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Q96SM3

- CPXM1_HUMAN

UniProt

Q96SM3 - CPXM1_HUMAN

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Protein

Probable carboxypeptidase X1

Gene

CPXM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in cell-cell interactions. No carboxypeptidase activity was found yet (By similarity).By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi360 – 3601ZincBy similarity
Metal bindingi363 – 3631ZincBy similarity
Metal bindingi498 – 4981ZincBy similarity
Active sitei591 – 5911NucleophileBy similarity

GO - Molecular functioni

  1. metallocarboxypeptidase activity Source: InterPro
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM14.952.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable carboxypeptidase X1 (EC:3.4.17.-)
Alternative name(s):
Metallocarboxypeptidase CPX-1
Gene namesi
Name:CPXM1
Synonyms:CPX1, CPXM
ORF Names:UNQ3015/PRO9782
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:15771. CPXM1.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162382779.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 734714Probable carboxypeptidase X1PRO_0000004407Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi115 ↔ 274PROSITE-ProRule annotation
Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi318 – 3181N-linked (GlcNAc...)Sequence Analysis
Glycosylationi428 – 4281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi472 – 4721N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96SM3.
PRIDEiQ96SM3.

PTM databases

PhosphoSiteiQ96SM3.

Expressioni

Gene expression databases

BgeeiQ96SM3.
CleanExiHS_CPXM1.
ExpressionAtlasiQ96SM3. baseline and differential.
GenevestigatoriQ96SM3.

Organism-specific databases

HPAiHPA055044.

Interactioni

Protein-protein interaction databases

BioGridi121127. 1 interaction.
IntActiQ96SM3. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ96SM3.
SMRiQ96SM3. Positions 87-278, 295-703.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini113 – 274162F5/8 type CPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi70 – 734Poly-Lys
Compositional biasi369 – 3735Poly-Leu

Sequence similaritiesi

Belongs to the peptidase M14 family.Curated
Contains 1 F5/8 type C domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG322453.
GeneTreeiENSGT00760000119124.
HOGENOMiHOG000232185.
HOVERGENiHBG003410.
InParanoidiQ96SM3.
KOiK08638.
OMAiRYDWVTS.
OrthoDBiEOG7B8S32.
PhylomeDBiQ96SM3.
TreeFamiTF315592.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.1120. 1 hit.
InterProiIPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR008979. Galactose-bd-like.
IPR000834. Peptidase_M14.
[Graphical view]
PfamiPF00754. F5_F8_type_C. 1 hit.
PF00246. Peptidase_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00231. FA58C. 1 hit.
SM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF49464. SSF49464. 1 hit.
SSF49785. SSF49785. 1 hit.
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
PS50022. FA58C_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96SM3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWGLLLALAA FAPAVGPALG APRNSVLGLA QPGTTKVPGS TPALHSSPAQ
60 70 80 90 100
PPAETANGTS EQHVRIRVIK KKKVIMKKRK KLTLTRPTPL VTAGPLVTPT
110 120 130 140 150
PAGTLDPAEK QETGCPPLGL ESLRVSDSRL EASSSQSFGL GPHRGRLNIQ
160 170 180 190 200
SGLEDGDLYD GAWCAEEQDA DPWFQVDAGH PTRFSGVITQ GRNSVWRYDW
210 220 230 240 250
VTSYKVQFSN DSRTWWGSRN HSSGMDAVFP ANSDPETPVL NLLPEPQVAR
260 270 280 290 300
FIRLLPQTWL QGGAPCLRAE ILACPVSDPN DLFLEAPASG SSDPLDFQHH
310 320 330 340 350
NYKAMRKLMK QVQEQCPNIT RIYSIGKSYQ GLKLYVMEMS DKPGEHELGE
360 370 380 390 400
PEVRYVAGMH GNEALGRELL LLLMQFLCHE FLRGNPRVTR LLSEMRIHLL
410 420 430 440 450
PSMNPDGYEI AYHRGSELVG WAEGRWNNQS IDLNHNFADL NTPLWEAQDD
460 470 480 490 500
GKVPHIVPNH HLPLPTYYTL PNATVAPETR AVIKWMKRIP FVLSANLHGG
510 520 530 540 550
ELVVSYPFDM TRTPWAAREL TPTPDDAVFR WLSTVYAGSN LAMQDTSRRP
560 570 580 590 600
CHSQDFSVHG NIINGADWHT VPGSMNDFSY LHTNCFEVTV ELSCDKFPHE
610 620 630 640 650
NELPQEWENN KDALLTYLEQ VRMGIAGVVR DKDTELGIAD AVIAVDGINH
660 670 680 690 700
DVTTAWGGDY WRLLTPGDYM VTASAEGYHS VTRNCRVTFE EGPFPCNFVL
710 720 730
TKTPKQRLRE LLAAGAKVPP DLRRRLERLR GQKD
Length:734
Mass (Da):81,668
Last modified:April 12, 2005 - v2
Checksum:iB1205522889F6FE5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401S → L in AAH63430. (PubMed:15489334)Curated
Sequence conflicti150 – 1501Q → H in AAQ89315. (PubMed:12975309)Curated
Sequence conflicti390 – 3901R → W in BAB55275. (PubMed:14702039)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027661 mRNA. Translation: BAB55275.1.
AY358956 mRNA. Translation: AAQ89315.1.
AL035460 Genomic DNA. Translation: CAB82246.1.
BC063430 mRNA. Translation: AAH63430.1.
CCDSiCCDS13033.1.
RefSeqiNP_001171628.1. NM_001184699.1.
NP_062555.1. NM_019609.4.
UniGeneiHs.659346.

Genome annotation databases

EnsembliENST00000380605; ENSP00000369979; ENSG00000088882.
GeneIDi56265.
KEGGihsa:56265.
UCSCiuc002wgu.3. human.

Polymorphism databases

DMDMi62512151.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027661 mRNA. Translation: BAB55275.1 .
AY358956 mRNA. Translation: AAQ89315.1 .
AL035460 Genomic DNA. Translation: CAB82246.1 .
BC063430 mRNA. Translation: AAH63430.1 .
CCDSi CCDS13033.1.
RefSeqi NP_001171628.1. NM_001184699.1.
NP_062555.1. NM_019609.4.
UniGenei Hs.659346.

3D structure databases

ProteinModelPortali Q96SM3.
SMRi Q96SM3. Positions 87-278, 295-703.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121127. 1 interaction.
IntActi Q96SM3. 1 interaction.

Protein family/group databases

MEROPSi M14.952.

PTM databases

PhosphoSitei Q96SM3.

Polymorphism databases

DMDMi 62512151.

Proteomic databases

PaxDbi Q96SM3.
PRIDEi Q96SM3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000380605 ; ENSP00000369979 ; ENSG00000088882 .
GeneIDi 56265.
KEGGi hsa:56265.
UCSCi uc002wgu.3. human.

Organism-specific databases

CTDi 56265.
GeneCardsi GC20M002723.
HGNCi HGNC:15771. CPXM1.
HPAi HPA055044.
MIMi 609555. gene.
neXtProti NX_Q96SM3.
PharmGKBi PA162382779.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG322453.
GeneTreei ENSGT00760000119124.
HOGENOMi HOG000232185.
HOVERGENi HBG003410.
InParanoidi Q96SM3.
KOi K08638.
OMAi RYDWVTS.
OrthoDBi EOG7B8S32.
PhylomeDBi Q96SM3.
TreeFami TF315592.

Miscellaneous databases

ChiTaRSi CPXM1. human.
GeneWikii CPXM1.
GenomeRNAii 56265.
NextBioi 61925.
PROi Q96SM3.
SOURCEi Search...

Gene expression databases

Bgeei Q96SM3.
CleanExi HS_CPXM1.
ExpressionAtlasi Q96SM3. baseline and differential.
Genevestigatori Q96SM3.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
2.60.40.1120. 1 hit.
InterProi IPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR008979. Galactose-bd-like.
IPR000834. Peptidase_M14.
[Graphical view ]
Pfami PF00754. F5_F8_type_C. 1 hit.
PF00246. Peptidase_M14. 1 hit.
[Graphical view ]
PRINTSi PR00765. CRBOXYPTASEA.
SMARTi SM00231. FA58C. 1 hit.
SM00631. Zn_pept. 1 hit.
[Graphical view ]
SUPFAMi SSF49464. SSF49464. 1 hit.
SSF49785. SSF49785. 1 hit.
PROSITEi PS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
PS50022. FA58C_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.

Entry informationi

Entry nameiCPXM1_HUMAN
AccessioniPrimary (citable) accession number: Q96SM3
Secondary accession number(s): Q6P4G8, Q6UW65, Q9NUB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: April 12, 2005
Last modified: November 26, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3