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Q96SL8

- FIZ1_HUMAN

UniProt

Q96SL8 - FIZ1_HUMAN

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Protein

Flt3-interacting zinc finger protein 1

Gene

FIZ1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri23 – 4523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri51 – 7323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri79 – 10123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri107 – 13024C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri331 – 35222C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri358 – 38124C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri414 – 43623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri442 – 46423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri470 – 49223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. nucleic acid binding Source: InterPro
  3. receptor tyrosine kinase binding Source: UniProtKB

GO - Biological processi

  1. positive regulation of protein phosphorylation Source: Ensembl
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Flt3-interacting zinc finger protein 1
Alternative name(s):
Zinc finger protein 798
Gene namesi
Name:FIZ1
Synonyms:ZNF798
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:25917. FIZ1.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162388597.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Flt3-interacting zinc finger protein 1PRO_0000046937Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ96SL8.
PaxDbiQ96SL8.
PRIDEiQ96SL8.

PTM databases

PhosphoSiteiQ96SL8.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ96SL8.
CleanExiHS_FIZ1.
ExpressionAtlasiQ96SL8. baseline and differential.
GenevestigatoriQ96SL8.

Interactioni

Subunit structurei

Interacts with FLT3 cytoplasmic catalytic domain, following receptor stimulation, in a kinase-independent manner. Does not interact with other structurally related receptor tyrosine kinases, including KIT, CSF1R and PDGFR. Interacts with NRL (By similarity).By similarity

Protein-protein interaction databases

BioGridi124357. 1 interaction.
IntActiQ96SL8. 1 interaction.
STRINGi9606.ENSP00000221665.

Structurei

3D structure databases

ProteinModelPortaliQ96SL8.
SMRiQ96SL8. Positions 22-495.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 11 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri23 – 4523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri51 – 7323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri79 – 10123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri107 – 13024C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri331 – 35222C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri358 – 38124C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri414 – 43623C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri442 – 46423C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri470 – 49223C2H2-type 11PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00490000043512.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96SL8.
OMAiCCNVGPC.
OrthoDBiEOG7WDN2W.
PhylomeDBiQ96SL8.
TreeFamiTF337381.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 11 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96SL8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDDVPAPTPA PAPPAAAAPR VPFHCSECGK SFRYRSDLRR HFARHTALKP
60 70 80 90 100
HACPRCGKGF KHSFNLANHL RSHTGERPYR CSACPKGFRD STGLLHHQVV
110 120 130 140 150
HTGEKPYCCL VCELRFSSRS SLGRHLKRQH RGVLPSPLQP GPGLPALSAP
160 170 180 190 200
CSVCCNVGPC SVCGGSGAGG GEGPEGAGAG LGSWGLAEAA AAAAASLPPF
210 220 230 240 250
ACGACARRFD HGRELAAHWA AHTDVKPFKC PRCERDFNAP ALLERHKLTH
260 270 280 290 300
DLQGPGAPPA QAWAAGPGAG PETAGEGTAA EAGDAPLASD RRLLLGPAGG
310 320 330 340 350
GVPKLGGLLP EGGGEAPAPA AAAEPSEDTL YQCDCGTFFA SAAALASHLE
360 370 380 390 400
AHSGPATYGC GHCGALYAAL AALEEHRRVS HGEGGGEEAA TAAREREPAS
410 420 430 440 450
GEPPSGSGRG KKIFGCSECE KLFRSPRDLE RHVLVHTGEK PFPCLECGKF
460 470 480 490
FRHECYLKRH RLLHGTERPF PCHICGKGFI TLSNLSRHLK LHRGMD
Length:496
Mass (Da):51,996
Last modified:May 18, 2010 - v2
Checksum:iD4DD7E435249B0C5
GO

Sequence cautioni

The sequence BAD18728.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti127 – 1271K → R in BAB55286. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti391 – 3911T → A.3 Publications
Corresponds to variant rs7247236 [ dbSNP | Ensembl ].
VAR_060269

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK027674 mRNA. Translation: BAB55286.1.
AK160385 mRNA. Translation: BAD18728.1. Different initiation.
AC008735 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72392.1.
BC132777 mRNA. Translation: AAI32778.1.
BC136512 mRNA. Translation: AAI36513.1.
CCDSiCCDS12928.1.
RefSeqiNP_116225.2. NM_032836.2.
XP_005259409.1. XM_005259352.2.
XP_005259410.1. XM_005259353.2.
UniGeneiHs.515617.

Genome annotation databases

EnsembliENST00000221665; ENSP00000221665; ENSG00000179943.
GeneIDi84922.
KEGGihsa:84922.
UCSCiuc002qli.4. human.

Polymorphism databases

DMDMi296434506.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK027674 mRNA. Translation: BAB55286.1 .
AK160385 mRNA. Translation: BAD18728.1 . Different initiation.
AC008735 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW72392.1 .
BC132777 mRNA. Translation: AAI32778.1 .
BC136512 mRNA. Translation: AAI36513.1 .
CCDSi CCDS12928.1.
RefSeqi NP_116225.2. NM_032836.2.
XP_005259409.1. XM_005259352.2.
XP_005259410.1. XM_005259353.2.
UniGenei Hs.515617.

3D structure databases

ProteinModelPortali Q96SL8.
SMRi Q96SL8. Positions 22-495.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124357. 1 interaction.
IntActi Q96SL8. 1 interaction.
STRINGi 9606.ENSP00000221665.

PTM databases

PhosphoSitei Q96SL8.

Polymorphism databases

DMDMi 296434506.

Proteomic databases

MaxQBi Q96SL8.
PaxDbi Q96SL8.
PRIDEi Q96SL8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000221665 ; ENSP00000221665 ; ENSG00000179943 .
GeneIDi 84922.
KEGGi hsa:84922.
UCSCi uc002qli.4. human.

Organism-specific databases

CTDi 84922.
GeneCardsi GC19M056102.
HGNCi HGNC:25917. FIZ1.
MIMi 609133. gene.
neXtProti NX_Q96SL8.
PharmGKBi PA162388597.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00490000043512.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q96SL8.
OMAi CCNVGPC.
OrthoDBi EOG7WDN2W.
PhylomeDBi Q96SL8.
TreeFami TF337381.

Miscellaneous databases

GenomeRNAii 84922.
NextBioi 75332.
PROi Q96SL8.
SOURCEi Search...

Gene expression databases

Bgeei Q96SL8.
CleanExi HS_FIZ1.
ExpressionAtlasi Q96SL8. baseline and differential.
Genevestigatori Q96SL8.

Family and domain databases

Gene3Di 3.30.160.60. 8 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00096. zf-C2H2. 2 hits.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 11 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-391.
    Tissue: Spleen and Teratocarcinoma.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-391.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-391.
    Tissue: Brain.
  5. "Interaction of retinal bZIP transcription factor NRL with Flt3-interacting zinc-finger protein Fiz1: possible role of Fiz1 as a transcriptional repressor."
    Mitton K.P., Swain P.K., Khanna H., Dowd M., Apel I.J., Swaroop A.
    Hum. Mol. Genet. 12:365-373(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFIZ1_HUMAN
AccessioniPrimary (citable) accession number: Q96SL8
Secondary accession number(s): A2RU72, Q6ZMJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3