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Protein

Transmembrane protein 209

Gene

TMEM209

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 209
Gene namesi
Name:TMEM209
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21898. TMEM209.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei28 – 48HelicalSequence analysisAdd BLAST21
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi84928.
OpenTargetsiENSG00000146842.
PharmGKBiPA162406425.

Polymorphism and mutation databases

BioMutaiTMEM209.
DMDMi187663981.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003316321 – 561Transmembrane protein 209Add BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1
Modified residuei11PhosphoserineCombined sources1
Glycosylationi57N-linked (GlcNAc...)Sequence analysis1
Modified residuei98PhosphoserineCombined sources1
Modified residuei201PhosphoserineCombined sources1
Modified residuei222PhosphoserineCombined sources1
Modified residuei248PhosphoserineCombined sources1
Glycosylationi274N-linked (GlcNAc...)Sequence analysis1
Modified residuei278PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ96SK2.
MaxQBiQ96SK2.
PaxDbiQ96SK2.
PeptideAtlasiQ96SK2.
PRIDEiQ96SK2.

PTM databases

iPTMnetiQ96SK2.
PhosphoSitePlusiQ96SK2.

Expressioni

Gene expression databases

BgeeiENSG00000146842.
CleanExiHS_TMEM209.
ExpressionAtlasiQ96SK2. baseline and differential.
GenevisibleiQ96SK2. HS.

Organism-specific databases

HPAiHPA031678.

Interactioni

Protein-protein interaction databases

BioGridi124362. 22 interactors.
IntActiQ96SK2. 19 interactors.
STRINGi9606.ENSP00000380747.

Structurei

3D structure databases

ProteinModelPortaliQ96SK2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi131 – 222Ser-richAdd BLAST92

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4670. Eukaryota.
ENOG410XQWI. LUCA.
GeneTreeiENSGT00390000013963.
HOGENOMiHOG000154623.
HOVERGENiHBG056529.
InParanoidiQ96SK2.
OMAiYYNITYW.
OrthoDBiEOG091G047K.
PhylomeDBiQ96SK2.
TreeFamiTF320043.

Family and domain databases

InterProiIPR019176. Cytochrome_B561-rel.
[Graphical view]
PfamiPF09786. CytochromB561_N. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96SK2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMQGEAHPSA SLIDRTIKMR KETEARKVVL AWGLLNVSMA GMIYTEMTGK
60 70 80 90 100
LISSYYNVTY WPLWYIELAL ASLFSLNALF DFWRYFKYTV APTSLVVSPG
110 120 130 140 150
QQTLLGLKTA VVQTTPPHDL AATQIPPAPP SPSIQGQSVL SYSPSRSPST
160 170 180 190 200
SPKFTTSCMT GYSPQLQGLS SGGSGSYSPG VTYSPVSGYN KLASFSPSPP
210 220 230 240 250
SPYPTTVGPV ESSGLRSRYR SSPTVYNSPT DKEDYMTDLR TLDTFLRSEE
260 270 280 290 300
EKQHRVKLGS PDSTSPSSSP TFWNYSRSMG DYAQTLKKFQ YQLACRSQAP
310 320 330 340 350
CANKDEADLS SKQAAEEVWA RVAMNRQLLD HMDSWTAKFR NWINETILVP
360 370 380 390 400
LVQEIESVST QMRRMGCPEL QIGEASITSL KQAALVKAPL IPTLNTIVQY
410 420 430 440 450
LDLTPNQEYL FERIKELSQG GCMSSFRWNR GGDFKGRKWD TDLPTDSAII
460 470 480 490 500
MHVFCTYLDS RLPPHPKYPD GKTFTSQHFV QTPNKPDVTN ENVFCIYQSA
510 520 530 540 550
INPPHYELIY QRHVYNLPKG RNNMFHTLLM FLYIIKTKES GMLGRVNLGL
560
SGVNILWIFG E
Length:561
Mass (Da):62,922
Last modified:April 29, 2008 - v2
Checksum:i0075314FEBC3DBA7
GO
Isoform 2 (identifier: Q96SK2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: Missing.

Show »
Length:560
Mass (Da):62,790
Checksum:i15CC3FB13F7BEBA7
GO
Isoform 3 (identifier: Q96SK2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     375-416: Missing.

Note: No experimental confirmation available.
Show »
Length:519
Mass (Da):58,195
Checksum:i78D7E5086190E19F
GO
Isoform 4 (identifier: Q96SK2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     192-203: LASFSPSPPSPY → VMTLFSCLVTLF
     204-561: Missing.

Note: No experimental confirmation available.
Show »
Length:203
Mass (Da):22,090
Checksum:iD8622C9507C25A78
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti379S → G in BAC11168 (PubMed:14702039).Curated1
Sequence conflicti395N → D in BAB55314 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042918469P → R.1 PublicationCorresponds to variant rs17857472dbSNPEnsembl.1
Natural variantiVAR_042919505H → R.1 PublicationCorresponds to variant rs17854938dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0332801Missing in isoform 2. Curated1
Alternative sequenceiVSP_033281192 – 203LASFS…PPSPY → VMTLFSCLVTLF in isoform 4. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_033282204 – 561Missing in isoform 4. 1 PublicationAdd BLAST358
Alternative sequenceiVSP_033283375 – 416Missing in isoform 3. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027678 mRNA. Translation: BAB55289.1.
AK027709 mRNA. Translation: BAB55314.1.
AK074732 mRNA. Translation: BAC11168.1.
CH236950 Genomic DNA. Translation: EAL24094.1.
CH471070 Genomic DNA. Translation: EAW83748.1.
CH471070 Genomic DNA. Translation: EAW83749.1.
BC045618 mRNA. Translation: AAH45618.1.
BC057784 mRNA. Translation: AAH57784.1.
CCDSiCCDS47712.1. [Q96SK2-1]
CCDS75661.1. [Q96SK2-3]
RefSeqiNP_001288092.1. NM_001301163.1. [Q96SK2-3]
NP_116231.2. NM_032842.3. [Q96SK2-1]
XP_005250712.1. XM_005250655.1. [Q96SK2-2]
XP_011514948.1. XM_011516646.2. [Q96SK2-2]
UniGeneiHs.267245.

Genome annotation databases

EnsembliENST00000397622; ENSP00000380747; ENSG00000146842. [Q96SK2-1]
ENST00000462753; ENSP00000419697; ENSG00000146842. [Q96SK2-2]
ENST00000473456; ENSP00000417258; ENSG00000146842. [Q96SK2-3]
GeneIDi84928.
KEGGihsa:84928.
UCSCiuc003vpn.2. human. [Q96SK2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027678 mRNA. Translation: BAB55289.1.
AK027709 mRNA. Translation: BAB55314.1.
AK074732 mRNA. Translation: BAC11168.1.
CH236950 Genomic DNA. Translation: EAL24094.1.
CH471070 Genomic DNA. Translation: EAW83748.1.
CH471070 Genomic DNA. Translation: EAW83749.1.
BC045618 mRNA. Translation: AAH45618.1.
BC057784 mRNA. Translation: AAH57784.1.
CCDSiCCDS47712.1. [Q96SK2-1]
CCDS75661.1. [Q96SK2-3]
RefSeqiNP_001288092.1. NM_001301163.1. [Q96SK2-3]
NP_116231.2. NM_032842.3. [Q96SK2-1]
XP_005250712.1. XM_005250655.1. [Q96SK2-2]
XP_011514948.1. XM_011516646.2. [Q96SK2-2]
UniGeneiHs.267245.

3D structure databases

ProteinModelPortaliQ96SK2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124362. 22 interactors.
IntActiQ96SK2. 19 interactors.
STRINGi9606.ENSP00000380747.

PTM databases

iPTMnetiQ96SK2.
PhosphoSitePlusiQ96SK2.

Polymorphism and mutation databases

BioMutaiTMEM209.
DMDMi187663981.

Proteomic databases

EPDiQ96SK2.
MaxQBiQ96SK2.
PaxDbiQ96SK2.
PeptideAtlasiQ96SK2.
PRIDEiQ96SK2.

Protocols and materials databases

DNASUi84928.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397622; ENSP00000380747; ENSG00000146842. [Q96SK2-1]
ENST00000462753; ENSP00000419697; ENSG00000146842. [Q96SK2-2]
ENST00000473456; ENSP00000417258; ENSG00000146842. [Q96SK2-3]
GeneIDi84928.
KEGGihsa:84928.
UCSCiuc003vpn.2. human. [Q96SK2-1]

Organism-specific databases

CTDi84928.
DisGeNETi84928.
GeneCardsiTMEM209.
HGNCiHGNC:21898. TMEM209.
HPAiHPA031678.
neXtProtiNX_Q96SK2.
OpenTargetsiENSG00000146842.
PharmGKBiPA162406425.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4670. Eukaryota.
ENOG410XQWI. LUCA.
GeneTreeiENSGT00390000013963.
HOGENOMiHOG000154623.
HOVERGENiHBG056529.
InParanoidiQ96SK2.
OMAiYYNITYW.
OrthoDBiEOG091G047K.
PhylomeDBiQ96SK2.
TreeFamiTF320043.

Miscellaneous databases

GenomeRNAii84928.
PROiQ96SK2.

Gene expression databases

BgeeiENSG00000146842.
CleanExiHS_TMEM209.
ExpressionAtlasiQ96SK2. baseline and differential.
GenevisibleiQ96SK2. HS.

Family and domain databases

InterProiIPR019176. Cytochrome_B561-rel.
[Graphical view]
PfamiPF09786. CytochromB561_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTM209_HUMAN
AccessioniPrimary (citable) accession number: Q96SK2
Secondary accession number(s): A4D1L1
, Q49A50, Q6PF00, Q8NCH3, Q96SL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: November 2, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.