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Q96SR6 (ZN382_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 382
Alternative name(s):
KRAB/zinc finger suppressor protein 1
Short name=KS1
Multiple zinc finger and krueppel-associated box protein KS1
Gene names
Name:ZNF382
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length550 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Functions as a sequence-specific transcriptional repressor By similarity.

Subunit structure

Interacts with TRIM28; enhances the transcriptional repressor activity By similarity.

Subcellular location

Nucleus By similarity.

Tissue specificity

Specifically expressed in heart with a weaker expression also detected in skeletal muscle. Ref.1

Developmental stage

Primarily detected in 34 day-old embryos. Widely expressed at different levels during embryonic development where it is predominantly expressed in cerebellum, kidney, and cerebrum and to a lesser extent in lung, heart, skeletal muscle, tongue, and adrenal gland. Ref.1

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 10 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionRepressor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: Ensembl

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96SR6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96SR6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MPL → MS
Isoform 3 (identifier: Q96SR6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     78-78: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 550550Zinc finger protein 382
PRO_0000047549

Regions

Domain7 – 7872KRAB
Zinc finger212 – 23423C2H2-type 1; degenerate
Zinc finger296 – 31823C2H2-type 2
Zinc finger324 – 34623C2H2-type 3
Zinc finger352 – 37423C2H2-type 4
Zinc finger380 – 40223C2H2-type 5
Zinc finger408 – 43023C2H2-type 6
Zinc finger436 – 45823C2H2-type 7
Zinc finger464 – 48623C2H2-type 8
Zinc finger492 – 51423C2H2-type 9
Zinc finger520 – 54223C2H2-type 10
Region1 – 105105Mediates interaction with TRIM28 By similarity
Region5 – 4642Represses transcription By similarity
Region70 – 211142Represses transcription By similarity
Region296 – 550255Required for transcriptional repression activity; probably mediates sequence-specific DNA-binding By similarity

Natural variations

Alternative sequence1 – 33MPL → MS in isoform 2.
VSP_036224
Alternative sequence781Missing in isoform 3.
VSP_036225
Natural variant1681E → G. Ref.4 Ref.6
Corresponds to variant rs3108171 [ dbSNP | Ensembl ].
VAR_054226

Experimental info

Sequence conflict129 – 1302Missing in AAM48246. Ref.1
Sequence conflict129 – 1302Missing in AAO72308. Ref.2
Sequence conflict129 – 1302Missing in BAB55217. Ref.3
Sequence conflict5471T → M in AAI32676. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 30, 2010. Version 3.
Checksum: 6D0706EA069DDD0B

FASTA55064,010
        10         20         30         40         50         60 
MPLQGSVSFK DVTVDFTQEE WQQLDPAQKA LYRDVMLENY CHFVSVGFHM AKPDMIRKLE 

        70         80         90        100        110        120 
QGEELWTQRI FPSYSYLEED GKTEDVLVKF KEYQDRHSRP LIFINHKKLI KERSNIYGKT 

       130        140        150        160        170        180 
FTLGKNRISK TILCEYKPDG KVLKNISELV IRNISPIKEK FGDSTGWEKS LLNTKHEKIH 

       190        200        210        220        230        240 
PAVNLHKQTE RVLSGKQELI QHQKVQAPEQ PFDHNECEKS FLMKGMLFTH TRAHRGERTF 

       250        260        270        280        290        300 
EYNKDGIAFI EKSSLSVHPS NLMEKKPSAY NKYGKFLCRK PVFIMPQRPQ TEEKPFHCPY 

       310        320        330        340        350        360 
CGNNFRRKSY LIEHQRIHTG EKPYVCNQCG KAFRQKTALT LHEKTHIEGK PFICIDCGKS 

       370        380        390        400        410        420 
FRQKATLTRH HKTHTGEKAY ECPQCGSAFR KKSYLIDHQR THTGEKPYQC NECGKAFIQK 

       430        440        450        460        470        480 
TTLTVHQRTH TGEKPYICNE CGKSFCQKTT LTLHQRIHTG EKPYICNECG KSFRQKAILT 

       490        500        510        520        530        540 
VHHRIHTGEK SNGCPQCGKA FSRKSNLIRH QKTHTGEKPY ECKQCGKFFS CKSNLIVHQK 

       550 
THKVETTGIQ 

« Hide

Isoform 2 [UniParc].

Checksum: 7E1ECFED0C1D8816
Show »

FASTA54963,886
Isoform 3 [UniParc].

Checksum: 6CF371E4DF3F660E
Show »

FASTA54963,880

References

« Hide 'large scale' references
[1]"Expression of a novel Kruppel-like zinc-finger gene, ZNF382, in human heart."
Luo K., Yuan W., Zhu C., Li Y., Wang Y., Zeng W., Jiao W., Liu M., Wu X.
Biochem. Biophys. Res. Commun. 299:606-612(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Tissue: Embryonic heart.
[2]Urrutia R., Folch-Puy E., Fernandez-Zapico M.
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Teratocarcinoma.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT GLY-168.
Tissue: Lymph node.
[5]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT GLY-168.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF513816 mRNA. Translation: AAM48246.1.
AY227449 mRNA. Translation: AAO72308.1.
AK027592 mRNA. Translation: BAB55217.1.
AL832265 mRNA. Translation: CAI46159.1.
AC074138 Genomic DNA. No translation available.
AC092295 Genomic DNA. No translation available.
BC132675 mRNA. Translation: AAI32676.2.
RefSeqNP_001243767.1. NM_001256838.1.
NP_116214.2. NM_032825.4.
UniGeneHs.631591.

3D structure databases

ProteinModelPortalQ96SR6.
SMRQ96SR6. Positions 7-49, 133-542.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124348. 3 interactions.
STRING9606.ENSP00000292928.

PTM databases

PhosphoSiteQ96SR6.

Polymorphism databases

DMDM313104256.

Proteomic databases

PaxDbQ96SR6.
PRIDEQ96SR6.

Protocols and materials databases

DNASU84911.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000292928; ENSP00000292928; ENSG00000161298. [Q96SR6-1]
ENST00000435416; ENSP00000410113; ENSG00000161298. [Q96SR6-3]
ENST00000439428; ENSP00000407593; ENSG00000161298. [Q96SR6-2]
GeneID84911.
KEGGhsa:84911.
UCSCuc002oek.4. human. [Q96SR6-1]
uc002oel.3. human. [Q96SR6-3]
uc010efb.4. human. [Q96SR6-2]

Organism-specific databases

CTD84911.
GeneCardsGC19P037095.
HGNCHGNC:17409. ZNF382.
HPAHPA049259.
MIM609516. gene.
neXtProtNX_Q96SR6.
PharmGKBPA134869965.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ96SR6.
KOK09228.
OMAHNECEKS.
OrthoDBEOG7KSX7Q.
PhylomeDBQ96SR6.
TreeFamTF337898.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ96SR6.
BgeeQ96SR6.
CleanExHS_ZNF382.
GenevestigatorQ96SR6.

Family and domain databases

Gene3D3.30.160.60. 10 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 10 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 9 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi84911.
NextBio75296.
PROQ96SR6.
SOURCESearch...

Entry information

Entry nameZN382_HUMAN
AccessionPrimary (citable) accession number: Q96SR6
Secondary accession number(s): A3KMP6 expand/collapse secondary AC list , A8MT55, C9K0V5, Q53ZY8, Q5JPJ2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: November 30, 2010
Last modified: April 16, 2014
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM