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Q96SN7 (ORAI2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein orai-2
Alternative name(s):
CAP-binding protein complex-interacting protein 2
Transmembrane protein 142B
Gene names
Name:ORAI2
Synonyms:C7orf19, CBCIP2, TMEM142B
ORF Names:PP1729
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Ca2+ release-activated Ca2+-like (CRAC-like) channel subunit which mediates Ca2+ influx and increase in Ca2+-selective current by synergy with the Ca2+ sensor, STIM1. Ref.6 Ref.8

Subunit structure

Interacts with EFCAB4B/CRACR2A. Ref.9

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the Orai family.

Sequence caution

The sequence AAG23755.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.

The sequence AAP22352.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAG33568.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentgrowth cone

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 254254Protein orai-2
PRO_0000234391

Regions

Transmembrane66 – 8318Helical; Potential
Transmembrane94 – 11421Helical; Potential
Transmembrane148 – 16821Helical; Potential
Transmembrane196 – 21621Helical; Potential

Natural variations

Natural variant151A → P.
Corresponds to variant rs34947403 [ dbSNP | Ensembl ].
VAR_053543

Sequences

Sequence LengthMass (Da)Tools
Q96SN7 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: D53CD2376F48E23C

FASTA25428,570
        10         20         30         40         50         60 
MSAELNVPID PSAPACPEPG HKGMDYRDWV RRSYLELVTS NHHSVQALSW RKLYLSRAKL 

        70         80         90        100        110        120 
KASSRTSALL SGFAMVAMVE VQLETQYQYP RPLLIAFSAC TTVLVAVHLF ALLISTCILP 

       130        140        150        160        170        180 
NVEAVSNIHN LNSISESPHE RMHPYIELAW GFSTVLGILL FLAEVVLLCW IKFLPVDARR 

       190        200        210        220        230        240 
QPGPPPGPGS HTGWQAALVS TIIMVPVGLI FVVFTIHFYR SLVRHKTERH NREIEELHKL 

       250 
KVQLDGHERS LQVL 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Teratocarcinoma.
[2]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[4]"Large-scale cDNA transfection screening for genes related to cancer development and progression."
Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X. expand/collapse author list , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 191-254.
[5]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1."
Mercer J.C., Dehaven W.I., Smyth J.T., Wedel B., Boyles R.R., Bird G.S., Putney J.W. Jr.
J. Biol. Chem. 281:24979-24990(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function."
Feske S., Gwack Y., Prakriya M., Srikanth S., Puppel S.-H., Tanasa B., Hogan P.G., Lewis R.S., Daly M., Rao A.
Nature 441:179-185(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[8]"Calcium inhibition and calcium potentiation of orai1, orai2, and orai3 calcium release-activated calcium channels."
Dehaven W.I., Smyth J.T., Boyles R.R., Putney J.W. Jr.
J. Biol. Chem. 282:17548-17556(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[9]"A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells."
Srikanth S., Jung H.J., Kim K.D., Souda P., Whitelegge J., Gwack Y.
Nat. Cell Biol. 12:436-446(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH EFCAB4B.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK027639 mRNA. Translation: BAB55256.1.
AC093668 Genomic DNA. Translation: AAP22351.1.
AC093668 Genomic DNA. Translation: AAP22352.1. Sequence problems.
BC069270 mRNA. Translation: AAH69270.1.
AF258552 mRNA. Translation: AAG23755.1. Sequence problems.
CR457287 mRNA. Translation: CAG33568.1. Sequence problems.
RefSeqNP_001119812.1. NM_001126340.2.
NP_001258747.1. NM_001271818.1.
NP_116220.1. NM_032831.3.
UniGeneHs.363308.
Hs.736659.

3D structure databases

ProteinModelPortalQ96SN7.
SMRQ96SN7. Positions 48-245.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123192. 5 interactions.
DIPDIP-48944N.
IntActQ96SN7. 7 interactions.
MINTMINT-1373233.
STRING9606.ENSP00000348752.

PTM databases

PhosphoSiteQ96SN7.

Polymorphism databases

DMDM74732728.

Proteomic databases

PaxDbQ96SN7.
PRIDEQ96SN7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000356387; ENSP00000348752; ENSG00000160991.
ENST00000403646; ENSP00000385489; ENSG00000160991.
ENST00000473939; ENSP00000417928; ENSG00000160991.
ENST00000478730; ENSP00000418140; ENSG00000160991.
GeneID80228.
KEGGhsa:80228.
UCSCuc003uzj.3. human.

Organism-specific databases

CTD80228.
GeneCardsGC07P102074.
HGNCHGNC:21667. ORAI2.
HPAHPA055137.
MIM610929. gene.
neXtProtNX_Q96SN7.
PharmGKBPA162398454.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG263788.
HOGENOMHOG000246925.
HOVERGENHBG081343.
InParanoidQ96SN7.
KOK16057.
OMAPACSEPG.
PhylomeDBQ96SN7.
TreeFamTF313576.

Gene expression databases

ArrayExpressQ96SN7.
BgeeQ96SN7.
CleanExHS_ORAI2.
GenevestigatorQ96SN7.

Family and domain databases

InterProIPR012446. CRAC_channel.
[Graphical view]
PfamPF07856. Orai-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSORAI2. human.
GeneWikiORAI2.
GenomeRNAi80228.
NextBio70657.
PROQ96SN7.
SOURCESearch...

Entry information

Entry nameORAI2_HUMAN
AccessionPrimary (citable) accession number: Q96SN7
Secondary accession number(s): Q6IA68, Q8WY94, Q9H9Y3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM