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Q96SN8

- CK5P2_HUMAN

UniProt

Q96SN8 - CK5P2_HUMAN

Protein

CDK5 regulatory subunit-associated protein 2

Gene

CDK5RAP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 5 (18 May 2010)
      Previous versions | rss
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    Functioni

    Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation By similarity. Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with MAPRE1, it may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends.By similarity4 Publications

    GO - Molecular functioni

    1. calmodulin binding Source: UniProtKB
    2. microtubule binding Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. protein kinase binding Source: UniProtKB
    5. transcription regulatory region DNA binding Source: UniProtKB
    6. tubulin binding Source: UniProtKB

    GO - Biological processi

    1. brain development Source: UniProtKB
    2. centrosome organization Source: UniProtKB
    3. chromosome segregation Source: UniProtKB
    4. establishment of mitotic spindle orientation Source: UniProtKB
    5. G2/M transition of mitotic cell cycle Source: Reactome
    6. microtubule bundle formation Source: UniProtKB
    7. microtubule cytoskeleton organization Source: UniProtKB
    8. mitotic cell cycle Source: Reactome
    9. negative regulation of centriole replication Source: UniProtKB
    10. negative regulation of neuron differentiation Source: Ensembl
    11. neurogenesis Source: UniProtKB
    12. positive regulation of transcription, DNA-templated Source: UniProtKB
    13. regulation of neuron differentiation Source: UniProtKB
    14. regulation of spindle checkpoint Source: UniProtKB

    Keywords - Ligandi

    Calmodulin-binding

    Enzyme and pathway databases

    ReactomeiREACT_15296. Recruitment of mitotic centrosome proteins and complexes.
    REACT_15364. Loss of Nlp from mitotic centrosomes.
    REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
    REACT_160315. Regulation of PLK1 Activity at G2/M Transition.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CDK5 regulatory subunit-associated protein 2
    Alternative name(s):
    CDK5 activator-binding protein C48
    Centrosome-associated protein 215
    Gene namesi
    Name:CDK5RAP2
    Synonyms:CEP215, KIAA1633
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:18672. CDK5RAP2.

    Subcellular locationi

    Cytoplasmcytoskeletonmicrotubule organizing centercentrosome. Golgi apparatus. Cytoplasm
    Note: Found in the pericentriolar region adhering to the surface of the centrosome and in the region of the centrosomal appendages. Localizes to microtubule plus ends.

    GO - Cellular componenti

    1. cell junction Source: HPA
    2. centrosome Source: UniProtKB
    3. cytoplasm Source: UniProtKB
    4. cytoskeleton Source: UniProtKB
    5. cytosol Source: Reactome
    6. extracellular vesicular exosome Source: UniProt
    7. Golgi apparatus Source: UniProtKB
    8. microtubule Source: UniProtKB
    9. pericentriolar material Source: UniProtKB
    10. perinuclear region of cytoplasm Source: UniProtKB
    11. spindle pole Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Golgi apparatus, Microtubule

    Pathology & Biotechi

    Involvement in diseasei

    Microcephaly 3, primary, autosomal recessive (MCPH3) [MIM:604804]: A disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Affected individuals are mentally retarded. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits due to degenerative brain disorder.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi938 – 9381L → A: Loss of interaction with MAPRE1; when associated with A-939. 1 Publication
    Mutagenesisi939 – 9391P → A: Loss of interaction with MAPRE1; when associated with A-938. 1 Publication
    Mutagenesisi1865 – 18651K → A: No effect on centrosomal attachment, Golgi localization and loss of interaction with CALM1; when associated with A-1869. 1 Publication
    Mutagenesisi1869 – 18691K → A: No effect on centrosomal attachment, Golgi localization and loss of interaction to CALM1; when associated with A-1865. 1 Publication

    Keywords - Diseasei

    Mental retardation, Primary microcephaly

    Organism-specific databases

    MIMi604804. phenotype.
    Orphaneti2512. Autosomal recessive primary microcephaly.
    PharmGKBiPA38632.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18931893CDK5 regulatory subunit-associated protein 2PRO_0000089835Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei547 – 5471Phosphoserine1 Publication
    Modified residuei1001 – 10011Phosphothreonine1 Publication
    Modified residuei1238 – 12381Phosphoserine2 Publications
    Modified residuei1893 – 18931Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylated in vitro by CDK5.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96SN8.
    PaxDbiQ96SN8.
    PRIDEiQ96SN8.

    PTM databases

    PhosphoSiteiQ96SN8.

    Expressioni

    Tissue specificityi

    Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.1 Publication

    Gene expression databases

    ArrayExpressiQ96SN8.
    BgeeiQ96SN8.
    GenevestigatoriQ96SN8.

    Organism-specific databases

    HPAiHPA035820.
    HPA046529.

    Interactioni

    Subunit structurei

    Interacts with CDK5R1 (p35 form). CDK5RAP1, CDK5RAP2 and CDK5RAP3 show competitive binding to CDK5R1. Probably forms a complex with CDK5R1 and CDK5 By similarity. Interacts with PCNT; the interaction is leading to centrosomal and Golgi localization of CDK5RAP2 and PCNT. Interacts with AKAP9; the interaction is leading to Golgi localization of CDK5RAP2 and AKAP9. Interacts with MAPRE1; the interaction is leading to microtubule attachment at plus ends of CDK5RAP2 and MAPRE1. Interacts with TUBG1; the interaction is leading to the centrosomal localization of CDK5RAP2 and TUBG1. Interacts with TUBGCP3. Interacts with CALM1. Interacts with CDC20.By similarity4 Publications

    Protein-protein interaction databases

    BioGridi120873. 37 interactions.
    DIPiDIP-31632N.
    IntActiQ96SN8. 25 interactions.
    MINTiMINT-1369618.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96SN8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni926 – 1208283Interaction with MAPRE1Add
    BLAST
    Regioni1726 – 1893168Interaction with PCNT and AKAP9Add
    BLAST
    Regioni1726 – 176843Interaction with CDK5R1By similarityAdd
    BLAST
    Regioni1861 – 187010Required for centrosomal attachment, Golgi localization and CALM1 interaction

    Phylogenomic databases

    eggNOGiNOG46262.
    HOVERGENiHBG050976.
    InParanoidiQ96SN8.
    KOiK16542.
    OMAiPEPSASH.
    OrthoDBiEOG7GBFW3.
    PhylomeDBiQ96SN8.
    TreeFamiTF329233.

    Family and domain databases

    InterProiIPR012943. Spindle_assoc.
    [Graphical view]
    PfamiPF07989. Microtub_assoc. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96SN8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMDLVLEEDV TVPGTLSGCS GLVPSVPDDL DGINPNAGLG NGLLPNVSEE     50
    TVSPTRARNM KDFENQITEL KKENFNLKLR IYFLEERMQQ EFHGPTEHIY 100
    KTNIELKVEV ESLKRELQER EQLLIKASKA VESLAEAGGS EIQRVKEDAR 150
    KKVQQVEDLL TKRILLLEKD VTAAQAELEK AFAGTETEKA LRLRLESKLS 200
    EMKKMHEGDL AMALVLDEKD RLIEELKLSL KSKEALIQCL KEEKSQMACP 250
    DENVSSGELR GLCAAPREEK ERETEAAQME HQKERNSFEE RIQALEEDLR 300
    EKEREIATEK KNSLKRDKAI QGLTMALKSK EKKVEELNSE IEKLSAAFAK 350
    AREALQKAQT QEFQGSEDYE TALSGKEALS AALRSQNLTK STENHRLRRS 400
    IKKITQELSD LQQERERLEK DLEEAHREKS KGDCTIRDLR NEVEKLRNEV 450
    NEREKAMENR YKSLLSESNK KLHNQEQVIK HLTESTNQKD VLLQKFNEKD 500
    LEVIQQNCYL MAAEDLELRS EGLITEKCSS QQPPGSKTIF SKEKKQSSDY 550
    EELIQVLKKE QDIYTHLVKS LQESDSINNL QAELNKIFAL RKQLEQDVLS 600
    YQNLRKTLEE QISEIRRREE ESFSLYSDQT SYLSICLEEN NRFQVEHFSQ 650
    EELKKKVSDL IQLVKELYTD NQHLKKTIFD LSCMGFQGNG FPDRLASTEQ 700
    TELLASKEDE DTIKIGEDDE INFLSDQHLQ QSNEIMKDLS KGGCKNGYLR 750
    HTESKISDCD GAHAPGCLEE GAFINLLAPL FNEKATLLLE SRPDLLKVVR 800
    ELLLGQLFLT EQEVSGEHLD GKTEKTPKQK GELVHFVQTN SFSKPHDELK 850
    LSCEAQLVKA GEVPKVGLKD ASVQTVATEG DLLRFKHEAT REAWEEKPIN 900
    TALSAEHRPE NLHGVPGWQA ALLSLPGITN REAKKSRLPI LIKPSRSLGN 950
    MYRLPATQEV VTQLQSQILE LQGELKEFKT CNKQLHQKLI LAEAVMEGRP 1000
    TPDKTLLNAQ PPVGAAYQDS PGEQKGIKTT SSVWRDKEMD SDQQRSYEID 1050
    SEICPPDDLA SLPSCKENPE DVLSPTSVAT YLSSKSQPSA KVSVMGTDQS 1100
    ESINTSNETE YLKQKIHDLE TELEGYQNFI FQLQKHSQCS EAIITVLCGT 1150
    EGAQDGLSKP KNGSDGEEMT FSSLHQVRYV KHVKILGPLA PEMIDSRVLE 1200
    NLKQQLEEQE YKLQKEQNLN MQLFSEIHNL QNKFRDLSPP RYDSLVQSQA 1250
    RELSLQRQQI KDGHGICVIS RQHMNTMIKA FEELLQASDV DYCVAEGFQE 1300
    QLNQCAELLE KLEKLFLNGK SVGVEMNTQN ELMERIEEDN LTYQHLLPES 1350
    PEPSASHALS DYETSEKSFF SRDQKQDNET EKTSVMVNSF SQDLLMEHIQ 1400
    EIRTLRKRLE ESIKTNEKLR KQLERQGSEF VQGSTSIFAS GSELHSSLTS 1450
    EIHFLRKQNQ ALNAMLIKGS RDKQKENDKL RESLSRKTVS LEHLQREYAS 1500
    VKEENERLQK EGSEKERHNQ QLIQEVRCSG QELSRVQEEV KLRQQLLSQN 1550
    DKLLQSLRVE LKAYEKLDEE HRRLREASGE GWKGQDPFRD LHSLLMEIQA 1600
    LRLQLERSIE TSSTLQSRLK EQLARGAEKA QEGALTLAVQ AVSIPEVPLQ 1650
    PDKHDGDKYP MESDNSFDLF DSSQAVTPKS VSETPPLSGN DTDSLSCDSG 1700
    SSATSTPCVS RLVTGHHLWA SKNGRHVLGL IEDYEALLKQ ISQGQRLLAE 1750
    MDIQTQEAPS STSQELGTKG PHPAPLSKFV SSVSTAKLTL EEAYRRLKLL 1800
    WRVSLPEDGQ CPLHCEQIGE MKAEVTKLHK KLFEQEKKLQ NTMKLLQLSK 1850
    RQEKVIFDQL VVTHKILRKA RGNLELRPGG AHPGTCSPSR PGS 1893

    Note: No experimental confirmation available.

    Length:1,893
    Mass (Da):215,038
    Last modified:May 18, 2010 - v5
    Checksum:i833B9F9EF3CE8D07
    GO
    Isoform 2 (identifier: Q96SN8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         702-733: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,861
    Mass (Da):211,381
    Checksum:iC56C74BE444511C8
    GO
    Isoform 3 (identifier: Q96SN8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1009-1049: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,852
    Mass (Da):210,471
    Checksum:iD34C2C2D6EABDE08
    GO
    Isoform 4 (identifier: Q96SN8-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1576-1654: Missing.

    Show »
    Length:1,814
    Mass (Da):206,323
    Checksum:iC28575B525292309
    GO

    Sequence cautioni

    The sequence CAD97828.1 differs from that shown. Reason: Frameshift at position 1831.
    The sequence AAH04526.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAA91865.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAB13459.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence BAB15263.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAB55253.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAD97663.1 differs from that shown. Reason: Erroneous termination at position 1205. Translated as Gln.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti27 – 271P → S in CAD97663. (PubMed:17974005)Curated
    Sequence conflicti43 – 431L → V in AAP41926. 1 PublicationCurated
    Sequence conflicti292 – 2921I → F in CAD97828. (PubMed:17974005)Curated
    Sequence conflicti414 – 4141E → K in CAD97828. (PubMed:17974005)Curated
    Sequence conflicti1254 – 12541S → F in CAD97663. (PubMed:17974005)Curated
    Sequence conflicti1458 – 14581Q → R in BAA91865. (PubMed:14702039)Curated
    Sequence conflicti1483 – 14831S → P in CAD97663. (PubMed:17974005)Curated
    Sequence conflicti1550 – 15501N → D in BAB55253. (PubMed:14702039)Curated
    Sequence conflicti1838 – 18381K → R in BAA91865. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti183 – 1831A → P.
    Corresponds to variant rs13287734 [ dbSNP | Ensembl ].
    VAR_056831
    Natural varianti289 – 2891E → Q.2 Publications
    Corresponds to variant rs4836822 [ dbSNP | Ensembl ].
    VAR_017443
    Natural varianti1045 – 10451R → T.
    Corresponds to variant rs3780679 [ dbSNP | Ensembl ].
    VAR_032426
    Natural varianti1330 – 13301N → I.
    Corresponds to variant rs7875294 [ dbSNP | Ensembl ].
    VAR_059616
    Natural varianti1540 – 15401V → L.2 Publications
    Corresponds to variant rs4837768 [ dbSNP | Ensembl ].
    VAR_017444
    Natural varianti1607 – 16071R → S.
    Corresponds to variant rs16909747 [ dbSNP | Ensembl ].
    VAR_056832

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei702 – 73332Missing in isoform 2. 1 PublicationVSP_007563Add
    BLAST
    Alternative sequencei1009 – 104941Missing in isoform 3. 1 PublicationVSP_007564Add
    BLAST
    Alternative sequencei1576 – 165479Missing in isoform 4. 3 PublicationsVSP_007565Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB046853 mRNA. Translation: BAB13459.2. Different initiation.
    AF448860 mRNA. Translation: AAP41926.1.
    AL133161 mRNA. Translation: CAB61487.1.
    BX537421 mRNA. Translation: CAD97663.1. Sequence problems.
    BX537759 mRNA. Translation: CAD97828.1. Frameshift.
    AL590642
    , AL138836, AL353736, AL391870 Genomic DNA. Translation: CAH70769.1.
    AL138836
    , AL353736, AL391870, AL590642 Genomic DNA. Translation: CAI16963.1.
    AL353736
    , AL138836, AL391870, AL590642 Genomic DNA. Translation: CAI40653.1.
    AL391870
    , AL138836, AL353736, AL590642 Genomic DNA. Translation: CAI40925.1.
    AK001729 mRNA. Translation: BAA91865.1. Different initiation.
    AK025867 mRNA. Translation: BAB15263.1. Different initiation.
    AK027636 mRNA. Translation: BAB55253.1. Different initiation.
    BC004526 mRNA. Translation: AAH04526.2. Different initiation.
    CCDSiCCDS43871.1. [Q96SN8-4]
    CCDS6823.1. [Q96SN8-1]
    PIRiT42658.
    RefSeqiNP_001011649.1. NM_001011649.2. [Q96SN8-4]
    NP_001258968.1. NM_001272039.1.
    NP_060719.4. NM_018249.5. [Q96SN8-1]
    XP_006717245.1. XM_006717182.1. [Q96SN8-2]
    UniGeneiHs.269560.

    Genome annotation databases

    EnsembliENST00000349780; ENSP00000343818; ENSG00000136861. [Q96SN8-1]
    ENST00000360190; ENSP00000353317; ENSG00000136861. [Q96SN8-4]
    ENST00000360822; ENSP00000354065; ENSG00000136861. [Q96SN8-2]
    GeneIDi55755.
    KEGGihsa:55755.
    UCSCiuc004bkf.4. human. [Q96SN8-1]
    uc004bkg.4. human. [Q96SN8-4]
    uc004bki.3. human. [Q96SN8-2]

    Polymorphism databases

    DMDMi296439505.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB046853 mRNA. Translation: BAB13459.2 . Different initiation.
    AF448860 mRNA. Translation: AAP41926.1 .
    AL133161 mRNA. Translation: CAB61487.1 .
    BX537421 mRNA. Translation: CAD97663.1 . Sequence problems.
    BX537759 mRNA. Translation: CAD97828.1 . Frameshift.
    AL590642
    , AL138836 , AL353736 , AL391870 Genomic DNA. Translation: CAH70769.1 .
    AL138836
    , AL353736 , AL391870 , AL590642 Genomic DNA. Translation: CAI16963.1 .
    AL353736
    , AL138836 , AL391870 , AL590642 Genomic DNA. Translation: CAI40653.1 .
    AL391870
    , AL138836 , AL353736 , AL590642 Genomic DNA. Translation: CAI40925.1 .
    AK001729 mRNA. Translation: BAA91865.1 . Different initiation.
    AK025867 mRNA. Translation: BAB15263.1 . Different initiation.
    AK027636 mRNA. Translation: BAB55253.1 . Different initiation.
    BC004526 mRNA. Translation: AAH04526.2 . Different initiation.
    CCDSi CCDS43871.1. [Q96SN8-4 ]
    CCDS6823.1. [Q96SN8-1 ]
    PIRi T42658.
    RefSeqi NP_001011649.1. NM_001011649.2. [Q96SN8-4 ]
    NP_001258968.1. NM_001272039.1.
    NP_060719.4. NM_018249.5. [Q96SN8-1 ]
    XP_006717245.1. XM_006717182.1. [Q96SN8-2 ]
    UniGenei Hs.269560.

    3D structure databases

    ProteinModelPortali Q96SN8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120873. 37 interactions.
    DIPi DIP-31632N.
    IntActi Q96SN8. 25 interactions.
    MINTi MINT-1369618.

    PTM databases

    PhosphoSitei Q96SN8.

    Polymorphism databases

    DMDMi 296439505.

    Proteomic databases

    MaxQBi Q96SN8.
    PaxDbi Q96SN8.
    PRIDEi Q96SN8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000349780 ; ENSP00000343818 ; ENSG00000136861 . [Q96SN8-1 ]
    ENST00000360190 ; ENSP00000353317 ; ENSG00000136861 . [Q96SN8-4 ]
    ENST00000360822 ; ENSP00000354065 ; ENSG00000136861 . [Q96SN8-2 ]
    GeneIDi 55755.
    KEGGi hsa:55755.
    UCSCi uc004bkf.4. human. [Q96SN8-1 ]
    uc004bkg.4. human. [Q96SN8-4 ]
    uc004bki.3. human. [Q96SN8-2 ]

    Organism-specific databases

    CTDi 55755.
    GeneCardsi GC09M123151.
    GeneReviewsi CDK5RAP2.
    H-InvDB HIX0008336.
    HGNCi HGNC:18672. CDK5RAP2.
    HPAi HPA035820.
    HPA046529.
    MIMi 604804. phenotype.
    608201. gene.
    neXtProti NX_Q96SN8.
    Orphaneti 2512. Autosomal recessive primary microcephaly.
    PharmGKBi PA38632.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46262.
    HOVERGENi HBG050976.
    InParanoidi Q96SN8.
    KOi K16542.
    OMAi PEPSASH.
    OrthoDBi EOG7GBFW3.
    PhylomeDBi Q96SN8.
    TreeFami TF329233.

    Enzyme and pathway databases

    Reactomei REACT_15296. Recruitment of mitotic centrosome proteins and complexes.
    REACT_15364. Loss of Nlp from mitotic centrosomes.
    REACT_15451. Loss of proteins required for interphase microtubule organization from the centrosome.
    REACT_160315. Regulation of PLK1 Activity at G2/M Transition.

    Miscellaneous databases

    ChiTaRSi CDK5RAP2. human.
    GeneWikii CDK5RAP2.
    GenomeRNAii 55755.
    NextBioi 60757.
    PROi Q96SN8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96SN8.
    Bgeei Q96SN8.
    Genevestigatori Q96SN8.

    Family and domain databases

    InterProi IPR012943. Spindle_assoc.
    [Graphical view ]
    Pfami PF07989. Microtub_assoc. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T., Kikuno R., Nakayama M., Hirosawa M., Ohara O.
      DNA Res. 7:273-281(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), VARIANT GLN-289.
      Tissue: Brain.
    2. Ohara O., Nagase T., Kikuno R.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. Guo J.H., Zan Q., Yu L.
      Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 575-1893 (ISOFORM 2), VARIANTS GLN-289 AND LEU-1540.
      Tissue: Amygdala, Retina and Testis.
    5. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 950-1893 (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1576-1654 (ISOFORM 4), VARIANT LEU-1540.
      Tissue: Kidney and Teratocarcinoma.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1401-1893.
      Tissue: Lung.
    8. "Cloning of three novel neuronal Cdk5 activator binding proteins."
      Ching Y.-P., Qi Z., Wang J.H.
      Gene 242:285-294(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    9. "Proteomic characterization of the human centrosome by protein correlation profiling."
      Andersen J.S., Wilkinson C.J., Mayor T., Mortensen P., Nigg E.A., Mann M.
      Nature 426:570-574(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Lymphoblast.
    10. Cited for: INVOLVEMENT IN MCPH3.
    11. "Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion."
      Graser S., Stierhof Y.D., Nigg E.A.
      J. Cell Sci. 120:4321-4331(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    12. "CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex."
      Fong K.W., Choi Y.K., Rattner J.B., Qi R.Z.
      Mol. Biol. Cell 19:115-125(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH TUBG1 AND TUBGCP3.
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1238 AND SER-1893, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "CDK5RAP2 is required for spindle checkpoint function."
      Zhang X., Liu D., Lv S., Wang H., Zhong X., Liu B., Wang B., Liao J., Li J., Pfeifer G.P., Xu X.
      Cell Cycle 8:1206-1216(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CDC20.
    15. "Interaction of CDK5RAP2 with EB1 to track growing microtubule tips and to regulate microtubule dynamics."
      Fong K.W., Hau S.Y., Kho Y.S., Jia Y., He L., Qi R.Z.
      Mol. Biol. Cell 20:3660-3670(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH MAPRE1, SUBCELLULAR LOCATION, MUTAGENESIS OF LEU-938 AND PRO-939.
    16. "Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM components."
      Haren L., Stearns T., Lueders J.
      PLoS ONE 4:E5976-E5976(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1238, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    18. "Conserved motif of CDK5RAP2 mediates its localization to centrosomes and the Golgi complex."
      Wang Z., Wu T., Shi L., Zhang L., Zheng W., Qu J.Y., Niu R., Qi R.Z.
      J. Biol. Chem. 285:22658-22665(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INTERACTION WITH AKAP9; CALM1 AND PCNT, MUTAGENESIS OF LYS-1865 AND LYS-1869.
    19. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-547 AND THR-1001, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    20. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCK5P2_HUMAN
    AccessioniPrimary (citable) accession number: Q96SN8
    Secondary accession number(s): Q5JV18
    , Q7Z3L4, Q7Z3U1, Q7Z7I6, Q9BSW0, Q9H6J6, Q9HCD9, Q9NV90, Q9UIW9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2003
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 128 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3