zinc-finger protein family. Contains 4 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Differentiation Neurogenesis
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Developmental protein
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 639	639	Zinc finger protein ZIC 5		PRO_0000047255
Regions
	Zinc finger	434 – 461	28	C2H2-type 1; atypical
	Zinc finger	467 – 491	25	C2H2-type 2
	Zinc finger	497 – 521	25	C2H2-type 3
	Zinc finger	527 – 551	25	C2H2-type 4
	Compositional bias	82 – 400	319	Pro-rich
	Compositional bias	262 – 321	60	Ala-rich
Amino acid modifications
	Modified residue	554	1	Phosphoserine Ref.3
	Modified residue	576	1	Phosphoserine Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q96T25-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: FB1E966ED28D38BF	FASTA	639	65,849
	10 20 30 40 50 60 MEPPLSKRNP PALRLADLAT AQVQPLQNMT GFPALAGPPA HSQLRAAVAH LRLRDLGADP 70 80 90 100 110 120 GVATTPLGPE HMAQASTLGL SPPSQAFPAH PEAPAAAARA AALVAHPGAG SYPCGGGSSG 130 140 150 160 170 180 AQPSAPPPPA PPLPPTPSPP PPPPPPPPPA LSGYTTTNSG GGGSSGKGHS RDFVLRRDLS 190 200 210 220 230 240 ATAPAAAMHG APLGGEQRSG TGSPQHPAPP PHSAGMFISA SGTYAGPDGS GGPALFPALH 250 260 270 280 290 300 DTPGAPGGHP HPLNGQMRLG LAAAAAAAAA ELYGRAEPPF APRSGDAHYG AVAAAAAAAL 310 320 330 340 350 360 HGYGAVNLNL NLAAAAAAAA AGPGPHLQHH APPPAPPPPP APAQHPHQHH PHLPGAAGAF 370 380 390 400 410 420 LRYMRQPIKQ ELICKWIDPD ELAGLPPPPP PPPPPPPPPP AGGAKPCSKT FGTMHELVNH 430 440 450 460 470 480 VTVEHVGGPE QSSHVCFWED CPREGKPFKA KYKLINHIRV HTGEKPFPCP FPGCGKVFAR 490 500 510 520 530 540 SENLKIHKRT HTGEKPFKCE FDGCDRKFAN SSDRKKHSHV HTSDKPYYCK IRGCDKSYTH 550 560 570 580 590 600 PSSLRKHMKI HCKSPPPSPG PLGYSSVGTP VGAPLSPVLD PARSHSSTLS PQVTNLNEWY 610 620 630 VCQASGAPSH LHTPSSNGTT SETEDEEIYG NPEVVRTIH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel human zinc finger gene, hZic5." Gou D.M., Li W.X., Gao L., Sun Y. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-554 AND SER-576, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF378304 mRNA. Translation: AAK55418.1. AL355338 Genomic DNA. Translation: CAH70366.2.
IPI	IPI00163395.
RefSeq	NP_149123.2.
UniGene	Hs.508570
3D structure databases
SMR	Q96T25. Positions 366-468, 405-551.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96T25.
PTM databases
PhosphoSite	Q96T25.
Proteomic databases
PRIDE	Q96T25.
Genome annotation databases
Ensembl	ENST00000267294; ENSP00000267294; ENSG00000139800; Homo sapiens. [Genome view]
GeneID	85416.
KEGG	hsa:85416.
UCSC	uc001vom.1. human.
Organism-specific databases
CTD	85416.
GeneCards	GC13M099415.
HGNC	HGNC:20322. ZIC5.
PharmGKB	PA134941698.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG19187.
HOGENOM	HBG506538.
HOVERGEN	HBG007135.
InParanoid	Q96T25.
PhylomeDB	Q96T25.
Gene expression databases
ArrayExpress	Q96T25.
Bgee	Q96T25.
CleanEx	HS_ZIC5.
Genevestigator	Q96T25.
GermOnline	ENSG00000139800. Homo sapiens.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 3 hits.
Pfam	PF00096. zf-C2H2. 1 hit. [Graphical view]
SMART	SM00355. ZnF_C2H2. 5 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	75994.

Entry information

Entry name

ZIC5_HUMAN

Accession

Primary (citable) accession number: Q96T25
Secondary accession number(s): Q5VYB0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 23, 2003
Last sequence update:	December 1, 2001
Last modified:	March 2, 2010
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.