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Protein

Cytochrome P450 2S1

Gene

CYP2S1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has a potential importance for extrahepatic xenobiotic metabolism.

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi440Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:HS09588-MONOMER.
ReactomeiR-HSA-211958. Miscellaneous substrates.
R-HSA-211981. Xenobiotics.
R-HSA-211999. CYP2E1 reactions.

Chemistry databases

SwissLipidsiSLP:000001465.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2S1 (EC:1.14.14.1)
Alternative name(s):
CYPIIS1
Gene namesi
Name:CYP2S1
ORF Names:UNQ891/PRO1906
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:15654. CYP2S1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

DisGeNETi29785.
OpenTargetsiENSG00000167600.
PharmGKBiPA27113.

Polymorphism and mutation databases

BioMutaiCYP2S1.
DMDMi48428134.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517801 – 504Cytochrome P450 2S1Add BLAST504

Proteomic databases

EPDiQ96SQ9.
MaxQBiQ96SQ9.
PaxDbiQ96SQ9.
PeptideAtlasiQ96SQ9.
PRIDEiQ96SQ9.

PTM databases

iPTMnetiQ96SQ9.
PhosphoSitePlusiQ96SQ9.

Expressioni

Tissue specificityi

High level of expression in trachea, lung, stomach, small intestine, and spleen.1 Publication

Gene expression databases

BgeeiENSG00000167600.
CleanExiHS_CYP2S1.
ExpressionAtlasiQ96SQ9. baseline and differential.
GenevisibleiQ96SQ9. HS.

Organism-specific databases

HPAiHPA037692.
HPA049227.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-33EBI-8633740,EBI-10173507

Protein-protein interaction databases

BioGridi118915. 37 interactors.
IntActiQ96SQ9. 3 interactors.
STRINGi9606.ENSP00000308032.

Structurei

3D structure databases

ProteinModelPortaliQ96SQ9.
SMRiQ96SQ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiQ96SQ9.
KOiK07420.
OMAiTIYLGPW.
OrthoDBiEOG091G0BT8.
PhylomeDBiQ96SQ9.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96SQ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEATGTWALL LALALLLLLT LALSGTRARG HLPPGPTPLP LLGNLLQLRP
60 70 80 90 100
GALYSGLMRL SKKYGPVFTI YLGPWRPVVV LVGQEAVREA LGGQAEEFSG
110 120 130 140 150
RGTVAMLEGT FDGHGVFFSN GERWRQLRKF TMLALRDLGM GKREGEELIQ
160 170 180 190 200
AEARCLVETF QGTEGRPFDP SLLLAQATSN VVCSLLFGLR FSYEDKEFQA
210 220 230 240 250
VVRAAGGTLL GVSSQGGQTY EMFSWFLRPL PGPHKQLLHH VSTLAAFTVR
260 270 280 290 300
QVQQHQGNLD ASGPARDLVD AFLLKMAQEE QNPGTEFTNK NMLMTVIYLL
310 320 330 340 350
FAGTMTVSTT VGYTLLLLMK YPHVQKWVRE ELNRELGAGQ APSLGDRTRL
360 370 380 390 400
PYTDAVLHEA QRLLALVPMG IPRTLMRTTR FRGYTLPQGT EVFPLLGSIL
410 420 430 440 450
HDPNIFKHPE EFNPDRFLDA DGRFRKHEAF LPFSLGKRVC LGEGLAKAEL
460 470 480 490 500
FLFFTTILQA FSLESPCPPD TLSLKPTVSG LFNIPPAFQL QVRPTDLHST

TQTR
Length:504
Mass (Da):55,817
Last modified:June 7, 2004 - v2
Checksum:i853513370F65E25A
GO
Isoform 2 (identifier: Q96SQ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     488-504: FQLQVRPTDLHSTTQTR → STVGMDRVNV...KYSPSAITST

Note: No experimental confirmation available.
Show »
Length:564
Mass (Da):62,231
Checksum:i03B2E9376A494D12
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033820466P → L.Corresponds to variant rs34971233dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010531488 – 504FQLQV…TTQTR → STVGMDRVNVSRVYTAGSHI YTPAVVFRSLSHGPHAHLTH AAKMHNRTPIHNYKGHKATA GLAFHRHKYSPSAITST in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF335278 mRNA. Translation: AAK13498.1.
AY358603 mRNA. Translation: AAQ88966.1.
AK027605 mRNA. Translation: BAB55227.1.
BC033691 mRNA. Translation: AAH33691.1.
CCDSiCCDS12573.1. [Q96SQ9-1]
PIRiJC7613.
RefSeqiNP_085125.1. NM_030622.7. [Q96SQ9-1]
UniGeneiHs.98370.

Genome annotation databases

EnsembliENST00000310054; ENSP00000308032; ENSG00000167600. [Q96SQ9-1]
GeneIDi29785.
KEGGihsa:29785.
UCSCiuc002opw.4. human. [Q96SQ9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF335278 mRNA. Translation: AAK13498.1.
AY358603 mRNA. Translation: AAQ88966.1.
AK027605 mRNA. Translation: BAB55227.1.
BC033691 mRNA. Translation: AAH33691.1.
CCDSiCCDS12573.1. [Q96SQ9-1]
PIRiJC7613.
RefSeqiNP_085125.1. NM_030622.7. [Q96SQ9-1]
UniGeneiHs.98370.

3D structure databases

ProteinModelPortaliQ96SQ9.
SMRiQ96SQ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118915. 37 interactors.
IntActiQ96SQ9. 3 interactors.
STRINGi9606.ENSP00000308032.

Chemistry databases

SwissLipidsiSLP:000001465.

PTM databases

iPTMnetiQ96SQ9.
PhosphoSitePlusiQ96SQ9.

Polymorphism and mutation databases

BioMutaiCYP2S1.
DMDMi48428134.

Proteomic databases

EPDiQ96SQ9.
MaxQBiQ96SQ9.
PaxDbiQ96SQ9.
PeptideAtlasiQ96SQ9.
PRIDEiQ96SQ9.

Protocols and materials databases

DNASUi29785.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000310054; ENSP00000308032; ENSG00000167600. [Q96SQ9-1]
GeneIDi29785.
KEGGihsa:29785.
UCSCiuc002opw.4. human. [Q96SQ9-1]

Organism-specific databases

CTDi29785.
DisGeNETi29785.
GeneCardsiCYP2S1.
H-InvDBHIX0015148.
HGNCiHGNC:15654. CYP2S1.
HPAiHPA037692.
HPA049227.
MIMi611529. gene.
neXtProtiNX_Q96SQ9.
OpenTargetsiENSG00000167600.
PharmGKBiPA27113.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0156. Eukaryota.
COG2124. LUCA.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiQ96SQ9.
KOiK07420.
OMAiTIYLGPW.
OrthoDBiEOG091G0BT8.
PhylomeDBiQ96SQ9.
TreeFamiTF352043.

Enzyme and pathway databases

BioCyciZFISH:HS09588-MONOMER.
ReactomeiR-HSA-211958. Miscellaneous substrates.
R-HSA-211981. Xenobiotics.
R-HSA-211999. CYP2E1 reactions.

Miscellaneous databases

ChiTaRSiCYP2S1. human.
GeneWikiiCYP2S1.
GenomeRNAii29785.
PROiQ96SQ9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167600.
CleanExiHS_CYP2S1.
ExpressionAtlasiQ96SQ9. baseline and differential.
GenevisibleiQ96SQ9. HS.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01684. EP450ICYP2A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCP2S1_HUMAN
AccessioniPrimary (citable) accession number: Q96SQ9
Secondary accession number(s): Q9BZ66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: November 30, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.