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Q96SZ6

- CK5P1_HUMAN

UniProt

Q96SZ6 - CK5P1_HUMAN

Protein

CDK5 regulatory subunit-associated protein 1

Gene

CDK5RAP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (16 Jun 2003)
      Previous versions | rss
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    Functioni

    Specifically inhibits CDK5 activation by CDK5R1.

    Cofactori

    Binds 2 4Fe-4S clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi109 – 1091Iron-sulfur (4Fe-4S)By similarity
    Metal bindingi145 – 1451Iron-sulfur (4Fe-4S)By similarity
    Metal bindingi183 – 1831Iron-sulfur (4Fe-4S)By similarity
    Metal bindingi258 – 2581Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
    Metal bindingi262 – 2621Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
    Metal bindingi265 – 2651Iron-sulfur (4Fe-4S-S-AdoMet)By similarity

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein kinase binding Source: UniProtKB
    4. transferase activity Source: InterPro

    GO - Biological processi

    1. brain development Source: UniProtKB
    2. negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB
    3. regulation of neuron differentiation Source: UniProtKB
    4. tRNA modification Source: InterPro

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CDK5 regulatory subunit-associated protein 1
    Alternative name(s):
    CDK5 activator-binding protein C42
    Gene namesi
    Name:CDK5RAP1
    Synonyms:C20orf34
    ORF Names:CGI-05, HSPC167
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:15880. CDK5RAP1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26313.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 601601CDK5 regulatory subunit-associated protein 1PRO_0000141764Add
    BLAST

    Proteomic databases

    MaxQBiQ96SZ6.
    PaxDbiQ96SZ6.
    PRIDEiQ96SZ6.

    PTM databases

    PhosphoSiteiQ96SZ6.

    Expressioni

    Tissue specificityi

    Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.1 Publication

    Gene expression databases

    ArrayExpressiQ96SZ6.
    BgeeiQ96SZ6.
    CleanExiHS_CDK5RAP1.
    GenevestigatoriQ96SZ6.

    Interactioni

    Subunit structurei

    Interacts with CDK5R1 (p35 form). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1. Forms a complex with CDK5R1 and CDK5.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EXOSC3Q9NQT51EBI-372956,EBI-371866
    EXOSC5Q9NQT41EBI-372956,EBI-371876

    Protein-protein interaction databases

    BioGridi119661. 6 interactions.
    IntActiQ96SZ6. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96SZ6.
    SMRiQ96SZ6. Positions 272-528.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini100 – 220121MTTase N-terminalAdd
    BLAST
    Domaini515 – 59076TRAMAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni22 – 157136CDK5 activation inhibitionAdd
    BLAST
    Regioni475 – 586112CDK5R1-bindingAdd
    BLAST

    Sequence similaritiesi

    Contains 1 MTTase N-terminal domain.Curated
    Contains 1 TRAM domain.Curated

    Phylogenomic databases

    eggNOGiCOG0621.
    HOVERGENiHBG050975.
    InParanoidiQ96SZ6.
    OMAiIEVYKDT.
    OrthoDBiEOG744T8N.
    PhylomeDBiQ96SZ6.
    TreeFamiTF101033.

    Family and domain databases

    Gene3Di3.80.30.20. 1 hit.
    HAMAPiMF_01864. tRNA_metthiotr_MiaB.
    InterProiIPR006638. Elp3/MiaB/NifB.
    IPR023970. MeThioTfrase/rSAM.
    IPR005839. Methylthiotransferase.
    IPR020612. Methylthiotransferase_CS.
    IPR013848. Methylthiotransferase_N.
    IPR006463. MiaB_methiolase.
    IPR007197. rSAM.
    IPR023404. rSAM_horseshoe.
    IPR002792. TRAM_dom.
    [Graphical view]
    PANTHERiPTHR11918. PTHR11918. 1 hit.
    PfamiPF04055. Radical_SAM. 1 hit.
    PF01938. TRAM. 1 hit.
    PF00919. UPF0004. 1 hit.
    [Graphical view]
    SMARTiSM00729. Elp3. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00089. TIGR00089. 1 hit.
    PROSITEiPS51449. MTTASE_N. 1 hit.
    PS01278. MTTASE_RADICAL. 1 hit.
    PS50926. TRAM. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96SZ6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MHPLQCVLQV QRSLGWGPLA SVSWLSLRMC RAHSSLSSTM CPSPERQEDG    50
    ARKDFSSRLA AGPTFQHFLK SASAPQEKLS SEVEDPPPYL MMDELLGRQR 100
    KVYLETYGCQ MNVNDTEIAW SILQKSGYLR TSNLQEADVI LLVTCSIREK 150
    AEQTIWNRLH QLKALKTRRP RSRVPLRIGI LGCMAERLKE EILNREKMVD 200
    ILAGPDAYRD LPRLLAVAES GQQAANVLLS LDETYADVMP VQTSASATSA 250
    FVSIMRGCDN MCSYCIVPFT RGRERSRPIA SILEEVKKLS EQVFLPPRPP 300
    KVLGLQGLKE VTLLGQNVNS FRDNSEVQFN SAVPTNLSRG FTTNYKTKQG 350
    GLRFAHLLDQ VSRVDPEMRI RFTSPHPKDF PDEVLQLIHE RDNICKQIHL 400
    PAQSGSSRVL EAMRRGYSRE AYVELVHHIR ESIPGVSLSS DFIAGFCGET 450
    EEDHVQTVSL LREVQYNMGF LFAYSMRQKT RAYHRLKDDV PEEVKLRRLE 500
    ELITIFREEA TKANQTSVGC TQLVLVEGLS KRSATDLCGR NDGNLKVIFP 550
    DAEMEDVNNP GLRVRAQPGD YVLVKITSAS SQTLRGHVLC RTTLRDSSAY 600
    C 601

    Note: May be due to intron retention. No experimental confirmation available.

    Length:601
    Mass (Da):67,689
    Last modified:June 16, 2003 - v2
    Checksum:i4AEBFD7DA5400902
    GO
    Isoform 2 (identifier: Q96SZ6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-90: Missing.
         293-306: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:497
    Mass (Da):56,223
    Checksum:iC8FFBA14A5C3EB09
    GO
    Isoform 3 (identifier: Q96SZ6-3) [UniParc]FASTAAdd to Basket

    Also known as: a

    The sequence of this isoform differs from the canonical sequence as follows:
         293-306: Missing.

    Show »
    Length:587
    Mass (Da):66,146
    Checksum:i314E826B35C346EB
    GO
    Isoform 4 (identifier: Q96SZ6-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         293-383: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:510
    Mass (Da):57,413
    Checksum:i8F0DFB3B71E135BB
    GO
    Isoform 5 (identifier: Q96SZ6-5) [UniParc]FASTAAdd to Basket

    Also known as: CDK5RAP1_v4

    The sequence of this isoform differs from the canonical sequence as follows:
         292-305: Missing.
         435-440: GVSLSS → EDTGIS
         441-601: Missing.

    Note: Mainly expressed in brain, placenta and testis.

    Show »
    Length:426
    Mass (Da):48,072
    Checksum:iD74ADCD179EA4FDC
    GO
    Isoform 6 (identifier: Q96SZ6-6) [UniParc]FASTAAdd to Basket

    Also known as: CDK5RAP1_v3

    The sequence of this isoform differs from the canonical sequence as follows:
         292-305: Missing.
         576-601: ITSASSQTLRGHVLCRTTLRDSSAYC → VRSPFGLLACTVK

    Note: High expression in placenta and lung.

    Show »
    Length:574
    Mass (Da):64,709
    Checksum:iA542DA7E2496A56B
    GO

    Sequence cautioni

    The sequence AAD34147.1 differs from that shown. Reason: Frameshift at positions 3, 32, 128, 133 and 569.
    The sequence AAF29131.1 differs from that shown. Reason: Frameshift at positions 213, 244, 267 and 282.
    The sequence BAB55120.1 differs from that shown. Reason: Erroneous termination at position 500. Translated as Glu.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti213 – 2131R → Q in AAH01215. (PubMed:15489334)Curated
    Sequence conflicti217 – 2171V → D(PubMed:11042152)Curated
    Sequence conflicti269 – 2691F → L in BAB55120. (PubMed:14702039)Curated
    Sequence conflicti282 – 2821I → T in BAB55120. (PubMed:14702039)Curated
    Sequence conflicti323 – 3231D → G in BAB55120. (PubMed:14702039)Curated
    Sequence conflicti464 – 4641V → A in BAB14760. (PubMed:14702039)Curated
    Sequence conflicti511 – 5111T → S in AAF29131. (PubMed:11042152)Curated
    Sequence conflicti579 – 5791Missing(PubMed:10810093)Curated
    Sequence conflicti585 – 5851R → K in BAB14760. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9090Missing in isoform 2. 1 PublicationVSP_007560Add
    BLAST
    Alternative sequencei292 – 30514Missing in isoform 5 and isoform 6. 1 PublicationVSP_047799Add
    BLAST
    Alternative sequencei293 – 38391Missing in isoform 4. 1 PublicationVSP_007561Add
    BLAST
    Alternative sequencei293 – 30614Missing in isoform 2 and isoform 3. 2 PublicationsVSP_007562Add
    BLAST
    Alternative sequencei435 – 4406GVSLSS → EDTGIS in isoform 5. 1 PublicationVSP_047800
    Alternative sequencei441 – 601161Missing in isoform 5. 1 PublicationVSP_047801Add
    BLAST
    Alternative sequencei576 – 60126ITSAS…SSAYC → VRSPFGLLACTVK in isoform 6. 1 PublicationVSP_047802Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF152097 mRNA. Translation: AAD34147.1. Frameshift.
    AF161516 mRNA. Translation: AAF29131.1. Frameshift.
    AY462283 mRNA. Translation: AAS18317.1.
    AY462284 mRNA. Translation: AAS18318.1.
    AK023992 mRNA. Translation: BAB14760.1.
    AK027449 mRNA. Translation: BAB55120.1. Sequence problems.
    AK292075 mRNA. Translation: BAF84764.1.
    AL355392 Genomic DNA. Translation: CAI19392.1.
    AL355392 Genomic DNA. Translation: CAI19393.1.
    AL355392 Genomic DNA. Translation: CAI19394.1.
    CH471077 Genomic DNA. Translation: EAW76319.1.
    CH471077 Genomic DNA. Translation: EAW76322.1.
    CH471077 Genomic DNA. Translation: EAW76323.1.
    BC001215 mRNA. Translation: AAH01215.1.
    BC050706 mRNA. Translation: AAH50706.1.
    CCDSiCCDS13219.1. [Q96SZ6-3]
    CCDS63255.1. [Q96SZ6-4]
    RefSeqiNP_001265097.1. NM_001278168.1. [Q96SZ6-4]
    NP_001265098.1. NM_001278169.1.
    NP_057166.4. NM_016082.4.
    NP_057492.2. NM_016408.3. [Q96SZ6-3]
    UniGeneiHs.435952.

    Genome annotation databases

    EnsembliENST00000339269; ENSP00000341840; ENSG00000101391. [Q96SZ6-4]
    ENST00000346416; ENSP00000217372; ENSG00000101391. [Q96SZ6-3]
    ENST00000357886; ENSP00000350558; ENSG00000101391. [Q96SZ6-1]
    ENST00000473997; ENSP00000476857; ENSG00000101391. [Q96SZ6-2]
    GeneIDi51654.
    KEGGihsa:51654.
    UCSCiuc002wyy.4. human. [Q96SZ6-3]
    uc010gek.4. human. [Q96SZ6-1]
    uc010gem.4. human. [Q96SZ6-4]

    Polymorphism databases

    DMDMi32129446.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF152097 mRNA. Translation: AAD34147.1 . Frameshift.
    AF161516 mRNA. Translation: AAF29131.1 . Frameshift.
    AY462283 mRNA. Translation: AAS18317.1 .
    AY462284 mRNA. Translation: AAS18318.1 .
    AK023992 mRNA. Translation: BAB14760.1 .
    AK027449 mRNA. Translation: BAB55120.1 . Sequence problems.
    AK292075 mRNA. Translation: BAF84764.1 .
    AL355392 Genomic DNA. Translation: CAI19392.1 .
    AL355392 Genomic DNA. Translation: CAI19393.1 .
    AL355392 Genomic DNA. Translation: CAI19394.1 .
    CH471077 Genomic DNA. Translation: EAW76319.1 .
    CH471077 Genomic DNA. Translation: EAW76322.1 .
    CH471077 Genomic DNA. Translation: EAW76323.1 .
    BC001215 mRNA. Translation: AAH01215.1 .
    BC050706 mRNA. Translation: AAH50706.1 .
    CCDSi CCDS13219.1. [Q96SZ6-3 ]
    CCDS63255.1. [Q96SZ6-4 ]
    RefSeqi NP_001265097.1. NM_001278168.1. [Q96SZ6-4 ]
    NP_001265098.1. NM_001278169.1.
    NP_057166.4. NM_016082.4.
    NP_057492.2. NM_016408.3. [Q96SZ6-3 ]
    UniGenei Hs.435952.

    3D structure databases

    ProteinModelPortali Q96SZ6.
    SMRi Q96SZ6. Positions 272-528.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119661. 6 interactions.
    IntActi Q96SZ6. 2 interactions.

    PTM databases

    PhosphoSitei Q96SZ6.

    Polymorphism databases

    DMDMi 32129446.

    Proteomic databases

    MaxQBi Q96SZ6.
    PaxDbi Q96SZ6.
    PRIDEi Q96SZ6.

    Protocols and materials databases

    DNASUi 51654.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000339269 ; ENSP00000341840 ; ENSG00000101391 . [Q96SZ6-4 ]
    ENST00000346416 ; ENSP00000217372 ; ENSG00000101391 . [Q96SZ6-3 ]
    ENST00000357886 ; ENSP00000350558 ; ENSG00000101391 . [Q96SZ6-1 ]
    ENST00000473997 ; ENSP00000476857 ; ENSG00000101391 . [Q96SZ6-2 ]
    GeneIDi 51654.
    KEGGi hsa:51654.
    UCSCi uc002wyy.4. human. [Q96SZ6-3 ]
    uc010gek.4. human. [Q96SZ6-1 ]
    uc010gem.4. human. [Q96SZ6-4 ]

    Organism-specific databases

    CTDi 51654.
    GeneCardsi GC20M031946.
    HGNCi HGNC:15880. CDK5RAP1.
    MIMi 608200. gene.
    neXtProti NX_Q96SZ6.
    PharmGKBi PA26313.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0621.
    HOVERGENi HBG050975.
    InParanoidi Q96SZ6.
    OMAi IEVYKDT.
    OrthoDBi EOG744T8N.
    PhylomeDBi Q96SZ6.
    TreeFami TF101033.

    Miscellaneous databases

    ChiTaRSi CDK5RAP1. human.
    GeneWikii CDK5RAP1.
    GenomeRNAii 51654.
    NextBioi 55620.
    PROi Q96SZ6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96SZ6.
    Bgeei Q96SZ6.
    CleanExi HS_CDK5RAP1.
    Genevestigatori Q96SZ6.

    Family and domain databases

    Gene3Di 3.80.30.20. 1 hit.
    HAMAPi MF_01864. tRNA_metthiotr_MiaB.
    InterProi IPR006638. Elp3/MiaB/NifB.
    IPR023970. MeThioTfrase/rSAM.
    IPR005839. Methylthiotransferase.
    IPR020612. Methylthiotransferase_CS.
    IPR013848. Methylthiotransferase_N.
    IPR006463. MiaB_methiolase.
    IPR007197. rSAM.
    IPR023404. rSAM_horseshoe.
    IPR002792. TRAM_dom.
    [Graphical view ]
    PANTHERi PTHR11918. PTHR11918. 1 hit.
    Pfami PF04055. Radical_SAM. 1 hit.
    PF01938. TRAM. 1 hit.
    PF00919. UPF0004. 1 hit.
    [Graphical view ]
    SMARTi SM00729. Elp3. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00089. TIGR00089. 1 hit.
    PROSITEi PS51449. MTTASE_N. 1 hit.
    PS01278. MTTASE_RADICAL. 1 hit.
    PS50926. TRAM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Umbilical cord blood.
    3. "Cloning, characterization and expression of CDK5RAP1_v3 and CDK5RAP1_v4, two novel splice variants of human CDK5RAP1."
      Zou X., Ji C., Jin F., Liu J., Wu M., Zheng H., Wang Y., Li X., Xu J., Gu S., Xie Y., Mao Y.
      Genes Genet. Syst. 79:177-182(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5 AND 6).
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Retinoblastoma, Stomach and Teratocarcinoma.
    5. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Duodenum and Lung.
    8. "Cloning of three novel neuronal Cdk5 activator binding proteins."
      Ching Y.-P., Qi Z., Wang J.H.
      Gene 242:285-294(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    9. "Identification of a neuronal Cdk5 activator-binding protein as Cdk5 inhibitor."
      Ching Y.-P., Pang A.S.H., Lam W.-H., Qi R.Z., Wang J.H.
      J. Biol. Chem. 277:15237-15240(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CDK5 AND CDK5R1.

    Entry informationi

    Entry nameiCK5P1_HUMAN
    AccessioniPrimary (citable) accession number: Q96SZ6
    Secondary accession number(s): A8K7R0
    , Q5QP46, Q5QP47, Q5QP48, Q675N4, Q675N5, Q9BVG6, Q9BWZ5, Q9H859, Q9NZZ9, Q9Y3F0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2003
    Last sequence update: June 16, 2003
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3