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Q96SL8

- FIZ1_HUMAN

UniProt

Q96SL8 - FIZ1_HUMAN

Protein

Flt3-interacting zinc finger protein 1

Gene

FIZ1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri23 – 4523C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri51 – 7323C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri79 – 10123C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri107 – 13024C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri200 – 22223C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri228 – 25023C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri331 – 35222C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri358 – 38124C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri414 – 43623C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri442 – 46423C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri470 – 49223C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. nucleic acid binding Source: InterPro
    3. receptor tyrosine kinase binding Source: UniProtKB

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Flt3-interacting zinc finger protein 1
    Alternative name(s):
    Zinc finger protein 798
    Gene namesi
    Name:FIZ1
    Synonyms:ZNF798
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:25917. FIZ1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162388597.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 496496Flt3-interacting zinc finger protein 1PRO_0000046937Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ96SL8.
    PaxDbiQ96SL8.
    PRIDEiQ96SL8.

    PTM databases

    PhosphoSiteiQ96SL8.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ96SL8.
    BgeeiQ96SL8.
    CleanExiHS_FIZ1.
    GenevestigatoriQ96SL8.

    Interactioni

    Subunit structurei

    Interacts with FLT3 cytoplasmic catalytic domain, following receptor stimulation, in a kinase-independent manner. Does not interact with other structurally related receptor tyrosine kinases, including KIT, CSF1R and PDGFR. Interacts with NRL By similarity.By similarity

    Protein-protein interaction databases

    BioGridi124357. 1 interaction.
    IntActiQ96SL8. 1 interaction.
    STRINGi9606.ENSP00000221665.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96SL8.
    SMRiQ96SL8. Positions 22-492.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri23 – 4523C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri51 – 7323C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri79 – 10123C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri107 – 13024C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri200 – 22223C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri228 – 25023C2H2-type 6PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri331 – 35222C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri358 – 38124C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri414 – 43623C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri442 – 46423C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri470 – 49223C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ96SL8.
    OMAiCCNVGPC.
    OrthoDBiEOG7WDN2W.
    PhylomeDBiQ96SL8.
    TreeFamiTF337381.

    Family and domain databases

    Gene3Di3.30.160.60. 8 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00096. zf-C2H2. 2 hits.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 11 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 11 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96SL8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDDVPAPTPA PAPPAAAAPR VPFHCSECGK SFRYRSDLRR HFARHTALKP    50
    HACPRCGKGF KHSFNLANHL RSHTGERPYR CSACPKGFRD STGLLHHQVV 100
    HTGEKPYCCL VCELRFSSRS SLGRHLKRQH RGVLPSPLQP GPGLPALSAP 150
    CSVCCNVGPC SVCGGSGAGG GEGPEGAGAG LGSWGLAEAA AAAAASLPPF 200
    ACGACARRFD HGRELAAHWA AHTDVKPFKC PRCERDFNAP ALLERHKLTH 250
    DLQGPGAPPA QAWAAGPGAG PETAGEGTAA EAGDAPLASD RRLLLGPAGG 300
    GVPKLGGLLP EGGGEAPAPA AAAEPSEDTL YQCDCGTFFA SAAALASHLE 350
    AHSGPATYGC GHCGALYAAL AALEEHRRVS HGEGGGEEAA TAAREREPAS 400
    GEPPSGSGRG KKIFGCSECE KLFRSPRDLE RHVLVHTGEK PFPCLECGKF 450
    FRHECYLKRH RLLHGTERPF PCHICGKGFI TLSNLSRHLK LHRGMD 496
    Length:496
    Mass (Da):51,996
    Last modified:May 18, 2010 - v2
    Checksum:iD4DD7E435249B0C5
    GO

    Sequence cautioni

    The sequence BAD18728.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti127 – 1271K → R in BAB55286. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti391 – 3911T → A.3 Publications
    Corresponds to variant rs7247236 [ dbSNP | Ensembl ].
    VAR_060269

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027674 mRNA. Translation: BAB55286.1.
    AK160385 mRNA. Translation: BAD18728.1. Different initiation.
    AC008735 Genomic DNA. No translation available.
    CH471135 Genomic DNA. Translation: EAW72392.1.
    BC132777 mRNA. Translation: AAI32778.1.
    BC136512 mRNA. Translation: AAI36513.1.
    CCDSiCCDS12928.1.
    RefSeqiNP_116225.2. NM_032836.2.
    XP_005259409.1. XM_005259352.2.
    XP_005259410.1. XM_005259353.2.
    UniGeneiHs.515617.

    Genome annotation databases

    EnsembliENST00000221665; ENSP00000221665; ENSG00000179943.
    GeneIDi84922.
    KEGGihsa:84922.
    UCSCiuc002qli.4. human.

    Polymorphism databases

    DMDMi296434506.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027674 mRNA. Translation: BAB55286.1 .
    AK160385 mRNA. Translation: BAD18728.1 . Different initiation.
    AC008735 Genomic DNA. No translation available.
    CH471135 Genomic DNA. Translation: EAW72392.1 .
    BC132777 mRNA. Translation: AAI32778.1 .
    BC136512 mRNA. Translation: AAI36513.1 .
    CCDSi CCDS12928.1.
    RefSeqi NP_116225.2. NM_032836.2.
    XP_005259409.1. XM_005259352.2.
    XP_005259410.1. XM_005259353.2.
    UniGenei Hs.515617.

    3D structure databases

    ProteinModelPortali Q96SL8.
    SMRi Q96SL8. Positions 22-492.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124357. 1 interaction.
    IntActi Q96SL8. 1 interaction.
    STRINGi 9606.ENSP00000221665.

    PTM databases

    PhosphoSitei Q96SL8.

    Polymorphism databases

    DMDMi 296434506.

    Proteomic databases

    MaxQBi Q96SL8.
    PaxDbi Q96SL8.
    PRIDEi Q96SL8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000221665 ; ENSP00000221665 ; ENSG00000179943 .
    GeneIDi 84922.
    KEGGi hsa:84922.
    UCSCi uc002qli.4. human.

    Organism-specific databases

    CTDi 84922.
    GeneCardsi GC19M056102.
    HGNCi HGNC:25917. FIZ1.
    MIMi 609133. gene.
    neXtProti NX_Q96SL8.
    PharmGKBi PA162388597.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q96SL8.
    OMAi CCNVGPC.
    OrthoDBi EOG7WDN2W.
    PhylomeDBi Q96SL8.
    TreeFami TF337381.

    Miscellaneous databases

    GenomeRNAii 84922.
    NextBioi 75332.
    PROi Q96SL8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96SL8.
    Bgeei Q96SL8.
    CleanExi HS_FIZ1.
    Genevestigatori Q96SL8.

    Family and domain databases

    Gene3Di 3.30.160.60. 8 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00096. zf-C2H2. 2 hits.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 11 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 10 hits.
    PS50157. ZINC_FINGER_C2H2_2. 11 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-391.
      Tissue: Spleen and Teratocarcinoma.
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-391.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-391.
      Tissue: Brain.
    5. "Interaction of retinal bZIP transcription factor NRL with Flt3-interacting zinc-finger protein Fiz1: possible role of Fiz1 as a transcriptional repressor."
      Mitton K.P., Swain P.K., Khanna H., Dowd M., Apel I.J., Swaroop A.
      Hum. Mol. Genet. 12:365-373(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFIZ1_HUMAN
    AccessioniPrimary (citable) accession number: Q96SL8
    Secondary accession number(s): A2RU72, Q6ZMJ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2005
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3