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Q96SQ9

- CP2S1_HUMAN

UniProt

Q96SQ9 - CP2S1_HUMAN

Protein

Cytochrome P450 2S1

Gene

CYP2S1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (07 Jun 2004)
      Previous versions | rss
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    Functioni

    Has a potential importance for extrahepatic xenobiotic metabolism.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi440 – 4401Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. small molecule metabolic process Source: Reactome
    2. xenobiotic metabolic process Source: Reactome

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_13425. Miscellaneous substrates.
    REACT_13543. Xenobiotics.
    REACT_13797. CYP2E1 reactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2S1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIS1
    Gene namesi
    Name:CYP2S1
    ORF Names:UNQ891/PRO1906
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:15654. CYP2S1.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Peripheral membrane protein 1 Publication. Microsome membrane 1 Publication; Peripheral membrane protein 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: Reactome

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27113.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 504504Cytochrome P450 2S1PRO_0000051780Add
    BLAST

    Proteomic databases

    MaxQBiQ96SQ9.
    PaxDbiQ96SQ9.
    PRIDEiQ96SQ9.

    PTM databases

    PhosphoSiteiQ96SQ9.

    Expressioni

    Tissue specificityi

    High level of expression in trachea, lung, stomach, small intestine, and spleen.1 Publication

    Gene expression databases

    ArrayExpressiQ96SQ9.
    BgeeiQ96SQ9.
    CleanExiHS_CYP2S1.
    GenevestigatoriQ96SQ9.

    Organism-specific databases

    HPAiHPA037692.

    Interactioni

    Protein-protein interaction databases

    BioGridi118915. 2 interactions.
    IntActiQ96SQ9. 1 interaction.
    STRINGi9606.ENSP00000308032.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96SQ9.
    SMRiQ96SQ9. Positions 30-491.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.
    KOiK07420.
    OMAiGSHIYTP.
    OrthoDBiEOG7RBZ85.
    PhylomeDBiQ96SQ9.
    TreeFamiTF352043.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01684. EP450ICYP2A.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96SQ9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEATGTWALL LALALLLLLT LALSGTRARG HLPPGPTPLP LLGNLLQLRP    50
    GALYSGLMRL SKKYGPVFTI YLGPWRPVVV LVGQEAVREA LGGQAEEFSG 100
    RGTVAMLEGT FDGHGVFFSN GERWRQLRKF TMLALRDLGM GKREGEELIQ 150
    AEARCLVETF QGTEGRPFDP SLLLAQATSN VVCSLLFGLR FSYEDKEFQA 200
    VVRAAGGTLL GVSSQGGQTY EMFSWFLRPL PGPHKQLLHH VSTLAAFTVR 250
    QVQQHQGNLD ASGPARDLVD AFLLKMAQEE QNPGTEFTNK NMLMTVIYLL 300
    FAGTMTVSTT VGYTLLLLMK YPHVQKWVRE ELNRELGAGQ APSLGDRTRL 350
    PYTDAVLHEA QRLLALVPMG IPRTLMRTTR FRGYTLPQGT EVFPLLGSIL 400
    HDPNIFKHPE EFNPDRFLDA DGRFRKHEAF LPFSLGKRVC LGEGLAKAEL 450
    FLFFTTILQA FSLESPCPPD TLSLKPTVSG LFNIPPAFQL QVRPTDLHST 500
    TQTR 504
    Length:504
    Mass (Da):55,817
    Last modified:June 7, 2004 - v2
    Checksum:i853513370F65E25A
    GO
    Isoform 2 (identifier: Q96SQ9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         488-504: FQLQVRPTDLHSTTQTR → STVGMDRVNV...KYSPSAITST

    Note: No experimental confirmation available.

    Show »
    Length:564
    Mass (Da):62,231
    Checksum:i03B2E9376A494D12
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti466 – 4661P → L.
    Corresponds to variant rs34971233 [ dbSNP | Ensembl ].
    VAR_033820

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei488 – 50417FQLQV…TTQTR → STVGMDRVNVSRVYTAGSHI YTPAVVFRSLSHGPHAHLTH AAKMHNRTPIHNYKGHKATA GLAFHRHKYSPSAITST in isoform 2. 1 PublicationVSP_010531Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF335278 mRNA. Translation: AAK13498.1.
    AY358603 mRNA. Translation: AAQ88966.1.
    AK027605 mRNA. Translation: BAB55227.1.
    BC033691 mRNA. Translation: AAH33691.1.
    CCDSiCCDS12573.1. [Q96SQ9-1]
    PIRiJC7613.
    RefSeqiNP_085125.1. NM_030622.6. [Q96SQ9-1]
    UniGeneiHs.98370.

    Genome annotation databases

    EnsembliENST00000310054; ENSP00000308032; ENSG00000167600. [Q96SQ9-1]
    GeneIDi29785.
    KEGGihsa:29785.
    UCSCiuc002opw.3. human. [Q96SQ9-1]

    Polymorphism databases

    DMDMi48428134.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF335278 mRNA. Translation: AAK13498.1 .
    AY358603 mRNA. Translation: AAQ88966.1 .
    AK027605 mRNA. Translation: BAB55227.1 .
    BC033691 mRNA. Translation: AAH33691.1 .
    CCDSi CCDS12573.1. [Q96SQ9-1 ]
    PIRi JC7613.
    RefSeqi NP_085125.1. NM_030622.6. [Q96SQ9-1 ]
    UniGenei Hs.98370.

    3D structure databases

    ProteinModelPortali Q96SQ9.
    SMRi Q96SQ9. Positions 30-491.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118915. 2 interactions.
    IntActi Q96SQ9. 1 interaction.
    STRINGi 9606.ENSP00000308032.

    PTM databases

    PhosphoSitei Q96SQ9.

    Polymorphism databases

    DMDMi 48428134.

    Proteomic databases

    MaxQBi Q96SQ9.
    PaxDbi Q96SQ9.
    PRIDEi Q96SQ9.

    Protocols and materials databases

    DNASUi 29785.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000310054 ; ENSP00000308032 ; ENSG00000167600 . [Q96SQ9-1 ]
    GeneIDi 29785.
    KEGGi hsa:29785.
    UCSCi uc002opw.3. human. [Q96SQ9-1 ]

    Organism-specific databases

    CTDi 29785.
    GeneCardsi GC19P041699.
    H-InvDB HIX0015148.
    HGNCi HGNC:15654. CYP2S1.
    HPAi HPA037692.
    MIMi 611529. gene.
    neXtProti NX_Q96SQ9.
    PharmGKBi PA27113.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.
    KOi K07420.
    OMAi GSHIYTP.
    OrthoDBi EOG7RBZ85.
    PhylomeDBi Q96SQ9.
    TreeFami TF352043.

    Enzyme and pathway databases

    Reactomei REACT_13425. Miscellaneous substrates.
    REACT_13543. Xenobiotics.
    REACT_13797. CYP2E1 reactions.

    Miscellaneous databases

    GeneWikii CYP2S1.
    GenomeRNAii 29785.
    NextBioi 52318.
    PROi Q96SQ9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96SQ9.
    Bgeei Q96SQ9.
    CleanExi HS_CYP2S1.
    Genevestigatori Q96SQ9.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008067. Cyt_P450_E_grp-I_CYP2A-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01684. EP450ICYP2A.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and tissue distribution of the novel human cytochrome P450 2S1 (CYP2S1)."
      Rylander T., Neve E., Ingelman-Sundberg M., Oscarson M.
      Biochem. Biophys. Res. Commun. 281:529-535(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Blood.

    Entry informationi

    Entry nameiCP2S1_HUMAN
    AccessioniPrimary (citable) accession number: Q96SQ9
    Secondary accession number(s): Q9BZ66
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 7, 2004
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3