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Protein

Tetraspanin-18

Gene

TSPAN18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraspanin-18
Short name:
Tspan-18
Gene namesi
Name:TSPAN18
ORF Names:UNQ3042/PRO9858
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:20660. TSPAN18.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1313CytoplasmicSequence analysisAdd
BLAST
Transmembranei14 – 3421HelicalSequence analysisAdd
BLAST
Topological domaini35 – 4915ExtracellularSequence analysisAdd
BLAST
Transmembranei50 – 7021HelicalSequence analysisAdd
BLAST
Topological domaini71 – 8313CytoplasmicSequence analysisAdd
BLAST
Transmembranei84 – 10421HelicalSequence analysisAdd
BLAST
Topological domaini105 – 223119ExtracellularSequence analysisAdd
BLAST
Transmembranei224 – 24421HelicalSequence analysisAdd
BLAST
Topological domaini245 – 2484CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670688.

Polymorphism and mutation databases

BioMutaiTSPAN18.
DMDMi68053316.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 248248Tetraspanin-18PRO_0000219268Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence analysis
Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ96SJ8.
PRIDEiQ96SJ8.

PTM databases

SwissPalmiQ96SJ8.

Expressioni

Gene expression databases

BgeeiQ96SJ8.
CleanExiHS_TSPAN18.
ExpressionAtlasiQ96SJ8. baseline and differential.
GenevisibleiQ96SJ8. HS.

Interactioni

Protein-protein interaction databases

BioGridi124669. 2 interactions.
IntActiQ96SJ8. 1 interaction.
STRINGi9606.ENSP00000339820.

Structurei

3D structure databases

ProteinModelPortaliQ96SJ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG107159.
InParanoidiQ96SJ8.
KOiK17353.
PhylomeDBiQ96SJ8.
TreeFamiTF352892.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96SJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGDCLSCMK YLMFVFNFFI FLGGACLLAI GIWVMVDPTG FREIVAANPL
60 70 80 90 100
LLTGAYILLA MGGLLFLLGF LGCCGAVREN KCLLLFFFLF ILIIFLAELS
110 120 130 140 150
AAILAFIFRE NLTREFFTKE LTKHYQGNND TDVFSATWNS VMITFGCCGV
160 170 180 190 200
NGPEDFKFAS VFRLLTLDSE EVPEACCRRE PQSRDGVLLS REECLLGRSL
210 220 230 240
FLNKQGCYTV ILNTFETYVY LAGALAIGVL AIELFAMIFA MCLFRGIQ
Length:248
Mass (Da):27,710
Last modified:December 1, 2001 - v1
Checksum:i6E2869E9D1D35C8E
GO

Sequence cautioni

The sequence BAC11690.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti133 – 1331V → I.1 Publication
Corresponds to variant rs2291334 [ dbSNP | Ensembl ].
VAR_057279

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027715 mRNA. Translation: BAB55318.1.
AK075547 mRNA. Translation: BAC11690.1. Different initiation.
AY358087 mRNA. Translation: AAQ88454.1.
CCDSiCCDS7910.1.
RefSeqiNP_570139.3. NM_130783.4.
XP_006718436.1. XM_006718373.2.
XP_011518761.1. XM_011520459.1.
UniGeneiHs.385634.

Genome annotation databases

EnsembliENST00000340160; ENSP00000339820; ENSG00000157570.
ENST00000520358; ENSP00000429993; ENSG00000157570.
GeneIDi90139.
KEGGihsa:90139.
UCSCiuc001mye.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027715 mRNA. Translation: BAB55318.1.
AK075547 mRNA. Translation: BAC11690.1. Different initiation.
AY358087 mRNA. Translation: AAQ88454.1.
CCDSiCCDS7910.1.
RefSeqiNP_570139.3. NM_130783.4.
XP_006718436.1. XM_006718373.2.
XP_011518761.1. XM_011520459.1.
UniGeneiHs.385634.

3D structure databases

ProteinModelPortaliQ96SJ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124669. 2 interactions.
IntActiQ96SJ8. 1 interaction.
STRINGi9606.ENSP00000339820.

PTM databases

SwissPalmiQ96SJ8.

Polymorphism and mutation databases

BioMutaiTSPAN18.
DMDMi68053316.

Proteomic databases

PaxDbiQ96SJ8.
PRIDEiQ96SJ8.

Protocols and materials databases

DNASUi90139.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340160; ENSP00000339820; ENSG00000157570.
ENST00000520358; ENSP00000429993; ENSG00000157570.
GeneIDi90139.
KEGGihsa:90139.
UCSCiuc001mye.5. human.

Organism-specific databases

CTDi90139.
GeneCardsiTSPAN18.
H-InvDBHIX0036374.
HGNCiHGNC:20660. TSPAN18.
neXtProtiNX_Q96SJ8.
PharmGKBiPA142670688.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3882. Eukaryota.
ENOG4111IRY. LUCA.
GeneTreeiENSGT00760000118983.
HOGENOMiHOG000230651.
HOVERGENiHBG107159.
InParanoidiQ96SJ8.
KOiK17353.
PhylomeDBiQ96SJ8.
TreeFamiTF352892.

Miscellaneous databases

ChiTaRSiTSPAN18. human.
GenomeRNAii90139.
NextBioi76551.
PROiQ96SJ8.

Gene expression databases

BgeeiQ96SJ8.
CleanExiHS_TSPAN18.
ExpressionAtlasiQ96SJ8. baseline and differential.
GenevisibleiQ96SJ8. HS.

Family and domain databases

InterProiIPR000301. Tetraspanin.
IPR018499. Tetraspanin/Peripherin.
IPR018503. Tetraspanin_CS.
IPR008952. Tetraspanin_EC2.
[Graphical view]
PfamiPF00335. Tetraspannin. 1 hit.
[Graphical view]
PIRSFiPIRSF002419. Tetraspanin. 1 hit.
PRINTSiPR00259. TMFOUR.
SUPFAMiSSF48652. SSF48652. 1 hit.
PROSITEiPS00421. TM4_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-133.

Entry informationi

Entry nameiTSN18_HUMAN
AccessioniPrimary (citable) accession number: Q96SJ8
Secondary accession number(s): Q6UY44, Q8NBI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 1, 2001
Last modified: March 16, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.