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Protein

Spermatid perinuclear RNA-binding protein

Gene

STRBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in spermatogenesis and sperm function. Plays a role in regulation of cell growth. Binds to double-stranded DNA and RNA. Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA PRM1 3'-UTR and adenovirus VA RNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, RNA-binding
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatid perinuclear RNA-binding protein
Gene namesi
Name:STRBP
Synonyms:SPNR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000165209.18.
HGNCiHGNC:16462. STRBP.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165209.
PharmGKBiPA38145.

Polymorphism and mutation databases

BioMutaiSTRBP.
DMDMi74752134.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002749171 – 672Spermatid perinuclear RNA-binding proteinAdd BLAST672

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei612Asymmetric dimethylarginineBy similarity1
Modified residuei617Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

EPDiQ96SI9.
PaxDbiQ96SI9.
PeptideAtlasiQ96SI9.
PRIDEiQ96SI9.

PTM databases

iPTMnetiQ96SI9.
PhosphoSitePlusiQ96SI9.
SwissPalmiQ96SI9.

Expressioni

Gene expression databases

BgeeiENSG00000165209.
CleanExiHS_STRBP.
ExpressionAtlasiQ96SI9. baseline and differential.
GenevisibleiQ96SI9. HS.

Organism-specific databases

HPAiHPA020651.

Interactioni

Subunit structurei

Interacts with EIF2AK2. Associates with microtubules; it is unsure whether such interaction is direct or indirect.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi120623. 62 interactors.
IntActiQ96SI9. 28 interactors.
MINTiMINT-1434039.
STRINGi9606.ENSP00000321347.

Structurei

Secondary structure

1672
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi385 – 387Combined sources3
Helixi390 – 398Combined sources9
Beta strandi405 – 411Combined sources7
Beta strandi413 – 415Combined sources3
Beta strandi417 – 424Combined sources8
Beta strandi427 – 435Combined sources9
Helixi436 – 451Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DMYNMR-A378-461[»]
ProteinModelPortaliQ96SI9.
SMRiQ96SI9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96SI9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 363DZFPROSITE-ProRule annotationAdd BLAST359
Domaini387 – 453DRBM 1PROSITE-ProRule annotationAdd BLAST67
Domaini510 – 576DRBM 2PROSITE-ProRule annotationAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi584 – 587Poly-Lys4

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IN2U. Eukaryota.
ENOG410Z2M4. LUCA.
GeneTreeiENSGT00550000074528.
HOVERGENiHBG069915.
InParanoidiQ96SI9.
KOiK13200.
OMAiQVEQCVD.
OrthoDBiEOG091G022L.
PhylomeDBiQ96SI9.
TreeFamiTF320194.

Family and domain databases

InterProiView protein in InterPro
IPR014720. dsRBD_dom.
IPR006561. DZF_dom.
IPR030446. STRBP.
PANTHERiPTHR10910:SF135. PTHR10910:SF135. 1 hit.
PfamiView protein in Pfam
PF00035. dsrm. 2 hits.
PF07528. DZF. 1 hit.
SMARTiView protein in SMART
SM00358. DSRM. 2 hits.
SM00572. DZF. 1 hit.
PROSITEiView protein in PROSITE
PS50137. DS_RBD. 2 hits.
PS51703. DZF. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96SI9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRSIRSFAND DRHVMVKHST IYPSPEELEA VQNMVSTVEC ALKHVSDWLD
60 70 80 90 100
ETNKGTKTEG ETEVKKDEAG ENYSKDQGGR TLCGVMRIGL VAKGLLIKDD
110 120 130 140 150
MDLELVLMCK DKPTETLLNT VKDNLPIQIQ KLTEEKYQVE QCVNEASIII
160 170 180 190 200
RNTKEPTLTL KVILTSPLIR DELEKKDGEN VSMKDPPDLL DRQKCLNALA
210 220 230 240 250
SLRHAKWFQA RANGLKSCVI VLRILRDLCN RVPTWAPLKG WPLELICEKS
260 270 280 290 300
IGTCNRPLGA GEALRRVMEC LASGILLPGG PGLHDPCERD PTDALSYMTI
310 320 330 340 350
QQKEDITHSA QHALRLSAFG QIYKVLEMDP LPSSKPFQKY SWSVTDKEGA
360 370 380 390 400
GSSALKRPFE DGLGDDKDPN KKMKRNLRKI LDSKAIDLMN ALMRLNQIRP
410 420 430 440 450
GLQYKLLSQS GPVHAPVFTM SVDVDGTTYE ASGPSKKTAK LHVAVKVLQA
460 470 480 490 500
MGYPTGFDAD IECMSSDEKS DNESKNETVS SNSSNNTGNS TTETSSTLEV
510 520 530 540 550
RTQGPILTAS GKNPVMELNE KRRGLKYELI SETGGSHDKR FVMEVEVDGQ
560 570 580 590 600
KFRGAGPNKK VAKASAALAA LEKLFSGPNA ANNKKKKIIP QAKGVVNTAV
610 620 630 640 650
SAAVQAVRGR GRGTLTRGAF VGATAAPGYI APGYGTPYGY STAAPAYGLP
660 670
KRMVLLPVMK FPTYPVPHYS FF
Length:672
Mass (Da):73,653
Last modified:December 1, 2001 - v1
Checksum:i26465F4D3A429FBC
GO
Isoform 2 (identifier: Q96SI9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: Missing.

Show »
Length:658
Mass (Da):71,967
Checksum:i131F93237EEF70B1
GO

Sequence cautioni

The sequence AAI08732 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA92120 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB14873 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti173 – 175LEK → IGRR in AAK20832 (Ref. 1) Curated3
Sequence conflicti196L → P in BAA92120 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035662280G → R in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0229371 – 14Missing in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF333337 mRNA. Translation: AAK20832.1.
AL136866 mRNA. Translation: CAB66800.1.
AK002169 mRNA. Translation: BAA92120.1. Different initiation.
AK024285 mRNA. Translation: BAB14873.1. Different initiation.
AK027890 mRNA. Translation: BAB55434.1.
AL365338 Genomic DNA. Translation: CAH70299.1.
AL365338 Genomic DNA. Translation: CAH70300.1.
BC002693 mRNA. Translation: AAH02693.2.
BC017732 mRNA. Translation: AAH17732.1.
BC108731 mRNA. Translation: AAI08732.1. Sequence problems.
CCDSiCCDS55337.1. [Q96SI9-2]
CCDS6851.1. [Q96SI9-1]
RefSeqiNP_001164608.1. NM_001171137.1. [Q96SI9-2]
NP_060857.2. NM_018387.4. [Q96SI9-1]
XP_016870383.1. XM_017014894.1. [Q96SI9-1]
XP_016870384.1. XM_017014895.1. [Q96SI9-1]
XP_016870385.1. XM_017014896.1. [Q96SI9-1]
UniGeneiHs.287659.
Hs.694157.

Genome annotation databases

EnsembliENST00000348403; ENSP00000321347; ENSG00000165209. [Q96SI9-1]
ENST00000360998; ENSP00000354271; ENSG00000165209. [Q96SI9-2]
ENST00000447404; ENSP00000415968; ENSG00000165209. [Q96SI9-1]
GeneIDi55342.
KEGGihsa:55342.
UCSCiuc004bnu.4. human. [Q96SI9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSTRBP_HUMAN
AccessioniPrimary (citable) accession number: Q96SI9
Secondary accession number(s): Q32NB9
, Q9BUE1, Q9BXG4, Q9H0B4, Q9H7V1, Q9NUK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 1, 2001
Last modified: September 27, 2017
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references