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Q96SM3

- CPXM1_HUMAN

UniProt

Q96SM3 - CPXM1_HUMAN

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Protein

Probable carboxypeptidase X1

Gene
CPXM1, CPX1, CPXM, UNQ3015/PRO9782
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in cell-cell interactions. No carboxypeptidase activity was found yet By similarity.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi360 – 3601Zinc By similarity
Metal bindingi363 – 3631Zinc By similarity
Metal bindingi498 – 4981Zinc By similarity
Active sitei591 – 5911Nucleophile By similarity

GO - Molecular functioni

  1. metallocarboxypeptidase activity Source: InterPro
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. cell adhesion Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM14.952.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable carboxypeptidase X1 (EC:3.4.17.-)
Alternative name(s):
Metallocarboxypeptidase CPX-1
Gene namesi
Name:CPXM1
Synonyms:CPX1, CPXM
ORF Names:UNQ3015/PRO9782
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:15771. CPXM1.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162382779.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 734714Probable carboxypeptidase X1PRO_0000004407Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi115 ↔ 274 By similarity
Glycosylationi210 – 2101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi220 – 2201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi318 – 3181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi428 – 4281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi472 – 4721N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96SM3.
PRIDEiQ96SM3.

PTM databases

PhosphoSiteiQ96SM3.

Expressioni

Gene expression databases

ArrayExpressiQ96SM3.
BgeeiQ96SM3.
CleanExiHS_CPXM1.
GenevestigatoriQ96SM3.

Organism-specific databases

HPAiHPA055044.

Interactioni

Protein-protein interaction databases

BioGridi121127. 1 interaction.
IntActiQ96SM3. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ96SM3.
SMRiQ96SM3. Positions 87-278, 295-703.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini113 – 274162F5/8 type CAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi70 – 734Poly-Lys
Compositional biasi369 – 3735Poly-Leu

Sequence similaritiesi

Belongs to the peptidase M14 family.
Contains 1 F5/8 type C domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG322453.
HOGENOMiHOG000232185.
HOVERGENiHBG003410.
InParanoidiQ96SM3.
KOiK08638.
OMAiRYDWVTS.
OrthoDBiEOG7B8S32.
PhylomeDBiQ96SM3.
TreeFamiTF315592.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.1120. 1 hit.
InterProiIPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR008979. Galactose-bd-like.
IPR000834. Peptidase_M14.
[Graphical view]
PfamiPF00754. F5_F8_type_C. 1 hit.
PF00246. Peptidase_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00231. FA58C. 1 hit.
SM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF49464. SSF49464. 1 hit.
SSF49785. SSF49785. 1 hit.
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
PS50022. FA58C_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96SM3-1 [UniParc]FASTAAdd to Basket

« Hide

MWGLLLALAA FAPAVGPALG APRNSVLGLA QPGTTKVPGS TPALHSSPAQ    50
PPAETANGTS EQHVRIRVIK KKKVIMKKRK KLTLTRPTPL VTAGPLVTPT 100
PAGTLDPAEK QETGCPPLGL ESLRVSDSRL EASSSQSFGL GPHRGRLNIQ 150
SGLEDGDLYD GAWCAEEQDA DPWFQVDAGH PTRFSGVITQ GRNSVWRYDW 200
VTSYKVQFSN DSRTWWGSRN HSSGMDAVFP ANSDPETPVL NLLPEPQVAR 250
FIRLLPQTWL QGGAPCLRAE ILACPVSDPN DLFLEAPASG SSDPLDFQHH 300
NYKAMRKLMK QVQEQCPNIT RIYSIGKSYQ GLKLYVMEMS DKPGEHELGE 350
PEVRYVAGMH GNEALGRELL LLLMQFLCHE FLRGNPRVTR LLSEMRIHLL 400
PSMNPDGYEI AYHRGSELVG WAEGRWNNQS IDLNHNFADL NTPLWEAQDD 450
GKVPHIVPNH HLPLPTYYTL PNATVAPETR AVIKWMKRIP FVLSANLHGG 500
ELVVSYPFDM TRTPWAAREL TPTPDDAVFR WLSTVYAGSN LAMQDTSRRP 550
CHSQDFSVHG NIINGADWHT VPGSMNDFSY LHTNCFEVTV ELSCDKFPHE 600
NELPQEWENN KDALLTYLEQ VRMGIAGVVR DKDTELGIAD AVIAVDGINH 650
DVTTAWGGDY WRLLTPGDYM VTASAEGYHS VTRNCRVTFE EGPFPCNFVL 700
TKTPKQRLRE LLAAGAKVPP DLRRRLERLR GQKD 734
Length:734
Mass (Da):81,668
Last modified:April 12, 2005 - v2
Checksum:iB1205522889F6FE5
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401S → L in AAH63430. 1 Publication
Sequence conflicti150 – 1501Q → H in AAQ89315. 1 Publication
Sequence conflicti390 – 3901R → W in BAB55275. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK027661 mRNA. Translation: BAB55275.1.
AY358956 mRNA. Translation: AAQ89315.1.
AL035460 Genomic DNA. Translation: CAB82246.1.
BC063430 mRNA. Translation: AAH63430.1.
CCDSiCCDS13033.1.
RefSeqiNP_001171628.1. NM_001184699.1.
NP_062555.1. NM_019609.4.
UniGeneiHs.659346.

Genome annotation databases

EnsembliENST00000380605; ENSP00000369979; ENSG00000088882.
GeneIDi56265.
KEGGihsa:56265.
UCSCiuc002wgu.3. human.

Polymorphism databases

DMDMi62512151.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK027661 mRNA. Translation: BAB55275.1 .
AY358956 mRNA. Translation: AAQ89315.1 .
AL035460 Genomic DNA. Translation: CAB82246.1 .
BC063430 mRNA. Translation: AAH63430.1 .
CCDSi CCDS13033.1.
RefSeqi NP_001171628.1. NM_001184699.1.
NP_062555.1. NM_019609.4.
UniGenei Hs.659346.

3D structure databases

ProteinModelPortali Q96SM3.
SMRi Q96SM3. Positions 87-278, 295-703.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121127. 1 interaction.
IntActi Q96SM3. 1 interaction.

Protein family/group databases

MEROPSi M14.952.

PTM databases

PhosphoSitei Q96SM3.

Polymorphism databases

DMDMi 62512151.

Proteomic databases

PaxDbi Q96SM3.
PRIDEi Q96SM3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000380605 ; ENSP00000369979 ; ENSG00000088882 .
GeneIDi 56265.
KEGGi hsa:56265.
UCSCi uc002wgu.3. human.

Organism-specific databases

CTDi 56265.
GeneCardsi GC20M002723.
HGNCi HGNC:15771. CPXM1.
HPAi HPA055044.
MIMi 609555. gene.
neXtProti NX_Q96SM3.
PharmGKBi PA162382779.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG322453.
HOGENOMi HOG000232185.
HOVERGENi HBG003410.
InParanoidi Q96SM3.
KOi K08638.
OMAi RYDWVTS.
OrthoDBi EOG7B8S32.
PhylomeDBi Q96SM3.
TreeFami TF315592.

Miscellaneous databases

ChiTaRSi CPXM1. human.
GeneWikii CPXM1.
GenomeRNAii 56265.
NextBioi 61925.
PROi Q96SM3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96SM3.
Bgeei Q96SM3.
CleanExi HS_CPXM1.
Genevestigatori Q96SM3.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
2.60.40.1120. 1 hit.
InterProi IPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR000421. Coagulation_fac_5/8-C_type_dom.
IPR008979. Galactose-bd-like.
IPR000834. Peptidase_M14.
[Graphical view ]
Pfami PF00754. F5_F8_type_C. 1 hit.
PF00246. Peptidase_M14. 1 hit.
[Graphical view ]
PRINTSi PR00765. CRBOXYPTASEA.
SMARTi SM00231. FA58C. 1 hit.
SM00631. Zn_pept. 1 hit.
[Graphical view ]
SUPFAMi SSF49464. SSF49464. 1 hit.
SSF49785. SSF49785. 1 hit.
PROSITEi PS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
PS50022. FA58C_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.

Entry informationi

Entry nameiCPXM1_HUMAN
AccessioniPrimary (citable) accession number: Q96SM3
Secondary accession number(s): Q6P4G8, Q6UW65, Q9NUB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: April 12, 2005
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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