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Q96SN7

- ORAI2_HUMAN

UniProt

Q96SN7 - ORAI2_HUMAN

Protein

Protein orai-2

Gene

ORAI2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Ca2+ release-activated Ca2+-like (CRAC-like) channel subunit which mediates Ca2+ influx and increase in Ca2+-selective current by synergy with the Ca2+ sensor, STIM1.2 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein orai-2
    Alternative name(s):
    CAP-binding protein complex-interacting protein 2
    Transmembrane protein 142B
    Gene namesi
    Name:ORAI2
    Synonyms:C7orf19, CBCIP2, TMEM142B
    ORF Names:PP1729
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:21667. ORAI2.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. growth cone Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162398454.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 254254Protein orai-2PRO_0000234391Add
    BLAST

    Proteomic databases

    PaxDbiQ96SN7.
    PRIDEiQ96SN7.

    PTM databases

    PhosphoSiteiQ96SN7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96SN7.
    BgeeiQ96SN7.
    CleanExiHS_ORAI2.
    GenevestigatoriQ96SN7.

    Organism-specific databases

    HPAiHPA055137.

    Interactioni

    Subunit structurei

    Interacts with CRACR2A/EFCAB4B.1 Publication

    Protein-protein interaction databases

    BioGridi123192. 5 interactions.
    DIPiDIP-48944N.
    IntActiQ96SN7. 7 interactions.
    MINTiMINT-1373233.
    STRINGi9606.ENSP00000348752.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96SN7.
    SMRiQ96SN7. Positions 48-245.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei66 – 8318HelicalSequence AnalysisAdd
    BLAST
    Transmembranei94 – 11421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei148 – 16821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei196 – 21621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Orai family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG263788.
    HOGENOMiHOG000246925.
    HOVERGENiHBG081343.
    InParanoidiQ96SN7.
    KOiK16057.
    OMAiPACSEPG.
    PhylomeDBiQ96SN7.
    TreeFamiTF313576.

    Family and domain databases

    InterProiIPR012446. CRAC_channel.
    [Graphical view]
    PfamiPF07856. Orai-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96SN7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAELNVPID PSAPACPEPG HKGMDYRDWV RRSYLELVTS NHHSVQALSW    50
    RKLYLSRAKL KASSRTSALL SGFAMVAMVE VQLETQYQYP RPLLIAFSAC 100
    TTVLVAVHLF ALLISTCILP NVEAVSNIHN LNSISESPHE RMHPYIELAW 150
    GFSTVLGILL FLAEVVLLCW IKFLPVDARR QPGPPPGPGS HTGWQAALVS 200
    TIIMVPVGLI FVVFTIHFYR SLVRHKTERH NREIEELHKL KVQLDGHERS 250
    LQVL 254
    Length:254
    Mass (Da):28,570
    Last modified:December 1, 2001 - v1
    Checksum:iD53CD2376F48E23C
    GO

    Sequence cautioni

    The sequence AAP22352.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti15 – 151A → P.
    Corresponds to variant rs34947403 [ dbSNP | Ensembl ].
    VAR_053543

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027639 mRNA. Translation: BAB55256.1.
    AC093668 Genomic DNA. Translation: AAP22351.1.
    AC093668 Genomic DNA. Translation: AAP22352.1. Sequence problems.
    BC069270 mRNA. Translation: AAH69270.1.
    AF258552 mRNA. Translation: AAG23755.1. Sequence problems.
    CR457287 mRNA. Translation: CAG33568.1. Sequence problems.
    CCDSiCCDS5722.1.
    RefSeqiNP_001119812.1. NM_001126340.2.
    NP_001258747.1. NM_001271818.1.
    NP_116220.1. NM_032831.3.
    UniGeneiHs.363308.
    Hs.736659.

    Genome annotation databases

    EnsembliENST00000356387; ENSP00000348752; ENSG00000160991.
    ENST00000403646; ENSP00000385489; ENSG00000160991.
    ENST00000473939; ENSP00000417928; ENSG00000160991.
    ENST00000478730; ENSP00000418140; ENSG00000160991.
    GeneIDi80228.
    KEGGihsa:80228.
    UCSCiuc003uzj.3. human.

    Polymorphism databases

    DMDMi74732728.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027639 mRNA. Translation: BAB55256.1 .
    AC093668 Genomic DNA. Translation: AAP22351.1 .
    AC093668 Genomic DNA. Translation: AAP22352.1 . Sequence problems.
    BC069270 mRNA. Translation: AAH69270.1 .
    AF258552 mRNA. Translation: AAG23755.1 . Sequence problems.
    CR457287 mRNA. Translation: CAG33568.1 . Sequence problems.
    CCDSi CCDS5722.1.
    RefSeqi NP_001119812.1. NM_001126340.2.
    NP_001258747.1. NM_001271818.1.
    NP_116220.1. NM_032831.3.
    UniGenei Hs.363308.
    Hs.736659.

    3D structure databases

    ProteinModelPortali Q96SN7.
    SMRi Q96SN7. Positions 48-245.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 123192. 5 interactions.
    DIPi DIP-48944N.
    IntActi Q96SN7. 7 interactions.
    MINTi MINT-1373233.
    STRINGi 9606.ENSP00000348752.

    Chemistry

    ChEMBLi CHEMBL3038476.

    PTM databases

    PhosphoSitei Q96SN7.

    Polymorphism databases

    DMDMi 74732728.

    Proteomic databases

    PaxDbi Q96SN7.
    PRIDEi Q96SN7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000356387 ; ENSP00000348752 ; ENSG00000160991 .
    ENST00000403646 ; ENSP00000385489 ; ENSG00000160991 .
    ENST00000473939 ; ENSP00000417928 ; ENSG00000160991 .
    ENST00000478730 ; ENSP00000418140 ; ENSG00000160991 .
    GeneIDi 80228.
    KEGGi hsa:80228.
    UCSCi uc003uzj.3. human.

    Organism-specific databases

    CTDi 80228.
    GeneCardsi GC07P102074.
    HGNCi HGNC:21667. ORAI2.
    HPAi HPA055137.
    MIMi 610929. gene.
    neXtProti NX_Q96SN7.
    PharmGKBi PA162398454.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG263788.
    HOGENOMi HOG000246925.
    HOVERGENi HBG081343.
    InParanoidi Q96SN7.
    KOi K16057.
    OMAi PACSEPG.
    PhylomeDBi Q96SN7.
    TreeFami TF313576.

    Miscellaneous databases

    ChiTaRSi ORAI2. human.
    GeneWikii ORAI2.
    GenomeRNAii 80228.
    NextBioi 70657.
    PROi Q96SN7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96SN7.
    Bgeei Q96SN7.
    CleanExi HS_ORAI2.
    Genevestigatori Q96SN7.

    Family and domain databases

    InterProi IPR012446. CRAC_channel.
    [Graphical view ]
    Pfami PF07856. Orai-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Teratocarcinoma.
    2. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 191-254.
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1."
      Mercer J.C., Dehaven W.I., Smyth J.T., Wedel B., Boyles R.R., Bird G.S., Putney J.W. Jr.
      J. Biol. Chem. 281:24979-24990(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function."
      Feske S., Gwack Y., Prakriya M., Srikanth S., Puppel S.-H., Tanasa B., Hogan P.G., Lewis R.S., Daly M., Rao A.
      Nature 441:179-185(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    8. "Calcium inhibition and calcium potentiation of orai1, orai2, and orai3 calcium release-activated calcium channels."
      Dehaven W.I., Smyth J.T., Boyles R.R., Putney J.W. Jr.
      J. Biol. Chem. 282:17548-17556(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    9. "A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells."
      Srikanth S., Jung H.J., Kim K.D., Souda P., Whitelegge J., Gwack Y.
      Nat. Cell Biol. 12:436-446(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CRACR2A.

    Entry informationi

    Entry nameiORAI2_HUMAN
    AccessioniPrimary (citable) accession number: Q96SN7
    Secondary accession number(s): Q6IA68, Q8WY94, Q9H9Y3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3