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Protein

BTB/POZ domain-containing protein KCTD15

Gene

KCTD15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

During embryonic development, interferes with neural crest formation (By similarity). Inhibits AP2 transcriptional activity by interaction with its activation domain.By similarity1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Enzyme and pathway databases

ReactomeiR-HSA-8866904. Negative regulation of activity of TFAP2 (AP-2) family transcription factors.

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD15
Alternative name(s):
Potassium channel tetramerization domain-containing protein 15
Gene namesi
Name:KCTD15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23297. KCTD15.

Pathology & Biotechi

Organism-specific databases

DisGeNETi79047.
OpenTargetsiENSG00000153885.
PharmGKBiPA134916319.

Polymorphism and mutation databases

BioMutaiKCTD15.
DMDMi74732704.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002472511 – 283BTB/POZ domain-containing protein KCTD15Add BLAST283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31PhosphoserineCombined sources1
Modified residuei35PhosphoserineCombined sources1
Modified residuei38PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96SI1.
MaxQBiQ96SI1.
PaxDbiQ96SI1.
PeptideAtlasiQ96SI1.
PRIDEiQ96SI1.

PTM databases

iPTMnetiQ96SI1.
PhosphoSitePlusiQ96SI1.

Expressioni

Gene expression databases

BgeeiENSG00000153885.
CleanExiHS_KCTD15.
ExpressionAtlasiQ96SI1. baseline and differential.
GenevisibleiQ96SI1. HS.

Organism-specific databases

HPAiHPA050822.

Interactioni

Subunit structurei

Interacts with TFAP2A; this interaction inhibits TFAP2A transcriptional activation.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
KCTD1Q719H93EBI-715783,EBI-9027502
NOTCH2NLQ7Z3S93EBI-715783,EBI-945833

Protein-protein interaction databases

BioGridi122506. 15 interactors.
IntActiQ96SI1. 9 interactors.
MINTiMINT-1381152.
STRINGi9606.ENSP00000394390.

Structurei

3D structure databases

ProteinModelPortaliQ96SI1.
SMRiQ96SI1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 126BTBAdd BLAST71

Sequence similaritiesi

Contains 1 BTB (POZ) domain.Curated

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000232179.
HOVERGENiHBG055358.
InParanoidiQ96SI1.
OMAiLCREERR.
OrthoDBiEOG091G0SU5.
PhylomeDBiQ96SI1.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96SI1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPHRKERPSG SSLHTHGSTG TAEGGNMSRL SLTRSPVSPL AAQGIPLPAQ
60 70 80 90 100
LTKSNAPVHI DVGGHMYTSS LATLTKYPDS RISRLFNGTE PIVLDSLKQH
110 120 130 140 150
YFIDRDGEIF RYVLSFLRTS KLLLPDDFKD FSLLYEEARY YQLQPMVREL
160 170 180 190 200
ERWQQEQEQR RRSRACDCLV VRVTPDLGER IALSGEKALI EEVFPETGDV
210 220 230 240 250
MCNSVNAGWN QDPTHVIRFP LNGYCRLNSV QVLERLFQRG FSVAASCGGG
260 270 280
VDSSQFSEYV LCREERRPQP TPTAVRIKQE PLD
Length:283
Mass (Da):31,942
Last modified:December 1, 2001 - v1
Checksum:i29E2ED079DB4E5CC
GO
Isoform 2 (identifier: Q96SI1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     232-234: VLE → DVL
     235-283: Missing.

Note: No experimental confirmation available.
Show »
Length:234
Mass (Da):26,476
Checksum:i7D1A451215804C87
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02709064G → S.1 PublicationCorresponds to variant rs17849437dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019958232 – 234VLE → DVL in isoform 2. 1 Publication3
Alternative sequenceiVSP_019959235 – 283Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027901 mRNA. Translation: BAB55443.1.
AK291465 mRNA. Translation: BAF84154.1.
BC001185 mRNA. Translation: AAH01185.1.
BC009335 mRNA. Translation: AAH09335.1.
CCDSiCCDS12434.1. [Q96SI1-2]
CCDS46039.1. [Q96SI1-1]
RefSeqiNP_001123466.1. NM_001129994.1. [Q96SI1-1]
NP_001123467.1. NM_001129995.1. [Q96SI1-1]
NP_076981.2. NM_024076.2. [Q96SI1-2]
XP_011525599.1. XM_011527297.2. [Q96SI1-1]
XP_011525600.1. XM_011527298.2. [Q96SI1-1]
XP_016882772.1. XM_017027283.1. [Q96SI1-1]
UniGeneiHs.221873.
Hs.606506.

Genome annotation databases

EnsembliENST00000284006; ENSP00000284006; ENSG00000153885. [Q96SI1-2]
ENST00000430256; ENSP00000394390; ENSG00000153885. [Q96SI1-1]
ENST00000588881; ENSP00000464812; ENSG00000153885. [Q96SI1-1]
ENST00000589786; ENSP00000467612; ENSG00000153885. [Q96SI1-1]
GeneIDi79047.
KEGGihsa:79047.
UCSCiuc002nuv.4. human. [Q96SI1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027901 mRNA. Translation: BAB55443.1.
AK291465 mRNA. Translation: BAF84154.1.
BC001185 mRNA. Translation: AAH01185.1.
BC009335 mRNA. Translation: AAH09335.1.
CCDSiCCDS12434.1. [Q96SI1-2]
CCDS46039.1. [Q96SI1-1]
RefSeqiNP_001123466.1. NM_001129994.1. [Q96SI1-1]
NP_001123467.1. NM_001129995.1. [Q96SI1-1]
NP_076981.2. NM_024076.2. [Q96SI1-2]
XP_011525599.1. XM_011527297.2. [Q96SI1-1]
XP_011525600.1. XM_011527298.2. [Q96SI1-1]
XP_016882772.1. XM_017027283.1. [Q96SI1-1]
UniGeneiHs.221873.
Hs.606506.

3D structure databases

ProteinModelPortaliQ96SI1.
SMRiQ96SI1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122506. 15 interactors.
IntActiQ96SI1. 9 interactors.
MINTiMINT-1381152.
STRINGi9606.ENSP00000394390.

PTM databases

iPTMnetiQ96SI1.
PhosphoSitePlusiQ96SI1.

Polymorphism and mutation databases

BioMutaiKCTD15.
DMDMi74732704.

Proteomic databases

EPDiQ96SI1.
MaxQBiQ96SI1.
PaxDbiQ96SI1.
PeptideAtlasiQ96SI1.
PRIDEiQ96SI1.

Protocols and materials databases

DNASUi79047.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000284006; ENSP00000284006; ENSG00000153885. [Q96SI1-2]
ENST00000430256; ENSP00000394390; ENSG00000153885. [Q96SI1-1]
ENST00000588881; ENSP00000464812; ENSG00000153885. [Q96SI1-1]
ENST00000589786; ENSP00000467612; ENSG00000153885. [Q96SI1-1]
GeneIDi79047.
KEGGihsa:79047.
UCSCiuc002nuv.4. human. [Q96SI1-1]

Organism-specific databases

CTDi79047.
DisGeNETi79047.
GeneCardsiKCTD15.
HGNCiHGNC:23297. KCTD15.
HPAiHPA050822.
MIMi615240. gene.
neXtProtiNX_Q96SI1.
OpenTargetsiENSG00000153885.
PharmGKBiPA134916319.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2723. Eukaryota.
ENOG410Z155. LUCA.
GeneTreeiENSGT00760000119013.
HOGENOMiHOG000232179.
HOVERGENiHBG055358.
InParanoidiQ96SI1.
OMAiLCREERR.
OrthoDBiEOG091G0SU5.
PhylomeDBiQ96SI1.

Enzyme and pathway databases

ReactomeiR-HSA-8866904. Negative regulation of activity of TFAP2 (AP-2) family transcription factors.

Miscellaneous databases

ChiTaRSiKCTD15. human.
GeneWikiiKCTD15.
GenomeRNAii79047.
PROiQ96SI1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153885.
CleanExiHS_KCTD15.
ExpressionAtlasiQ96SI1. baseline and differential.
GenevisibleiQ96SI1. HS.

Family and domain databases

InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
[Graphical view]
PfamiPF02214. BTB_2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKCD15_HUMAN
AccessioniPrimary (citable) accession number: Q96SI1
Secondary accession number(s): A8K600, Q9BVI6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.