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Q96SI1

- KCD15_HUMAN

UniProt

Q96SI1 - KCD15_HUMAN

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Protein

BTB/POZ domain-containing protein KCTD15

Gene

KCTD15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain.By similarity1 Publication

GO - Biological processi

  1. multicellular organismal development Source: UniProtKB-KW
  2. protein homooligomerization Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD15
Alternative name(s):
Potassium channel tetramerization domain-containing protein 15
Gene namesi
Name:KCTD15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:23297. KCTD15.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134916319.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 283283BTB/POZ domain-containing protein KCTD15PRO_0000247251Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei31 – 311Phosphoserine1 Publication
Modified residuei35 – 351Phosphoserine3 Publications
Modified residuei38 – 381Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96SI1.
PaxDbiQ96SI1.
PRIDEiQ96SI1.

PTM databases

PhosphoSiteiQ96SI1.

Expressioni

Gene expression databases

BgeeiQ96SI1.
CleanExiHS_KCTD15.
ExpressionAtlasiQ96SI1. baseline and differential.
GenevestigatoriQ96SI1.

Organism-specific databases

HPAiHPA050822.

Interactioni

Subunit structurei

Interacts with TFAP2A; this interaction inhibits TFAP2A transcriptional activation.1 Publication

Protein-protein interaction databases

BioGridi122506. 10 interactions.
IntActiQ96SI1. 5 interactions.
MINTiMINT-1381152.
STRINGi9606.ENSP00000394390.

Structurei

3D structure databases

ProteinModelPortaliQ96SI1.
SMRiQ96SI1. Positions 58-151.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 12671BTBAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.Curated

Phylogenomic databases

eggNOGiNOG318666.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000232179.
HOVERGENiHBG055358.
InParanoidiQ96SI1.
OMAiLCREERR.
PhylomeDBiQ96SI1.

Family and domain databases

Gene3Di3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96SI1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPHRKERPSG SSLHTHGSTG TAEGGNMSRL SLTRSPVSPL AAQGIPLPAQ
60 70 80 90 100
LTKSNAPVHI DVGGHMYTSS LATLTKYPDS RISRLFNGTE PIVLDSLKQH
110 120 130 140 150
YFIDRDGEIF RYVLSFLRTS KLLLPDDFKD FSLLYEEARY YQLQPMVREL
160 170 180 190 200
ERWQQEQEQR RRSRACDCLV VRVTPDLGER IALSGEKALI EEVFPETGDV
210 220 230 240 250
MCNSVNAGWN QDPTHVIRFP LNGYCRLNSV QVLERLFQRG FSVAASCGGG
260 270 280
VDSSQFSEYV LCREERRPQP TPTAVRIKQE PLD
Length:283
Mass (Da):31,942
Last modified:December 1, 2001 - v1
Checksum:i29E2ED079DB4E5CC
GO
Isoform 2 (identifier: Q96SI1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-234: VLE → DVL
     235-283: Missing.

Note: No experimental confirmation available.

Show »
Length:234
Mass (Da):26,476
Checksum:i7D1A451215804C87
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti64 – 641G → S.1 Publication
Corresponds to variant rs17849437 [ dbSNP | Ensembl ].
VAR_027090

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei232 – 2343VLE → DVL in isoform 2. 1 PublicationVSP_019958
Alternative sequencei235 – 28349Missing in isoform 2. 1 PublicationVSP_019959Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027901 mRNA. Translation: BAB55443.1.
AK291465 mRNA. Translation: BAF84154.1.
BC001185 mRNA. Translation: AAH01185.1.
BC009335 mRNA. Translation: AAH09335.1.
CCDSiCCDS12434.1. [Q96SI1-2]
CCDS46039.1. [Q96SI1-1]
RefSeqiNP_001123466.1. NM_001129994.1. [Q96SI1-1]
NP_001123467.1. NM_001129995.1. [Q96SI1-1]
NP_076981.2. NM_024076.2. [Q96SI1-2]
UniGeneiHs.221873.
Hs.606506.

Genome annotation databases

EnsembliENST00000284006; ENSP00000284006; ENSG00000153885. [Q96SI1-2]
ENST00000430256; ENSP00000394390; ENSG00000153885. [Q96SI1-1]
ENST00000588881; ENSP00000464812; ENSG00000153885. [Q96SI1-1]
ENST00000589786; ENSP00000467612; ENSG00000153885. [Q96SI1-1]
GeneIDi79047.
KEGGihsa:79047.
UCSCiuc002nuv.3. human. [Q96SI1-2]
uc002nuw.4. human. [Q96SI1-1]

Polymorphism databases

DMDMi74732704.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027901 mRNA. Translation: BAB55443.1 .
AK291465 mRNA. Translation: BAF84154.1 .
BC001185 mRNA. Translation: AAH01185.1 .
BC009335 mRNA. Translation: AAH09335.1 .
CCDSi CCDS12434.1. [Q96SI1-2 ]
CCDS46039.1. [Q96SI1-1 ]
RefSeqi NP_001123466.1. NM_001129994.1. [Q96SI1-1 ]
NP_001123467.1. NM_001129995.1. [Q96SI1-1 ]
NP_076981.2. NM_024076.2. [Q96SI1-2 ]
UniGenei Hs.221873.
Hs.606506.

3D structure databases

ProteinModelPortali Q96SI1.
SMRi Q96SI1. Positions 58-151.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122506. 10 interactions.
IntActi Q96SI1. 5 interactions.
MINTi MINT-1381152.
STRINGi 9606.ENSP00000394390.

PTM databases

PhosphoSitei Q96SI1.

Polymorphism databases

DMDMi 74732704.

Proteomic databases

MaxQBi Q96SI1.
PaxDbi Q96SI1.
PRIDEi Q96SI1.

Protocols and materials databases

DNASUi 79047.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000284006 ; ENSP00000284006 ; ENSG00000153885 . [Q96SI1-2 ]
ENST00000430256 ; ENSP00000394390 ; ENSG00000153885 . [Q96SI1-1 ]
ENST00000588881 ; ENSP00000464812 ; ENSG00000153885 . [Q96SI1-1 ]
ENST00000589786 ; ENSP00000467612 ; ENSG00000153885 . [Q96SI1-1 ]
GeneIDi 79047.
KEGGi hsa:79047.
UCSCi uc002nuv.3. human. [Q96SI1-2 ]
uc002nuw.4. human. [Q96SI1-1 ]

Organism-specific databases

CTDi 79047.
GeneCardsi GC19P034287.
HGNCi HGNC:23297. KCTD15.
HPAi HPA050822.
MIMi 615240. gene.
neXtProti NX_Q96SI1.
PharmGKBi PA134916319.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG318666.
GeneTreei ENSGT00760000119013.
HOGENOMi HOG000232179.
HOVERGENi HBG055358.
InParanoidi Q96SI1.
OMAi LCREERR.
PhylomeDBi Q96SI1.

Miscellaneous databases

ChiTaRSi KCTD15. human.
GeneWikii KCTD15.
GenomeRNAii 79047.
NextBioi 67787.
PROi Q96SI1.
SOURCEi Search...

Gene expression databases

Bgeei Q96SI1.
CleanExi HS_KCTD15.
ExpressionAtlasi Q96SI1. baseline and differential.
Genevestigatori Q96SI1.

Family and domain databases

Gene3Di 3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR003131. T1-type_BTB.
[Graphical view ]
Pfami PF02214. BTB_2. 1 hit.
[Graphical view ]
SMARTi SM00225. BTB. 1 hit.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT SER-64.
    Tissue: Brain.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31; SER-35 AND SER-38, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-35 AND SER-38, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Inhibition of neural crest formation by Kctd15 involves regulation of transcription factor AP-2."
    Zarelli V.E., Dawid I.B.
    Proc. Natl. Acad. Sci. U.S.A. 110:2870-2875(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TFAP2A.

Entry informationi

Entry nameiKCD15_HUMAN
AccessioniPrimary (citable) accession number: Q96SI1
Secondary accession number(s): A8K600, Q9BVI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3