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Protein

Zinc finger protein 587

Gene

ZNF587

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri92 – 11423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri240 – 26223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri296 – 31823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri324 – 34623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri352 – 37423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri408 – 43023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri436 – 45823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri464 – 48623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri492 – 51423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri520 – 54223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri548 – 57023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 587
Gene namesi
Name:ZNF587
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:30955. ZNF587.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134940421.

Polymorphism and mutation databases

BioMutaiZNF587.
DMDMi74762694.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 575575Zinc finger protein 587PRO_0000233987Add
BLAST

Proteomic databases

MaxQBiQ96SQ5.
PaxDbiQ96SQ5.
PeptideAtlasiQ96SQ5.
PRIDEiQ96SQ5.

PTM databases

iPTMnetiQ96SQ5.
PhosphoSiteiQ96SQ5.

Expressioni

Gene expression databases

BgeeiENSG00000198466.
CleanExiHS_ZNF587.
ExpressionAtlasiQ96SQ5. baseline and differential.
GenevisibleiQ96SQ5. HS.

Organism-specific databases

HPAiHPA042125.
HPA043288.
HPA056213.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADAMTSL4Q6UY14-33EBI-6427977,EBI-10173507
CARD9Q9H2573EBI-6427977,EBI-751319
CCDC136Q96JN2-23EBI-6427977,EBI-10171416
CEP44Q9C0F13EBI-6427977,EBI-744115
CEP70Q8NHQ13EBI-6427977,EBI-739624
CSRNP1Q96S653EBI-6427977,EBI-4311573
FSD2A1L4K13EBI-6427977,EBI-5661036
GOLGA2Q083793EBI-6427977,EBI-618309
GOPCQ9HD263EBI-6427977,EBI-349832
HMBOX1Q6NT763EBI-6427977,EBI-2549423
KRT38O760153EBI-6427977,EBI-1047263
KRT40Q6A1623EBI-6427977,EBI-10171697
KRTAP10-5P603703EBI-6427977,EBI-10172150
KRTAP10-7P604093EBI-6427977,EBI-10172290
KRTAP10-8P604103EBI-6427977,EBI-10171774
KRTAP10-9P604113EBI-6427977,EBI-10172052
KRTAP2-3P0C7H83EBI-6427977,EBI-10196781
KRTAP5-9P263713EBI-6427977,EBI-3958099
MDFIQ997503EBI-6427977,EBI-724076
MEOX2A4D1273EBI-6427977,EBI-10172134
MID2Q9UJV3-23EBI-6427977,EBI-10172526
MTUS2Q5JR593EBI-6427977,EBI-742948
NOTCH2NLQ7Z3S93EBI-6427977,EBI-945833
PLSCR1O151623EBI-6427977,EBI-740019
PNMA2Q9UL423EBI-6427977,EBI-302355
PRPF31F1T0A53EBI-6427977,EBI-10177194
RUNDC3AQ59EK93EBI-6427977,EBI-747225
SPRY2O435973EBI-6427977,EBI-742487
SSX2IPQ9Y2D83EBI-6427977,EBI-2212028
STX11O755583EBI-6427977,EBI-714135
TCF4P158843EBI-6427977,EBI-533224
TMCC2Q7Z6C63EBI-6427977,EBI-10177480
TNS2Q63HR23EBI-6427977,EBI-949753
TRAF1Q130773EBI-6427977,EBI-359224
TRIM36Q9NQ863EBI-6427977,EBI-2341518
TRIM41Q8WV443EBI-6427977,EBI-725997
TRIM54Q9BYV23EBI-6427977,EBI-2130429
TSGA10Q9BZW73EBI-6427977,EBI-744794
ZBTB8AQ96BR93EBI-6427977,EBI-742740
ZNF417Q8TAU33EBI-6427977,EBI-740727

Protein-protein interaction databases

BioGridi124351. 42 interactions.
IntActiQ96SQ5. 41 interactions.
STRINGi9606.ENSP00000345479.

Structurei

3D structure databases

ProteinModelPortaliQ96SQ5.
SMRiQ96SQ5. Positions 106-573.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 8874KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri92 – 11423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri240 – 26223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 29023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri296 – 31823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri324 – 34623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri352 – 37423C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri380 – 40223C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri408 – 43023C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri436 – 45823C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri464 – 48623C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri492 – 51423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri520 – 54223C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri548 – 57023C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96SQ5.
KOiK09228.
OMAiEPFVFHE.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96SQ5.
TreeFamiTF339848.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96SQ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAVPRRPT QQGTVTFEDV AVNFSQEEWC LLSEAQRCLY RDVMLENLAL
60 70 80 90 100
ISSLGCWCGS KDEEAPCKQR ISVQRESQSR TPRAGVSPKK AHPCEMCGLI
110 120 130 140 150
LEDVFHFADH QETHHKQKLN RSGACGKNLD DTAYLHQHQK QHIGEKFYRK
160 170 180 190 200
SVREASFVKK RKLRVSQEPF VFREFGKDVL PSSGLCQEEA AVEKTDSETM
210 220 230 240 250
HGPPFQEGKT NYSCGKRTKA FSTKHSVIPH QKLFTRDGCY VCSDCGKSFS
260 270 280 290 300
RYVSFSNHQR DHTAKGPYDC GECGKSYSRK SSLIQHQRVH TGQTAYPCEE
310 320 330 340 350
CGKSFSQKGS LISHQLVHTG EGPYECRECG KSFGQKGNLI QHQQGHTGER
360 370 380 390 400
AYHCGECGKS FRQKFCFINH QRVHTGERPY KCGECGKSFG QKGNLVHHQR
410 420 430 440 450
GHTGERPYEC KECGKSFRYR SHLTEHQRLH TGERPYNCRE CGKLFNRKYH
460 470 480 490 500
LLVHERVHTG ERPYACEVCG KLFGNKHSVT IHQRIHTGER PYECSECGKS
510 520 530 540 550
FLSSSALHVH KRVHSGQKPY KCSECGKSFS ECSSLIKHRR IHTGERPYEC
560 570
TKCGKTFQRS STLLHHQSSH RRKAL
Length:575
Mass (Da):65,622
Last modified:December 1, 2001 - v1
Checksum:i61134F2814963397
GO
Isoform 2 (identifier: Q96SQ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-11: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:574
Mass (Da):65,494
Checksum:iDED642F4A347D10F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei11 – 111Missing in isoform 2. CuratedVSP_046842

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027616 mRNA. Translation: BAB55235.1.
AC010326 Genomic DNA. No translation available.
AC010522 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72537.1.
BC126237 mRNA. Translation: AAI26238.1.
BC126239 mRNA. Translation: AAI26240.1.
AK160374 mRNA. Translation: BAD18717.1.
CCDSiCCDS12964.1. [Q96SQ5-1]
CCDS56110.1. [Q96SQ5-2]
RefSeqiNP_001191746.1. NM_001204817.1. [Q96SQ5-2]
NP_116217.1. NM_032828.3. [Q96SQ5-1]
UniGeneiHs.642598.
Hs.744891.

Genome annotation databases

EnsembliENST00000339656; ENSP00000345479; ENSG00000198466. [Q96SQ5-1]
ENST00000423137; ENSP00000393865; ENSG00000198466. [Q96SQ5-2]
GeneIDi84914.
KEGGihsa:84914.
UCSCiuc002qql.4. human. [Q96SQ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027616 mRNA. Translation: BAB55235.1.
AC010326 Genomic DNA. No translation available.
AC010522 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72537.1.
BC126237 mRNA. Translation: AAI26238.1.
BC126239 mRNA. Translation: AAI26240.1.
AK160374 mRNA. Translation: BAD18717.1.
CCDSiCCDS12964.1. [Q96SQ5-1]
CCDS56110.1. [Q96SQ5-2]
RefSeqiNP_001191746.1. NM_001204817.1. [Q96SQ5-2]
NP_116217.1. NM_032828.3. [Q96SQ5-1]
UniGeneiHs.642598.
Hs.744891.

3D structure databases

ProteinModelPortaliQ96SQ5.
SMRiQ96SQ5. Positions 106-573.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124351. 42 interactions.
IntActiQ96SQ5. 41 interactions.
STRINGi9606.ENSP00000345479.

PTM databases

iPTMnetiQ96SQ5.
PhosphoSiteiQ96SQ5.

Polymorphism and mutation databases

BioMutaiZNF587.
DMDMi74762694.

Proteomic databases

MaxQBiQ96SQ5.
PaxDbiQ96SQ5.
PeptideAtlasiQ96SQ5.
PRIDEiQ96SQ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339656; ENSP00000345479; ENSG00000198466. [Q96SQ5-1]
ENST00000423137; ENSP00000393865; ENSG00000198466. [Q96SQ5-2]
GeneIDi84914.
KEGGihsa:84914.
UCSCiuc002qql.4. human. [Q96SQ5-1]

Organism-specific databases

CTDi84914.
GeneCardsiZNF587.
HGNCiHGNC:30955. ZNF587.
HPAiHPA042125.
HPA043288.
HPA056213.
neXtProtiNX_Q96SQ5.
PharmGKBiPA134940421.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96SQ5.
KOiK09228.
OMAiEPFVFHE.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96SQ5.
TreeFamiTF339848.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF587. human.
GenomeRNAii84914.
PROiQ96SQ5.

Gene expression databases

BgeeiENSG00000198466.
CleanExiHS_ZNF587.
ExpressionAtlasiQ96SQ5. baseline and differential.
GenevisibleiQ96SQ5. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN587_HUMAN
AccessioniPrimary (citable) accession number: Q96SQ5
Secondary accession number(s): A0AV72, G3V0H5, Q6ZMK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.