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Q96SZ5

- AEDO_HUMAN

UniProt

Q96SZ5 - AEDO_HUMAN

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Protein

2-aminoethanethiol dioxygenase

Gene
ADO, C10orf22
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

2-aminoethanethiol + O2 = hypotaurine.1 Publication

Cofactori

Iron By similarity.

GO - Molecular functioni

  1. cysteamine dioxygenase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS17749-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
2-aminoethanethiol dioxygenase (EC:1.13.11.19)
Alternative name(s):
Cysteamine dioxygenase
Gene namesi
Name:ADO
Synonyms:C10orf22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:23506. ADO.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162375713.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2702702-aminoethanethiol dioxygenasePRO_0000089784Add
BLAST

Proteomic databases

MaxQBiQ96SZ5.
PaxDbiQ96SZ5.
PRIDEiQ96SZ5.

PTM databases

PhosphoSiteiQ96SZ5.

Expressioni

Gene expression databases

BgeeiQ96SZ5.
CleanExiHS_ADO.
GenevestigatoriQ96SZ5.

Organism-specific databases

HPAiHPA039194.
HPA040437.

Interactioni

Protein-protein interaction databases

BioGridi124330. 1 interaction.
STRINGi9606.ENSP00000362888.

Structurei

3D structure databases

ProteinModelPortaliQ96SZ5.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG301373.
HOGENOMiHOG000037604.
HOVERGENiHBG050966.
InParanoidiQ96SZ5.
KOiK10712.
OMAiPPGFPEN.
OrthoDBiEOG7NKKMH.
PhylomeDBiQ96SZ5.
TreeFamiTF314673.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR012864. Cysteamine_dioxygenase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF07847. DUF1637. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96SZ5-1 [UniParc]FASTAAdd to Basket

« Hide

MPRDNMASLI QRIARQACLT FRGSGGGRGA SDRDAASGPE APMQPGFPEN    50
LSKLKSLLTQ LRAEDLNIAP RKATLQPLPP NLPPVTYMHI YETDGFSLGV 100
FLLKSGTSIP LHDHPGMHGM LKVLYGTVRI SCMDKLDAGG GQRPRALPPE 150
QQFEPPLQPR EREAVRPGVL RSRAEYTEAS GPCILTPHRD NLHQIDAVEG 200
PAAFLDILAP PYDPDDGRDC HYYRVLEPVR PKEASSSACD LPREVWLLET 250
PQADDFWCEG EPYPGPKVFP 270
Length:270
Mass (Da):29,751
Last modified:February 21, 2006 - v2
Checksum:i6B496CCF16E92C9D
GO

Sequence cautioni

The sequence BAB55123.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti25 – 251G → W.1 Publication
Corresponds to variant rs2236295 [ dbSNP | Ensembl ].
VAR_025333
Natural varianti39 – 391P → A.2 Publications
Corresponds to variant rs10995311 [ dbSNP | Ensembl ].
VAR_025334
Natural varianti266 – 2661P → S.
Corresponds to variant rs569705 [ dbSNP | Ensembl ].
VAR_033691

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL133417 Genomic DNA. Translation: CAH73826.2.
CH471083 Genomic DNA. Translation: EAW54235.1.
BC018660 mRNA. Translation: AAH18660.3.
BC028589 mRNA. Translation: AAH28589.2.
BC067740 mRNA. Translation: AAH67740.2.
AK027453 mRNA. Translation: BAB55123.1. Different initiation.
CCDSiCCDS7266.2.
RefSeqiNP_116193.2. NM_032804.5.
UniGeneiHs.99821.

Genome annotation databases

EnsembliENST00000373783; ENSP00000362888; ENSG00000181915.
GeneIDi84890.
KEGGihsa:84890.
UCSCiuc001jmg.3. human.

Polymorphism databases

DMDMi88984104.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL133417 Genomic DNA. Translation: CAH73826.2 .
CH471083 Genomic DNA. Translation: EAW54235.1 .
BC018660 mRNA. Translation: AAH18660.3 .
BC028589 mRNA. Translation: AAH28589.2 .
BC067740 mRNA. Translation: AAH67740.2 .
AK027453 mRNA. Translation: BAB55123.1 . Different initiation.
CCDSi CCDS7266.2.
RefSeqi NP_116193.2. NM_032804.5.
UniGenei Hs.99821.

3D structure databases

ProteinModelPortali Q96SZ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124330. 1 interaction.
STRINGi 9606.ENSP00000362888.

PTM databases

PhosphoSitei Q96SZ5.

Polymorphism databases

DMDMi 88984104.

Proteomic databases

MaxQBi Q96SZ5.
PaxDbi Q96SZ5.
PRIDEi Q96SZ5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373783 ; ENSP00000362888 ; ENSG00000181915 .
GeneIDi 84890.
KEGGi hsa:84890.
UCSCi uc001jmg.3. human.

Organism-specific databases

CTDi 84890.
GeneCardsi GC10P064564.
H-InvDB HIX0008860.
HGNCi HGNC:23506. ADO.
HPAi HPA039194.
HPA040437.
MIMi 611392. gene.
neXtProti NX_Q96SZ5.
PharmGKBi PA162375713.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG301373.
HOGENOMi HOG000037604.
HOVERGENi HBG050966.
InParanoidi Q96SZ5.
KOi K10712.
OMAi PPGFPEN.
OrthoDBi EOG7NKKMH.
PhylomeDBi Q96SZ5.
TreeFami TF314673.

Enzyme and pathway databases

BioCyci MetaCyc:HS17749-MONOMER.

Miscellaneous databases

GenomeRNAii 84890.
NextBioi 75218.
PROi Q96SZ5.
SOURCEi Search...

Gene expression databases

Bgeei Q96SZ5.
CleanExi HS_ADO.
Genevestigatori Q96SZ5.

Family and domain databases

Gene3Di 2.60.120.10. 1 hit.
InterProi IPR012864. Cysteamine_dioxygenase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
Pfami PF07847. DUF1637. 1 hit.
[Graphical view ]
SUPFAMi SSF51182. SSF51182. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS TRP-25 AND ALA-39.
    Tissue: Brain and Testis.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 35-270, VARIANT ALA-39.
    Tissue: Teratocarcinoma.
  5. "Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase."
    Dominy J.E. Jr., Simmons C.R., Hirschberger L.L., Hwang J., Coloso R.M., Stipanuk M.H.
    J. Biol. Chem. 282:25189-25198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: CATALYTIC ACTIVITY.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAEDO_HUMAN
AccessioniPrimary (citable) accession number: Q96SZ5
Secondary accession number(s): B1AL29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: February 21, 2006
Last modified: July 9, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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