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Protein

Oxysterol-binding protein-related protein 9

Gene

OSBPL9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein-related protein 9
Short name:
ORP-9
Short name:
OSBP-related protein 9
Gene namesi
Name:OSBPL9
Synonyms:ORP9, OSBP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:16386. OSBPL9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32833.

Polymorphism and mutation databases

BioMutaiOSBPL9.
DMDMi20139075.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 736735Oxysterol-binding protein-related protein 9PRO_0000100379Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Modified residuei306 – 3061PhosphoserineCombined sources
Modified residuei326 – 3261PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96SU4.
MaxQBiQ96SU4.
PaxDbiQ96SU4.
PRIDEiQ96SU4.

PTM databases

iPTMnetiQ96SU4.
PhosphoSiteiQ96SU4.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ96SU4.
CleanExiHS_OSBPL9.
ExpressionAtlasiQ96SU4. baseline and differential.
GenevisibleiQ96SU4. HS.

Organism-specific databases

HPAiHPA027378.
HPA027397.

Interactioni

Subunit structurei

Heterodimer with OSBPL11 (PubMed:20599956). Interacts with OSBPL10 (PubMed:22906437).2 Publications

Protein-protein interaction databases

BioGridi125384. 24 interactions.
IntActiQ96SU4. 16 interactions.
STRINGi9606.ENSP00000412733.

Structurei

3D structure databases

ProteinModelPortaliQ96SU4.
SMRiQ96SU4. Positions 7-96, 373-714.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 9998PHPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the OSBP family.Curated
Contains 1 PH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2210. Eukaryota.
ENOG410XRW6. LUCA.
GeneTreeiENSGT00550000074515.
HOGENOMiHOG000233872.
HOVERGENiHBG053376.
InParanoidiQ96SU4.
OMAiKMASIME.
OrthoDBiEOG7PK8ZG.
PhylomeDBiQ96SU4.
TreeFamiTF312807.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR10972. PTHR10972. 2 hits.
PfamiPF01237. Oxysterol_BP. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS01013. OSBP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96SU4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASIMEGPLS KWTNVMKGWQ YRWFVLDYNA GLLSYYTSKD KMMRGSRRGC
60 70 80 90 100
VRLRGAVIGI DDEDDSTFTI TVDQKTFHFQ ARDADEREKW IHALEETILR
110 120 130 140 150
HTLQLQGLDS GFVPSVQDFD KKLTEADAYL QILIEQLKLF DDKLQNCKED
160 170 180 190 200
EQRKKIETLK ETTNSMVESI KHCIVLLQIA KDQSNAEKHA DGMISTINPV
210 220 230 240 250
DAIYQPSPLE PVISTMPSQT VLPPEPVQLC KSEQRPSSLP VGPVLATLGH
260 270 280 290 300
HQTPTPNSTG SGHSPPSSSL TSPSHVNLSP NTVPEFSYSS SEDEFYDADE
310 320 330 340 350
FHQSGSSPKR LIDSSGSASV LTHSSSGNSL KRPDTTESLN SSLSNGTSDA
360 370 380 390 400
DLFDSHDDRD DDAEAGSVEE HKSVIMHLLS QVRLGMDLTK VVLPTFILER
410 420 430 440 450
RSLLEMYADF FAHPDLFVSI SDQKDPKDRM VQVVKWYLSA FHAGRKGSVA
460 470 480 490 500
KKPYNPILGE IFQCHWTLPN DTEENTELVS EGPVPWVSKN SVTFVAEQVS
510 520 530 540 550
HHPPISAFYA ECFNKKIQFN AHIWTKSKFL GMSIGVHNIG QGCVSCLDYD
560 570 580 590 600
EHYILTFPNG YGRSILTVPW VELGGECNIN CSKTGYSANI IFHTKPFYGG
610 620 630 640 650
KKHRITAEIF SPNDKKSFCS IEGEWNGVMY AKYATGENTV FVDTKKLPII
660 670 680 690 700
KKKVRKLEDQ NEYESRSLWK DVTFNLKIRD IDAATEAKHR LEERQRAEAR
710 720 730
ERKEKEIQWE TRLFHEDGEC WVYDEPLLKR LGAAKH
Length:736
Mass (Da):83,185
Last modified:February 11, 2002 - v2
Checksum:iA689D5D68E95EC6C
GO
Isoform 2 (identifier: Q96SU4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     182-194: Missing.

Note: No experimental confirmation available.
Show »
Length:723
Mass (Da):81,787
Checksum:i78932D752B0723F6
GO
Isoform 3 (identifier: Q96SU4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.
     98-106: ILRHTLQLQ → MAFLLATCG
     182-194: Missing.

Show »
Length:626
Mass (Da):70,237
Checksum:i1C984FB8AB2CDFBD
GO
Isoform 4 (identifier: Q96SU4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-165: Missing.

Show »
Length:571
Mass (Da):63,926
Checksum:iAA036C69EDF55051
GO
Isoform 5 (identifier: Q96SU4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-165: Missing.
     182-194: Missing.

Show »
Length:558
Mass (Da):62,528
Checksum:i199A2599C5758F91
GO
Isoform 6 (identifier: Q96SU4-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     106-106: Q → QISTTLAFFQSSGISPVLEFSKII
     182-194: Missing.

Note: No experimental confirmation available.
Show »
Length:746
Mass (Da):84,255
Checksum:iB1F7010845472342
GO
Isoform 7 (identifier: Q96SU4-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-54: Missing.

Show »
Length:719
Mass (Da):81,166
Checksum:iBB27FF9E489B52F0
GO

Sequence cautioni

The sequence CAH71119.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti295 – 2951F → L in BAC03727 (PubMed:14702039).Curated
Sequence conflicti735 – 7351K → R in BAB55312 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti266 – 2661P → L.1 Publication
VAR_069380

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 165165Missing in isoform 4 and isoform 5. 3 PublicationsVSP_036779Add
BLAST
Alternative sequencei1 – 9797Missing in isoform 3. 1 PublicationVSP_036780Add
BLAST
Alternative sequencei38 – 5417Missing in isoform 7. 1 PublicationVSP_043630Add
BLAST
Alternative sequencei98 – 1069ILRHTLQLQ → MAFLLATCG in isoform 3. 1 PublicationVSP_036781
Alternative sequencei106 – 1061Q → QISTTLAFFQSSGISPVLEF SKII in isoform 6. 1 PublicationVSP_043631
Alternative sequencei182 – 19413Missing in isoform 2, isoform 3, isoform 5 and isoform 6. 2 PublicationsVSP_003782Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF392445 mRNA. Translation: AAL40658.1.
AY178997 mRNA. Translation: AAO20108.1.
AK022554 mRNA. Translation: BAB14096.1.
AK027535 mRNA. Translation: BAB55184.1.
AK027707 mRNA. Translation: BAB55312.1.
AK056617 mRNA. Translation: BAG51766.1.
AK091703 mRNA. Translation: BAC03727.1.
CR457288 mRNA. Translation: CAG33569.1.
AL772260, AL050343, AL831767 Genomic DNA. Translation: CAH71118.1.
AL772260, AL050343, AL831767 Genomic DNA. Translation: CAH71119.1. Different initiation.
AL831767, AL050343, AL772260 Genomic DNA. Translation: CAI14843.1.
AL831767, AL050343, AL772260 Genomic DNA. Translation: CAI14844.1.
AL050343, AL772260, AL831767 Genomic DNA. Translation: CAI22219.1.
AL050343, AL772260, AL831767 Genomic DNA. Translation: CAI22220.1.
AL050343 Genomic DNA. Translation: CAI22221.1.
CH471059 Genomic DNA. Translation: EAX06810.1.
CH471059 Genomic DNA. Translation: EAX06813.1.
CH471059 Genomic DNA. Translation: EAX06816.1.
CH471059 Genomic DNA. Translation: EAX06819.1.
CH471059 Genomic DNA. Translation: EAX06817.1.
BC025978 mRNA. Translation: AAH25978.1.
CCDSiCCDS41332.3. [Q96SU4-1]
CCDS41333.2. [Q96SU4-7]
CCDS41334.1. [Q96SU4-5]
CCDS44145.1. [Q96SU4-6]
CCDS55598.1. [Q96SU4-2]
CCDS558.1. [Q96SU4-3]
RefSeqiNP_078862.4. NM_024586.5. [Q96SU4-1]
NP_683702.1. NM_148904.3. [Q96SU4-5]
NP_683703.1. NM_148905.3. [Q96SU4-5]
NP_683704.2. NM_148906.2. [Q96SU4-7]
NP_683705.1. NM_148907.2. [Q96SU4-3]
NP_683706.3. NM_148908.3. [Q96SU4-2]
NP_683707.3. NM_148909.3. [Q96SU4-6]
XP_006710385.1. XM_006710322.2. [Q96SU4-4]
XP_006710386.1. XM_006710323.1. [Q96SU4-4]
XP_006710387.1. XM_006710324.2. [Q96SU4-5]
XP_006710388.1. XM_006710325.2. [Q96SU4-5]
XP_006710389.1. XM_006710326.1. [Q96SU4-5]
XP_011538905.1. XM_011540603.1. [Q96SU4-4]
XP_011538906.1. XM_011540604.1. [Q96SU4-4]
UniGeneiHs.21938.
Hs.738830.

Genome annotation databases

EnsembliENST00000361556; ENSP00000354970; ENSG00000117859. [Q96SU4-3]
ENST00000371714; ENSP00000360779; ENSG00000117859. [Q96SU4-2]
ENST00000428468; ENSP00000407168; ENSG00000117859. [Q96SU4-1]
ENST00000447887; ENSP00000412733; ENSG00000117859. [Q96SU4-6]
ENST00000453295; ENSP00000413263; ENSG00000117859. [Q96SU4-7]
ENST00000462759; ENSP00000433279; ENSG00000117859. [Q96SU4-5]
ENST00000486942; ENSP00000431980; ENSG00000117859. [Q96SU4-5]
ENST00000531828; ENSP00000433083; ENSG00000117859. [Q96SU4-4]
GeneIDi114883.
KEGGihsa:114883.
UCSCiuc001cst.5. human. [Q96SU4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF392445 mRNA. Translation: AAL40658.1.
AY178997 mRNA. Translation: AAO20108.1.
AK022554 mRNA. Translation: BAB14096.1.
AK027535 mRNA. Translation: BAB55184.1.
AK027707 mRNA. Translation: BAB55312.1.
AK056617 mRNA. Translation: BAG51766.1.
AK091703 mRNA. Translation: BAC03727.1.
CR457288 mRNA. Translation: CAG33569.1.
AL772260, AL050343, AL831767 Genomic DNA. Translation: CAH71118.1.
AL772260, AL050343, AL831767 Genomic DNA. Translation: CAH71119.1. Different initiation.
AL831767, AL050343, AL772260 Genomic DNA. Translation: CAI14843.1.
AL831767, AL050343, AL772260 Genomic DNA. Translation: CAI14844.1.
AL050343, AL772260, AL831767 Genomic DNA. Translation: CAI22219.1.
AL050343, AL772260, AL831767 Genomic DNA. Translation: CAI22220.1.
AL050343 Genomic DNA. Translation: CAI22221.1.
CH471059 Genomic DNA. Translation: EAX06810.1.
CH471059 Genomic DNA. Translation: EAX06813.1.
CH471059 Genomic DNA. Translation: EAX06816.1.
CH471059 Genomic DNA. Translation: EAX06819.1.
CH471059 Genomic DNA. Translation: EAX06817.1.
BC025978 mRNA. Translation: AAH25978.1.
CCDSiCCDS41332.3. [Q96SU4-1]
CCDS41333.2. [Q96SU4-7]
CCDS41334.1. [Q96SU4-5]
CCDS44145.1. [Q96SU4-6]
CCDS55598.1. [Q96SU4-2]
CCDS558.1. [Q96SU4-3]
RefSeqiNP_078862.4. NM_024586.5. [Q96SU4-1]
NP_683702.1. NM_148904.3. [Q96SU4-5]
NP_683703.1. NM_148905.3. [Q96SU4-5]
NP_683704.2. NM_148906.2. [Q96SU4-7]
NP_683705.1. NM_148907.2. [Q96SU4-3]
NP_683706.3. NM_148908.3. [Q96SU4-2]
NP_683707.3. NM_148909.3. [Q96SU4-6]
XP_006710385.1. XM_006710322.2. [Q96SU4-4]
XP_006710386.1. XM_006710323.1. [Q96SU4-4]
XP_006710387.1. XM_006710324.2. [Q96SU4-5]
XP_006710388.1. XM_006710325.2. [Q96SU4-5]
XP_006710389.1. XM_006710326.1. [Q96SU4-5]
XP_011538905.1. XM_011540603.1. [Q96SU4-4]
XP_011538906.1. XM_011540604.1. [Q96SU4-4]
UniGeneiHs.21938.
Hs.738830.

3D structure databases

ProteinModelPortaliQ96SU4.
SMRiQ96SU4. Positions 7-96, 373-714.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125384. 24 interactions.
IntActiQ96SU4. 16 interactions.
STRINGi9606.ENSP00000412733.

PTM databases

iPTMnetiQ96SU4.
PhosphoSiteiQ96SU4.

Polymorphism and mutation databases

BioMutaiOSBPL9.
DMDMi20139075.

Proteomic databases

EPDiQ96SU4.
MaxQBiQ96SU4.
PaxDbiQ96SU4.
PRIDEiQ96SU4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361556; ENSP00000354970; ENSG00000117859. [Q96SU4-3]
ENST00000371714; ENSP00000360779; ENSG00000117859. [Q96SU4-2]
ENST00000428468; ENSP00000407168; ENSG00000117859. [Q96SU4-1]
ENST00000447887; ENSP00000412733; ENSG00000117859. [Q96SU4-6]
ENST00000453295; ENSP00000413263; ENSG00000117859. [Q96SU4-7]
ENST00000462759; ENSP00000433279; ENSG00000117859. [Q96SU4-5]
ENST00000486942; ENSP00000431980; ENSG00000117859. [Q96SU4-5]
ENST00000531828; ENSP00000433083; ENSG00000117859. [Q96SU4-4]
GeneIDi114883.
KEGGihsa:114883.
UCSCiuc001cst.5. human. [Q96SU4-1]

Organism-specific databases

CTDi114883.
GeneCardsiOSBPL9.
HGNCiHGNC:16386. OSBPL9.
HPAiHPA027378.
HPA027397.
MIMi606737. gene.
neXtProtiNX_Q96SU4.
PharmGKBiPA32833.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2210. Eukaryota.
ENOG410XRW6. LUCA.
GeneTreeiENSGT00550000074515.
HOGENOMiHOG000233872.
HOVERGENiHBG053376.
InParanoidiQ96SU4.
OMAiKMASIME.
OrthoDBiEOG7PK8ZG.
PhylomeDBiQ96SU4.
TreeFamiTF312807.

Miscellaneous databases

ChiTaRSiOSBPL9. human.
GeneWikiiOSBPL9.
GenomeRNAii114883.
NextBioi79369.
PROiQ96SU4.
SOURCEiSearch...

Gene expression databases

BgeeiQ96SU4.
CleanExiHS_OSBPL9.
ExpressionAtlasiQ96SU4. baseline and differential.
GenevisibleiQ96SU4. HS.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR10972. PTHR10972. 2 hits.
PfamiPF01237. Oxysterol_BP. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00233. PH. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS01013. OSBP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A family of 12 human genes containing oxysterol-binding domains."
    Jaworski C.J., Moreira E., Li A., Lee R., Rodriguez I.R.
    Genomics 78:185-196(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
  2. Hao D.C., Hooi S.C.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 7).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3; 4; 5 AND 6).
    Tissue: Tongue.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Tissue: Lymph.
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the Golgi-late endosome interface."
    Zhou Y., Li S., Mayranpaa M.I., Zhong W., Back N., Yan D., Olkkonen V.M.
    Exp. Cell Res. 316:3304-3316(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, SUBCELLULAR LOCATION.
  11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "ORP10, a cholesterol binding protein associated with microtubules, regulates apolipoprotein B-100 secretion."
    Nissila E., Ohsaki Y., Weber-Boyvat M., Perttila J., Ikonen E., Olkkonen V.M.
    Biochim. Biophys. Acta 1821:1472-1484(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH OSBPL10.
  13. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS], IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-306, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  15. Cited for: VARIANT LEU-266.

Entry informationi

Entry nameiOSBL9_HUMAN
AccessioniPrimary (citable) accession number: Q96SU4
Secondary accession number(s): B1AKJ8
, B3KPQ4, D3DQ31, Q5TFC0, Q6IA67, Q86YQ3, Q8NB17, Q8TAS8, Q96SK4, Q9H9X2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: February 11, 2002
Last modified: April 13, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.