Q96SJ9 (Q96SJ9_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: cDNA FLJ14807 fis, clone NT2RP4001760, weakly similar to PUTATIVE RHO/RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR EMBL BAB55317.1
Organism	Homo sapiens (Human) EMBL BAB55317.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 DH (DBL-homology) domain. SAAS SAAS000219 Contains 1 PH domain. SAAS SAAS000219

Ontologies

Gene Ontology (GO)
Biological_process	cell morphogenesis Inferred from electronic annotation. Source: Compara cytokinesis Inferred from electronic annotation. Source: InterPro intracellular signal transduction Inferred from electronic annotation. Source: InterPro positive regulation of GTPase activity Inferred from electronic annotation. Source: GOC positive regulation of neuron differentiation Inferred from electronic annotation. Source: Compara positive regulation of protein import into nucleus Inferred from electronic annotation. Source: Compara regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara
Molecular_function	GTPase activator activity Inferred from electronic annotation. Source: InterPro Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: InterPro phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q96SJ9 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 2423AC2A4A92370E	FASTA	359	40,488
	10 20 30 40 50 60 MSKETIIKCE KQKPRFHAFL KINQAKPECG RQSLVELLIR PVQRLPSVAL LLNDLKKHTA 70 80 90 100 110 120 DENPDKSTLE KAIGSLKEVM THINEDKRKT EAQKQIFDVV YEVDGCPANL LSSHRSLVQR 130 140 150 160 170 180 VETISLGEHP CDRGEQVTLF LFNDCLEIAR KRHKVIGTFR SPHGQTRPPA SLKHIHLMPL 190 200 210 220 230 240 SQIKKVLDIR ETEDCHNAFA LLVRPPTEQA NVLLSFQMTS DELPKENWLK MLCRHVANTI 250 260 270 280 290 300 CKADAENLIY TADPESFEVN TKDMDSTLSR ASRAIKKTSK KVTRAFSFSK TPKRALRRAL 310 320 330 340 350 MTSHGSVEGR SPSSNDKHVM SRLSSTSSLA GIPSPSLVSL PSFFERRSHT LSRSTTHLI

References

[1]

"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK027713 mRNA. Translation: BAB55317.1.
IPI	IPI00924582.
UniGene	Hs.518299.
3D structure databases
ProteinModelPortal	Q96SJ9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96SJ9.
Proteomic databases
PRIDE	Q96SJ9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
PharmGKB	PA27600.
Phylogenomic databases
HOVERGEN	HBG075223.
Gene expression databases
ArrayExpress	Q96SJ9.
Bgee	Q96SJ9.
Family and domain databases
Gene3D	1.20.900.10. 1 hit. 2.30.29.30. 1 hit.
InterPro	IPR000219. DH-domain. IPR026817. Ect2. IPR001331. GDS_CDC24_CS. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. [Graphical view]
PANTHER	PTHR16777:SF0. PTHR16777:SF0. 1 hit.
Pfam	PF00621. RhoGEF. 1 hit. [Graphical view]
SMART	SM00233. PH. 1 hit. [Graphical view]
SUPFAM	SSF48065. DH-domain. 1 hit.
PROSITE	PS00741. DH_1. 1 hit. PS50010. DH_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	13647232.

Entry information

Entry name

Q96SJ9_HUMAN

Accession

Primary (citable) accession number: Q96SJ9

Entry history

Integrated into UniProtKB/TrEMBL:	December 1, 2001
Last sequence update:	December 1, 2001
Last modified:	April 3, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.