Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96SM3

- CPXM1_HUMAN

UniProt

Q96SM3 - CPXM1_HUMAN

Protein

Probable carboxypeptidase X1

Gene

CPXM1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 2 (12 Apr 2005)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May be involved in cell-cell interactions. No carboxypeptidase activity was found yet By similarity.By similarity

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi360 – 3601ZincBy similarity
    Metal bindingi363 – 3631ZincBy similarity
    Metal bindingi498 – 4981ZincBy similarity
    Active sitei591 – 5911NucleophileBy similarity

    GO - Molecular functioni

    1. metallocarboxypeptidase activity Source: InterPro
    2. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cell adhesion Source: InterPro

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM14.952.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable carboxypeptidase X1 (EC:3.4.17.-)
    Alternative name(s):
    Metallocarboxypeptidase CPX-1
    Gene namesi
    Name:CPXM1
    Synonyms:CPX1, CPXM
    ORF Names:UNQ3015/PRO9782
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:15771. CPXM1.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162382779.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 734714Probable carboxypeptidase X1PRO_0000004407Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi57 – 571N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi115 ↔ 274PROSITE-ProRule annotation
    Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi220 – 2201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi318 – 3181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi428 – 4281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi472 – 4721N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ96SM3.
    PRIDEiQ96SM3.

    PTM databases

    PhosphoSiteiQ96SM3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96SM3.
    BgeeiQ96SM3.
    CleanExiHS_CPXM1.
    GenevestigatoriQ96SM3.

    Organism-specific databases

    HPAiHPA055044.

    Interactioni

    Protein-protein interaction databases

    BioGridi121127. 1 interaction.
    IntActiQ96SM3. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96SM3.
    SMRiQ96SM3. Positions 87-278, 295-703.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini113 – 274162F5/8 type CPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi70 – 734Poly-Lys
    Compositional biasi369 – 3735Poly-Leu

    Sequence similaritiesi

    Belongs to the peptidase M14 family.Curated
    Contains 1 F5/8 type C domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG322453.
    HOGENOMiHOG000232185.
    HOVERGENiHBG003410.
    InParanoidiQ96SM3.
    KOiK08638.
    OMAiRYDWVTS.
    OrthoDBiEOG7B8S32.
    PhylomeDBiQ96SM3.
    TreeFamiTF315592.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    2.60.40.1120. 1 hit.
    InterProiIPR008969. CarboxyPept-like_regulatory.
    IPR014766. CarboxyPept_regulatory_dom.
    IPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR008979. Galactose-bd-like.
    IPR000834. Peptidase_M14.
    [Graphical view]
    PfamiPF00754. F5_F8_type_C. 1 hit.
    PF00246. Peptidase_M14. 1 hit.
    [Graphical view]
    PRINTSiPR00765. CRBOXYPTASEA.
    SMARTiSM00231. FA58C. 1 hit.
    SM00631. Zn_pept. 1 hit.
    [Graphical view]
    SUPFAMiSSF49464. SSF49464. 1 hit.
    SSF49785. SSF49785. 1 hit.
    PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
    PS00133. CARBOXYPEPT_ZN_2. 1 hit.
    PS50022. FA58C_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q96SM3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWGLLLALAA FAPAVGPALG APRNSVLGLA QPGTTKVPGS TPALHSSPAQ    50
    PPAETANGTS EQHVRIRVIK KKKVIMKKRK KLTLTRPTPL VTAGPLVTPT 100
    PAGTLDPAEK QETGCPPLGL ESLRVSDSRL EASSSQSFGL GPHRGRLNIQ 150
    SGLEDGDLYD GAWCAEEQDA DPWFQVDAGH PTRFSGVITQ GRNSVWRYDW 200
    VTSYKVQFSN DSRTWWGSRN HSSGMDAVFP ANSDPETPVL NLLPEPQVAR 250
    FIRLLPQTWL QGGAPCLRAE ILACPVSDPN DLFLEAPASG SSDPLDFQHH 300
    NYKAMRKLMK QVQEQCPNIT RIYSIGKSYQ GLKLYVMEMS DKPGEHELGE 350
    PEVRYVAGMH GNEALGRELL LLLMQFLCHE FLRGNPRVTR LLSEMRIHLL 400
    PSMNPDGYEI AYHRGSELVG WAEGRWNNQS IDLNHNFADL NTPLWEAQDD 450
    GKVPHIVPNH HLPLPTYYTL PNATVAPETR AVIKWMKRIP FVLSANLHGG 500
    ELVVSYPFDM TRTPWAAREL TPTPDDAVFR WLSTVYAGSN LAMQDTSRRP 550
    CHSQDFSVHG NIINGADWHT VPGSMNDFSY LHTNCFEVTV ELSCDKFPHE 600
    NELPQEWENN KDALLTYLEQ VRMGIAGVVR DKDTELGIAD AVIAVDGINH 650
    DVTTAWGGDY WRLLTPGDYM VTASAEGYHS VTRNCRVTFE EGPFPCNFVL 700
    TKTPKQRLRE LLAAGAKVPP DLRRRLERLR GQKD 734
    Length:734
    Mass (Da):81,668
    Last modified:April 12, 2005 - v2
    Checksum:iB1205522889F6FE5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti40 – 401S → L in AAH63430. (PubMed:15489334)Curated
    Sequence conflicti150 – 1501Q → H in AAQ89315. (PubMed:12975309)Curated
    Sequence conflicti390 – 3901R → W in BAB55275. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027661 mRNA. Translation: BAB55275.1.
    AY358956 mRNA. Translation: AAQ89315.1.
    AL035460 Genomic DNA. Translation: CAB82246.1.
    BC063430 mRNA. Translation: AAH63430.1.
    CCDSiCCDS13033.1.
    RefSeqiNP_001171628.1. NM_001184699.1.
    NP_062555.1. NM_019609.4.
    UniGeneiHs.659346.

    Genome annotation databases

    EnsembliENST00000380605; ENSP00000369979; ENSG00000088882.
    GeneIDi56265.
    KEGGihsa:56265.
    UCSCiuc002wgu.3. human.

    Polymorphism databases

    DMDMi62512151.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027661 mRNA. Translation: BAB55275.1 .
    AY358956 mRNA. Translation: AAQ89315.1 .
    AL035460 Genomic DNA. Translation: CAB82246.1 .
    BC063430 mRNA. Translation: AAH63430.1 .
    CCDSi CCDS13033.1.
    RefSeqi NP_001171628.1. NM_001184699.1.
    NP_062555.1. NM_019609.4.
    UniGenei Hs.659346.

    3D structure databases

    ProteinModelPortali Q96SM3.
    SMRi Q96SM3. Positions 87-278, 295-703.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121127. 1 interaction.
    IntActi Q96SM3. 1 interaction.

    Protein family/group databases

    MEROPSi M14.952.

    PTM databases

    PhosphoSitei Q96SM3.

    Polymorphism databases

    DMDMi 62512151.

    Proteomic databases

    PaxDbi Q96SM3.
    PRIDEi Q96SM3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000380605 ; ENSP00000369979 ; ENSG00000088882 .
    GeneIDi 56265.
    KEGGi hsa:56265.
    UCSCi uc002wgu.3. human.

    Organism-specific databases

    CTDi 56265.
    GeneCardsi GC20M002723.
    HGNCi HGNC:15771. CPXM1.
    HPAi HPA055044.
    MIMi 609555. gene.
    neXtProti NX_Q96SM3.
    PharmGKBi PA162382779.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG322453.
    HOGENOMi HOG000232185.
    HOVERGENi HBG003410.
    InParanoidi Q96SM3.
    KOi K08638.
    OMAi RYDWVTS.
    OrthoDBi EOG7B8S32.
    PhylomeDBi Q96SM3.
    TreeFami TF315592.

    Miscellaneous databases

    ChiTaRSi CPXM1. human.
    GeneWikii CPXM1.
    GenomeRNAii 56265.
    NextBioi 61925.
    PROi Q96SM3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96SM3.
    Bgeei Q96SM3.
    CleanExi HS_CPXM1.
    Genevestigatori Q96SM3.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    2.60.40.1120. 1 hit.
    InterProi IPR008969. CarboxyPept-like_regulatory.
    IPR014766. CarboxyPept_regulatory_dom.
    IPR000421. Coagulation_fac_5/8-C_type_dom.
    IPR008979. Galactose-bd-like.
    IPR000834. Peptidase_M14.
    [Graphical view ]
    Pfami PF00754. F5_F8_type_C. 1 hit.
    PF00246. Peptidase_M14. 1 hit.
    [Graphical view ]
    PRINTSi PR00765. CRBOXYPTASEA.
    SMARTi SM00231. FA58C. 1 hit.
    SM00631. Zn_pept. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49464. SSF49464. 1 hit.
    SSF49785. SSF49785. 1 hit.
    PROSITEi PS00132. CARBOXYPEPT_ZN_1. 1 hit.
    PS00133. CARBOXYPEPT_ZN_2. 1 hit.
    PS50022. FA58C_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Teratocarcinoma.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Fetal brain.

    Entry informationi

    Entry nameiCPXM1_HUMAN
    AccessioniPrimary (citable) accession number: Q96SM3
    Secondary accession number(s): Q6P4G8, Q6UW65, Q9NUB5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2002
    Last sequence update: April 12, 2005
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Peptidase families
      Classification of peptidase families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3