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Q96SI1

- KCD15_HUMAN

UniProt

Q96SI1 - KCD15_HUMAN

Protein

BTB/POZ domain-containing protein KCTD15

Gene

KCTD15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    During embryonic development, interferes with neural crest formation By similarity. Inhibits AP2 transcriptional activity by interaction with its activation domain.By similarity1 Publication

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. protein homooligomerization Source: InterPro

    Keywords - Molecular functioni

    Developmental protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    BTB/POZ domain-containing protein KCTD15
    Alternative name(s):
    Potassium channel tetramerization domain-containing protein 15
    Gene namesi
    Name:KCTD15
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:23297. KCTD15.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134916319.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 283283BTB/POZ domain-containing protein KCTD15PRO_0000247251Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei31 – 311Phosphoserine1 Publication
    Modified residuei35 – 351Phosphoserine3 Publications
    Modified residuei38 – 381Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96SI1.
    PaxDbiQ96SI1.
    PRIDEiQ96SI1.

    PTM databases

    PhosphoSiteiQ96SI1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96SI1.
    BgeeiQ96SI1.
    CleanExiHS_KCTD15.
    GenevestigatoriQ96SI1.

    Organism-specific databases

    HPAiHPA050822.

    Interactioni

    Subunit structurei

    Interacts with TFAP2A; this interaction inhibits TFAP2A transcriptional activation.1 Publication

    Protein-protein interaction databases

    BioGridi122506. 7 interactions.
    IntActiQ96SI1. 5 interactions.
    MINTiMINT-1381152.
    STRINGi9606.ENSP00000394390.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96SI1.
    SMRiQ96SI1. Positions 58-151.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini56 – 12671BTBAdd
    BLAST

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.Curated

    Phylogenomic databases

    eggNOGiNOG318666.
    HOGENOMiHOG000232179.
    HOVERGENiHBG055358.
    InParanoidiQ96SI1.
    OMAiLCREERR.
    PhylomeDBiQ96SI1.

    Family and domain databases

    Gene3Di3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR003131. T1-type_BTB.
    [Graphical view]
    PfamiPF02214. BTB_2. 1 hit.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96SI1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPHRKERPSG SSLHTHGSTG TAEGGNMSRL SLTRSPVSPL AAQGIPLPAQ    50
    LTKSNAPVHI DVGGHMYTSS LATLTKYPDS RISRLFNGTE PIVLDSLKQH 100
    YFIDRDGEIF RYVLSFLRTS KLLLPDDFKD FSLLYEEARY YQLQPMVREL 150
    ERWQQEQEQR RRSRACDCLV VRVTPDLGER IALSGEKALI EEVFPETGDV 200
    MCNSVNAGWN QDPTHVIRFP LNGYCRLNSV QVLERLFQRG FSVAASCGGG 250
    VDSSQFSEYV LCREERRPQP TPTAVRIKQE PLD 283
    Length:283
    Mass (Da):31,942
    Last modified:December 1, 2001 - v1
    Checksum:i29E2ED079DB4E5CC
    GO
    Isoform 2 (identifier: Q96SI1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         232-234: VLE → DVL
         235-283: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:234
    Mass (Da):26,476
    Checksum:i7D1A451215804C87
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti64 – 641G → S.1 Publication
    Corresponds to variant rs17849437 [ dbSNP | Ensembl ].
    VAR_027090

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei232 – 2343VLE → DVL in isoform 2. 1 PublicationVSP_019958
    Alternative sequencei235 – 28349Missing in isoform 2. 1 PublicationVSP_019959Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027901 mRNA. Translation: BAB55443.1.
    AK291465 mRNA. Translation: BAF84154.1.
    BC001185 mRNA. Translation: AAH01185.1.
    BC009335 mRNA. Translation: AAH09335.1.
    CCDSiCCDS12434.1. [Q96SI1-2]
    CCDS46039.1. [Q96SI1-1]
    RefSeqiNP_001123466.1. NM_001129994.1. [Q96SI1-1]
    NP_001123467.1. NM_001129995.1. [Q96SI1-1]
    NP_076981.2. NM_024076.2. [Q96SI1-2]
    UniGeneiHs.221873.
    Hs.606506.

    Genome annotation databases

    EnsembliENST00000284006; ENSP00000284006; ENSG00000153885. [Q96SI1-2]
    ENST00000430256; ENSP00000394390; ENSG00000153885. [Q96SI1-1]
    ENST00000588881; ENSP00000464812; ENSG00000153885. [Q96SI1-1]
    ENST00000589786; ENSP00000467612; ENSG00000153885. [Q96SI1-1]
    GeneIDi79047.
    KEGGihsa:79047.
    UCSCiuc002nuv.3. human. [Q96SI1-2]
    uc002nuw.4. human. [Q96SI1-1]

    Polymorphism databases

    DMDMi74732704.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027901 mRNA. Translation: BAB55443.1 .
    AK291465 mRNA. Translation: BAF84154.1 .
    BC001185 mRNA. Translation: AAH01185.1 .
    BC009335 mRNA. Translation: AAH09335.1 .
    CCDSi CCDS12434.1. [Q96SI1-2 ]
    CCDS46039.1. [Q96SI1-1 ]
    RefSeqi NP_001123466.1. NM_001129994.1. [Q96SI1-1 ]
    NP_001123467.1. NM_001129995.1. [Q96SI1-1 ]
    NP_076981.2. NM_024076.2. [Q96SI1-2 ]
    UniGenei Hs.221873.
    Hs.606506.

    3D structure databases

    ProteinModelPortali Q96SI1.
    SMRi Q96SI1. Positions 58-151.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122506. 7 interactions.
    IntActi Q96SI1. 5 interactions.
    MINTi MINT-1381152.
    STRINGi 9606.ENSP00000394390.

    PTM databases

    PhosphoSitei Q96SI1.

    Polymorphism databases

    DMDMi 74732704.

    Proteomic databases

    MaxQBi Q96SI1.
    PaxDbi Q96SI1.
    PRIDEi Q96SI1.

    Protocols and materials databases

    DNASUi 79047.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000284006 ; ENSP00000284006 ; ENSG00000153885 . [Q96SI1-2 ]
    ENST00000430256 ; ENSP00000394390 ; ENSG00000153885 . [Q96SI1-1 ]
    ENST00000588881 ; ENSP00000464812 ; ENSG00000153885 . [Q96SI1-1 ]
    ENST00000589786 ; ENSP00000467612 ; ENSG00000153885 . [Q96SI1-1 ]
    GeneIDi 79047.
    KEGGi hsa:79047.
    UCSCi uc002nuv.3. human. [Q96SI1-2 ]
    uc002nuw.4. human. [Q96SI1-1 ]

    Organism-specific databases

    CTDi 79047.
    GeneCardsi GC19P034287.
    HGNCi HGNC:23297. KCTD15.
    HPAi HPA050822.
    MIMi 615240. gene.
    neXtProti NX_Q96SI1.
    PharmGKBi PA134916319.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG318666.
    HOGENOMi HOG000232179.
    HOVERGENi HBG055358.
    InParanoidi Q96SI1.
    OMAi LCREERR.
    PhylomeDBi Q96SI1.

    Miscellaneous databases

    ChiTaRSi KCTD15. human.
    GeneWikii KCTD15.
    GenomeRNAii 79047.
    NextBioi 67787.
    PROi Q96SI1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96SI1.
    Bgeei Q96SI1.
    CleanExi HS_KCTD15.
    Genevestigatori Q96SI1.

    Family and domain databases

    Gene3Di 3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR003131. T1-type_BTB.
    [Graphical view ]
    Pfami PF02214. BTB_2. 1 hit.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT SER-64.
      Tissue: Brain.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31; SER-35 AND SER-38, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35 AND SER-38, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Inhibition of neural crest formation by Kctd15 involves regulation of transcription factor AP-2."
      Zarelli V.E., Dawid I.B.
      Proc. Natl. Acad. Sci. U.S.A. 110:2870-2875(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TFAP2A.

    Entry informationi

    Entry nameiKCD15_HUMAN
    AccessioniPrimary (citable) accession number: Q96SI1
    Secondary accession number(s): A8K600, Q9BVI6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3