Q96SR6 (ZN382_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 382

Alternative name(s):
KRAB/zinc finger suppressor protein 1
Short name=KS1
Multiple zinc finger and krueppel-associated box protein KS1

Gene names

Name:

ZNF382

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	550 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Functions as a sequence-specific transcriptional repressor By similarity.
Subunit structure	Interacts with TRIM28; enhances the transcriptional repressor activity By similarity.
Subcellular location	Nucleus By similarity.
Tissue specificity	Specifically expressed in heart with a weaker expression also detected in skeletal muscle. Ref.1
Developmental stage	Primarily detected in 34 day-old embryos. Widely expressed at different levels during embryonic development where it is predominantly expressed in cerebellum, kidney, and cerebrum and to a lesser extent in lung, heart, skeletal muscle, tongue, and adrenal gland. Ref.1
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 10 C2H2-type zinc fingers. Contains 1 KRAB domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Repressor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96SR6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96SR6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MPL → MS

Isoform 3 (identifier: Q96SR6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     78-78: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 550	550	Zinc finger protein 382		PRO_0000047549
Regions
	Domain	7 – 78	72	KRAB
	Zinc finger	212 – 234	23	C2H2-type 1; degenerate
	Zinc finger	296 – 318	23	C2H2-type 2
	Zinc finger	324 – 346	23	C2H2-type 3
	Zinc finger	352 – 374	23	C2H2-type 4
	Zinc finger	380 – 402	23	C2H2-type 5
	Zinc finger	408 – 430	23	C2H2-type 6
	Zinc finger	436 – 458	23	C2H2-type 7
	Zinc finger	464 – 486	23	C2H2-type 8
	Zinc finger	492 – 514	23	C2H2-type 9
	Zinc finger	520 – 542	23	C2H2-type 10
	Region	1 – 105	105	Mediates interaction with TRIM28 By similarity
	Region	5 – 46	42	Represses transcription By similarity
	Region	70 – 211	142	Represses transcription By similarity
	Region	296 – 550	255	Required for transcriptional repression activity; probably mediates sequence-specific DNA-binding By similarity
Natural variations
	Alternative sequence	1 – 3	3	MPL → MS in isoform 2.		VSP_036224
	Alternative sequence	78	1	Missing in isoform 3.		VSP_036225
	Natural variant	168	1	E → G. Ref.4 Ref.6 Corresponds to variant rs3108171 [ dbSNP | Ensembl ].		VAR_054226
Experimental info
	Sequence conflict	129 – 130	2	Missing in AAM48246. Ref.1
	Sequence conflict	129 – 130	2	Missing in AAO72308. Ref.2
	Sequence conflict	129 – 130	2	Missing in BAB55217. Ref.3
	Sequence conflict	547	1	T → M in AAI32676. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 30, 2010. Version 3. Checksum: 6D0706EA069DDD0B	FASTA	550	64,010
	10 20 30 40 50 60 MPLQGSVSFK DVTVDFTQEE WQQLDPAQKA LYRDVMLENY CHFVSVGFHM AKPDMIRKLE 70 80 90 100 110 120 QGEELWTQRI FPSYSYLEED GKTEDVLVKF KEYQDRHSRP LIFINHKKLI KERSNIYGKT 130 140 150 160 170 180 FTLGKNRISK TILCEYKPDG KVLKNISELV IRNISPIKEK FGDSTGWEKS LLNTKHEKIH 190 200 210 220 230 240 PAVNLHKQTE RVLSGKQELI QHQKVQAPEQ PFDHNECEKS FLMKGMLFTH TRAHRGERTF 250 260 270 280 290 300 EYNKDGIAFI EKSSLSVHPS NLMEKKPSAY NKYGKFLCRK PVFIMPQRPQ TEEKPFHCPY 310 320 330 340 350 360 CGNNFRRKSY LIEHQRIHTG EKPYVCNQCG KAFRQKTALT LHEKTHIEGK PFICIDCGKS 370 380 390 400 410 420 FRQKATLTRH HKTHTGEKAY ECPQCGSAFR KKSYLIDHQR THTGEKPYQC NECGKAFIQK 430 440 450 460 470 480 TTLTVHQRTH TGEKPYICNE CGKSFCQKTT LTLHQRIHTG EKPYICNECG KSFRQKAILT 490 500 510 520 530 540 VHHRIHTGEK SNGCPQCGKA FSRKSNLIRH QKTHTGEKPY ECKQCGKFFS CKSNLIVHQK 550 THKVETTGIQ
	Isoform 2 [UniParc]. Checksum: 7E1ECFED0C1D8816	FASTA	549	63,886
	10 20 30 40 50 60 MSQGSVSFKD VTVDFTQEEW QQLDPAQKAL YRDVMLENYC HFVSVGFHMA KPDMIRKLEQ 70 80 90 100 110 120 GEELWTQRIF PSYSYLEEDG KTEDVLVKFK EYQDRHSRPL IFINHKKLIK ERSNIYGKTF 130 140 150 160 170 180 TLGKNRISKT ILCEYKPDGK VLKNISELVI RNISPIKEKF GDSTGWEKSL LNTKHEKIHP 190 200 210 220 230 240 AVNLHKQTER VLSGKQELIQ HQKVQAPEQP FDHNECEKSF LMKGMLFTHT RAHRGERTFE 250 260 270 280 290 300 YNKDGIAFIE KSSLSVHPSN LMEKKPSAYN KYGKFLCRKP VFIMPQRPQT EEKPFHCPYC 310 320 330 340 350 360 GNNFRRKSYL IEHQRIHTGE KPYVCNQCGK AFRQKTALTL HEKTHIEGKP FICIDCGKSF 370 380 390 400 410 420 RQKATLTRHH KTHTGEKAYE CPQCGSAFRK KSYLIDHQRT HTGEKPYQCN ECGKAFIQKT 430 440 450 460 470 480 TLTVHQRTHT GEKPYICNEC GKSFCQKTTL TLHQRIHTGE KPYICNECGK SFRQKAILTV 490 500 510 520 530 540 HHRIHTGEKS NGCPQCGKAF SRKSNLIRHQ KTHTGEKPYE CKQCGKFFSC KSNLIVHQKT HKVETTGIQ
	Isoform 3 [UniParc]. Checksum: 6CF371E4DF3F660E	FASTA	549	63,880
	10 20 30 40 50 60 MPLQGSVSFK DVTVDFTQEE WQQLDPAQKA LYRDVMLENY CHFVSVGFHM AKPDMIRKLE 70 80 90 100 110 120 QGEELWTQRI FPSYSYLEDG KTEDVLVKFK EYQDRHSRPL IFINHKKLIK ERSNIYGKTF 130 140 150 160 170 180 TLGKNRISKT ILCEYKPDGK VLKNISELVI RNISPIKEKF GDSTGWEKSL LNTKHEKIHP 190 200 210 220 230 240 AVNLHKQTER VLSGKQELIQ HQKVQAPEQP FDHNECEKSF LMKGMLFTHT RAHRGERTFE 250 260 270 280 290 300 YNKDGIAFIE KSSLSVHPSN LMEKKPSAYN KYGKFLCRKP VFIMPQRPQT EEKPFHCPYC 310 320 330 340 350 360 GNNFRRKSYL IEHQRIHTGE KPYVCNQCGK AFRQKTALTL HEKTHIEGKP FICIDCGKSF 370 380 390 400 410 420 RQKATLTRHH KTHTGEKAYE CPQCGSAFRK KSYLIDHQRT HTGEKPYQCN ECGKAFIQKT 430 440 450 460 470 480 TLTVHQRTHT GEKPYICNEC GKSFCQKTTL TLHQRIHTGE KPYICNECGK SFRQKAILTV 490 500 510 520 530 540 HHRIHTGEKS NGCPQCGKAF SRKSNLIRHQ KTHTGEKPYE CKQCGKFFSC KSNLIVHQKT HKVETTGIQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of a novel Kruppel-like zinc-finger gene, ZNF382, in human heart." Luo K., Yuan W., Zhu C., Li Y., Wang Y., Zeng W., Jiao W., Liu M., Wu X. Biochem. Biophys. Res. Commun. 299:606-612(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Tissue: Embryonic heart.
[2]	Urrutia R., Folch-Puy E., Fernandez-Zapico M. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Teratocarcinoma.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT GLY-168. Tissue: Lymph node.
[5]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT GLY-168. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF513816 mRNA. Translation: AAM48246.1. AY227449 mRNA. Translation: AAO72308.1. AK027592 mRNA. Translation: BAB55217.1. AL832265 mRNA. Translation: CAI46159.1. AC074138 Genomic DNA. No translation available. AC092295 Genomic DNA. No translation available. BC132675 mRNA. Translation: AAI32676.2.
IPI	IPI00027563. IPI00639866. IPI00797562.
RefSeq	NP_001243767.1. NM_001256838.1. NP_116214.2. NM_032825.4.
UniGene	Hs.631591.
3D structure databases
ProteinModelPortal	Q96SR6.
SMR	Q96SR6. Positions 7-49, 133-542.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000292928.
PTM databases
PhosphoSite	Q96SR6.
Polymorphism databases
DMDM	221222507.
Proteomic databases
PaxDb	Q96SR6.
PRIDE	Q96SR6.
Protocols and materials databases
DNASU	84911.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000292928; ENSP00000292928; ENSG00000161298. ENST00000435416; ENSP00000410113; ENSG00000161298. ENST00000439428; ENSP00000407593; ENSG00000161298.
GeneID	84911.
KEGG	hsa:84911.
UCSC	uc002oek.3. human. uc002oel.3. human. uc010efb.3. human.
Organism-specific databases
CTD	84911.
GeneCards	GC19P037095.
HGNC	HGNC:17409. ZNF382.
HPA	HPA049259.
MIM	609516. gene.
neXtProt	NX_Q96SR6.
PharmGKB	PA134869965.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	Q96SR6.
KO	K09228.
OMA	AILTVHH.
OrthoDB	EOG4R23T9.
PhylomeDB	Q96SR6.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q96SR6.
Bgee	Q96SR6.
CleanEx	HS_ZNF382.
Genevestigator	Q96SR6.
GermOnline	ENSG00000161298. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 10 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 10 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 9 hits. PS50157. ZINC_FINGER_C2H2_2. 10 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	84911.
NextBio	75296.
SOURCE	Search...

Entry information

Entry name

ZN382_HUMAN

Accession

Primary (citable) accession number: Q96SR6
Secondary accession number(s): A3KMP6 , A8MT55, C9K0V5, Q53ZY8, Q5JPJ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 28, 2003
Last sequence update:	November 30, 2010
Last modified:	May 1, 2013
This is version 104 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.