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Protein

Flt3-interacting zinc finger protein 1

Gene

FIZ1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a transcriptional repressor of NRL function in photoreceptors. Does not repress CRX-mediated transactivation (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri23 – 45C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri51 – 73C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri79 – 101C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri107 – 130C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri200 – 222C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri331 – 352C2H2-type 7PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri358 – 381C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri414 – 436C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ96SL8

Names & Taxonomyi

Protein namesi
Recommended name:
Flt3-interacting zinc finger protein 1
Alternative name(s):
Zinc finger protein 798
Gene namesi
Name:FIZ1
Synonyms:ZNF798
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000179943.7
HGNCiHGNC:25917 FIZ1
MIMi609133 gene
neXtProtiNX_Q96SL8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179943
PharmGKBiPA162388597

Polymorphism and mutation databases

BioMutaiFIZ1
DMDMi296434506

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000469371 – 496Flt3-interacting zinc finger protein 1Add BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ96SL8
MaxQBiQ96SL8
PaxDbiQ96SL8
PeptideAtlasiQ96SL8
PRIDEiQ96SL8

PTM databases

iPTMnetiQ96SL8
PhosphoSitePlusiQ96SL8

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000179943
CleanExiHS_FIZ1
ExpressionAtlasiQ96SL8 baseline and differential
GenevisibleiQ96SL8 HS

Organism-specific databases

HPAiHPA074026

Interactioni

Subunit structurei

Interacts with FLT3 cytoplasmic catalytic domain, following receptor stimulation, in a kinase-independent manner. Does not interact with other structurally related receptor tyrosine kinases, including KIT, CSF1R and PDGFR. Interacts with NRL (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi1243575 interactors.
IntActiQ96SL8 1 interactor.
STRINGi9606.ENSP00000221665

Structurei

3D structure databases

ProteinModelPortaliQ96SL8
SMRiQ96SL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri23 – 45C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri51 – 73C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri79 – 101C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri107 – 130C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri200 – 222C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri331 – 352C2H2-type 7PROSITE-ProRule annotationAdd BLAST22
Zinc fingeri358 – 381C2H2-type 8PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri414 – 436C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000141050
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ96SL8
OMAiCCNVGPC
OrthoDBiEOG091G0I07
PhylomeDBiQ96SL8
TreeFamiTF337381

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 11 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 11 hits

Sequencei

Sequence statusi: Complete.

Q96SL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDDVPAPTPA PAPPAAAAPR VPFHCSECGK SFRYRSDLRR HFARHTALKP
60 70 80 90 100
HACPRCGKGF KHSFNLANHL RSHTGERPYR CSACPKGFRD STGLLHHQVV
110 120 130 140 150
HTGEKPYCCL VCELRFSSRS SLGRHLKRQH RGVLPSPLQP GPGLPALSAP
160 170 180 190 200
CSVCCNVGPC SVCGGSGAGG GEGPEGAGAG LGSWGLAEAA AAAAASLPPF
210 220 230 240 250
ACGACARRFD HGRELAAHWA AHTDVKPFKC PRCERDFNAP ALLERHKLTH
260 270 280 290 300
DLQGPGAPPA QAWAAGPGAG PETAGEGTAA EAGDAPLASD RRLLLGPAGG
310 320 330 340 350
GVPKLGGLLP EGGGEAPAPA AAAEPSEDTL YQCDCGTFFA SAAALASHLE
360 370 380 390 400
AHSGPATYGC GHCGALYAAL AALEEHRRVS HGEGGGEEAA TAAREREPAS
410 420 430 440 450
GEPPSGSGRG KKIFGCSECE KLFRSPRDLE RHVLVHTGEK PFPCLECGKF
460 470 480 490
FRHECYLKRH RLLHGTERPF PCHICGKGFI TLSNLSRHLK LHRGMD
Length:496
Mass (Da):51,996
Last modified:May 18, 2010 - v2
Checksum:iD4DD7E435249B0C5
GO

Sequence cautioni

The sequence BAD18728 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti127K → R in BAB55286 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060269391T → A3 PublicationsCorresponds to variant dbSNP:rs7247236Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027674 mRNA Translation: BAB55286.1
AK160385 mRNA Translation: BAD18728.1 Different initiation.
AC008735 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72392.1
BC132777 mRNA Translation: AAI32778.1
BC136512 mRNA Translation: AAI36513.1
CCDSiCCDS12928.1
RefSeqiNP_116225.2, NM_032836.2
XP_005259409.1, XM_005259352.4
UniGeneiHs.515617

Genome annotation databases

EnsembliENST00000221665; ENSP00000221665; ENSG00000179943
GeneIDi84922
KEGGihsa:84922
UCSCiuc002qli.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFIZ1_HUMAN
AccessioniPrimary (citable) accession number: Q96SL8
Secondary accession number(s): A2RU72, Q6ZMJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: May 18, 2010
Last modified: March 28, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome