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Protein

Protein orai-2

Gene

ORAI2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Ca2+ release-activated Ca2+-like (CRAC-like) channel subunit which mediates Ca2+ influx and increase in Ca2+-selective current by synergy with the Ca2+ sensor, STIM1.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein orai-2
Alternative name(s):
CAP-binding protein complex-interacting protein 2
Transmembrane protein 142B
Gene namesi
Name:ORAI2
Synonyms:C7orf19, CBCIP2, TMEM142B
ORF Names:PP1729
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21667. ORAI2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei66 – 8318HelicalSequence AnalysisAdd
BLAST
Transmembranei94 – 11421HelicalSequence AnalysisAdd
BLAST
Transmembranei148 – 16821HelicalSequence AnalysisAdd
BLAST
Transmembranei196 – 21621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162398454.

Polymorphism and mutation databases

DMDMi74732728.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Protein orai-2PRO_0000234391Add
BLAST

Proteomic databases

MaxQBiQ96SN7.
PaxDbiQ96SN7.
PRIDEiQ96SN7.

PTM databases

PhosphoSiteiQ96SN7.

Expressioni

Gene expression databases

BgeeiQ96SN7.
CleanExiHS_ORAI2.
ExpressionAtlasiQ96SN7. baseline and differential.
GenevisibleiQ96SN7. HS.

Organism-specific databases

HPAiHPA055137.
HPA065937.

Interactioni

Subunit structurei

Interacts with CRACR2A/EFCAB4B.1 Publication

Protein-protein interaction databases

BioGridi123192. 5 interactions.
DIPiDIP-48944N.
IntActiQ96SN7. 7 interactions.
MINTiMINT-1373233.
STRINGi9606.ENSP00000348752.

Structurei

3D structure databases

ProteinModelPortaliQ96SN7.
SMRiQ96SN7. Positions 48-245.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Orai family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG263788.
GeneTreeiENSGT00390000015354.
HOGENOMiHOG000246925.
HOVERGENiHBG081343.
InParanoidiQ96SN7.
KOiK16057.
OMAiPACSEPG.
PhylomeDBiQ96SN7.
TreeFamiTF313576.

Family and domain databases

InterProiIPR012446. CRAC_channel.
IPR030034. Orai-2.
[Graphical view]
PANTHERiPTHR31501. PTHR31501. 1 hit.
PTHR31501:SF5. PTHR31501:SF5. 1 hit.
PfamiPF07856. Orai-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96SN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAELNVPID PSAPACPEPG HKGMDYRDWV RRSYLELVTS NHHSVQALSW
60 70 80 90 100
RKLYLSRAKL KASSRTSALL SGFAMVAMVE VQLETQYQYP RPLLIAFSAC
110 120 130 140 150
TTVLVAVHLF ALLISTCILP NVEAVSNIHN LNSISESPHE RMHPYIELAW
160 170 180 190 200
GFSTVLGILL FLAEVVLLCW IKFLPVDARR QPGPPPGPGS HTGWQAALVS
210 220 230 240 250
TIIMVPVGLI FVVFTIHFYR SLVRHKTERH NREIEELHKL KVQLDGHERS

LQVL
Length:254
Mass (Da):28,570
Last modified:December 1, 2001 - v1
Checksum:iD53CD2376F48E23C
GO

Sequence cautioni

The sequence AAG23755.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence AAP22352.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAG33568.1 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151A → P.
Corresponds to variant rs34947403 [ dbSNP | Ensembl ].
VAR_053543

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027639 mRNA. Translation: BAB55256.1.
AC093668 Genomic DNA. Translation: AAP22351.1.
AC093668 Genomic DNA. Translation: AAP22352.1. Sequence problems.
BC069270 mRNA. Translation: AAH69270.1.
AF258552 mRNA. Translation: AAG23755.1. Sequence problems.
CR457287 mRNA. Translation: CAG33568.1. Sequence problems.
CCDSiCCDS5722.1.
RefSeqiNP_001119812.1. NM_001126340.2.
NP_001258747.1. NM_001271818.1.
NP_116220.1. NM_032831.3.
UniGeneiHs.363308.
Hs.736659.

Genome annotation databases

EnsembliENST00000356387; ENSP00000348752; ENSG00000160991.
ENST00000403646; ENSP00000385489; ENSG00000160991.
ENST00000473939; ENSP00000417928; ENSG00000160991.
ENST00000478730; ENSP00000418140; ENSG00000160991.
ENST00000611770; ENSP00000478113; ENSG00000160991.
GeneIDi80228.
KEGGihsa:80228.
UCSCiuc003uzj.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027639 mRNA. Translation: BAB55256.1.
AC093668 Genomic DNA. Translation: AAP22351.1.
AC093668 Genomic DNA. Translation: AAP22352.1. Sequence problems.
BC069270 mRNA. Translation: AAH69270.1.
AF258552 mRNA. Translation: AAG23755.1. Sequence problems.
CR457287 mRNA. Translation: CAG33568.1. Sequence problems.
CCDSiCCDS5722.1.
RefSeqiNP_001119812.1. NM_001126340.2.
NP_001258747.1. NM_001271818.1.
NP_116220.1. NM_032831.3.
UniGeneiHs.363308.
Hs.736659.

3D structure databases

ProteinModelPortaliQ96SN7.
SMRiQ96SN7. Positions 48-245.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123192. 5 interactions.
DIPiDIP-48944N.
IntActiQ96SN7. 7 interactions.
MINTiMINT-1373233.
STRINGi9606.ENSP00000348752.

Chemistry

ChEMBLiCHEMBL3038476.

PTM databases

PhosphoSiteiQ96SN7.

Polymorphism and mutation databases

DMDMi74732728.

Proteomic databases

MaxQBiQ96SN7.
PaxDbiQ96SN7.
PRIDEiQ96SN7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356387; ENSP00000348752; ENSG00000160991.
ENST00000403646; ENSP00000385489; ENSG00000160991.
ENST00000473939; ENSP00000417928; ENSG00000160991.
ENST00000478730; ENSP00000418140; ENSG00000160991.
ENST00000611770; ENSP00000478113; ENSG00000160991.
GeneIDi80228.
KEGGihsa:80228.
UCSCiuc003uzj.3. human.

Organism-specific databases

CTDi80228.
GeneCardsiGC07P102074.
HGNCiHGNC:21667. ORAI2.
HPAiHPA055137.
HPA065937.
MIMi610929. gene.
neXtProtiNX_Q96SN7.
PharmGKBiPA162398454.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG263788.
GeneTreeiENSGT00390000015354.
HOGENOMiHOG000246925.
HOVERGENiHBG081343.
InParanoidiQ96SN7.
KOiK16057.
OMAiPACSEPG.
PhylomeDBiQ96SN7.
TreeFamiTF313576.

Miscellaneous databases

ChiTaRSiORAI2. human.
GeneWikiiORAI2.
GenomeRNAii80228.
NextBioi70657.
PROiQ96SN7.
SOURCEiSearch...

Gene expression databases

BgeeiQ96SN7.
CleanExiHS_ORAI2.
ExpressionAtlasiQ96SN7. baseline and differential.
GenevisibleiQ96SN7. HS.

Family and domain databases

InterProiIPR012446. CRAC_channel.
IPR030034. Orai-2.
[Graphical view]
PANTHERiPTHR31501. PTHR31501. 1 hit.
PTHR31501:SF5. PTHR31501:SF5. 1 hit.
PfamiPF07856. Orai-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 191-254.
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1."
    Mercer J.C., Dehaven W.I., Smyth J.T., Wedel B., Boyles R.R., Bird G.S., Putney J.W. Jr.
    J. Biol. Chem. 281:24979-24990(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function."
    Feske S., Gwack Y., Prakriya M., Srikanth S., Puppel S.-H., Tanasa B., Hogan P.G., Lewis R.S., Daly M., Rao A.
    Nature 441:179-185(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  8. "Calcium inhibition and calcium potentiation of orai1, orai2, and orai3 calcium release-activated calcium channels."
    Dehaven W.I., Smyth J.T., Boyles R.R., Putney J.W. Jr.
    J. Biol. Chem. 282:17548-17556(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells."
    Srikanth S., Jung H.J., Kim K.D., Souda P., Whitelegge J., Gwack Y.
    Nat. Cell Biol. 12:436-446(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CRACR2A.

Entry informationi

Entry nameiORAI2_HUMAN
AccessioniPrimary (citable) accession number: Q96SN7
Secondary accession number(s): Q6IA68, Q8WY94, Q9H9Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: June 24, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.