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Protein

2-aminoethanethiol dioxygenase

Gene

ADO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

2-aminoethanethiol + O2 = hypotaurine.1 Publication

Cofactori

Fe cationBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:HS17749-MONOMER.
BRENDAi1.13.11.19. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
2-aminoethanethiol dioxygenase (EC:1.13.11.19)
Alternative name(s):
Cysteamine dioxygenase
Gene namesi
Name:ADO
Synonyms:C10orf22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23506. ADO.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162375713.

Polymorphism and mutation databases

BioMutaiADO.
DMDMi88984104.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2702702-aminoethanethiol dioxygenasePRO_0000089784Add
BLAST

Proteomic databases

MaxQBiQ96SZ5.
PaxDbiQ96SZ5.
PRIDEiQ96SZ5.

PTM databases

PhosphoSiteiQ96SZ5.

Expressioni

Gene expression databases

BgeeiQ96SZ5.
CleanExiHS_ADO.
GenevisibleiQ96SZ5. HS.

Organism-specific databases

HPAiHPA039194.
HPA040437.

Interactioni

Protein-protein interaction databases

BioGridi124330. 4 interactions.
STRINGi9606.ENSP00000362888.

Structurei

3D structure databases

ProteinModelPortaliQ96SZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG301373.
GeneTreeiENSGT00390000014082.
HOGENOMiHOG000037604.
HOVERGENiHBG050966.
InParanoidiQ96SZ5.
KOiK10712.
OMAiCETDGFS.
OrthoDBiEOG7NKKMH.
PhylomeDBiQ96SZ5.
TreeFamiTF314673.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR012864. PCO/ADO.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF07847. DUF1637. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96SZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRDNMASLI QRIARQACLT FRGSGGGRGA SDRDAASGPE APMQPGFPEN
60 70 80 90 100
LSKLKSLLTQ LRAEDLNIAP RKATLQPLPP NLPPVTYMHI YETDGFSLGV
110 120 130 140 150
FLLKSGTSIP LHDHPGMHGM LKVLYGTVRI SCMDKLDAGG GQRPRALPPE
160 170 180 190 200
QQFEPPLQPR EREAVRPGVL RSRAEYTEAS GPCILTPHRD NLHQIDAVEG
210 220 230 240 250
PAAFLDILAP PYDPDDGRDC HYYRVLEPVR PKEASSSACD LPREVWLLET
260 270
PQADDFWCEG EPYPGPKVFP
Length:270
Mass (Da):29,751
Last modified:February 21, 2006 - v2
Checksum:i6B496CCF16E92C9D
GO

Sequence cautioni

The sequence BAB55123.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti25 – 251G → W.1 Publication
Corresponds to variant rs2236295 [ dbSNP | Ensembl ].
VAR_025333
Natural varianti39 – 391P → A.2 Publications
Corresponds to variant rs10995311 [ dbSNP | Ensembl ].
VAR_025334
Natural varianti266 – 2661P → S.
Corresponds to variant rs569705 [ dbSNP | Ensembl ].
VAR_033691

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133417 Genomic DNA. Translation: CAH73826.2.
CH471083 Genomic DNA. Translation: EAW54235.1.
BC018660 mRNA. Translation: AAH18660.3.
BC028589 mRNA. Translation: AAH28589.2.
BC067740 mRNA. Translation: AAH67740.2.
AK027453 mRNA. Translation: BAB55123.1. Different initiation.
CCDSiCCDS7266.2.
RefSeqiNP_116193.2. NM_032804.5.
UniGeneiHs.99821.

Genome annotation databases

EnsembliENST00000373783; ENSP00000362888; ENSG00000181915.
GeneIDi84890.
KEGGihsa:84890.
UCSCiuc001jmg.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133417 Genomic DNA. Translation: CAH73826.2.
CH471083 Genomic DNA. Translation: EAW54235.1.
BC018660 mRNA. Translation: AAH18660.3.
BC028589 mRNA. Translation: AAH28589.2.
BC067740 mRNA. Translation: AAH67740.2.
AK027453 mRNA. Translation: BAB55123.1. Different initiation.
CCDSiCCDS7266.2.
RefSeqiNP_116193.2. NM_032804.5.
UniGeneiHs.99821.

3D structure databases

ProteinModelPortaliQ96SZ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124330. 4 interactions.
STRINGi9606.ENSP00000362888.

PTM databases

PhosphoSiteiQ96SZ5.

Polymorphism and mutation databases

BioMutaiADO.
DMDMi88984104.

Proteomic databases

MaxQBiQ96SZ5.
PaxDbiQ96SZ5.
PRIDEiQ96SZ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373783; ENSP00000362888; ENSG00000181915.
GeneIDi84890.
KEGGihsa:84890.
UCSCiuc001jmg.3. human.

Organism-specific databases

CTDi84890.
GeneCardsiGC10P064564.
H-InvDBHIX0008860.
HGNCiHGNC:23506. ADO.
HPAiHPA039194.
HPA040437.
MIMi611392. gene.
neXtProtiNX_Q96SZ5.
PharmGKBiPA162375713.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG301373.
GeneTreeiENSGT00390000014082.
HOGENOMiHOG000037604.
HOVERGENiHBG050966.
InParanoidiQ96SZ5.
KOiK10712.
OMAiCETDGFS.
OrthoDBiEOG7NKKMH.
PhylomeDBiQ96SZ5.
TreeFamiTF314673.

Enzyme and pathway databases

BioCyciMetaCyc:HS17749-MONOMER.
BRENDAi1.13.11.19. 2681.

Miscellaneous databases

ChiTaRSiADO. human.
GenomeRNAii84890.
NextBioi75218.
PROiQ96SZ5.
SOURCEiSearch...

Gene expression databases

BgeeiQ96SZ5.
CleanExiHS_ADO.
GenevisibleiQ96SZ5. HS.

Family and domain databases

Gene3Di2.60.120.10. 1 hit.
InterProiIPR012864. PCO/ADO.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PfamiPF07847. DUF1637. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS TRP-25 AND ALA-39.
    Tissue: Brain and Testis.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 35-270, VARIANT ALA-39.
    Tissue: Teratocarcinoma.
  5. "Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase."
    Dominy J.E. Jr., Simmons C.R., Hirschberger L.L., Hwang J., Coloso R.M., Stipanuk M.H.
    J. Biol. Chem. 282:25189-25198(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: CATALYTIC ACTIVITY.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAEDO_HUMAN
AccessioniPrimary (citable) accession number: Q96SZ5
Secondary accession number(s): B1AL29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: February 21, 2006
Last modified: June 24, 2015
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.