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Q96SZ5

- AEDO_HUMAN

UniProt

Q96SZ5 - AEDO_HUMAN

Protein

2-aminoethanethiol dioxygenase

Gene

ADO

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (21 Feb 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    2-aminoethanethiol + O2 = hypotaurine.1 Publication

    Cofactori

    Iron.By similarity

    GO - Molecular functioni

    1. cysteamine dioxygenase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:HS17749-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-aminoethanethiol dioxygenase (EC:1.13.11.19)
    Alternative name(s):
    Cysteamine dioxygenase
    Gene namesi
    Name:ADO
    Synonyms:C10orf22
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:23506. ADO.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162375713.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2702702-aminoethanethiol dioxygenasePRO_0000089784Add
    BLAST

    Proteomic databases

    MaxQBiQ96SZ5.
    PaxDbiQ96SZ5.
    PRIDEiQ96SZ5.

    PTM databases

    PhosphoSiteiQ96SZ5.

    Expressioni

    Gene expression databases

    BgeeiQ96SZ5.
    CleanExiHS_ADO.
    GenevestigatoriQ96SZ5.

    Organism-specific databases

    HPAiHPA039194.
    HPA040437.

    Interactioni

    Protein-protein interaction databases

    BioGridi124330. 1 interaction.
    STRINGi9606.ENSP00000362888.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96SZ5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG301373.
    HOGENOMiHOG000037604.
    HOVERGENiHBG050966.
    InParanoidiQ96SZ5.
    KOiK10712.
    OMAiPPGFPEN.
    OrthoDBiEOG7NKKMH.
    PhylomeDBiQ96SZ5.
    TreeFamiTF314673.

    Family and domain databases

    Gene3Di2.60.120.10. 1 hit.
    InterProiIPR012864. Cysteamine_dioxygenase.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PfamiPF07847. DUF1637. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q96SZ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRDNMASLI QRIARQACLT FRGSGGGRGA SDRDAASGPE APMQPGFPEN    50
    LSKLKSLLTQ LRAEDLNIAP RKATLQPLPP NLPPVTYMHI YETDGFSLGV 100
    FLLKSGTSIP LHDHPGMHGM LKVLYGTVRI SCMDKLDAGG GQRPRALPPE 150
    QQFEPPLQPR EREAVRPGVL RSRAEYTEAS GPCILTPHRD NLHQIDAVEG 200
    PAAFLDILAP PYDPDDGRDC HYYRVLEPVR PKEASSSACD LPREVWLLET 250
    PQADDFWCEG EPYPGPKVFP 270
    Length:270
    Mass (Da):29,751
    Last modified:February 21, 2006 - v2
    Checksum:i6B496CCF16E92C9D
    GO

    Sequence cautioni

    The sequence BAB55123.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti25 – 251G → W.1 Publication
    Corresponds to variant rs2236295 [ dbSNP | Ensembl ].
    VAR_025333
    Natural varianti39 – 391P → A.2 Publications
    Corresponds to variant rs10995311 [ dbSNP | Ensembl ].
    VAR_025334
    Natural varianti266 – 2661P → S.
    Corresponds to variant rs569705 [ dbSNP | Ensembl ].
    VAR_033691

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL133417 Genomic DNA. Translation: CAH73826.2.
    CH471083 Genomic DNA. Translation: EAW54235.1.
    BC018660 mRNA. Translation: AAH18660.3.
    BC028589 mRNA. Translation: AAH28589.2.
    BC067740 mRNA. Translation: AAH67740.2.
    AK027453 mRNA. Translation: BAB55123.1. Different initiation.
    CCDSiCCDS7266.2.
    RefSeqiNP_116193.2. NM_032804.5.
    UniGeneiHs.99821.

    Genome annotation databases

    EnsembliENST00000373783; ENSP00000362888; ENSG00000181915.
    GeneIDi84890.
    KEGGihsa:84890.
    UCSCiuc001jmg.3. human.

    Polymorphism databases

    DMDMi88984104.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL133417 Genomic DNA. Translation: CAH73826.2 .
    CH471083 Genomic DNA. Translation: EAW54235.1 .
    BC018660 mRNA. Translation: AAH18660.3 .
    BC028589 mRNA. Translation: AAH28589.2 .
    BC067740 mRNA. Translation: AAH67740.2 .
    AK027453 mRNA. Translation: BAB55123.1 . Different initiation.
    CCDSi CCDS7266.2.
    RefSeqi NP_116193.2. NM_032804.5.
    UniGenei Hs.99821.

    3D structure databases

    ProteinModelPortali Q96SZ5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124330. 1 interaction.
    STRINGi 9606.ENSP00000362888.

    PTM databases

    PhosphoSitei Q96SZ5.

    Polymorphism databases

    DMDMi 88984104.

    Proteomic databases

    MaxQBi Q96SZ5.
    PaxDbi Q96SZ5.
    PRIDEi Q96SZ5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373783 ; ENSP00000362888 ; ENSG00000181915 .
    GeneIDi 84890.
    KEGGi hsa:84890.
    UCSCi uc001jmg.3. human.

    Organism-specific databases

    CTDi 84890.
    GeneCardsi GC10P064564.
    H-InvDB HIX0008860.
    HGNCi HGNC:23506. ADO.
    HPAi HPA039194.
    HPA040437.
    MIMi 611392. gene.
    neXtProti NX_Q96SZ5.
    PharmGKBi PA162375713.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG301373.
    HOGENOMi HOG000037604.
    HOVERGENi HBG050966.
    InParanoidi Q96SZ5.
    KOi K10712.
    OMAi PPGFPEN.
    OrthoDBi EOG7NKKMH.
    PhylomeDBi Q96SZ5.
    TreeFami TF314673.

    Enzyme and pathway databases

    BioCyci MetaCyc:HS17749-MONOMER.

    Miscellaneous databases

    GenomeRNAii 84890.
    NextBioi 75218.
    PROi Q96SZ5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96SZ5.
    CleanExi HS_ADO.
    Genevestigatori Q96SZ5.

    Family and domain databases

    Gene3Di 2.60.120.10. 1 hit.
    InterProi IPR012864. Cysteamine_dioxygenase.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    Pfami PF07847. DUF1637. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS TRP-25 AND ALA-39.
      Tissue: Brain and Testis.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 35-270, VARIANT ALA-39.
      Tissue: Teratocarcinoma.
    5. "Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase."
      Dominy J.E. Jr., Simmons C.R., Hirschberger L.L., Hwang J., Coloso R.M., Stipanuk M.H.
      J. Biol. Chem. 282:25189-25198(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: CATALYTIC ACTIVITY.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiAEDO_HUMAN
    AccessioniPrimary (citable) accession number: Q96SZ5
    Secondary accession number(s): B1AL29
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: February 21, 2006
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3