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Q96SM3 (CPXM1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable carboxypeptidase X1

EC=3.4.17.-
Alternative name(s):
Metallocarboxypeptidase CPX-1
Gene names
Name:CPXM1
Synonyms:CPX1, CPXM
ORF Names:UNQ3015/PRO9782
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length734 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in cell-cell interactions. No carboxypeptidase activity was found yet By similarity.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the peptidase M14 family.

Contains 1 F5/8 type C domain.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   LigandMetal-binding
Zinc
   Molecular functionCarboxypeptidase
Hydrolase
Metalloprotease
Protease
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell adhesion

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionmetallocarboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 734714Probable carboxypeptidase X1
PRO_0000004407

Regions

Domain113 – 274162F5/8 type C
Compositional bias70 – 734Poly-Lys
Compositional bias369 – 3735Poly-Leu

Sites

Active site5911Nucleophile By similarity
Metal binding3601Zinc By similarity
Metal binding3631Zinc By similarity
Metal binding4981Zinc By similarity

Amino acid modifications

Glycosylation571N-linked (GlcNAc...) Potential
Glycosylation2101N-linked (GlcNAc...) Potential
Glycosylation2201N-linked (GlcNAc...) Potential
Glycosylation3181N-linked (GlcNAc...) Potential
Glycosylation4281N-linked (GlcNAc...) Potential
Glycosylation4721N-linked (GlcNAc...) Potential
Disulfide bond115 ↔ 274 By similarity

Experimental info

Sequence conflict401S → L in AAH63430. Ref.4
Sequence conflict1501Q → H in AAQ89315. Ref.2
Sequence conflict3901R → W in BAB55275. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q96SM3 [UniParc].

Last modified April 12, 2005. Version 2.
Checksum: B1205522889F6FE5

FASTA73481,668
        10         20         30         40         50         60 
MWGLLLALAA FAPAVGPALG APRNSVLGLA QPGTTKVPGS TPALHSSPAQ PPAETANGTS 

        70         80         90        100        110        120 
EQHVRIRVIK KKKVIMKKRK KLTLTRPTPL VTAGPLVTPT PAGTLDPAEK QETGCPPLGL 

       130        140        150        160        170        180 
ESLRVSDSRL EASSSQSFGL GPHRGRLNIQ SGLEDGDLYD GAWCAEEQDA DPWFQVDAGH 

       190        200        210        220        230        240 
PTRFSGVITQ GRNSVWRYDW VTSYKVQFSN DSRTWWGSRN HSSGMDAVFP ANSDPETPVL 

       250        260        270        280        290        300 
NLLPEPQVAR FIRLLPQTWL QGGAPCLRAE ILACPVSDPN DLFLEAPASG SSDPLDFQHH 

       310        320        330        340        350        360 
NYKAMRKLMK QVQEQCPNIT RIYSIGKSYQ GLKLYVMEMS DKPGEHELGE PEVRYVAGMH 

       370        380        390        400        410        420 
GNEALGRELL LLLMQFLCHE FLRGNPRVTR LLSEMRIHLL PSMNPDGYEI AYHRGSELVG 

       430        440        450        460        470        480 
WAEGRWNNQS IDLNHNFADL NTPLWEAQDD GKVPHIVPNH HLPLPTYYTL PNATVAPETR 

       490        500        510        520        530        540 
AVIKWMKRIP FVLSANLHGG ELVVSYPFDM TRTPWAAREL TPTPDDAVFR WLSTVYAGSN 

       550        560        570        580        590        600 
LAMQDTSRRP CHSQDFSVHG NIINGADWHT VPGSMNDFSY LHTNCFEVTV ELSCDKFPHE 

       610        620        630        640        650        660 
NELPQEWENN KDALLTYLEQ VRMGIAGVVR DKDTELGIAD AVIAVDGINH DVTTAWGGDY 

       670        680        690        700        710        720 
WRLLTPGDYM VTASAEGYHS VTRNCRVTFE EGPFPCNFVL TKTPKQRLRE LLAAGAKVPP 

       730 
DLRRRLERLR GQKD 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Teratocarcinoma.
[2]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The DNA sequence and comparative analysis of human chromosome 20."
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. expand/collapse author list , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Fetal brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK027661 mRNA. Translation: BAB55275.1.
AY358956 mRNA. Translation: AAQ89315.1.
AL035460 Genomic DNA. Translation: CAB82246.1.
BC063430 mRNA. Translation: AAH63430.1.
CCDSCCDS13033.1.
RefSeqNP_001171628.1. NM_001184699.1.
NP_062555.1. NM_019609.4.
UniGeneHs.659346.

3D structure databases

ProteinModelPortalQ96SM3.
SMRQ96SM3. Positions 87-278, 295-703.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121127. 1 interaction.
IntActQ96SM3. 1 interaction.

Protein family/group databases

MEROPSM14.952.

PTM databases

PhosphoSiteQ96SM3.

Polymorphism databases

DMDM62512151.

Proteomic databases

PaxDbQ96SM3.
PRIDEQ96SM3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000380605; ENSP00000369979; ENSG00000088882.
GeneID56265.
KEGGhsa:56265.
UCSCuc002wgu.3. human.

Organism-specific databases

CTD56265.
GeneCardsGC20M002723.
HGNCHGNC:15771. CPXM1.
HPAHPA055044.
MIM609555. gene.
neXtProtNX_Q96SM3.
PharmGKBPA162382779.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG322453.
HOGENOMHOG000232185.
HOVERGENHBG003410.
InParanoidQ96SM3.
KOK08638.
OMARYDWVTS.
OrthoDBEOG7B8S32.
PhylomeDBQ96SM3.
TreeFamTF315592.

Gene expression databases

ArrayExpressQ96SM3.
BgeeQ96SM3.
CleanExHS_CPXM1.
GenevestigatorQ96SM3.

Family and domain databases

Gene3D2.60.120.260. 1 hit.
2.60.40.1120. 1 hit.
InterProIPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR008979. Galactose-bd-like.
IPR000834. Peptidase_M14.
[Graphical view]
PfamPF00754. F5_F8_type_C. 1 hit.
PF00246. Peptidase_M14. 1 hit.
[Graphical view]
PRINTSPR00765. CRBOXYPTASEA.
SMARTSM00231. FA58C. 1 hit.
SM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMSSF49464. SSF49464. 1 hit.
SSF49785. SSF49785. 1 hit.
PROSITEPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
PS50022. FA58C_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCPXM1. human.
GeneWikiCPXM1.
GenomeRNAi56265.
NextBio61925.
PROQ96SM3.
SOURCESearch...

Entry information

Entry nameCPXM1_HUMAN
AccessionPrimary (citable) accession number: Q96SM3
Secondary accession number(s): Q6P4G8, Q6UW65, Q9NUB5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: April 12, 2005
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 20

Human chromosome 20: entries, gene names and cross-references to MIM