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Protein

Zinc finger protein 587

Gene

ZNF587

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri92 – 114C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri548 – 570C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 587
Gene namesi
Name:ZNF587
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:30955. ZNF587.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198466.
PharmGKBiPA134940421.

Polymorphism and mutation databases

BioMutaiZNF587.
DMDMi74762694.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002339871 – 575Zinc finger protein 587Add BLAST575

Proteomic databases

MaxQBiQ96SQ5.
PaxDbiQ96SQ5.
PeptideAtlasiQ96SQ5.
PRIDEiQ96SQ5.

PTM databases

iPTMnetiQ96SQ5.
PhosphoSitePlusiQ96SQ5.

Expressioni

Gene expression databases

BgeeiENSG00000198466.
CleanExiHS_ZNF587.
ExpressionAtlasiQ96SQ5. baseline and differential.
GenevisibleiQ96SQ5. HS.

Organism-specific databases

HPAiHPA042125.
HPA043288.
HPA056213.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi124351. 42 interactors.
IntActiQ96SQ5. 103 interactors.
STRINGi9606.ENSP00000345479.

Structurei

3D structure databases

ProteinModelPortaliQ96SQ5.
SMRiQ96SQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 88KRABPROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri92 – 114C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri240 – 262C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri268 – 290C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri296 – 318C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri324 – 346C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri352 – 374C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri380 – 402C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri548 – 570C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96SQ5.
KOiK09228.
OMAiEPFVFHE.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96SQ5.
TreeFamiTF339848.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 9 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96SQ5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAVPRRPT QQGTVTFEDV AVNFSQEEWC LLSEAQRCLY RDVMLENLAL
60 70 80 90 100
ISSLGCWCGS KDEEAPCKQR ISVQRESQSR TPRAGVSPKK AHPCEMCGLI
110 120 130 140 150
LEDVFHFADH QETHHKQKLN RSGACGKNLD DTAYLHQHQK QHIGEKFYRK
160 170 180 190 200
SVREASFVKK RKLRVSQEPF VFREFGKDVL PSSGLCQEEA AVEKTDSETM
210 220 230 240 250
HGPPFQEGKT NYSCGKRTKA FSTKHSVIPH QKLFTRDGCY VCSDCGKSFS
260 270 280 290 300
RYVSFSNHQR DHTAKGPYDC GECGKSYSRK SSLIQHQRVH TGQTAYPCEE
310 320 330 340 350
CGKSFSQKGS LISHQLVHTG EGPYECRECG KSFGQKGNLI QHQQGHTGER
360 370 380 390 400
AYHCGECGKS FRQKFCFINH QRVHTGERPY KCGECGKSFG QKGNLVHHQR
410 420 430 440 450
GHTGERPYEC KECGKSFRYR SHLTEHQRLH TGERPYNCRE CGKLFNRKYH
460 470 480 490 500
LLVHERVHTG ERPYACEVCG KLFGNKHSVT IHQRIHTGER PYECSECGKS
510 520 530 540 550
FLSSSALHVH KRVHSGQKPY KCSECGKSFS ECSSLIKHRR IHTGERPYEC
560 570
TKCGKTFQRS STLLHHQSSH RRKAL
Length:575
Mass (Da):65,622
Last modified:December 1, 2001 - v1
Checksum:i61134F2814963397
GO
Isoform 2 (identifier: Q96SQ5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-11: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:574
Mass (Da):65,494
Checksum:iDED642F4A347D10F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04684211Missing in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027616 mRNA. Translation: BAB55235.1.
AC010326 Genomic DNA. No translation available.
AC010522 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72537.1.
BC126237 mRNA. Translation: AAI26238.1.
BC126239 mRNA. Translation: AAI26240.1.
AK160374 mRNA. Translation: BAD18717.1.
CCDSiCCDS12964.1. [Q96SQ5-1]
CCDS56110.1. [Q96SQ5-2]
RefSeqiNP_001191746.1. NM_001204817.1. [Q96SQ5-2]
NP_116217.1. NM_032828.3. [Q96SQ5-1]
UniGeneiHs.642598.
Hs.744891.

Genome annotation databases

EnsembliENST00000339656; ENSP00000345479; ENSG00000198466. [Q96SQ5-1]
ENST00000423137; ENSP00000393865; ENSG00000198466. [Q96SQ5-2]
GeneIDi84914.
KEGGihsa:84914.
UCSCiuc002qql.4. human. [Q96SQ5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027616 mRNA. Translation: BAB55235.1.
AC010326 Genomic DNA. No translation available.
AC010522 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72537.1.
BC126237 mRNA. Translation: AAI26238.1.
BC126239 mRNA. Translation: AAI26240.1.
AK160374 mRNA. Translation: BAD18717.1.
CCDSiCCDS12964.1. [Q96SQ5-1]
CCDS56110.1. [Q96SQ5-2]
RefSeqiNP_001191746.1. NM_001204817.1. [Q96SQ5-2]
NP_116217.1. NM_032828.3. [Q96SQ5-1]
UniGeneiHs.642598.
Hs.744891.

3D structure databases

ProteinModelPortaliQ96SQ5.
SMRiQ96SQ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124351. 42 interactors.
IntActiQ96SQ5. 103 interactors.
STRINGi9606.ENSP00000345479.

PTM databases

iPTMnetiQ96SQ5.
PhosphoSitePlusiQ96SQ5.

Polymorphism and mutation databases

BioMutaiZNF587.
DMDMi74762694.

Proteomic databases

MaxQBiQ96SQ5.
PaxDbiQ96SQ5.
PeptideAtlasiQ96SQ5.
PRIDEiQ96SQ5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339656; ENSP00000345479; ENSG00000198466. [Q96SQ5-1]
ENST00000423137; ENSP00000393865; ENSG00000198466. [Q96SQ5-2]
GeneIDi84914.
KEGGihsa:84914.
UCSCiuc002qql.4. human. [Q96SQ5-1]

Organism-specific databases

CTDi84914.
GeneCardsiZNF587.
HGNCiHGNC:30955. ZNF587.
HPAiHPA042125.
HPA043288.
HPA056213.
neXtProtiNX_Q96SQ5.
OpenTargetsiENSG00000198466.
PharmGKBiPA134940421.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96SQ5.
KOiK09228.
OMAiEPFVFHE.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96SQ5.
TreeFamiTF339848.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZNF587. human.
GenomeRNAii84914.
PROiPR:Q96SQ5.

Gene expression databases

BgeeiENSG00000198466.
CleanExiHS_ZNF587.
ExpressionAtlasiQ96SQ5. baseline and differential.
GenevisibleiQ96SQ5. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 9 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiZN587_HUMAN
AccessioniPrimary (citable) accession number: Q96SQ5
Secondary accession number(s): A0AV72, G3V0H5, Q6ZMK8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 1, 2001
Last modified: May 10, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.