Q96SZ5 (AEDO_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2-aminoethanethiol dioxygenase
EC=1.13.11.19

Alternative name(s):
Cysteamine dioxygenase

Gene names

Name:	ADO
Synonyms:	C10orf22

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	270 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	2-aminoethanethiol + O2 = hypotaurine. Ref.5
Cofactor	Iron By similarity.
Sequence caution	The sequence BAB55123.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	cysteamine dioxygenase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 270	270	2-aminoethanethiol dioxygenase		PRO_0000089784
Natural variations
	Natural variant	25	1	G → W. Ref.3 Corresponds to variant rs2236295 [ dbSNP | Ensembl ].		VAR_025333
	Natural variant	39	1	P → A. Ref.3 Ref.4 Corresponds to variant rs10995311 [ dbSNP | Ensembl ].		VAR_025334
	Natural variant	266	1	P → S. Corresponds to variant rs569705 [ dbSNP | Ensembl ].		VAR_033691

Sequences

	Sequence		Length	Mass (Da)
	Q96SZ5 [UniParc]. Last modified February 21, 2006. Version 2. Checksum: 6B496CCF16E92C9D	FASTA	270	29,751
	10 20 30 40 50 60 MPRDNMASLI QRIARQACLT FRGSGGGRGA SDRDAASGPE APMQPGFPEN LSKLKSLLTQ 70 80 90 100 110 120 LRAEDLNIAP RKATLQPLPP NLPPVTYMHI YETDGFSLGV FLLKSGTSIP LHDHPGMHGM 130 140 150 160 170 180 LKVLYGTVRI SCMDKLDAGG GQRPRALPPE QQFEPPLQPR EREAVRPGVL RSRAEYTEAS 190 200 210 220 230 240 GPCILTPHRD NLHQIDAVEG PAAFLDILAP PYDPDDGRDC HYYRVLEPVR PKEASSSACD 250 260 270 LPREVWLLET PQADDFWCEG EPYPGPKVFP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS TRP-25 AND ALA-39. Tissue: Brain and Testis.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 35-270, VARIANT ALA-39. Tissue: Teratocarcinoma.
[5]	"Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase." Dominy J.E. Jr., Simmons C.R., Hirschberger L.L., Hwang J., Coloso R.M., Stipanuk M.H. J. Biol. Chem. 282:25189-25198(2007) [PubMed: 17581819] [Abstract] Cited for: CATALYTIC ACTIVITY.
[6]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Web resources

GeneReviews

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL133417 Genomic DNA. Translation: CAH73826.2. CH471083 Genomic DNA. Translation: EAW54235.1. BC018660 mRNA. Translation: AAH18660.3. BC028589 mRNA. Translation: AAH28589.2. BC067740 mRNA. Translation: AAH67740.2. AK027453 mRNA. Translation: BAB55123.1. Different initiation.
IPI	IPI00045939.
RefSeq	NP_116193.2. NM_032804.5.
UniGene	Hs.99821.
3D structure databases
ProteinModelPortal	Q96SZ5.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96SZ5.
PTM databases
PhosphoSite	Q96SZ5.
Polymorphism databases
DMDM	88984104.
Proteomic databases
PRIDE	Q96SZ5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000373783; ENSP00000362888; ENSG00000181915.
GeneID	84890.
KEGG	hsa:84890.
UCSC	uc001jmg.1. human.
Organism-specific databases
CTD	84890.
GeneCards	GC10P064564.
H-InvDB	HIX0008860.
HGNC	HGNC:23506. ADO.
HPA	HPA039194. HPA040437.
MIM	611392. gene.
neXtProt	NX_Q96SZ5.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000014082.
HOGENOM	HBG717459.
HOVERGEN	HBG050966.
InParanoid	Q96SZ5.
OMA	RIARQAC.
OrthoDB	EOG4894N9.
PhylomeDB	Q96SZ5.
Gene expression databases
ArrayExpress	Q96SZ5.
Bgee	Q96SZ5.
CleanEx	HS_ADO.
Genevestigator	Q96SZ5.
GermOnline	ENSG00000181915. Homo sapiens.
Family and domain databases
InterPro	IPR011051. Cupin_RmlC_type. IPR012864. Cysteamine_dioxygenase. IPR014710. RmlC-like_jellyroll. [Graphical view]
Gene3D	G3DSA:2.60.120.10. RmlC-like_jellyroll. 1 hit.
KO	K10712.
Pfam	PF07847. DUF1637. 1 hit. [Graphical view]
SUPFAM	SSF51182. RmlC_like_cupin. 1 hit.
ProtoNet	Search...
Other
NextBio	75218.
SOURCE	Search...

Entry information

Entry name

AEDO_HUMAN

Accession

Primary (citable) accession number: Q96SZ5
Secondary accession number(s): B1AL29

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 11, 2004
Last sequence update:	February 21, 2006
Last modified:	January 25, 2012
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.