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Q96SN7

- ORAI2_HUMAN

UniProt

Q96SN7 - ORAI2_HUMAN

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Protein
Protein orai-2
Gene
ORAI2, C7orf19, CBCIP2, TMEM142B, PP1729
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Ca2+ release-activated Ca2+-like (CRAC-like) channel subunit which mediates Ca2+ influx and increase in Ca2+-selective current by synergy with the Ca2+ sensor, STIM1.2 Publications

GO - Molecular functioni

  1. protein binding Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein orai-2
Alternative name(s):
CAP-binding protein complex-interacting protein 2
Transmembrane protein 142B
Gene namesi
Name:ORAI2
Synonyms:C7orf19, CBCIP2, TMEM142B
ORF Names:PP1729
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:21667. ORAI2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei66 – 8318Helical; Reviewed prediction
Add
BLAST
Transmembranei94 – 11421Helical; Reviewed prediction
Add
BLAST
Transmembranei148 – 16821Helical; Reviewed prediction
Add
BLAST
Transmembranei196 – 21621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. growth cone Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162398454.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Protein orai-2
PRO_0000234391Add
BLAST

Proteomic databases

PaxDbiQ96SN7.
PRIDEiQ96SN7.

PTM databases

PhosphoSiteiQ96SN7.

Expressioni

Gene expression databases

ArrayExpressiQ96SN7.
BgeeiQ96SN7.
CleanExiHS_ORAI2.
GenevestigatoriQ96SN7.

Organism-specific databases

HPAiHPA055137.

Interactioni

Subunit structurei

Interacts with EFCAB4B/CRACR2A.1 Publication

Protein-protein interaction databases

BioGridi123192. 5 interactions.
DIPiDIP-48944N.
IntActiQ96SN7. 7 interactions.
MINTiMINT-1373233.
STRINGi9606.ENSP00000348752.

Structurei

3D structure databases

ProteinModelPortaliQ96SN7.
SMRiQ96SN7. Positions 48-245.

Family & Domainsi

Sequence similaritiesi

Belongs to the Orai family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG263788.
HOGENOMiHOG000246925.
HOVERGENiHBG081343.
InParanoidiQ96SN7.
KOiK16057.
OMAiPACSEPG.
PhylomeDBiQ96SN7.
TreeFamiTF313576.

Family and domain databases

InterProiIPR012446. CRAC_channel.
[Graphical view]
PfamiPF07856. Orai-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96SN7-1 [UniParc]FASTAAdd to Basket

« Hide

MSAELNVPID PSAPACPEPG HKGMDYRDWV RRSYLELVTS NHHSVQALSW    50
RKLYLSRAKL KASSRTSALL SGFAMVAMVE VQLETQYQYP RPLLIAFSAC 100
TTVLVAVHLF ALLISTCILP NVEAVSNIHN LNSISESPHE RMHPYIELAW 150
GFSTVLGILL FLAEVVLLCW IKFLPVDARR QPGPPPGPGS HTGWQAALVS 200
TIIMVPVGLI FVVFTIHFYR SLVRHKTERH NREIEELHKL KVQLDGHERS 250
LQVL 254
Length:254
Mass (Da):28,570
Last modified:December 1, 2001 - v1
Checksum:iD53CD2376F48E23C
GO

Sequence cautioni

The sequence AAP22352.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151A → P.
Corresponds to variant rs34947403 [ dbSNP | Ensembl ].
VAR_053543

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK027639 mRNA. Translation: BAB55256.1.
AC093668 Genomic DNA. Translation: AAP22351.1.
AC093668 Genomic DNA. Translation: AAP22352.1. Sequence problems.
BC069270 mRNA. Translation: AAH69270.1.
AF258552 mRNA. Translation: AAG23755.1. Sequence problems.
CR457287 mRNA. Translation: CAG33568.1. Sequence problems.
CCDSiCCDS5722.1.
RefSeqiNP_001119812.1. NM_001126340.2.
NP_001258747.1. NM_001271818.1.
NP_116220.1. NM_032831.3.
UniGeneiHs.363308.
Hs.736659.

Genome annotation databases

EnsembliENST00000356387; ENSP00000348752; ENSG00000160991.
ENST00000403646; ENSP00000385489; ENSG00000160991.
ENST00000473939; ENSP00000417928; ENSG00000160991.
ENST00000478730; ENSP00000418140; ENSG00000160991.
GeneIDi80228.
KEGGihsa:80228.
UCSCiuc003uzj.3. human.

Polymorphism databases

DMDMi74732728.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK027639 mRNA. Translation: BAB55256.1 .
AC093668 Genomic DNA. Translation: AAP22351.1 .
AC093668 Genomic DNA. Translation: AAP22352.1 . Sequence problems.
BC069270 mRNA. Translation: AAH69270.1 .
AF258552 mRNA. Translation: AAG23755.1 . Sequence problems.
CR457287 mRNA. Translation: CAG33568.1 . Sequence problems.
CCDSi CCDS5722.1.
RefSeqi NP_001119812.1. NM_001126340.2.
NP_001258747.1. NM_001271818.1.
NP_116220.1. NM_032831.3.
UniGenei Hs.363308.
Hs.736659.

3D structure databases

ProteinModelPortali Q96SN7.
SMRi Q96SN7. Positions 48-245.
ModBasei Search...

Protein-protein interaction databases

BioGridi 123192. 5 interactions.
DIPi DIP-48944N.
IntActi Q96SN7. 7 interactions.
MINTi MINT-1373233.
STRINGi 9606.ENSP00000348752.

Chemistry

ChEMBLi CHEMBL3038476.

PTM databases

PhosphoSitei Q96SN7.

Polymorphism databases

DMDMi 74732728.

Proteomic databases

PaxDbi Q96SN7.
PRIDEi Q96SN7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000356387 ; ENSP00000348752 ; ENSG00000160991 .
ENST00000403646 ; ENSP00000385489 ; ENSG00000160991 .
ENST00000473939 ; ENSP00000417928 ; ENSG00000160991 .
ENST00000478730 ; ENSP00000418140 ; ENSG00000160991 .
GeneIDi 80228.
KEGGi hsa:80228.
UCSCi uc003uzj.3. human.

Organism-specific databases

CTDi 80228.
GeneCardsi GC07P102074.
HGNCi HGNC:21667. ORAI2.
HPAi HPA055137.
MIMi 610929. gene.
neXtProti NX_Q96SN7.
PharmGKBi PA162398454.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG263788.
HOGENOMi HOG000246925.
HOVERGENi HBG081343.
InParanoidi Q96SN7.
KOi K16057.
OMAi PACSEPG.
PhylomeDBi Q96SN7.
TreeFami TF313576.

Miscellaneous databases

ChiTaRSi ORAI2. human.
GeneWikii ORAI2.
GenomeRNAii 80228.
NextBioi 70657.
PROi Q96SN7.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96SN7.
Bgeei Q96SN7.
CleanExi HS_ORAI2.
Genevestigatori Q96SN7.

Family and domain databases

InterProi IPR012446. CRAC_channel.
[Graphical view ]
Pfami PF07856. Orai-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 191-254.
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1."
    Mercer J.C., Dehaven W.I., Smyth J.T., Wedel B., Boyles R.R., Bird G.S., Putney J.W. Jr.
    J. Biol. Chem. 281:24979-24990(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function."
    Feske S., Gwack Y., Prakriya M., Srikanth S., Puppel S.-H., Tanasa B., Hogan P.G., Lewis R.S., Daly M., Rao A.
    Nature 441:179-185(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  8. "Calcium inhibition and calcium potentiation of orai1, orai2, and orai3 calcium release-activated calcium channels."
    Dehaven W.I., Smyth J.T., Boyles R.R., Putney J.W. Jr.
    J. Biol. Chem. 282:17548-17556(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells."
    Srikanth S., Jung H.J., Kim K.D., Souda P., Whitelegge J., Gwack Y.
    Nat. Cell Biol. 12:436-446(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EFCAB4B.

Entry informationi

Entry nameiORAI2_HUMAN
AccessioniPrimary (citable) accession number: Q96SN7
Secondary accession number(s): Q6IA68, Q8WY94, Q9H9Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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