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Protein

Cytochrome P450 2S1

Gene

CYP2S1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has a potential importance for extrahepatic xenobiotic metabolism.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi440 – 4401Iron (heme axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_13425. Miscellaneous substrates.
REACT_13543. Xenobiotics.
REACT_13797. CYP2E1 reactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2S1 (EC:1.14.14.1)
Alternative name(s):
CYPIIS1
Gene namesi
Name:CYP2S1
ORF Names:UNQ891/PRO1906
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:15654. CYP2S1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27113.

Polymorphism and mutation databases

BioMutaiCYP2S1.
DMDMi48428134.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 504504Cytochrome P450 2S1PRO_0000051780Add
BLAST

Proteomic databases

MaxQBiQ96SQ9.
PaxDbiQ96SQ9.
PRIDEiQ96SQ9.

PTM databases

PhosphoSiteiQ96SQ9.

Expressioni

Tissue specificityi

High level of expression in trachea, lung, stomach, small intestine, and spleen.1 Publication

Gene expression databases

BgeeiQ96SQ9.
CleanExiHS_CYP2S1.
ExpressionAtlasiQ96SQ9. baseline and differential.
GenevisibleiQ96SQ9. HS.

Organism-specific databases

HPAiHPA037692.
HPA049227.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-33EBI-8633740,EBI-10173507

Protein-protein interaction databases

BioGridi118915. 31 interactions.
IntActiQ96SQ9. 1 interaction.
STRINGi9606.ENSP00000308032.

Structurei

3D structure databases

ProteinModelPortaliQ96SQ9.
SMRiQ96SQ9. Positions 30-491.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiQ96SQ9.
KOiK07420.
OMAiTIYLGPW.
OrthoDBiEOG7RBZ85.
PhylomeDBiQ96SQ9.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96SQ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEATGTWALL LALALLLLLT LALSGTRARG HLPPGPTPLP LLGNLLQLRP
60 70 80 90 100
GALYSGLMRL SKKYGPVFTI YLGPWRPVVV LVGQEAVREA LGGQAEEFSG
110 120 130 140 150
RGTVAMLEGT FDGHGVFFSN GERWRQLRKF TMLALRDLGM GKREGEELIQ
160 170 180 190 200
AEARCLVETF QGTEGRPFDP SLLLAQATSN VVCSLLFGLR FSYEDKEFQA
210 220 230 240 250
VVRAAGGTLL GVSSQGGQTY EMFSWFLRPL PGPHKQLLHH VSTLAAFTVR
260 270 280 290 300
QVQQHQGNLD ASGPARDLVD AFLLKMAQEE QNPGTEFTNK NMLMTVIYLL
310 320 330 340 350
FAGTMTVSTT VGYTLLLLMK YPHVQKWVRE ELNRELGAGQ APSLGDRTRL
360 370 380 390 400
PYTDAVLHEA QRLLALVPMG IPRTLMRTTR FRGYTLPQGT EVFPLLGSIL
410 420 430 440 450
HDPNIFKHPE EFNPDRFLDA DGRFRKHEAF LPFSLGKRVC LGEGLAKAEL
460 470 480 490 500
FLFFTTILQA FSLESPCPPD TLSLKPTVSG LFNIPPAFQL QVRPTDLHST

TQTR
Length:504
Mass (Da):55,817
Last modified:June 7, 2004 - v2
Checksum:i853513370F65E25A
GO
Isoform 2 (identifier: Q96SQ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     488-504: FQLQVRPTDLHSTTQTR → STVGMDRVNV...KYSPSAITST

Note: No experimental confirmation available.
Show »
Length:564
Mass (Da):62,231
Checksum:i03B2E9376A494D12
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti466 – 4661P → L.
Corresponds to variant rs34971233 [ dbSNP | Ensembl ].
VAR_033820

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei488 – 50417FQLQV…TTQTR → STVGMDRVNVSRVYTAGSHI YTPAVVFRSLSHGPHAHLTH AAKMHNRTPIHNYKGHKATA GLAFHRHKYSPSAITST in isoform 2. 1 PublicationVSP_010531Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF335278 mRNA. Translation: AAK13498.1.
AY358603 mRNA. Translation: AAQ88966.1.
AK027605 mRNA. Translation: BAB55227.1.
BC033691 mRNA. Translation: AAH33691.1.
CCDSiCCDS12573.1. [Q96SQ9-1]
PIRiJC7613.
RefSeqiNP_085125.1. NM_030622.7. [Q96SQ9-1]
UniGeneiHs.98370.

Genome annotation databases

EnsembliENST00000310054; ENSP00000308032; ENSG00000167600.
GeneIDi29785.
KEGGihsa:29785.
UCSCiuc002opw.3. human. [Q96SQ9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF335278 mRNA. Translation: AAK13498.1.
AY358603 mRNA. Translation: AAQ88966.1.
AK027605 mRNA. Translation: BAB55227.1.
BC033691 mRNA. Translation: AAH33691.1.
CCDSiCCDS12573.1. [Q96SQ9-1]
PIRiJC7613.
RefSeqiNP_085125.1. NM_030622.7. [Q96SQ9-1]
UniGeneiHs.98370.

3D structure databases

ProteinModelPortaliQ96SQ9.
SMRiQ96SQ9. Positions 30-491.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118915. 31 interactions.
IntActiQ96SQ9. 1 interaction.
STRINGi9606.ENSP00000308032.

PTM databases

PhosphoSiteiQ96SQ9.

Polymorphism and mutation databases

BioMutaiCYP2S1.
DMDMi48428134.

Proteomic databases

MaxQBiQ96SQ9.
PaxDbiQ96SQ9.
PRIDEiQ96SQ9.

Protocols and materials databases

DNASUi29785.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310054; ENSP00000308032; ENSG00000167600.
GeneIDi29785.
KEGGihsa:29785.
UCSCiuc002opw.3. human. [Q96SQ9-1]

Organism-specific databases

CTDi29785.
GeneCardsiGC19P041699.
H-InvDBHIX0015148.
HGNCiHGNC:15654. CYP2S1.
HPAiHPA037692.
HPA049227.
MIMi611529. gene.
neXtProtiNX_Q96SQ9.
PharmGKBiPA27113.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiQ96SQ9.
KOiK07420.
OMAiTIYLGPW.
OrthoDBiEOG7RBZ85.
PhylomeDBiQ96SQ9.
TreeFamiTF352043.

Enzyme and pathway databases

ReactomeiREACT_13425. Miscellaneous substrates.
REACT_13543. Xenobiotics.
REACT_13797. CYP2E1 reactions.

Miscellaneous databases

ChiTaRSiCYP2S1. human.
GeneWikiiCYP2S1.
GenomeRNAii29785.
NextBioi52318.
PROiQ96SQ9.
SOURCEiSearch...

Gene expression databases

BgeeiQ96SQ9.
CleanExiHS_CYP2S1.
ExpressionAtlasiQ96SQ9. baseline and differential.
GenevisibleiQ96SQ9. HS.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and tissue distribution of the novel human cytochrome P450 2S1 (CYP2S1)."
    Rylander T., Neve E., Ingelman-Sundberg M., Oscarson M.
    Biochem. Biophys. Res. Commun. 281:529-535(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Blood.

Entry informationi

Entry nameiCP2S1_HUMAN
AccessioniPrimary (citable) accession number: Q96SQ9
Secondary accession number(s): Q9BZ66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: July 22, 2015
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.