Q96SN8 (CK5P2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CDK5 regulatory subunit-associated protein 2

Alternative name(s):
CDK5 activator-binding protein C48
Centrosome-associated protein 215

Gene names

Name:	CDK5RAP2
Synonyms:	CEP215, KIAA1633

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1893 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation By similarity. Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with MAPRE1, it may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Ref.12 Ref.13 Ref.15 Ref.16
Subunit structure	Interacts with CDK5R1 (p35 form). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1. Probably forms a complex with CDK5R1 and CDK5 By similarity. Interacts with PCNT; the interaction is leading to centrosomal and Golgi localization of CDK5RAP2 and PCNT. Interacts with AKAP9; the interaction is leading to Golgi localization of CDK5RAP2 and AKAP9. Interacts with MAPRE1; the interaction is leading to microtubule attachment at plus ends of CDK5RAP2 and MAPRE1. Interacts with TUBG1; the interaction is leading to the centrosomal localization of CDK5RAP2 and TUBG1. Interacts with TUBGCP3. Interacts with CALM1. Interacts with CDC20. Ref.13 Ref.15 Ref.16 Ref.19
Subcellular location	Cytoplasm › cytoskeleton › centrosome. Golgi apparatus. Cytoplasm. Note: Found in the pericentriolar region adhering to the surface of the centrosome and in the region of the centrosomal appendages. Localizes to microtubule plus ends. Ref.9 Ref.12 Ref.13 Ref.15 Ref.16 Ref.17 Ref.19
Tissue specificity	Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Ref.8
Post-translational modification	Phosphorylated in vitro by CDK5 By similarity.
Involvement in disease	Microcephaly, primary, 3 (MCPH3) [MIM:604804]: A disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Affected individuals are mentally retarded. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits due to degenerative brain disorder. Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10
Sequence caution	The sequence AAH04526.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAA91865.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB13459.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAB15263.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB55253.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAD97663.1 differs from that shown. Reason: Erroneous termination at position 1205. Translated as Gln. The sequence CAD97828.1 differs from that shown. Reason: Frameshift at position 1831.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Golgi apparatus Microtubule
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Primary microcephaly
Ligand	Calmodulin-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	G2/M transition of mitotic cell cycle Traceable author statement. Source: Reactome brain development Inferred from sequence or structural similarity. Source: UniProtKB centrosome organization Inferred from mutant phenotype Ref.12. Source: UniProtKB chromosome segregation Inferred from mutant phenotype Ref.15. Source: UniProtKB establishment of mitotic spindle orientation Inferred from sequence or structural similarity. Source: UniProtKB microtubule bundle formation Inferred from direct assay Ref.16. Source: UniProtKB negative regulation of centriole replication Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of neuron differentiation Inferred from electronic annotation. Source: Compara positive regulation of transcription, DNA-dependent Inferred from direct assay Ref.15. Source: UniProtKB regulation of neuron differentiation Non-traceable author statement Ref.8. Source: UniProtKB regulation of spindle checkpoint Inferred from direct assay Ref.15. Source: UniProtKB
Cellular_component	Golgi apparatus Inferred from direct assay Ref.19. Source: UniProtKB cell junction Inferred from direct assay. Source: HPA cytosol Traceable author statement. Source: Reactome microtubule Inferred from direct assay Ref.16. Source: UniProtKB pericentriolar material Inferred from direct assay Ref.13. Source: UniProtKB perinuclear region of cytoplasm Inferred from direct assay Ref.13. Source: UniProtKB spindle pole Inferred from direct assay Ref.13Ref.15. Source: UniProtKB
Molecular_function	microtubule binding Inferred from direct assay Ref.9. Source: UniProtKB transcription regulatory region DNA binding Inferred from direct assay Ref.15. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96SN8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q96SN8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     702-733: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q96SN8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1009-1049: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q96SN8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1576-1654: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1893	1893	CDK5 regulatory subunit-associated protein 2		PRO_0000089835
Regions
	Region	926 – 1208	283	Interaction with MAPRE1
	Region	1726 – 1893	168	Interaction with PCNT and AKAP9
	Region	1726 – 1768	43	Interaction with CDK5R1 By similarity
	Region	1861 – 1870	10	Required for centrosomal attachment, Golgi localization and CALM1 interaction
Amino acid modifications
	Modified residue	547	1	Phosphoserine Ref.20
	Modified residue	1001	1	Phosphothreonine Ref.20
	Modified residue	1238	1	Phosphoserine Ref.14 Ref.18
	Modified residue	1893	1	Phosphoserine Ref.14
Natural variations
	Alternative sequence	702 – 733	32	Missing in isoform 2.		VSP_007563
	Alternative sequence	1009 – 1049	41	Missing in isoform 3.		VSP_007564
	Alternative sequence	1576 – 1654	79	Missing in isoform 4.		VSP_007565
	Natural variant	183	1	A → P. Corresponds to variant rs13287734 [ dbSNP | Ensembl ].		VAR_056831
	Natural variant	289	1	E → Q. Ref.1 Ref.4 Corresponds to variant rs4836822 [ dbSNP | Ensembl ].		VAR_017443
	Natural variant	1045	1	R → T. Corresponds to variant rs3780679 [ dbSNP | Ensembl ].		VAR_032426
	Natural variant	1330	1	N → I. Corresponds to variant rs7875294 [ dbSNP | Ensembl ].		VAR_059616
	Natural variant	1540	1	V → L. Ref.4 Ref.6 Corresponds to variant rs4837768 [ dbSNP | Ensembl ].		VAR_017444
	Natural variant	1607	1	R → S. Corresponds to variant rs16909747 [ dbSNP | Ensembl ].		VAR_056832
Experimental info
	Mutagenesis	938	1	L → A: Loss of interaction with MAPRE1; when associated with A-939. Ref.16
	Mutagenesis	939	1	P → A: Loss of interaction with MAPRE1; when associated with A-938. Ref.16
	Mutagenesis	1865	1	K → A: No effect on centrosomal attachment, Golgi localization and loss of interaction with CALM1; when associated with A-1869. Ref.19
	Mutagenesis	1869	1	K → A: No effect on centrosomal attachment, Golgi localization and loss of interaction to CALM1; when associated with A-1865. Ref.19
	Sequence conflict	27	1	P → S in CAD97663. Ref.4
	Sequence conflict	43	1	L → V in AAP41926. Ref.3
	Sequence conflict	292	1	I → F in CAD97828. Ref.4
	Sequence conflict	414	1	E → K in CAD97828. Ref.4
	Sequence conflict	1254	1	S → F in CAD97663. Ref.4
	Sequence conflict	1458	1	Q → R in BAA91865. Ref.6
	Sequence conflict	1483	1	S → P in CAD97663. Ref.4
	Sequence conflict	1550	1	N → D in BAB55253. Ref.6
	Sequence conflict	1838	1	K → R in BAA91865. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 5. Checksum: 833B9F9EF3CE8D07	FASTA	1,893	215,038
	10 20 30 40 50 60 MMDLVLEEDV TVPGTLSGCS GLVPSVPDDL DGINPNAGLG NGLLPNVSEE TVSPTRARNM 70 80 90 100 110 120 KDFENQITEL KKENFNLKLR IYFLEERMQQ EFHGPTEHIY KTNIELKVEV ESLKRELQER 130 140 150 160 170 180 EQLLIKASKA VESLAEAGGS EIQRVKEDAR KKVQQVEDLL TKRILLLEKD VTAAQAELEK 190 200 210 220 230 240 AFAGTETEKA LRLRLESKLS EMKKMHEGDL AMALVLDEKD RLIEELKLSL KSKEALIQCL 250 260 270 280 290 300 KEEKSQMACP DENVSSGELR GLCAAPREEK ERETEAAQME HQKERNSFEE RIQALEEDLR 310 320 330 340 350 360 EKEREIATEK KNSLKRDKAI QGLTMALKSK EKKVEELNSE IEKLSAAFAK AREALQKAQT 370 380 390 400 410 420 QEFQGSEDYE TALSGKEALS AALRSQNLTK STENHRLRRS IKKITQELSD LQQERERLEK 430 440 450 460 470 480 DLEEAHREKS KGDCTIRDLR NEVEKLRNEV NEREKAMENR YKSLLSESNK KLHNQEQVIK 490 500 510 520 530 540 HLTESTNQKD VLLQKFNEKD LEVIQQNCYL MAAEDLELRS EGLITEKCSS QQPPGSKTIF 550 560 570 580 590 600 SKEKKQSSDY EELIQVLKKE QDIYTHLVKS LQESDSINNL QAELNKIFAL RKQLEQDVLS 610 620 630 640 650 660 YQNLRKTLEE QISEIRRREE ESFSLYSDQT SYLSICLEEN NRFQVEHFSQ EELKKKVSDL 670 680 690 700 710 720 IQLVKELYTD NQHLKKTIFD LSCMGFQGNG FPDRLASTEQ TELLASKEDE DTIKIGEDDE 730 740 750 760 770 780 INFLSDQHLQ QSNEIMKDLS KGGCKNGYLR HTESKISDCD GAHAPGCLEE GAFINLLAPL 790 800 810 820 830 840 FNEKATLLLE SRPDLLKVVR ELLLGQLFLT EQEVSGEHLD GKTEKTPKQK GELVHFVQTN 850 860 870 880 890 900 SFSKPHDELK LSCEAQLVKA GEVPKVGLKD ASVQTVATEG DLLRFKHEAT REAWEEKPIN 910 920 930 940 950 960 TALSAEHRPE NLHGVPGWQA ALLSLPGITN REAKKSRLPI LIKPSRSLGN MYRLPATQEV 970 980 990 1000 1010 1020 VTQLQSQILE LQGELKEFKT CNKQLHQKLI LAEAVMEGRP TPDKTLLNAQ PPVGAAYQDS 1030 1040 1050 1060 1070 1080 PGEQKGIKTT SSVWRDKEMD SDQQRSYEID SEICPPDDLA SLPSCKENPE DVLSPTSVAT 1090 1100 1110 1120 1130 1140 YLSSKSQPSA KVSVMGTDQS ESINTSNETE YLKQKIHDLE TELEGYQNFI FQLQKHSQCS 1150 1160 1170 1180 1190 1200 EAIITVLCGT EGAQDGLSKP KNGSDGEEMT FSSLHQVRYV KHVKILGPLA PEMIDSRVLE 1210 1220 1230 1240 1250 1260 NLKQQLEEQE YKLQKEQNLN MQLFSEIHNL QNKFRDLSPP RYDSLVQSQA RELSLQRQQI 1270 1280 1290 1300 1310 1320 KDGHGICVIS RQHMNTMIKA FEELLQASDV DYCVAEGFQE QLNQCAELLE KLEKLFLNGK 1330 1340 1350 1360 1370 1380 SVGVEMNTQN ELMERIEEDN LTYQHLLPES PEPSASHALS DYETSEKSFF SRDQKQDNET 1390 1400 1410 1420 1430 1440 EKTSVMVNSF SQDLLMEHIQ EIRTLRKRLE ESIKTNEKLR KQLERQGSEF VQGSTSIFAS 1450 1460 1470 1480 1490 1500 GSELHSSLTS EIHFLRKQNQ ALNAMLIKGS RDKQKENDKL RESLSRKTVS LEHLQREYAS 1510 1520 1530 1540 1550 1560 VKEENERLQK EGSEKERHNQ QLIQEVRCSG QELSRVQEEV KLRQQLLSQN DKLLQSLRVE 1570 1580 1590 1600 1610 1620 LKAYEKLDEE HRRLREASGE GWKGQDPFRD LHSLLMEIQA LRLQLERSIE TSSTLQSRLK 1630 1640 1650 1660 1670 1680 EQLARGAEKA QEGALTLAVQ AVSIPEVPLQ PDKHDGDKYP MESDNSFDLF DSSQAVTPKS 1690 1700 1710 1720 1730 1740 VSETPPLSGN DTDSLSCDSG SSATSTPCVS RLVTGHHLWA SKNGRHVLGL IEDYEALLKQ 1750 1760 1770 1780 1790 1800 ISQGQRLLAE MDIQTQEAPS STSQELGTKG PHPAPLSKFV SSVSTAKLTL EEAYRRLKLL 1810 1820 1830 1840 1850 1860 WRVSLPEDGQ CPLHCEQIGE MKAEVTKLHK KLFEQEKKLQ NTMKLLQLSK RQEKVIFDQL 1870 1880 1890 VVTHKILRKA RGNLELRPGG AHPGTCSPSR PGS
	Isoform 2 [UniParc]. Checksum: C56C74BE444511C8	FASTA	1,861	211,381
	10 20 30 40 50 60 MMDLVLEEDV TVPGTLSGCS GLVPSVPDDL DGINPNAGLG NGLLPNVSEE TVSPTRARNM 70 80 90 100 110 120 KDFENQITEL KKENFNLKLR IYFLEERMQQ EFHGPTEHIY KTNIELKVEV ESLKRELQER 130 140 150 160 170 180 EQLLIKASKA VESLAEAGGS EIQRVKEDAR KKVQQVEDLL TKRILLLEKD VTAAQAELEK 190 200 210 220 230 240 AFAGTETEKA LRLRLESKLS EMKKMHEGDL AMALVLDEKD RLIEELKLSL KSKEALIQCL 250 260 270 280 290 300 KEEKSQMACP DENVSSGELR GLCAAPREEK ERETEAAQME HQKERNSFEE RIQALEEDLR 310 320 330 340 350 360 EKEREIATEK KNSLKRDKAI QGLTMALKSK EKKVEELNSE IEKLSAAFAK AREALQKAQT 370 380 390 400 410 420 QEFQGSEDYE TALSGKEALS AALRSQNLTK STENHRLRRS IKKITQELSD LQQERERLEK 430 440 450 460 470 480 DLEEAHREKS KGDCTIRDLR NEVEKLRNEV NEREKAMENR YKSLLSESNK KLHNQEQVIK 490 500 510 520 530 540 HLTESTNQKD VLLQKFNEKD LEVIQQNCYL MAAEDLELRS EGLITEKCSS QQPPGSKTIF 550 560 570 580 590 600 SKEKKQSSDY EELIQVLKKE QDIYTHLVKS LQESDSINNL QAELNKIFAL RKQLEQDVLS 610 620 630 640 650 660 YQNLRKTLEE QISEIRRREE ESFSLYSDQT SYLSICLEEN NRFQVEHFSQ EELKKKVSDL 670 680 690 700 710 720 IQLVKELYTD NQHLKKTIFD LSCMGFQGNG FPDRLASTEQ TEIMKDLSKG GCKNGYLRHT 730 740 750 760 770 780 ESKISDCDGA HAPGCLEEGA FINLLAPLFN EKATLLLESR PDLLKVVREL LLGQLFLTEQ 790 800 810 820 830 840 EVSGEHLDGK TEKTPKQKGE LVHFVQTNSF SKPHDELKLS CEAQLVKAGE VPKVGLKDAS 850 860 870 880 890 900 VQTVATEGDL LRFKHEATRE AWEEKPINTA LSAEHRPENL HGVPGWQAAL LSLPGITNRE 910 920 930 940 950 960 AKKSRLPILI KPSRSLGNMY RLPATQEVVT QLQSQILELQ GELKEFKTCN KQLHQKLILA 970 980 990 1000 1010 1020 EAVMEGRPTP DKTLLNAQPP VGAAYQDSPG EQKGIKTTSS VWRDKEMDSD QQRSYEIDSE 1030 1040 1050 1060 1070 1080 ICPPDDLASL PSCKENPEDV LSPTSVATYL SSKSQPSAKV SVMGTDQSES INTSNETEYL 1090 1100 1110 1120 1130 1140 KQKIHDLETE LEGYQNFIFQ LQKHSQCSEA IITVLCGTEG AQDGLSKPKN GSDGEEMTFS 1150 1160 1170 1180 1190 1200 SLHQVRYVKH VKILGPLAPE MIDSRVLENL KQQLEEQEYK LQKEQNLNMQ LFSEIHNLQN 1210 1220 1230 1240 1250 1260 KFRDLSPPRY DSLVQSQARE LSLQRQQIKD GHGICVISRQ HMNTMIKAFE ELLQASDVDY 1270 1280 1290 1300 1310 1320 CVAEGFQEQL NQCAELLEKL EKLFLNGKSV GVEMNTQNEL MERIEEDNLT YQHLLPESPE 1330 1340 1350 1360 1370 1380 PSASHALSDY ETSEKSFFSR DQKQDNETEK TSVMVNSFSQ DLLMEHIQEI RTLRKRLEES 1390 1400 1410 1420 1430 1440 IKTNEKLRKQ LERQGSEFVQ GSTSIFASGS ELHSSLTSEI HFLRKQNQAL NAMLIKGSRD 1450 1460 1470 1480 1490 1500 KQKENDKLRE SLSRKTVSLE HLQREYASVK EENERLQKEG SEKERHNQQL IQEVRCSGQE 1510 1520 1530 1540 1550 1560 LSRVQEEVKL RQQLLSQNDK LLQSLRVELK AYEKLDEEHR RLREASGEGW KGQDPFRDLH 1570 1580 1590 1600 1610 1620 SLLMEIQALR LQLERSIETS STLQSRLKEQ LARGAEKAQE GALTLAVQAV SIPEVPLQPD 1630 1640 1650 1660 1670 1680 KHDGDKYPME SDNSFDLFDS SQAVTPKSVS ETPPLSGNDT DSLSCDSGSS ATSTPCVSRL 1690 1700 1710 1720 1730 1740 VTGHHLWASK NGRHVLGLIE DYEALLKQIS QGQRLLAEMD IQTQEAPSST SQELGTKGPH 1750 1760 1770 1780 1790 1800 PAPLSKFVSS VSTAKLTLEE AYRRLKLLWR VSLPEDGQCP LHCEQIGEMK AEVTKLHKKL 1810 1820 1830 1840 1850 1860 FEQEKKLQNT MKLLQLSKRQ EKVIFDQLVV THKILRKARG NLELRPGGAH PGTCSPSRPG S
	Isoform 3 [UniParc]. Checksum: D34C2C2D6EABDE08	FASTA	1,852	210,471
	10 20 30 40 50 60 MMDLVLEEDV TVPGTLSGCS GLVPSVPDDL DGINPNAGLG NGLLPNVSEE TVSPTRARNM 70 80 90 100 110 120 KDFENQITEL KKENFNLKLR IYFLEERMQQ EFHGPTEHIY KTNIELKVEV ESLKRELQER 130 140 150 160 170 180 EQLLIKASKA VESLAEAGGS EIQRVKEDAR KKVQQVEDLL TKRILLLEKD VTAAQAELEK 190 200 210 220 230 240 AFAGTETEKA LRLRLESKLS EMKKMHEGDL AMALVLDEKD RLIEELKLSL KSKEALIQCL 250 260 270 280 290 300 KEEKSQMACP DENVSSGELR GLCAAPREEK ERETEAAQME HQKERNSFEE RIQALEEDLR 310 320 330 340 350 360 EKEREIATEK KNSLKRDKAI QGLTMALKSK EKKVEELNSE IEKLSAAFAK AREALQKAQT 370 380 390 400 410 420 QEFQGSEDYE TALSGKEALS AALRSQNLTK STENHRLRRS IKKITQELSD LQQERERLEK 430 440 450 460 470 480 DLEEAHREKS KGDCTIRDLR NEVEKLRNEV NEREKAMENR YKSLLSESNK KLHNQEQVIK 490 500 510 520 530 540 HLTESTNQKD VLLQKFNEKD LEVIQQNCYL MAAEDLELRS EGLITEKCSS QQPPGSKTIF 550 560 570 580 590 600 SKEKKQSSDY EELIQVLKKE QDIYTHLVKS LQESDSINNL QAELNKIFAL RKQLEQDVLS 610 620 630 640 650 660 YQNLRKTLEE QISEIRRREE ESFSLYSDQT SYLSICLEEN NRFQVEHFSQ EELKKKVSDL 670 680 690 700 710 720 IQLVKELYTD NQHLKKTIFD LSCMGFQGNG FPDRLASTEQ TELLASKEDE DTIKIGEDDE 730 740 750 760 770 780 INFLSDQHLQ QSNEIMKDLS KGGCKNGYLR HTESKISDCD GAHAPGCLEE GAFINLLAPL 790 800 810 820 830 840 FNEKATLLLE SRPDLLKVVR ELLLGQLFLT EQEVSGEHLD GKTEKTPKQK GELVHFVQTN 850 860 870 880 890 900 SFSKPHDELK LSCEAQLVKA GEVPKVGLKD ASVQTVATEG DLLRFKHEAT REAWEEKPIN 910 920 930 940 950 960 TALSAEHRPE NLHGVPGWQA ALLSLPGITN REAKKSRLPI LIKPSRSLGN MYRLPATQEV 970 980 990 1000 1010 1020 VTQLQSQILE LQGELKEFKT CNKQLHQKLI LAEAVMEGRP TPDKTLLNDS EICPPDDLAS 1030 1040 1050 1060 1070 1080 LPSCKENPED VLSPTSVATY LSSKSQPSAK VSVMGTDQSE SINTSNETEY LKQKIHDLET 1090 1100 1110 1120 1130 1140 ELEGYQNFIF QLQKHSQCSE AIITVLCGTE GAQDGLSKPK NGSDGEEMTF SSLHQVRYVK 1150 1160 1170 1180 1190 1200 HVKILGPLAP EMIDSRVLEN LKQQLEEQEY KLQKEQNLNM QLFSEIHNLQ NKFRDLSPPR 1210 1220 1230 1240 1250 1260 YDSLVQSQAR ELSLQRQQIK DGHGICVISR QHMNTMIKAF EELLQASDVD YCVAEGFQEQ 1270 1280 1290 1300 1310 1320 LNQCAELLEK LEKLFLNGKS VGVEMNTQNE LMERIEEDNL TYQHLLPESP EPSASHALSD 1330 1340 1350 1360 1370 1380 YETSEKSFFS RDQKQDNETE KTSVMVNSFS QDLLMEHIQE IRTLRKRLEE SIKTNEKLRK 1390 1400 1410 1420 1430 1440 QLERQGSEFV QGSTSIFASG SELHSSLTSE IHFLRKQNQA LNAMLIKGSR DKQKENDKLR 1450 1460 1470 1480 1490 1500 ESLSRKTVSL EHLQREYASV KEENERLQKE GSEKERHNQQ LIQEVRCSGQ ELSRVQEEVK 1510 1520 1530 1540 1550 1560 LRQQLLSQND KLLQSLRVEL KAYEKLDEEH RRLREASGEG WKGQDPFRDL HSLLMEIQAL 1570 1580 1590 1600 1610 1620 RLQLERSIET SSTLQSRLKE QLARGAEKAQ EGALTLAVQA VSIPEVPLQP DKHDGDKYPM 1630 1640 1650 1660 1670 1680 ESDNSFDLFD SSQAVTPKSV SETPPLSGND TDSLSCDSGS SATSTPCVSR LVTGHHLWAS 1690 1700 1710 1720 1730 1740 KNGRHVLGLI EDYEALLKQI SQGQRLLAEM DIQTQEAPSS TSQELGTKGP HPAPLSKFVS 1750 1760 1770 1780 1790 1800 SVSTAKLTLE EAYRRLKLLW RVSLPEDGQC PLHCEQIGEM KAEVTKLHKK LFEQEKKLQN 1810 1820 1830 1840 1850 TMKLLQLSKR QEKVIFDQLV VTHKILRKAR GNLELRPGGA HPGTCSPSRP GS
	Isoform 4 [UniParc]. Checksum: C28575B525292309	FASTA	1,814	206,323
	10 20 30 40 50 60 MMDLVLEEDV TVPGTLSGCS GLVPSVPDDL DGINPNAGLG NGLLPNVSEE TVSPTRARNM 70 80 90 100 110 120 KDFENQITEL KKENFNLKLR IYFLEERMQQ EFHGPTEHIY KTNIELKVEV ESLKRELQER 130 140 150 160 170 180 EQLLIKASKA VESLAEAGGS EIQRVKEDAR KKVQQVEDLL TKRILLLEKD VTAAQAELEK 190 200 210 220 230 240 AFAGTETEKA LRLRLESKLS EMKKMHEGDL AMALVLDEKD RLIEELKLSL KSKEALIQCL 250 260 270 280 290 300 KEEKSQMACP DENVSSGELR GLCAAPREEK ERETEAAQME HQKERNSFEE RIQALEEDLR 310 320 330 340 350 360 EKEREIATEK KNSLKRDKAI QGLTMALKSK EKKVEELNSE IEKLSAAFAK AREALQKAQT 370 380 390 400 410 420 QEFQGSEDYE TALSGKEALS AALRSQNLTK STENHRLRRS IKKITQELSD LQQERERLEK 430 440 450 460 470 480 DLEEAHREKS KGDCTIRDLR NEVEKLRNEV NEREKAMENR YKSLLSESNK KLHNQEQVIK 490 500 510 520 530 540 HLTESTNQKD VLLQKFNEKD LEVIQQNCYL MAAEDLELRS EGLITEKCSS QQPPGSKTIF 550 560 570 580 590 600 SKEKKQSSDY EELIQVLKKE QDIYTHLVKS LQESDSINNL QAELNKIFAL RKQLEQDVLS 610 620 630 640 650 660 YQNLRKTLEE QISEIRRREE ESFSLYSDQT SYLSICLEEN NRFQVEHFSQ EELKKKVSDL 670 680 690 700 710 720 IQLVKELYTD NQHLKKTIFD LSCMGFQGNG FPDRLASTEQ TELLASKEDE DTIKIGEDDE 730 740 750 760 770 780 INFLSDQHLQ QSNEIMKDLS KGGCKNGYLR HTESKISDCD GAHAPGCLEE GAFINLLAPL 790 800 810 820 830 840 FNEKATLLLE SRPDLLKVVR ELLLGQLFLT EQEVSGEHLD GKTEKTPKQK GELVHFVQTN 850 860 870 880 890 900 SFSKPHDELK LSCEAQLVKA GEVPKVGLKD ASVQTVATEG DLLRFKHEAT REAWEEKPIN 910 920 930 940 950 960 TALSAEHRPE NLHGVPGWQA ALLSLPGITN REAKKSRLPI LIKPSRSLGN MYRLPATQEV 970 980 990 1000 1010 1020 VTQLQSQILE LQGELKEFKT CNKQLHQKLI LAEAVMEGRP TPDKTLLNAQ PPVGAAYQDS 1030 1040 1050 1060 1070 1080 PGEQKGIKTT SSVWRDKEMD SDQQRSYEID SEICPPDDLA SLPSCKENPE DVLSPTSVAT 1090 1100 1110 1120 1130 1140 YLSSKSQPSA KVSVMGTDQS ESINTSNETE YLKQKIHDLE TELEGYQNFI FQLQKHSQCS 1150 1160 1170 1180 1190 1200 EAIITVLCGT EGAQDGLSKP KNGSDGEEMT FSSLHQVRYV KHVKILGPLA PEMIDSRVLE 1210 1220 1230 1240 1250 1260 NLKQQLEEQE YKLQKEQNLN MQLFSEIHNL QNKFRDLSPP RYDSLVQSQA RELSLQRQQI 1270 1280 1290 1300 1310 1320 KDGHGICVIS RQHMNTMIKA FEELLQASDV DYCVAEGFQE QLNQCAELLE KLEKLFLNGK 1330 1340 1350 1360 1370 1380 SVGVEMNTQN ELMERIEEDN LTYQHLLPES PEPSASHALS DYETSEKSFF SRDQKQDNET 1390 1400 1410 1420 1430 1440 EKTSVMVNSF SQDLLMEHIQ EIRTLRKRLE ESIKTNEKLR KQLERQGSEF VQGSTSIFAS 1450 1460 1470 1480 1490 1500 GSELHSSLTS EIHFLRKQNQ ALNAMLIKGS RDKQKENDKL RESLSRKTVS LEHLQREYAS 1510 1520 1530 1540 1550 1560 VKEENERLQK EGSEKERHNQ QLIQEVRCSG QELSRVQEEV KLRQQLLSQN DKLLQSLRVE 1570 1580 1590 1600 1610 1620 LKAYEKLDEE HRRLRDGDKY PMESDNSFDL FDSSQAVTPK SVSETPPLSG NDTDSLSCDS 1630 1640 1650 1660 1670 1680 GSSATSTPCV SRLVTGHHLW ASKNGRHVLG LIEDYEALLK QISQGQRLLA EMDIQTQEAP 1690 1700 1710 1720 1730 1740 SSTSQELGTK GPHPAPLSKF VSSVSTAKLT LEEAYRRLKL LWRVSLPEDG QCPLHCEQIG 1750 1760 1770 1780 1790 1800 EMKAEVTKLH KKLFEQEKKL QNTMKLLQLS KRQEKVIFDQ LVVTHKILRK ARGNLELRPG 1810 GAHPGTCSPS RPGS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O. DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT GLN-289. Tissue: Brain.
[2]	Ohara O., Nagase T., Kikuno R. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	Guo J.H., Zan Q., Yu L. Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 575-1893 (ISOFORM 2), VARIANTS GLN-289 AND LEU-1540. Tissue: Amygdala, Retina and Testis.
[5]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 950-1893 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1576-1654 (ISOFORM 4), VARIANT LEU-1540. Tissue: Kidney and Teratocarcinoma.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1401-1893. Tissue: Lung.
[8]	"Cloning of three novel neuronal Cdk5 activator binding proteins." Ching Y.-P., Qi Z., Wang J.H. Gene 242:285-294(2000) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[9]	"Proteomic characterization of the human centrosome by protein correlation profiling." Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M. Nature 426:570-574(2003) [PubMed] [Europe PMC] [Abstract] Cited for: MASS SPECTROMETRY, SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. Tissue: Lymphoblast.
[10]	"A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size." Bond J., Roberts E., Springell K., Lizarraga S.B., Scott S., Higgins J., Hampshire D.J., Morrison E.E., Leal G.F., Silva E.O., Costa S.M.R., Baralle D., Raponi M., Karbani G., Rashid Y., Jafri H., Bennett C., Corry P., Walsh C.A., Woods C.G. Nat. Genet. 37:353-355(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN MCPH3.
[11]	Erratum Bond J., Roberts E., Springell K., Lizarraga S.B., Scott S., Higgins J., Hampshire D.J., Morrison E.E., Leal G.F., Silva E.O., Costa S.M.R., Baralle D., Raponi M., Karbani G., Rashid Y., Jafri H., Bennett C., Corry P., Walsh C.A., Woods C.G. Nat. Genet. 37:555-555(2005)
[12]	"Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion." Graser S., Stierhof Y.D., Nigg E.A. J. Cell Sci. 120:4321-4331(2007) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[13]	"CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex." Fong K.W., Choi Y.K., Rattner J.B., Qi R.Z. Mol. Biol. Cell 19:115-125(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH TUBG1 AND TUBGCP3.
[14]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1238 AND SER-1893, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[15]	"CDK5RAP2 is required for spindle checkpoint function." Zhang X., Liu D., Lv S., Wang H., Zhong X., Liu B., Wang B., Liao J., Li J., Pfeifer G.P., Xu X. Cell Cycle 8:1206-1216(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CDC20.
[16]	"Interaction of CDK5RAP2 with EB1 to track growing microtubule tips and to regulate microtubule dynamics." Fong K.W., Hau S.Y., Kho Y.S., Jia Y., He L., Qi R.Z. Mol. Biol. Cell 20:3660-3670(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH MAPRE1, SUBCELLULAR LOCATION, MUTAGENESIS OF LEU-938 AND PRO-939.
[17]	"Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM components." Haren L., Stearns T., Lueders J. PLoS ONE 4:E5976-E5976(2009) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION.
[18]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1238, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[19]	"Conserved motif of CDK5RAP2 mediates its localization to centrosomes and the Golgi complex." Wang Z., Wu T., Shi L., Zhang L., Zheng W., Qu J.Y., Niu R., Qi R.Z. J. Biol. Chem. 285:22658-22665(2010) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, INTERACTION WITH AKAP9; CALM1 AND PCNT, MUTAGENESIS OF LYS-1865 AND LYS-1869.
[20]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-547 AND THR-1001, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[21]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB046853 mRNA. Translation: BAB13459.2. Different initiation. AF448860 mRNA. Translation: AAP41926.1. AL133161 mRNA. Translation: CAB61487.1. BX537421 mRNA. Translation: CAD97663.1. Sequence problems. BX537759 mRNA. Translation: CAD97828.1. Frameshift. AL590642 , AL138836, AL353736, AL391870 Genomic DNA. Translation: CAH70769.1. AL138836 , AL353736, AL391870, AL590642 Genomic DNA. Translation: CAI16963.1. AL353736 , AL138836, AL391870, AL590642 Genomic DNA. Translation: CAI40653.1. AL391870 , AL138836, AL353736, AL590642 Genomic DNA. Translation: CAI40925.1. AK001729 mRNA. Translation: BAA91865.1. Different initiation. AK025867 mRNA. Translation: BAB15263.1. Different initiation. AK027636 mRNA. Translation: BAB55253.1. Different initiation. BC004526 mRNA. Translation: AAH04526.2. Different initiation.
IPI	IPI00329038. IPI00329039. IPI00384417. IPI00384418.
PIR	T42658.
RefSeq	NP_001011649.1. NM_001011649.2. NP_001258968.1. NM_001272039.1. NP_060719.4. NM_018249.5.
UniGene	Hs.269560.
3D structure databases
ProteinModelPortal	Q96SN8.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-31632N.
IntAct	Q96SN8. 23 interactions.
MINT	MINT-1369618.
PTM databases
PhosphoSite	Q96SN8.
Polymorphism databases
DMDM	296439505.
Proteomic databases
PaxDb	Q96SN8.
PRIDE	Q96SN8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000349780; ENSP00000343818; ENSG00000136861. ENST00000359309; ENSP00000352258; ENSG00000136861. ENST00000360190; ENSP00000353317; ENSG00000136861. ENST00000360822; ENSP00000354065; ENSG00000136861.
GeneID	55755.
KEGG	hsa:55755.
UCSC	uc004bkf.3. human. uc004bkg.3. human. uc004bki.3. human.
Organism-specific databases
CTD	55755.
GeneCards	GC09M123151.
H-InvDB	HIX0008336.
HGNC	HGNC:18672. CDK5RAP2.
HPA	HPA035820.
MIM	604804. phenotype. 608201. gene.
neXtProt	NX_Q96SN8.
Orphanet	2512. Autosomal recessive primary microcephaly.
PharmGKB	PA38632.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG46262.
HOVERGEN	HBG050976.
InParanoid	Q96SN8.
KO	K16542.
OMA	PEPSASH.
OrthoDB	EOG41ZF95.
PhylomeDB	Q96SN8.
Enzyme and pathway databases
Reactome	REACT_115566. Cell Cycle.
Gene expression databases
ArrayExpress	Q96SN8.
Bgee	Q96SN8.
Genevestigator	Q96SN8.
GermOnline	ENSG00000136861. Homo sapiens.
Family and domain databases
InterPro	IPR012943. Spindle_assoc. [Graphical view]
Pfam	PF07989. Microtub_assoc. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CDK5RAP2. human.
GenomeRNAi	55755.
NextBio	60757.
SOURCE	Search...

Entry information

Entry name

CK5P2_HUMAN

Accession

Primary (citable) accession number: Q96SN8
Secondary accession number(s): Q5JV18 , Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2003
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 114 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.