Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 607

Gene

ZNF607

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri114 – 13623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri142 – 16423C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri170 – 19223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri197 – 21923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri225 – 24723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri281 – 30323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri309 – 33123C2H2-type 8; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri365 – 38723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri393 – 41523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri421 – 44323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri449 – 47123C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri477 – 49923C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri505 – 52723C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri533 – 55523C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri561 – 58323C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri589 – 61123C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri617 – 63923C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri645 – 66723C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri673 – 69523C2H2-type 20PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 607
Gene namesi
Name:ZNF607
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28192. ZNF607.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134938252.

Polymorphism and mutation databases

BioMutaiZNF607.
DMDMi239938814.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 696696Zinc finger protein 607PRO_0000047689Add
BLAST

Proteomic databases

MaxQBiQ96SK3.
PaxDbiQ96SK3.
PRIDEiQ96SK3.

PTM databases

PhosphoSiteiQ96SK3.

Expressioni

Gene expression databases

BgeeiQ96SK3.
CleanExiHS_ZNF607.
ExpressionAtlasiQ96SK3. baseline and differential.
GenevisibleiQ96SK3. HS.

Organism-specific databases

HPAiHPA049465.
HPA055018.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
MDFIQ997504EBI-747175,EBI-724076
MTUS2Q5JR593EBI-747175,EBI-742948

Protein-protein interaction databases

BioGridi124252. 3 interactions.
IntActiQ96SK3. 3 interactions.
STRINGi9606.ENSP00000347338.

Structurei

3D structure databases

ProteinModelPortaliQ96SK3.
SMRiQ96SK3. Positions 112-695.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 7873KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 20 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri114 – 13623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri142 – 16423C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri170 – 19223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri197 – 21923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri225 – 24723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri253 – 27523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri281 – 30323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri309 – 33123C2H2-type 8; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri365 – 38723C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri393 – 41523C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri421 – 44323C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri449 – 47123C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri477 – 49923C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri505 – 52723C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri533 – 55523C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri561 – 58323C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri589 – 61123C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri617 – 63923C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri645 – 66723C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri673 – 69523C2H2-type 20PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129692.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96SK3.
KOiK09228.
OMAiHASHLII.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ96SK3.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 21 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 18 hits.
PS50157. ZINC_FINGER_C2H2_2. 20 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96SK3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYGSITFGD VAIDFSHQEW EYLSLVQKTL YQEVMMENYD NLVSLAGHSV
60 70 80 90 100
SKPDLITLLE QGKEPWMIVR EETRGECTDL DSRCEIISDG KMQLYRKHSC
110 120 130 140 150
VTLHQRIHNG QKPYECKQCQ KSFSHLTELM VHQTIHTSEE PDQCEKFRKA
160 170 180 190 200
FSHLTDLRKH QKINAREKPY ECEECGKVFS YPANLAQHGK VHVEKPYECK
210 220 230 240 250
ECGEAFRTSR QLTVHHRFHY GEKPYECKEC GKAFSVYGRL SRHQSIHTGE
260 270 280 290 300
KPFECNKCGK SFRLKAGLKV HQSIHTGEKP HECKECGKAF RQFSHLVGHK
310 320 330 340 350
RIHTGEKPYE CKECGKGFTC RYQLTMHQRI YSGEKHYECK ENGEAFSSGH
360 370 380 390 400
QLTAPHTFES VEKPYKCEEC GKAFSVHGRL TRHQGIHSGK KPYECNKCGK
410 420 430 440 450
SFRLNSSLKI HQNIHTGEKP YKCKECGKAF SQRAHLAHHN RIHTGYKPFE
460 470 480 490 500
CKECGKSFRC ASYLVIHERI HTGEKPYVCQ ECGKGFSYSH KLTIHRRVHT
510 520 530 540 550
GEKPYECKEC GKAFSVSGQL TQHLSIHSGK KPFECNKCGK SFRFISVLKA
560 570 580 590 600
HQNIHSAEKP YECKECGKAF RHATSLIYHD RTHAGEKSYE CKECGETFSH
610 620 630 640 650
ASHLIIHERI HTSDKPYECK RCGKAFHCAS YLVRHESVHA DGNPYMCEEC
660 670 680 690
GKAFNSSHEL SIHHRVHTGE KPFKCNKCRR SFRLRSILEV HQRIHI
Length:696
Mass (Da):80,507
Last modified:June 16, 2009 - v3
Checksum:i62ABBBDA26A3F875
GO
Isoform 2 (identifier: Q96SK3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-325: Missing.

Show »
Length:371
Mass (Da):42,712
Checksum:i48EAAF78A7A7E350
GO
Isoform 3 (identifier: Q96SK3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     46-46: Missing.

Note: No experimental confirmation available.
Show »
Length:695
Mass (Da):80,435
Checksum:i141542D11FD6018A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti653 – 6542AF → GL in AAH14850 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21S → A.1 Publication
Corresponds to variant rs2909097 [ dbSNP | Ensembl ].
VAR_057974
Natural varianti70 – 701R → H.
Corresponds to variant rs2385006 [ dbSNP | Ensembl ].
VAR_057975
Natural varianti123 – 1231F → L.
Corresponds to variant rs35735839 [ dbSNP | Ensembl ].
VAR_057976
Natural varianti375 – 3751S → T.
Corresponds to variant rs960689 [ dbSNP | Ensembl ].
VAR_057977
Natural varianti433 – 4331R → H.
Corresponds to variant rs2385006 [ dbSNP | Ensembl ].
VAR_058306
Natural varianti531 – 5311K → R.2 Publications
Corresponds to variant rs958305 [ dbSNP | Ensembl ].
VAR_058307
Natural varianti653 – 6531A → P.
Corresponds to variant rs17856468 [ dbSNP | Ensembl ].
VAR_057978

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 325325Missing in isoform 2. 2 PublicationsVSP_037503Add
BLAST
Alternative sequencei46 – 461Missing in isoform 3. 1 PublicationVSP_046843

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131557 mRNA. Translation: BAD18691.1.
AK131559 mRNA. Translation: BAD18693.1.
AK027708 mRNA. Translation: BAB55313.1.
AC093227 Genomic DNA. No translation available.
BC014850 mRNA. Translation: AAH14850.1.
CCDSiCCDS33006.1. [Q96SK3-1]
CCDS54259.1. [Q96SK3-3]
RefSeqiNP_001166148.1. NM_001172677.1. [Q96SK3-3]
NP_116078.4. NM_032689.4. [Q96SK3-1]
XP_006723498.1. XM_006723435.2. [Q96SK3-1]
XP_006723499.1. XM_006723436.2. [Q96SK3-3]
UniGeneiHs.116622.

Genome annotation databases

EnsembliENST00000355202; ENSP00000347338; ENSG00000198182. [Q96SK3-1]
ENST00000395835; ENSP00000438015; ENSG00000198182. [Q96SK3-3]
GeneIDi84775.
KEGGihsa:84775.
UCSCiuc002ohb.3. human. [Q96SK3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131557 mRNA. Translation: BAD18691.1.
AK131559 mRNA. Translation: BAD18693.1.
AK027708 mRNA. Translation: BAB55313.1.
AC093227 Genomic DNA. No translation available.
BC014850 mRNA. Translation: AAH14850.1.
CCDSiCCDS33006.1. [Q96SK3-1]
CCDS54259.1. [Q96SK3-3]
RefSeqiNP_001166148.1. NM_001172677.1. [Q96SK3-3]
NP_116078.4. NM_032689.4. [Q96SK3-1]
XP_006723498.1. XM_006723435.2. [Q96SK3-1]
XP_006723499.1. XM_006723436.2. [Q96SK3-3]
UniGeneiHs.116622.

3D structure databases

ProteinModelPortaliQ96SK3.
SMRiQ96SK3. Positions 112-695.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124252. 3 interactions.
IntActiQ96SK3. 3 interactions.
STRINGi9606.ENSP00000347338.

PTM databases

PhosphoSiteiQ96SK3.

Polymorphism and mutation databases

BioMutaiZNF607.
DMDMi239938814.

Proteomic databases

MaxQBiQ96SK3.
PaxDbiQ96SK3.
PRIDEiQ96SK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355202; ENSP00000347338; ENSG00000198182. [Q96SK3-1]
ENST00000395835; ENSP00000438015; ENSG00000198182. [Q96SK3-3]
GeneIDi84775.
KEGGihsa:84775.
UCSCiuc002ohb.3. human. [Q96SK3-1]

Organism-specific databases

CTDi84775.
GeneCardsiZNF607.
HGNCiHGNC:28192. ZNF607.
HPAiHPA049465.
HPA055018.
neXtProtiNX_Q96SK3.
PharmGKBiPA134938252.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129692.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96SK3.
KOiK09228.
OMAiHASHLII.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ96SK3.
TreeFamiTF341817.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii84775.
NextBioi74928.
PROiQ96SK3.

Gene expression databases

BgeeiQ96SK3.
CleanExiHS_ZNF607.
ExpressionAtlasiQ96SK3. baseline and differential.
GenevisibleiQ96SK3. HS.

Family and domain databases

Gene3Di3.30.160.60. 21 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 18 hits.
PS50157. ZINC_FINGER_C2H2_2. 20 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), VARIANTS ALA-2 AND ARG-531.
    Tissue: Testis.
  2. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ARG-531.
    Tissue: Placenta.

Entry informationi

Entry nameiZN607_HUMAN
AccessioniPrimary (citable) accession number: Q96SK3
Secondary accession number(s): F5H141
, Q6ZMN2, Q6ZMN4, Q96C40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 16, 2009
Last modified: May 11, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.