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Q96ST3

- SIN3A_HUMAN

UniProt

Q96ST3 - SIN3A_HUMAN

Protein

Paired amphipathic helix protein Sin3a

Gene

SIN3A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 2 (24 Oct 2003)
      Previous versions | rss
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    Functioni

    Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation.1 Publication

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. protein binding Source: UniProtKB
    3. protein deacetylase activity Source: BHF-UCL
    4. RNA polymerase II activating transcription factor binding Source: BHF-UCL
    5. RNA polymerase II transcription corepressor activity Source: Ensembl
    6. sequence-specific DNA binding transcription factor activity Source: Ensembl
    7. transcription regulatory region sequence-specific DNA binding Source: UniProtKB

    GO - Biological processi

    1. activation of innate immune response Source: BHF-UCL
    2. aging Source: Ensembl
    3. blood coagulation Source: Reactome
    4. cellular lipid metabolic process Source: Reactome
    5. cellular protein localization Source: Ensembl
    6. cellular response to glucose stimulus Source: Ensembl
    7. DNA replication Source: Ensembl
    8. in utero embryonic development Source: Ensembl
    9. negative regulation of apoptotic process Source: Ensembl
    10. negative regulation of circadian rhythm Source: UniProtKB
    11. negative regulation of histone H3-K27 acetylation Source: BHF-UCL
    12. negative regulation of protein localization to nucleus Source: BHF-UCL
    13. negative regulation of transcription, DNA-templated Source: UniProtKB
    14. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    15. negative regulation of transcription regulatory region DNA binding Source: BHF-UCL
    16. positive regulation of chromatin silencing Source: BHF-UCL
    17. positive regulation of defense response to virus by host Source: BHF-UCL
    18. positive regulation of G2/M transition of mitotic cell cycle Source: Ensembl
    19. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    20. protein deacetylation Source: BHF-UCL
    21. regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: Ensembl
    22. response to methylglyoxal Source: Ensembl
    23. response to organonitrogen compound Source: Ensembl
    24. rhythmic process Source: UniProtKB-KW
    25. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Biological rhythms, Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_19241. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
    REACT_200856. NoRC negatively regulates rRNA expression.
    REACT_24970. Factors involved in megakaryocyte development and platelet production.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Paired amphipathic helix protein Sin3a
    Alternative name(s):
    Histone deacetylase complex subunit Sin3a
    Transcriptional corepressor Sin3a
    Gene namesi
    Name:SIN3AImported
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:19353. SIN3A.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation. Nucleusnucleolus 1 Publication
    Note: Recruited to the nucleolus by SAP30L.

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. intercellular bridge Source: HPA
    3. kinetochore Source: Ensembl
    4. nucleoplasm Source: Reactome
    5. nucleus Source: UniProtKB
    6. Sin3 complex Source: UniProtKB
    7. transcriptional repressor complex Source: Ensembl
    8. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134993567.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12731273Paired amphipathic helix protein Sin3aPRO_0000121537Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei10 – 101Phosphoserine2 Publications
    Modified residuei277 – 2771Phosphoserine1 Publication
    Modified residuei469 – 4691N6-acetyllysine1 Publication
    Modified residuei832 – 8321Phosphoserine4 Publications
    Modified residuei860 – 8601Phosphoserine3 Publications
    Modified residuei865 – 8651N6-acetyllysineBy similarity
    Modified residuei875 – 8751N6-acetyllysineBy similarity
    Modified residuei940 – 9401Phosphoserine2 Publications
    Modified residuei1112 – 11121Phosphoserine3 Publications

    Post-translational modificationi

    SUMO1 sumoylated by TOPORS. Probably desumoylated by SENP2.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ96ST3.
    PaxDbiQ96ST3.
    PeptideAtlasiQ96ST3.
    PRIDEiQ96ST3.

    PTM databases

    PhosphoSiteiQ96ST3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96ST3.
    BgeeiQ96ST3.
    CleanExiHS_SIN3A.
    GenevestigatoriQ96ST3.

    Organism-specific databases

    HPAiCAB004506.
    HPA047213.

    Interactioni

    Subunit structurei

    Interacts with ARID4B, BRMS1L, HCFC1, HDAC1, HDAC2, MXI1, SAP30L, SAP130, SFPQ and TOPORS. Interacts with OGT (via TPRs 1-6); the interaction mediates transcriptional repression in parallel with histone deacetylase By similarity. Interacts with BAZ2A, MXD3, MXD4, MBD2, DACH1, NCOR1, NR4A2, REST, RLIM, SAP30, SETDB1, SMYD2, and SUDS3. Interacts with PHF12 in a complex composed of HDAC1, PHF12 and SAP30. Interacts with TET1; the interaction recruits SIN3A to gene promoters. The large PER complex involved in the histone deacetylation is composed of at least HDAC1, PER2, SFPQ and SIN3A.By similarity10 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DHX30Q7L2E33EBI-347218,EBI-1211456
    HCFC1P516106EBI-347218,EBI-396176
    HDAC2Q927694EBI-347218,EBI-301821
    NR2E3Q9Y5X42EBI-347218,EBI-7216962
    PA2G4Q9UQ804EBI-347218,EBI-924893
    SFPQP232462EBI-347218,EBI-355453
    SKIP127553EBI-347218,EBI-347281
    TP53P046372EBI-347218,EBI-366083

    Protein-protein interaction databases

    BioGridi117439. 182 interactions.
    DIPiDIP-31515N.
    IntActiQ96ST3. 42 interactions.
    MINTiMINT-2815493.
    STRINGi9606.ENSP00000353622.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1PO4model-B295-383[»]
    ProteinModelPortaliQ96ST3.
    SMRiQ96ST3. Positions 119-189, 295-385, 453-527.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini119 – 18971PAH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini300 – 38384PAH 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini456 – 52570PAH 3PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni119 – 19678Interaction with HCFC11 PublicationAdd
    BLAST
    Regioni205 – 480276Interaction with RESTBy similarityAdd
    BLAST
    Regioni458 – 52568Interaction with SAP30By similarityAdd
    BLAST
    Regioni523 – 850328Interaction with NCOR1By similarityAdd
    BLAST
    Regioni524 – 659136Interaction with SUDS3 and SAP130Add
    BLAST
    Regioni687 – 829143Interaction with HDAC1 and ARID4BAdd
    BLAST
    Regioni888 – 96780Interaction with OGTAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili903 – 93230Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi218 – 28568Pro-richAdd
    BLAST
    Compositional biasi835 – 8417Poly-Glu

    Sequence similaritiesi

    Contains 3 PAH (paired amphipathic helix) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiCOG5602.
    HOVERGENiHBG060425.
    InParanoidiQ96ST3.
    KOiK11644.
    OMAiNDHGGTA.
    OrthoDBiEOG7SV0TV.
    PhylomeDBiQ96ST3.
    TreeFamiTF106187.

    Family and domain databases

    Gene3Di1.20.1160.11. 3 hits.
    InterProiIPR013194. HDAC_interact.
    IPR003822. PAH.
    [Graphical view]
    PfamiPF02671. PAH. 3 hits.
    PF08295. Sin3_corepress. 1 hit.
    [Graphical view]
    SMARTiSM00761. HDAC_interact. 1 hit.
    [Graphical view]
    SUPFAMiSSF47762. SSF47762. 3 hits.
    PROSITEiPS51477. PAH. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96ST3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKRRLDDQES PVYAAQQRRI PGSTEAFPHQ HRVLAPAPPV YEAVSETMQS     50
    ATGIQYSVTP SYQVSAMPQS SGSHGPAIAA VHSSHHHPTA VQPHGGQVVQ 100
    SHAHPAPPVA PVQGQQQFQR LKVEDALSYL DQVKLQFGSQ PQVYNDFLDI 150
    MKEFKSQSID TPGVISRVSQ LFKGHPDLIM GFNTFLPPGY KIEVQTNDMV 200
    NVTTPGQVHQ IPTHGIQPQP QPPPQHPSQP SAQSAPAPAQ PAPQPPPAKV 250
    SKPSQLQAHT PASQQTPPLP PYASPRSPPV QPHTPVTISL GTAPSLQNNQ 300
    PVEFNHAINY VNKIKNRFQG QPDIYKAFLE ILHTYQKEQR NAKEAGGNYT 350
    PALTEQEVYA QVARLFKNQE DLLSEFGQFL PDANSSVLLS KTTAEKVDSV 400
    RNDHGGTVKK PQLNNKPQRP SQNGCQIRRH PTGTTPPVKK KPKLLNLKDS 450
    SMADASKHGG GTESLFFDKV RKALRSAEAY ENFLRCLVIF NQEVISRAEL 500
    VQLVSPFLGK FPELFNWFKN FLGYKESVHL ETYPKERATE GIAMEIDYAS 550
    CKRLGSSYRA LPKSYQQPKC TGRTPLCKEV LNDTWVSFPS WSEDSTFVSS 600
    KKTQYEEHIY RCEDERFELD VVLETNLATI RVLEAIQKKL SRLSAEEQAK 650
    FRLDNTLGGT SEVIHRKALQ RIYADKAADI IDGLRKNPSI AVPIVLKRLK 700
    MKEEEWREAQ RGFNKVWREQ NEKYYLKSLD HQGINFKQND TKVLRSKSLL 750
    NEIESIYDER QEQATEENAG VPVGPHLSLA YEDKQILEDA AALIIHHVKR 800
    QTGIQKEDKY KIKQIMHHFI PDLLFAQRGD LSDVEEEEEE EMDVDEATGA 850
    VKKHNGVGGS PPKSKLLFSN TAAQKLRGMD EVYNLFYVNN NWYIFMRLHQ 900
    ILCLRLLRIC SQAERQIEEE NREREWEREV LGIKRDKSDS PAIQLRLKEP 950
    MDVDVEDYYP AFLDMVRSLL DGNIDSSQYE DSLREMFTIH AYIAFTMDKL 1000
    IQSIVRQLQH IVSDEICVQV TDLYLAENNN GATGGQLNTQ NSRSLLESTY 1050
    QRKAEQLMSD ENCFKLMFIQ SQGQVQLTIE LLDTEEENSD DPVEAERWSD 1100
    YVERYMNSDT TSPELREHLA QKPVFLPRNL RRIRKCQRGR EQQEKEGKEG 1150
    NSKKTMENVD SLDKLECRFK LNSYKMVYVI KSEDYMYRRT ALLRAHQSHE 1200
    RVSKRLHQRF QAWVDKWTKE HVPREMAAET SKWLMGEGLE GLVPCTTTCD 1250
    TETLHFVSIN KYRVKYGTVF KAP 1273
    Length:1,273
    Mass (Da):145,175
    Last modified:October 24, 2003 - v2
    Checksum:iE6A329BE0EAD84CD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti163 – 1631G → R in AAK95854. 1 PublicationCurated
    Sequence conflicti170 – 1778QLFKGHPD → HYSKGPPI in AAK95854. 1 PublicationCurated
    Sequence conflicti182 – 19211FNTFLPPGYKI → IQHLFAPWATKM in AAK95854. 1 PublicationCuratedAdd
    BLAST
    Sequence conflicti216 – 2161I → T in BAC04801. (PubMed:14702039)Curated
    Sequence conflicti386 – 3861S → F in AAK95854. 1 PublicationCurated
    Sequence conflicti536 – 5361E → D in AAK95854. 1 PublicationCurated
    Sequence conflicti562 – 5621P → G in AAK95854. 1 PublicationCurated
    Sequence conflicti575 – 5762PL → GV in AAK95854. 1 PublicationCurated
    Sequence conflicti595 – 5951S → C in AAK95854. 1 PublicationCurated
    Sequence conflicti618 – 6203ELD → DLM in AAK95854. 1 PublicationCurated
    Sequence conflicti1009 – 10091Q → R in BAC11280. (PubMed:14702039)Curated
    Sequence conflicti1247 – 12482TT → NN in AAP97288. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1156 – 11561M → L.
    Corresponds to variant rs60213317 [ dbSNP | Ensembl ].
    VAR_062129

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF418569 mRNA. Translation: AAP97288.1.
    BC018973 mRNA. Translation: AAH18973.1.
    BC137098 mRNA. Translation: AAI37099.1.
    BC137099 mRNA. Translation: AAI37100.1.
    AK027559 mRNA. Translation: BAB55197.1.
    AK074903 mRNA. Translation: BAC11280.1.
    AK096477 mRNA. Translation: BAC04801.1.
    AY044430 mRNA. Translation: AAK95854.1.
    AL117513 mRNA. Translation: CAB55972.1.
    CCDSiCCDS10279.1.
    PIRiT17282.
    RefSeqiNP_001138829.1. NM_001145357.1.
    NP_001138830.1. NM_001145358.1.
    NP_056292.1. NM_015477.2.
    XP_006720528.1. XM_006720465.1.
    XP_006720529.1. XM_006720466.1.
    XP_006720530.1. XM_006720467.1.
    UniGeneiHs.513039.

    Genome annotation databases

    EnsembliENST00000360439; ENSP00000353622; ENSG00000169375.
    ENST00000394947; ENSP00000378402; ENSG00000169375.
    ENST00000394949; ENSP00000378403; ENSG00000169375.
    GeneIDi25942.
    KEGGihsa:25942.
    UCSCiuc002bai.3. human.

    Polymorphism databases

    DMDMi37999759.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF418569 mRNA. Translation: AAP97288.1 .
    BC018973 mRNA. Translation: AAH18973.1 .
    BC137098 mRNA. Translation: AAI37099.1 .
    BC137099 mRNA. Translation: AAI37100.1 .
    AK027559 mRNA. Translation: BAB55197.1 .
    AK074903 mRNA. Translation: BAC11280.1 .
    AK096477 mRNA. Translation: BAC04801.1 .
    AY044430 mRNA. Translation: AAK95854.1 .
    AL117513 mRNA. Translation: CAB55972.1 .
    CCDSi CCDS10279.1.
    PIRi T17282.
    RefSeqi NP_001138829.1. NM_001145357.1.
    NP_001138830.1. NM_001145358.1.
    NP_056292.1. NM_015477.2.
    XP_006720528.1. XM_006720465.1.
    XP_006720529.1. XM_006720466.1.
    XP_006720530.1. XM_006720467.1.
    UniGenei Hs.513039.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1PO4 model - B 295-383 [» ]
    ProteinModelPortali Q96ST3.
    SMRi Q96ST3. Positions 119-189, 295-385, 453-527.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117439. 182 interactions.
    DIPi DIP-31515N.
    IntActi Q96ST3. 42 interactions.
    MINTi MINT-2815493.
    STRINGi 9606.ENSP00000353622.

    PTM databases

    PhosphoSitei Q96ST3.

    Polymorphism databases

    DMDMi 37999759.

    Proteomic databases

    MaxQBi Q96ST3.
    PaxDbi Q96ST3.
    PeptideAtlasi Q96ST3.
    PRIDEi Q96ST3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000360439 ; ENSP00000353622 ; ENSG00000169375 .
    ENST00000394947 ; ENSP00000378402 ; ENSG00000169375 .
    ENST00000394949 ; ENSP00000378403 ; ENSG00000169375 .
    GeneIDi 25942.
    KEGGi hsa:25942.
    UCSCi uc002bai.3. human.

    Organism-specific databases

    CTDi 25942.
    GeneCardsi GC15M075661.
    H-InvDB HIX0012443.
    HIX0019634.
    HIX0172841.
    HGNCi HGNC:19353. SIN3A.
    HPAi CAB004506.
    HPA047213.
    MIMi 607776. gene.
    neXtProti NX_Q96ST3.
    PharmGKBi PA134993567.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5602.
    HOVERGENi HBG060425.
    InParanoidi Q96ST3.
    KOi K11644.
    OMAi NDHGGTA.
    OrthoDBi EOG7SV0TV.
    PhylomeDBi Q96ST3.
    TreeFami TF106187.

    Enzyme and pathway databases

    Reactomei REACT_19241. Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).
    REACT_200856. NoRC negatively regulates rRNA expression.
    REACT_24970. Factors involved in megakaryocyte development and platelet production.

    Miscellaneous databases

    ChiTaRSi SIN3A. human.
    GeneWikii SIN3A.
    GenomeRNAii 25942.
    NextBioi 47516.
    PROi Q96ST3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96ST3.
    Bgeei Q96ST3.
    CleanExi HS_SIN3A.
    Genevestigatori Q96ST3.

    Family and domain databases

    Gene3Di 1.20.1160.11. 3 hits.
    InterProi IPR013194. HDAC_interact.
    IPR003822. PAH.
    [Graphical view ]
    Pfami PF02671. PAH. 3 hits.
    PF08295. Sin3_corepress. 1 hit.
    [Graphical view ]
    SMARTi SM00761. HDAC_interact. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47762. SSF47762. 3 hits.
    PROSITEi PS51477. PAH. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Guo J.H., Yu L.
      Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung and UterusImported.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1026.
      Tissue: Brain and Teratocarcinoma.
    4. Bu X., Fu Y., Jiang S., Avraham S., Avraham H.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-620.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 913-1273.
      Tissue: Testis.
    6. "PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors."
      Mathur M., Tucker P.W., Samuels H.H.
      Mol. Cell. Biol. 21:2298-2311(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SFPQ.
    7. "Recruitment of O-GlcNAc transferase to promoters by corepressor mSin3A: coupling protein O-GlcNAcylation to transcriptional repression."
      Yang X., Zhang F., Kudlow J.E.
      Cell 110:69-80(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH OGT, FUNCTION.
    8. "Transcriptional activation of human CYP17 in H295R adrenocortical cells depends on complex formation among p54(nrb)/NonO, protein-associated splicing factor, and SF-1, a complex that also participates in repression of transcription."
      Sewer M.B., Nguyen V.Q., Huang C.J., Tucker P.W., Kagawa N., Waterman M.R.
      Endocrinology 143:1280-1290(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SFPQ.
    9. Cited for: INTERACTION WITH DACH1.
    10. "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1."
      Wysocka J., Myers M.P., Laherty C.D., Eisenman R.N., Herr W.
      Genes Dev. 17:896-911(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HCFC1.
    11. "Identification and characterization of three new components of the mSin3A corepressor complex."
      Fleischer T.C., Yun U.J., Ayer D.E.
      Mol. Cell. Biol. 23:3456-3467(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SAP130; SUDS3; ARID4B; HDAC1 AND HDAC2.
    12. "Identification of a novel BRMS1-homologue protein p40 as a component of the mSin3A/p33(ING1b)/HDAC1 deacetylase complex."
      Nikolaev A.Y., Papanikolaou N.A., Li M., Qin J., Gu W.
      Biochem. Biophys. Res. Commun. 323:1216-1222(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BRMS1L.
    13. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-860, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus."
      Viiri K.M., Korkeamaeki H., Kukkonen M.K., Nieminen L.K., Lindfors K., Peterson P., Maeki M., Kainulainen H., Lohi O.
      Nucleic Acids Res. 34:3288-3298(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH SAP30L.
    15. "TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins."
      Pungaliya P., Kulkarni D., Park H.J., Marshall H., Zheng H., Lackland H., Saleem A., Rubin E.H.
      J. Proteome Res. 6:3918-3923(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TOPORS, SUMOYLATION BY TOPORS, DESUMOYLATION BY SENP2.
    16. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-10; SER-277; SER-832; SER-940 AND SER-1112, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    18. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-832 AND SER-1112, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    19. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-469, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-832; SER-860; SER-940 AND SER-1112, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    21. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    22. "TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity."
      Williams K., Christensen J., Pedersen M.T., Johansen J.V., Cloos P.A., Rappsilber J., Helin K.
      Nature 473:343-348(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TET1.
    23. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-832 AND SER-860, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSIN3A_HUMAN
    AccessioniPrimary (citable) accession number: Q96ST3
    Secondary accession number(s): B2RNS5
    , Q8N8N4, Q8NC83, Q8WV18, Q96L98, Q9UFQ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 24, 2003
    Last sequence update: October 24, 2003
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3