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Q96SI1 (KCD15_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
BTB/POZ domain-containing protein KCTD15
Alternative name(s):
Potassium channel tetramerization domain-containing protein 15
Gene names
Name:KCTD15
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length283 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

During embryonic development, interferes with neural crest formation By similarity. Inhibits AP2 transcriptional activity by interaction with its activation domain. Ref.7

Subunit structure

Interacts with TFAP2A; this interaction inhibits TFAP2A transcriptional activation. Ref.7

Sequence similarities

Contains 1 BTB (POZ) domain.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Molecular functionDevelopmental protein
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

protein homooligomerization

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q96SI1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q96SI1-2)

The sequence of this isoform differs from the canonical sequence as follows:
     232-234: VLE → DVL
     235-283: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 283283BTB/POZ domain-containing protein KCTD15
PRO_0000247251

Regions

Domain56 – 12671BTB

Amino acid modifications

Modified residue311Phosphoserine Ref.3
Modified residue351Phosphoserine Ref.3 Ref.4 Ref.5
Modified residue381Phosphoserine Ref.3 Ref.5

Natural variations

Alternative sequence232 – 2343VLE → DVL in isoform 2.
VSP_019958
Alternative sequence235 – 28349Missing in isoform 2.
VSP_019959
Natural variant641G → S. Ref.2
Corresponds to variant rs17849437 [ dbSNP | Ensembl ].
VAR_027090

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 29E2ED079DB4E5CC

FASTA28331,942
        10         20         30         40         50         60 
MPHRKERPSG SSLHTHGSTG TAEGGNMSRL SLTRSPVSPL AAQGIPLPAQ LTKSNAPVHI 

        70         80         90        100        110        120 
DVGGHMYTSS LATLTKYPDS RISRLFNGTE PIVLDSLKQH YFIDRDGEIF RYVLSFLRTS 

       130        140        150        160        170        180 
KLLLPDDFKD FSLLYEEARY YQLQPMVREL ERWQQEQEQR RRSRACDCLV VRVTPDLGER 

       190        200        210        220        230        240 
IALSGEKALI EEVFPETGDV MCNSVNAGWN QDPTHVIRFP LNGYCRLNSV QVLERLFQRG 

       250        260        270        280 
FSVAASCGGG VDSSQFSEYV LCREERRPQP TPTAVRIKQE PLD 

« Hide

Isoform 2 [UniParc].

Checksum: 7D1A451215804C87
Show »

FASTA23426,476

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT SER-64.
Tissue: Brain.
[3]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31; SER-35 AND SER-38, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[4]"Large-scale proteomics analysis of the human kinome."
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G., Mann M., Daub H.
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35 AND SER-38, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Inhibition of neural crest formation by Kctd15 involves regulation of transcription factor AP-2."
Zarelli V.E., Dawid I.B.
Proc. Natl. Acad. Sci. U.S.A. 110:2870-2875(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH TFAP2A.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK027901 mRNA. Translation: BAB55443.1.
AK291465 mRNA. Translation: BAF84154.1.
BC001185 mRNA. Translation: AAH01185.1.
BC009335 mRNA. Translation: AAH09335.1.
CCDSCCDS12434.1. [Q96SI1-2]
CCDS46039.1. [Q96SI1-1]
RefSeqNP_001123466.1. NM_001129994.1. [Q96SI1-1]
NP_001123467.1. NM_001129995.1. [Q96SI1-1]
NP_076981.2. NM_024076.2. [Q96SI1-2]
UniGeneHs.221873.
Hs.606506.

3D structure databases

ProteinModelPortalQ96SI1.
SMRQ96SI1. Positions 58-151.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122506. 6 interactions.
IntActQ96SI1. 5 interactions.
MINTMINT-1381152.
STRING9606.ENSP00000394390.

PTM databases

PhosphoSiteQ96SI1.

Polymorphism databases

DMDM74732704.

Proteomic databases

MaxQBQ96SI1.
PaxDbQ96SI1.
PRIDEQ96SI1.

Protocols and materials databases

DNASU79047.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000284006; ENSP00000284006; ENSG00000153885. [Q96SI1-2]
ENST00000430256; ENSP00000394390; ENSG00000153885. [Q96SI1-1]
ENST00000588881; ENSP00000464812; ENSG00000153885. [Q96SI1-1]
ENST00000589786; ENSP00000467612; ENSG00000153885. [Q96SI1-1]
GeneID79047.
KEGGhsa:79047.
UCSCuc002nuv.3. human. [Q96SI1-2]
uc002nuw.4. human. [Q96SI1-1]

Organism-specific databases

CTD79047.
GeneCardsGC19P034287.
HGNCHGNC:23297. KCTD15.
HPAHPA050822.
MIM615240. gene.
neXtProtNX_Q96SI1.
PharmGKBPA134916319.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG318666.
HOGENOMHOG000232179.
HOVERGENHBG055358.
InParanoidQ96SI1.
OMALCREERR.
PhylomeDBQ96SI1.

Gene expression databases

ArrayExpressQ96SI1.
BgeeQ96SI1.
CleanExHS_KCTD15.
GenevestigatorQ96SI1.

Family and domain databases

Gene3D3.30.710.10. 1 hit.
InterProIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR003131. T1-type_BTB.
[Graphical view]
PfamPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMSSF54695. SSF54695. 1 hit.
ProtoNetSearch...

Other

ChiTaRSKCTD15. human.
GeneWikiKCTD15.
GenomeRNAi79047.
NextBio67787.
PROQ96SI1.
SOURCESearch...

Entry information

Entry nameKCD15_HUMAN
AccessionPrimary (citable) accession number: Q96SI1
Secondary accession number(s): A8K600, Q9BVI6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM